PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CEP19	0	ALDH3A2	1	bioid	Gupta GD (2015)	1
ELAC2	3	IPO7	3	biochemical	Kristensen AR (2012)	1
RABL2A	0	CEP19	0	two hybrid	Rolland T (2014)	1
DVL1	5	DVL3	7	two hybrid, affinity chromatography technology, pull down	Kishida S (1999), Kishida S (1999), Kishida S (1999)	3
CEP19	0	SDAD1	1	bioid	Gupta GD (2015)	1
CEP19	0	ILKAP	2	bioid	Gupta GD (2015)	1
CEP19	0	MTR	4	bioid	Gupta GD (2015)	1
STK24	3	CCT7	2	affinity chromatography technology	Goudreault M (2009)	1
VCP	6	PKN2	6	affinity chromatography technology	Yu CC (2013)	1
NCK2	2	WASF2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WDR83	1	GPATCH1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FKBP3	0	NMT1	4	biochemical	Kristensen AR (2012)	1
CEP19	0	RNH1	8	bioid	Gupta GD (2015)	1
DVL3	7	WDR83	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP19	0	HBS1L	3	bioid	Gupta GD (2015)	1
IPO9	8	IPO7	3	biochemical	Wan C (2015)	1
VCP	6	CCT7	2	affinity chromatography technology	Yu CC (2013)	1
TBCE	1	NMT1	4	affinity chromatography technology	Boldt K (2016)	1
CEP19	0	NUDT19	2	bioid	Gupta GD (2015)	1
CEP19	0	CRK	0	bioid	Gupta GD (2015)	1
CEP19	0	PLEKHA1	1	bioid	Gupta GD (2015)	1
CRK	0	STRN4	2	two hybrid	Grossmann A (2015)	1
CEP19	0	GPATCH1	3	bioid	Gupta GD (2015)	1
CEP192	5	CEP350	4	bioid	Firat-Karalar EN (2014)	1
PPP2R3C	1	CEP350	4	affinity chromatography technology	Hein MY (2015)	1
MAPRE1	0	CEP350	4	affinity chromatography technology	Hein MY (2015)	1
USP5	2	IPO9	8	biochemical	Kristensen AR (2012)	1
VCP	6	TRIP12	20	affinity chromatography technology	Yu CC (2013)	1
AP3M1	2	FERMT2	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP19	0	KIAA1958	5	two hybrid	Rolland T (2014)	1
CEP19	0	COPB2	3	bioid	Gupta GD (2015)	1
CEP19	0	SRP72	5	bioid	Gupta GD (2015)	1
RABL2B	0	CEP19	0	two hybrid	Rual JF (2005)	1
CEP19	0	CCT7	2	bioid	Gupta GD (2015)	1
REL	5	CEP19	0	two hybrid	Rolland T (2014)	1
ZBTB14	2	CEP19	0	two hybrid	Rolland T (2014)	1
CEP19	0	LTV1	1	bioid	Gupta GD (2015)	1
CEP19	0	MGEA5	3	bioid	Gupta GD (2015)	1
CEP19	0	PPP6C	7	bioid	Gupta GD (2015)	1
CEP19	0	NCAPH	2	bioid	Gupta GD (2015)	1
USP5	2	YTHDF2	0	biochemical	Wan C (2015)	1
AP3M1	2	AP3D1	7	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kristensen AR (2012), Ivan V (2012), Wan C (2015), Huttlin EL (2017)	4
CEP19	0	CEP192	5	bioid	Gupta GD (2015)	1
CEP19	0	STRN4	2	bioid	Gupta GD (2015)	1
KIFAP3	1	CEP350	4	affinity chromatography technology	Hein MY (2015)	1
CALCOCO1	2	CEP19	0	two hybrid	Rolland T (2014)	1
CEP19	0	DVL3	7	bioid	Gupta GD (2015)	1
CEP19	0	MTMR6	2	bioid	Gupta GD (2015)	1
NCK2	2	PKN2	6	affinity chromatography technology	Braverman LE (1999)	1
ANKRD28	1	CEP192	5	bioid	Couzens AL (2013)	1
MSH2	4	MSH6	2	biochemical, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, biochemical, affinity chromatography technology, imaging technique	Wang Y (2000), Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Matton N (2000), Matton N (2000), Yang Q (2004), Havugimana PC (2012), Gradia S (1997), Owen BA (2009), Wan C (2015), Hein MY (2015), Chen TC (2014)	15
CEP19	0	CC2D1A	1	bioid	Gupta GD (2015)	1
CEP19	0	METTL3	2	bioid	Gupta GD (2015)	1
CEP19	0	NCK2	2	bioid	Gupta GD (2015)	1
CRK	0	PIK3R3	0	affinity chromatography technology, two hybrid	Brehme M (2009), Grossmann A (2015)	2
CEP19	0	HMGB2	2	bioid	Gupta GD (2015)	1
FGFR1OP	0	CEP19	0	two hybrid, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	5
CRK	0	WDR83	1	two hybrid	Grossmann A (2015)	1
CEP19	0	SLTM	2	bioid	Gupta GD (2015)	1
SMARCAD1	1	MSH2	4	affinity chromatography technology	Rowbotham SP (2011)	1
CEP19	0	ANKRD28	1	bioid	Gupta GD (2015)	1
SMARCAD1	1	GTF3C3	2	affinity chromatography technology	Rowbotham SP (2011)	1
CEP19	0	MSH2	4	bioid	Gupta GD (2015)	1
CEP19	0	MKL1	2	bioid	Gupta GD (2015)	1
CEP19	0	GTF3C3	2	bioid	Gupta GD (2015)	1
CEP19	0	INTS9	1	bioid	Gupta GD (2015)	1
FGFR1OP	0	WDR83	1	bioid	Gupta GD (2015)	1
DVL1	5	NCK2	2	two hybrid	Rolland T (2014)	1
VCP	6	GTF3C3	2	affinity chromatography technology	Yu CC (2013)	1
VCP	6	FERMT2	0	affinity chromatography technology	Yu CC (2013)	1
CEP19	0	SCYL3	0	bioid	Gupta GD (2015)	1
RABL2A	0	SEC23IP	3	affinity chromatography technology	Huttlin EL (2017)	1
SMARCAD1	1	ANAPC1	1	affinity chromatography technology	Rowbotham SP (2011)	1
CEP19	0	TSR1	1	bioid	Gupta GD (2015)	1
CEP19	0	NT5C2	1	bioid	Gupta GD (2015)	1
ABLIM1	3	NMT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP19	0	ZNF280C	0	bioid	Gupta GD (2015)	1
CEP19	0	UNC45A	1	bioid	Gupta GD (2015)	1
VCP	6	PPP6C	7	affinity chromatography technology	Yu CC (2013)	1
CEP19	0	YTHDF2	0	bioid	Gupta GD (2015)	1
TRIP12	20	GNL3	3	affinity chromatography technology	Lo D (2014)	1
CEP19	0	PDCD4	2	bioid	Gupta GD (2015)	1
DVL2	5	USP5	2	two hybrid	Rual JF (2005)	1
VCP	6	CEP19	0	two hybrid	Rolland T (2014)	1
CEP19	0	PARD3	5	bioid	Gupta GD (2015)	1
CEP19	0	EDC3	1	bioid	Gupta GD (2015)	1
STK24	3	STRN4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Goudreault M (2009), Varjosalo M (2013)	3
CEP19	0	ELAC2	3	bioid	Gupta GD (2015)	1
RABL6	3	AP3M1	2	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
CEP19	0	MSH6	2	bioid	Gupta GD (2015)	1
CEP19	0	PPP2R3C	1	bioid	Gupta GD (2015)	1
CEP19	0	PWP2	2	bioid	Gupta GD (2015)	1
CEP19	0	GPX1	0	bioid	Gupta GD (2015)	1
CEP19	0	MAPRE1	0	bioid	Gupta GD (2015)	1
CCDC102B	0	CEP19	0	two hybrid	Rolland T (2014)	1
CEP19	0	SRPK1	2	bioid	Gupta GD (2015)	1
CEP19	0	PIN1	0	bioid	Gupta GD (2015)	1
SRPK1	2	NCK2	2	enzymatic study	Varjosalo M (2013)	1
CEP19	0	FKBP3	0	bioid	Gupta GD (2015)	1
CEP19	0	STK24	3	bioid	Gupta GD (2015)	1
CEP19	0	SMARCAD1	1	bioid	Gupta GD (2015)	1
CEP19	0	ANAPC1	1	bioid	Gupta GD (2015)	1
CEP19	0	RCOR3	0	bioid	Gupta GD (2015)	1
FGFR1OP	0	GPATCH1	3	bioid	Gupta GD (2015)	1
CEP19	0	CDC123	1	bioid	Gupta GD (2015)	1
VCP	6	NCAPH	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Hein MY (2015)	2
ELAC2	3	FERMT2	0	biochemical	Wan C (2015)	1
CEP19	0	PDLIM5	0	bioid	Gupta GD (2015)	1
CEP19	0	IPO9	8	bioid	Gupta GD (2015)	1
CEP19	0	DVL2	5	bioid	Gupta GD (2015)	1
CEP19	0	ZC3H15	2	bioid	Gupta GD (2015)	1
CEP19	0	DICER1	4	bioid	Gupta GD (2015)	1
CEP19	0	SEC23IP	3	bioid	Gupta GD (2015)	1
CEP19	0	FERMT2	0	bioid	Gupta GD (2015)	1
CEP19	0	SYNE4	1	two hybrid	Rolland T (2014)	1
CEP19	0	SCRIB	8	bioid	Gupta GD (2015)	1
CEP19	0	PKN2	6	bioid	Gupta GD (2015)	1
CEP19	0	WASF2	0	bioid	Gupta GD (2015)	1
AK4	2	CEP19	0	two hybrid	Wang J (2011)	1
MAPRE1	0	FGFR1OP	0	affinity chromatography technology	Hein MY (2015)	1
VCP	6	PDCD4	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013)	2
CEP19	0	CEP350	4	bioid	Gupta GD (2015)	1
ANKRD28	1	PPP6R3	2	affinity chromatography technology, affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
CEP19	0	UPF1	8	bioid	Gupta GD (2015)	1
CEP19	0	ECD	3	bioid	Gupta GD (2015)	1
CEP19	0	ABLIM1	3	bioid	Gupta GD (2015)	1
WDR83	1	CCT7	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP19	0	R3HCC1L	0	bioid	Gupta GD (2015)	1
CEP19	0	AP3M1	2	bioid	Gupta GD (2015)	1
CEP19	0	DVL1	5	bioid	Gupta GD (2015)	1
SMARCAD1	1	MSH6	2	affinity chromatography technology	Rowbotham SP (2011)	1
PPP6C	7	ANKRD28	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng K (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), St-Denis N (2016), Yadav L (2017)	6
CEP19	0	GNL3	3	bioid	Gupta GD (2015)	1
CEP19	0	TRIP12	20	bioid	Gupta GD (2015)	1
CEP19	0	KCTD12	0	bioid	Gupta GD (2015)	1
RCOR3	0	CCDC102B	0	two hybrid	Rolland T (2014)	1
SRPK1	2	FKBP3	0	enzymatic study	Varjosalo M (2013)	1
CEP19	0	NVL	5	bioid	Gupta GD (2015)	1
KXD1	1	CEP19	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CEP19	0	NMT1	4	bioid	Gupta GD (2015)	1
EDC3	1	23380	0	affinity chromatography technology	Boldt K (2016)	1
TSR1	1	LTV1	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
UPF1	8	EDC3	1	affinity chromatography technology	Fenger-Gron M (2005)	1
CEP19	0	WDR83	1	bioid	Gupta GD (2015)	1
CEP19	0	RABL6	3	bioid	Gupta GD (2015)	1
FGFR1OP	0	CC2D1A	1	bioid	Gupta GD (2015)	1
CEP19	0	USP5	2	bioid	Gupta GD (2015)	1
CEP19	0	YTHDF3	6	bioid	Gupta GD (2015)	1
PPP6C	7	CCT7	2	affinity chromatography technology	Yadav L (2017)	1
CEP19	0	CREB3L2	0	two hybrid	Wang J (2011)	1
PIN1	0	ZBTB14	2	two hybrid	Rolland T (2014)	1
FGFR1OP	0	CEP350	4	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Huttlin EL (2015), Gupta GD (2015), Hein MY (2015), Huttlin EL (2017)	5
CEP19	0	PPP6R3	2	bioid	Gupta GD (2015)	1
REL	5	NCK2	2	two hybrid	Rolland T (2014)	1
CEP19	0	IPO7	3	bioid	Gupta GD (2015)	1
NT5C2	1	USP5	2	biochemical	Kristensen AR (2012)	1
FGFR1OP	0	PPP2R3C	1	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
DVL1	5	DVL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2015), Huttlin EL (2017)	3
DVL2	5	DVL3	7	affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2017)	2
CCDC102B	0	EDC3	1	affinity chromatography technology	Huttlin EL (2017)	1
SRPK1	2	HBS1L	3	enzymatic study	Varjosalo M (2013)	1
CEP19	0	23380	0	bioid	Gupta GD (2015)	1
CEP19	0	PUS1	0	bioid	Gupta GD (2015)	1
MAPRE1	0	ABLIM1	3	affinity chromatography technology	Hein MY (2015)	1
PPP6C	7	PPP6R3	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, bioid, biochemical, affinity chromatography technology, affinity chromatography technology	Zeng K (2010), Douglas P (2010), Havugimana PC (2012), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Wan C (2015), St-Denis N (2016), Yadav L (2017)	9
CEP19	0	KIFAP3	1	bioid	Gupta GD (2015)	1
FGFR1OP	0	UNC45A	1	bioid	Gupta GD (2015)	1
ECD	3	WDR83	1	affinity chromatography technology	Huttlin EL (2017)	1
PIK3R3	0	VCP	6	two hybrid	Grossmann A (2015)	1
CEP19	0	TBCE	1	bioid	Gupta GD (2015)	1
PIK3R3	0	CEP19	0	two hybrid	Grossmann A (2015)	1
SRP9	0	SRP72	5	affinity chromatography technology	Huttlin EL (2017)	1
CEP19	0	PIP4K2B	2	bioid	Gupta GD (2015)	1
CEP19	0	AP3D1	7	bioid	Gupta GD (2015)	1
CEP19	0	SRP9	0	bioid	Gupta GD (2015)	1