PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKAB2	0	RIMBP3	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
MVP	1	RIMBP3	0	two hybrid	Corominas R (2014)	1
NOXA1	0	RIMBP3	0	two hybrid	Rolland T (2014)	1
ARNT2	5	RIMBP3	0	two hybrid	Corominas R (2014)	1
POLR1C	2	RIMBP3	0	two hybrid	Rolland T (2014)	1
RIMBP3	0	CATSPER1	2	two hybrid	Rolland T (2014)	1
MVP	1	AES	2	two hybrid	Corominas R (2014)	1
DGCR6	0	ARNT2	5	two hybrid	Corominas R (2014)	1
DGCR6L	0	RIMBP3	0	two hybrid	Rolland T (2014)	1
DGCR6	0	AES	2	two hybrid	Corominas R (2014)	1
DGCR6	0	RIMBP3	0	two hybrid	Corominas R (2014)	1
TRAF3IP2	0	RIMBP3	0	two hybrid	Rolland T (2014)	1
CREB5	4	RIMBP3	0	two hybrid	Rolland T (2014)	1
RIMBP3	0	ZNF488	0	two hybrid	Rolland T (2014)	1
RIMBP3	0	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PPIL1	1	RIMBP3	0	two hybrid	Rolland T (2014)	1
FANCL	0	RIMBP3	0	two hybrid	Rolland T (2014)	1
ARNT2	5	DTX2	3	two hybrid	Corominas R (2014)	1
PRKAA1	2	RIMBP3	0	two hybrid	Rolland T (2014)	1
AES	2	PRKAA1	2	two hybrid	Rolland T (2014)	1
CTBP2	7	RIMBP3	0	two hybrid	Rolland T (2014)	1
PRKAA1	2	PRKAB2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Al-Hakim AK (2005), Wang J (2011), Varjosalo M (2013), Corominas R (2014), Rolland T (2014), So J (2015), Wan C (2015), Huttlin EL (2017)	10
AES	2	RIMBP3	0	two hybrid	Rolland T (2014)	1
AQP1	1	RIMBP3	0	two hybrid	Rolland T (2014)	1