PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
MAPK6	1	MAPKAPK5	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Vinayagam A (2011), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2017), Rodriguez J (2016)	6
TP53	0	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan J (2008), Fan J (2008), Kim SJ (2012)	3
STK40	4	MAPK6	1	affinity chromatography technology	Durzynska I (2017)	1
SRPK1	2	MAPK14	0	enzymatic study	Varjosalo M (2013)	1
CDCA8	0	MAPKAPK5	0	two hybrid	Wang J (2011)	1
SRPK1	2	MAPKAPK5	0	enzymatic study	Varjosalo M (2013)	1
LSR	0	MAPKAPK5	0	two hybrid	Wang J (2011)	1
STK40	4	TAB1	1	affinity chromatography technology	Durzynska I (2017)	1
SRPK2	1	RPL13	2	enzymatic study	Lipp JJ (2015)	1
MAPKAPK5	0	EIF4EBP1	1	imaging technique	Chen TC (2014)	1
MAPKAPK2	1	HSPB1	2	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Rane MJ (2001), Uddin S (2002), Coxon PY (2003), Rogalla T (1999), Werz O (2002), Clifton AD (1996), Rane MJ (2001), Sun L (2007), Chen TC (2014), Krump E (1997), Chrestensen CA (2004), Chang E (2011), Maitra S (2008), Rane MJ (2003), Singh S (2003), Chen G (2000), Eyers CE (2005), Tollenaere MA (2015)	18
MAPKAPK5	0	HSPB2	1	enzymatic study	New L (1998)	1
MAPK6	1	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
MAPKAPK5	0	ZNF282	1	two hybrid	Vinayagam A (2011)	1
SRPK1	2	TP53	0	two hybrid, pull down, affinity chromatography technology	Peidis P (2011), Peidis P (2011), Peidis P (2011)	3
TP53	0	MAPK9	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Hu MC (1997), Lin Y (2002), Li Y (2012)	3
MAPKAPK5	0	MAPKAPK5	0	enzymatic study	Kostenko S (2009)	1
MAPKAPK5	0	RPL13	2	two hybrid	Vinayagam A (2011)	1
MAPKAPK5	0	MAPK1	1	imaging technique	Chen TC (2014)	1
MAPK14	0	HSPB1	2	enzymatic study	Morley SJ (2000)	1
PARK7	0	MAPKAPK5	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Tang J (2014), Tang J (2014), Tang J (2014), Tang J (2014), Tang J (2014), Tang J (2014)	6
MAPKAPK5	0	TP53	0	enzymatic study	Sun P (2007)	1
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
TAB1	1	MAPK14	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Ge B (2002), Ge B (2002), Vinayagam A (2011), Ge B (2003), Chen TC (2014), Grimsey NJ (2015)	6
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
MAPK1	1	EIF4EBP1	1	enzymatic study	Choi KM (2003)	1
SRPK2	1	MAPKAPK5	0	enzymatic study	Varjosalo M (2013)	1
MAPKAPK5	0	HSPB1	2	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	New L (1998), Kostenko S (2009), Kostenko S (2009), Kostenko S (2009), Chen G (2000)	5
MAPKAPK2	1	MAPK14	0	affinity chromatography technology, protein complementation assay, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rane MJ (2001), Srivastav RK (2011), Wang J (2011), Varjosalo M (2013), Rane MJ (2001), White A (2007), ter Haar E (2007), Varjosalo M (2013), Gum RJ (1999), Gum RJ (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	16
PARK7	0	TAB1	1	affinity chromatography technology	Malty RH (2017)	1
MAPK1	1	MAPKAPK2	1	affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology	Yannoni YM (2004), Srivastav RK (2011), Powell DW (2003), Krump E (1997)	4
MAPKAPK5	0	MAPK4	1	protein complementation assay, affinity chromatography technology	Srivastav RK (2011), Varjosalo M (2013)	2
MAPKAPK5	0	MAPKAPK2	1	protein complementation assay, affinity chromatography technology	Srivastav RK (2011), Srivastav RK (2011)	2
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
MAPK6	1	HSPB1	2	affinity chromatography technology	Rodriguez J (2016)	1
MAPK14	0	EIF4EBP1	1	enzymatic study	Kumar A (2010)	1
TAB1	1	MAPKAPK5	0	two hybrid	Vinayagam A (2011)	1
MAPK14	0	MAPKAPK5	0	two hybrid	Bandyopadhyay S (2010)	1
MAPKAPK5	0	ZNF576	2	two hybrid	Wang J (2011)	1
MAPKAPK5	0	MAPK9	3	imaging technique	Chen TC (2014)	1
STK40	4	MAPKAPK5	0	affinity chromatography technology	Durzynska I (2017)	1
TP53	0	RPL13	2	affinity chromatography technology	Fogeron ML (2013)	1
HSPB1	2	TP53	0	two hybrid, affinity chromatography technology, imaging technique	Stelzl U (2005), Sun Y (2007), Chen TC (2014)	3