PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK6	1	RBL1	1	two hybrid	Vinayagam A (2011)	1
DGKZ	6	PARD6A	0	affinity chromatography technology	Iturrioz X (2007)	1
PIK3CA	8	DGKZ	6	enzymatic study, affinity chromatography technology	Luo B (2003), Luo B (2003)	2
TP53	0	DGKZ	6	affinity chromatography technology, affinity chromatography technology, pull down	Tanaka T (2013), Tanaka T (2013), Tanaka T (2013)	3
XPO1	8	ARRB2	5	affinity chromatography technology	Kirli K (2015)	1
PARD6A	0	VHL	0	affinity chromatography technology, affinity chromatography technology	Schermer B (2006), Schermer B (2006)	2
XPO1	8	SNTB2	4	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	POLR2M	0	affinity chromatography technology	Kirli K (2015)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
MAPK6	1	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
HRAS	2	TP53	0	affinity chromatography technology	Aylon Y (2010)	1
VHL	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2006), Roe JS (2006), Lai Y (2011), Lai Y (2011)	5
XPO1	8	DGKZ	6	affinity chromatography technology	Kirli K (2015)	1
ARRB1	2	DGKZ	6	affinity chromatography technology	Xiao K (2007)	1
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
VHL	0	RASGRP1	3	affinity chromatography technology	Ewing RM (2007)	1
SAT1	0	DGKZ	6	two hybrid	Stelzl U (2005)	1
DGKZ	6	RBL1	1	affinity chromatography technology	Los AP (2006)	1
POLR2M	0	DGKZ	6	two hybrid	Stelzl U (2005)	1
DGKZ	6	SNTB1	1	pull down	Hogan A (2001)	1
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
DGKZ	6	PLCG1	6	affinity chromatography technology	Luo B (2003)	1
DGKZ	6	HRAS	2	affinity chromatography technology	Topham MK (2001)	1
PIK3CA	8	HRAS	2	pull down, two hybrid, pull down	Vargiu P (2004), Li W (2000), Rodriguez-Viciana P (1996)	3
DGKZ	6	RB1	2	affinity chromatography technology	Los AP (2006)	1
DGKZ	6	SNTA1	1	pull down	Hogan A (2001)	1
DGKZ	6	RASGRP1	3	affinity chromatography technology	Topham MK (2001)	1
ARRB2	5	DGKZ	6	affinity chromatography technology	Xiao K (2007)	1
CBX8	3	DGKZ	6	affinity chromatography technology	Vandamme J (2011)	1
DGKZ	6	VHL	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Iturrioz X (2007), Iturrioz X (2007), Iturrioz X (2007)	3
DGKZ	6	SNTB2	4	pull down	Hogan A (2001)	1
MAPK6	1	DGKZ	6	two hybrid	Vinayagam A (2011)	1
SAT1	0	TP53	0	two hybrid	Stelzl U (2005)	1
DGKZ	6	RBL2	5	affinity chromatography technology	Los AP (2006)	1