Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
LGR5	8549	CIMETIDINE	CHEMBL30	agonist	GuideToPharmacologyInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
LGR5	rs17109924	CC + CT	fluorouracil	efficacy	yes	Patients who received 5-fluorouracil-based adjuvant chemotherapy and underwent surgery, who carried at least one C allele, had significantly increased time to tumor recurrence as compared to those with the TT genotype. No association was seen for patients who only underwent surgery (p=0.728; n=208).	Genotypes CC + CT is associated with increased response to fluorouracil in people with Colonic Neoplasms as compared to genotype TT.	25665511	1446903250