PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATG4D	2	GABARAPL1	0	enzymatic study, enzymatic study	Betin VM (2009), Betin VM (2009)	2
CASP3	0	ATG4D	2	enzymatic study	Betin VM (2009)	1
CASP8	1	ATG4D	2	enzymatic study	Betin VM (2009)	1
ATG4D	2	GABARAPL2	0	enzymatic study	Betin VM (2009)	1
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
GOPC	5	ATG4D	2	affinity chromatography technology	Huttlin EL (2017)	1
P4HA2	3	ATG4D	2	affinity chromatography technology	Huttlin EL (2017)	1
GABARAPL1	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
IMPDH1	2	ATG4D	2	affinity chromatography technology	Huttlin EL (2017)	1