PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LNX1	7	PPFIA3	5	affinity chromatography technology	Lenihan JA (2017)	1
PPFIA2	8	GIT1	10	two hybrid, pull down	Ko J (2003), Ko J (2003)	2
PPFIA3	5	PPFIA3	5	two hybrid	Serra-Pages C (1998)	1
PPP2CA	7	PPFIA1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	6
PPFIA2	8	PPFIBP1	0	two hybrid	Serra-Pages C (1998)	1
PTPRF	9	PPFIA1	5	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Pulido R (1995), Pulido R (1995), Pulido R (1995), Serra-Pages C (1995), Serra-Pages C (1998), Serra-Pages C (1998), St-Denis N (2016)	7
PTPRS	15	PTPRD	6	two hybrid, affinity chromatography technology	Wallace MJ (1998), Wallace MJ (1998)	2
PTPRF	9	PPFIA2	8	two hybrid, affinity chromatography technology	Serra-Pages C (1998), Serra-Pages C (1998)	2
TRIM25	5	PPP2CA	7	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PTPRS	15	affinity chromatography technology	Choudhury NR (2017)	1
PPP2CB	1	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Fogeron ML (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	15
PPFIA3	5	GIT1	10	two hybrid, pull down	Ko J (2003), Ko J (2003)	2
PPFIA3	5	ERC2	7	two hybrid, pull down	Ko J (2003), Ko J (2003)	2
PPP2CB	1	PPFIA3	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), St-Denis N (2016)	2
PPP2R1A	8	PPFIA1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Fogeron ML (2013), Hein MY (2015), Yadav L (2017), Yadav L (2017)	6
PTPRS	15	PPFIA3	5	two hybrid	Serra-Pages C (1998)	1
TRIM25	5	PPFIA1	5	affinity chromatography technology	Choudhury NR (2017)	1
EMILIN1	1	PPFIA3	5	affinity chromatography technology	Huttlin EL (2017)	1
PPP2R1A	8	PPFIBP1	0	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	PTPRF	9	affinity chromatography technology	Choudhury NR (2017)	1
LNX1	7	ERC2	7	affinity chromatography technology, imaging technique	Lenihan JA (2017), Lenihan JA (2017)	2
TRIM25	5	PPFIA3	5	affinity chromatography technology	Choudhury NR (2017)	1
PPP2R1A	8	PPFIA3	5	affinity chromatography technology, affinity chromatography technology, bioid	Fogeron ML (2013), Yadav L (2017), Yadav L (2017)	3
PTPRD	6	PPFIA1	5	two hybrid, pull down, two hybrid	Pulido R (1995), Pulido R (1995), Serra-Pages C (1998)	3
RAB3IL1	0	PPFIA3	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTPRF	9	PPFIA3	5	two hybrid	Serra-Pages C (1998)	1
PPP2CA	7	PPFIA3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), St-Denis N (2016), Yadav L (2017)	3
PPFIA2	8	ERC2	7	two hybrid, pull down, affinity chromatography technology	Ko J (2003), Ko J (2003), Ko J (2003)	3
PTPRS	15	PTPRF	9	bioid	St-Denis N (2016)	1
PPP2R1A	8	PPFIA2	8	affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Yadav L (2017), Yadav L (2017)	3
PPFIA1	5	PPFIA3	5	two hybrid	Serra-Pages C (1998)	1
PPFIA1	5	PPFIA2	8	pull down, pull down	Serra-Pages C (1998), Serra-Pages C (1998)	2
PPFIA1	5	GIT1	10	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003)	7
PPFIA1	5	PTPRS	15	two hybrid, pull down, two hybrid, bioid	Pulido R (1995), Pulido R (1995), Serra-Pages C (1998), St-Denis N (2016)	4
GPS2	0	PPFIA3	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPFIA3	5	PPFIBP1	0	two hybrid	Serra-Pages C (1998)	1
LNX1	7	PPP2R1A	8	affinity chromatography technology	Lenihan JA (2017)	1
PPFIA1	5	ERC2	7	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003)	4
LNX1	7	PPFIA1	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Lenihan JA (2017), Lenihan JA (2017), Lenihan JA (2017)	3
PTPRS	15	PPFIA2	8	two hybrid	Serra-Pages C (1998)	1
PPFIA2	8	PPFIA3	5	two hybrid	Serra-Pages C (1998)	1
TRIM25	5	PPP2CB	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PPP2R1A	8	affinity chromatography technology	Choudhury NR (2017)	1
PPFIA1	5	PPFIBP1	0	two hybrid	Serra-Pages C (1998)	1
PPP2CA	7	PPFIA2	8	affinity chromatography technology	Goudreault M (2009)	1
PTPRD	6	PPFIA3	5	two hybrid	Serra-Pages C (1998)	1
ERC2	7	GIT1	10	affinity chromatography technology	Ko J (2003)	1
GIT1	10	PTPRF	9	affinity chromatography technology	Ko J (2003)	1
PTPRD	6	PPFIA2	8	two hybrid	Serra-Pages C (1998)	1
PPP2CB	1	PPP2CA	7	biochemical, affinity chromatography technology	Wan C (2015), St-Denis N (2016)	2
TRIM25	5	PTPRD	6	affinity chromatography technology	Choudhury NR (2017)	1
LNX1	7	PPP2CA	7	affinity chromatography technology	Lenihan JA (2017)	1
GPS2	0	PPFIA1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP2CB	1	PPFIA1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017)	5
PPP2CA	7	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Kong M (2009), Kong M (2009), Shamay M (2012), Havugimana PC (2012), Junttila MR (2007), Junttila MR (2007), Nazarenko I (2007), Kristensen AR (2012), Fogeron ML (2013), Sablina AA (2010), Lee CW (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Cianfanelli V (2015), St-Denis N (2016), Bryant JC (1999), Shouse GP (2011), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	30