PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CREBBP	29	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chuang HC (2006), Chuang HC (2006), Chuang HC (2006), Chuang HC (2006)	4
GCM1	2	SKP1	0	affinity chromatography technology	Yang CS (2005)	1
GCM1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Chuang HC (2006), Chuang HC (2006)	2
HDAC1	4	SENP1	0	affinity chromatography technology	Cheng J (2004)	1
GCM1	2	HDAC5	4	affinity chromatography technology, affinity chromatography technology	Chuang HC (2006), Chuang HC (2006)	2
GCM1	2	CUL1	7	affinity chromatography technology	Yang CS (2005)	1
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
DUSP23	1	GCM1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Lin FY (2011), Lin FY (2011), Lin FY (2011), Lin FY (2011), Lin FY (2011)	5
HDAC4	10	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Fischle W (2002), Fischle W (2002), Fischle W (2001), Grozinger CM (2000), Wang X (2008)	7
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
FBXW2	0	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Busino L (2012), Saiga T (2009), Watanabe N (2004), Winston JT (1999), Tian X (2015), Hauri S (2016)	9
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
GCM1	2	UBE2I	0	affinity chromatography technology, pull down	Chou CC (2007), Chou CC (2007)	2
GCM1	2	CREBBP	29	affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Chang CW (2005), Chang CW (2005), Chang CW (2005), Chang CW (2005), Chang CW (2005), Lin FY (2011)	6
GCM1	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chuang HC (2006), Chuang HC (2006), Chuang HC (2006), Chuang HC (2006)	4
CAMK1	4	GCM1	2	enzymatic study	Chang CW (2011)	1
HDAC5	4	CAMK1	4	affinity chromatography technology	Backs J (2006)	1
GCM1	2	SENP1	0	affinity chromatography technology, affinity chromatography technology, pull down	Chang CW (2011), Chang CW (2011), Chang CW (2011)	3
UBE2I	0	HDAC4	10	enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Knipscheer P (2008), Zhao X (2005), Zhao X (2005), Dehennaut V (2013), Tatham MH (2001), Knipscheer P (2007)	6
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
GCM1	2	HDAC4	10	affinity chromatography technology, affinity chromatography technology	Chuang HC (2006), Chuang HC (2006)	2
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
GCM1	2	FBXW2	0	affinity chromatography technology, affinity chromatography technology	Yang CS (2005), Wang CC (2013)	2
HDAC4	10	SENP1	0	imaging technique	Maciejewska-Rodrigues H (2010)	1
FBXW2	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Saiga T (2009), Bennett EJ (2010), Busino L (2003), Liu B (2012), Low TY (2014), Xu J (2017), Reitsma JM (2017)	8
HDAC4	10	CAMK1	4	affinity chromatography technology	Backs J (2006)	1
HDAC5	4	UBE2I	0	two hybrid	Zhao X (2005)	1