PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
BHLHE40	5	TTC23	0	two hybrid	Rolland T (2014)	1
UBE2I	0	64396	0	two hybrid	Rolland T (2014)	1
BHLHE40	5	KRTAP23-1	0	two hybrid	Rolland T (2014)	1
CHD3	19	ZHX1	1	two hybrid	Goehler H (2004)	1
HIVEP1	13	MAGED1	0	two hybrid	Wang J (2011)	1
TP53	0	SMARCB1	1	pull down, affinity chromatography technology, pull down, biochemical	Lee D (2002), Lee D (2002), Lee D (2002), Lee D (2002)	4
BHLHE40	5	BHLHE40	5	two hybrid	Rolland T (2014)	1
BHLHE40	5	CHD3	19	two hybrid	Stelzl U (2005)	1
HDAC1	4	BHLHE41	0	pull down, affinity chromatography technology, biochemical, imaging technique	Fujimoto K (2007), Li Y (2011), Matsunaga N (2012), Matsunaga N (2012)	4
BHLHE40	5	STK19	4	two hybrid	Rolland T (2014)	1
BHLHE40	5	RHOJ	0	two hybrid	Rolland T (2014)	1
ENO1	3	CHD3	19	affinity chromatography technology	Castello A (2012)	1
MAGED1	0	NUMBL	1	two hybrid	Wang J (2011)	1
VIM	0	SETDB1	3	two hybrid	Goehler H (2004)	1
BTRC	1	HIVEP1	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Coyaud E (2015), Loveless TB (2015), Huttlin EL (2017)	5
BHLHE40	5	VIM	0	two hybrid	Stelzl U (2005)	1
BHLHE40	5	PLEKHB2	4	two hybrid	Rolland T (2014)	1
MAGED1	0	RBPMS	0	two hybrid	Rolland T (2014)	1
TOLLIP	3	ZHX1	1	two hybrid	Stelzl U (2005)	1
ELAVL1	0	CCNK	1	affinity chromatography technology	Abdelmohsen K (2009)	1
BHLHE40	5	TP53	0	affinity chromatography technology	Thin TH (2007)	1
ELAVL1	0	TXNL4B	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
PDE6G	0	BHLHE40	5	two hybrid	Rolland T (2014)	1
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
APH1A	2	BHLHE40	5	two hybrid	Wang J (2011)	1
RBFOX1	1	DAB1	1	two hybrid	Corominas R (2014)	1
SMARCB1	1	VIM	0	two hybrid	Daakour S (2016)	1
BHLHE41	0	MYOD1	0	pull down, pull down	Fujimoto K (2007), Fujimoto K (2007)	2
ELAVL1	0	ZHX1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TOLLIP	3	SETDB1	3	two hybrid	Stelzl U (2005)	1
DAB1	1	BHLHE40	5	two hybrid	Rolland T (2014)	1
MYOD1	0	TCF3	7	pull down, two hybrid, pull down, two hybrid	Maleki SJ (1997), Langlands K (1997), Dear TN (1997), Dear TN (1997)	4
AES	2	RBPMS	0	two hybrid	Rolland T (2014)	1
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
AANAT	0	BHLHE40	5	two hybrid	Rolland T (2014)	1
RBFOX1	1	NUMBL	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
VIM	0	ZHX1	1	two hybrid	Goehler H (2004)	1
SMARCB1	1	BHLHE40	5	two hybrid	Daakour S (2016)	1
BHLHE40	5	BRD7	2	two hybrid	Stelzl U (2005)	1
BHLHE40	5	STAT3	0	affinity chromatography technology	Ivanova AV (2004)	1
ELAVL1	0	APH1A	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HIVEP1	13	STAT3	0	two hybrid	Wang J (2011)	1
FBXW11	2	TP53	0	affinity chromatography technology	Low TY (2014)	1
ENO1	3	BTRC	1	affinity chromatography technology	Castello A (2012)	1
DAB1	1	MAGED1	0	two hybrid	Rolland T (2014)	1
SMARCB1	1	RXRA	1	two hybrid	Daakour S (2016)	1
STAT3	0	MYOD1	0	affinity chromatography technology, affinity chromatography technology, pull down	Kataoka Y (2003), Kataoka Y (2003), Kataoka Y (2003)	3
BHLHE40	5	HIVEP1	13	two hybrid	Wang J (2011)	1
BHLHE40	5	NOC4L	3	two hybrid	Rolland T (2014)	1
ELAVL1	0	TCF3	7	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Teachenor R (2012)	2
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BHLHE40	5	64396	0	two hybrid	Rolland T (2014)	1
AES	2	BHLHE40	5	two hybrid	Rolland T (2014)	1
BHLHE40	5	USP21	2	affinity chromatography technology	Kim J (2014)	1
BHLHE40	5	ENO1	3	two hybrid	Wang J (2011)	1
RBFOX1	1	MAGED1	0	two hybrid, two hybrid	Lim J (2006), Corominas R (2014)	2
DAB1	1	TOLLIP	3	two hybrid	Rolland T (2014)	1
MAGED1	0	RBM23	0	two hybrid	Rolland T (2014)	1
BHLHE40	5	RBPMS	0	two hybrid	Rolland T (2014)	1
BHLHE40	5	LARP4	1	two hybrid	Rolland T (2014)	1
MAGED1	0	TTC23	0	two hybrid	Rolland T (2014)	1
BHLHE40	5	CCNK	1	two hybrid	Rolland T (2014)	1
EHHADH	1	BHLHE40	5	two hybrid	Rolland T (2014)	1
SOX15	4	BHLHE40	5	two hybrid	Rolland T (2014)	1
BHLHE41	0	FBXW11	2	two hybrid	Wallach T (2013)	1
FBXW11	2	ELAVL1	0	affinity chromatography technology	Low TY (2014)	1
UBE2I	0	ZHX1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Chen S (2013), Chen S (2013), Chen S (2013)	4
BHLHE40	5	CDPF1	0	two hybrid	Rolland T (2014)	1
UBE2I	0	TCF3	7	pull down, two hybrid	Huggins GS (1999), Huggins GS (1999)	2
BHLHE40	5	TXNL4B	0	two hybrid	Rolland T (2014)	1
BHLHE40	5	MAGED1	0	two hybrid	Rolland T (2014)	1
BRD7	2	TP53	0	affinity chromatography technology, pull down, imaging technique	Drost J (2010), Drost J (2010), Drost J (2010)	3
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
BHLHE40	5	RBM23	0	two hybrid	Rolland T (2014)	1
SIN3A	13	CHD3	19	affinity chromatography technology	Nakamura T (2002)	1
RXRA	1	BHLHE41	0	affinity chromatography technology	Cho Y (2009)	1
FBXW11	2	HIVEP1	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Huttlin EL (2017)	3
APH1A	2	HIVEP1	13	two hybrid	Wang J (2011)	1
ELAVL1	0	PRKAA1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
RBFOX1	1	RBPMS	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
BHLHE40	5	RHOBTB3	1	two hybrid	Rolland T (2014)	1
BHLHE40	5	FBLN1	1	two hybrid	Wang J (2011)	1
BHLHE40	5	391627	0	affinity chromatography technology	Kim J (2014)	1
RBPMS	0	RHOBTB3	1	two hybrid	Rolland T (2014)	1
ELAVL1	0	TOLLIP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	AES	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMARCB1	1	HDAC1	4	biochemical	Sif S (2001)	1
BHLHE40	5	SETDB1	3	two hybrid	Stelzl U (2005)	1
BTRC	1	MAGED1	0	bioid	Coyaud E (2015)	1
BHLHE40	5	HDAC1	4	pull down	Sun H (2000)	1
MYOD1	0	BHLHE40	5	pull down	Fujimoto K (2007)	1
SIN3A	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Murphy M (1999), Murphy M (1999), Murphy M (1999), Zilfou JT (2001)	4
TCF3	7	BHLHE40	5	two hybrid, affinity chromatography technology	Dear TN (1997), Dear TN (1997)	2
ELAVL1	0	LARP4	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	BHLHE40	5	affinity chromatography technology	Abdelmohsen K (2009)	1
BHLHE40	5	NUMBL	1	two hybrid	Wang J (2011)	1
SIN3A	13	SETDB1	3	affinity chromatography technology	Yang L (2003)	1
CHD3	19	TP53	0	two hybrid, two hybrid	Minty A (2000), Goehler H (2004)	2
BHLHE40	5	UBE2I	0	affinity chromatography technology, two hybrid	Ivanova AV (2001), Ivanova AV (2001)	2
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
RXRA	1	BHLHE40	5	affinity chromatography technology	Cho Y (2009)	1
BTRC	1	BHLHE40	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim J (2014), Kim J (2014), Kim J (2014), Loveless TB (2015), Huttlin EL (2017)	5
RBPMS	0	TOLLIP	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ELAVL1	0	TOB2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
BHLHE40	5	VAC14	5	two hybrid	Rolland T (2014)	1
UBE2I	0	SETDB1	3	two hybrid	Bandyopadhyay S (2010)	1
SIN3A	13	STAT3	0	affinity chromatography technology, pull down	Icardi L (2012), Icardi L (2012)	2
BHLHE41	0	BHLHE40	5	affinity chromatography technology	Sato F (2004)	1
RBFOX1	1	BHLHE40	5	two hybrid	Corominas R (2014)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
TP53	0	VIM	0	affinity chromatography technology	Horikawa I (2014)	1
COX5B	0	BHLHE40	5	two hybrid	Rolland T (2014)	1
USP21	2	TP53	0	enzymatic study	Fernandez-Majada V (2016)	1
AES	2	CCNK	1	two hybrid	Rolland T (2014)	1
TP53	0	ZHX1	1	two hybrid	Goehler H (2004)	1
TOLLIP	3	BHLHE40	5	two hybrid	Bandyopadhyay S (2010)	1
HDAC1	4	CHD3	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong JK (1998), Tong JK (1998), Kuzmichev A (2002), Sun JM (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Xue Y (1998), Havugimana PC (2012), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	12
SMARCB1	1	AES	2	two hybrid	Daakour S (2016)	1
PRKAA1	2	BHLHE40	5	two hybrid	Rolland T (2014)	1
HDAC1	4	MYOD1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Puri PL (2001), Puri PL (2001), Mal A (2001), Bruscoli S (2010)	4
CCNK	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
AES	2	PRKAA1	2	two hybrid	Rolland T (2014)	1
BHLHE40	5	CALML3	0	two hybrid	Wang J (2011)	1
BHLHE40	5	SIN3A	13	pull down	Sun H (2000)	1
BHLHE40	5	TOB2	5	two hybrid	Rolland T (2014)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
VIM	0	NOC4L	3	two hybrid	Rual JF (2005)	1
PRKAA1	2	RBPMS	0	two hybrid	Rolland T (2014)	1
UBE2I	0	CHD3	19	two hybrid	Lee BH (2003)	1
RXRA	1	MYOD1	0	pull down, pull down	Froeschle A (1998), Froeschle A (1998)	2
ELAVL1	0	STAT3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ENO1	3	HDAC1	4	pull down, affinity chromatography technology	Ghosh AK (1999), Ghosh AK (1999)	2
FBXW11	2	BHLHE40	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim J (2014), Kim J (2014), Low TY (2014), Low TY (2014)	4
BHLHE40	5	SMYD1	2	two hybrid	Rolland T (2014)	1
HDAC1	4	VIM	0	affinity chromatography technology	Terhune SS (2010)	1
BHLHE40	5	NAA50	0	two hybrid	Rolland T (2014)	1
TOLLIP	3	MAGED1	0	affinity chromatography technology	Li S (2011)	1
SMARCB1	1	SIN3A	13	biochemical, pull down, affinity chromatography technology	Sif S (2001), Pal S (2003), Nakamura T (2002)	3
STAT3	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang Q (2005), Yuan ZL (2005), Gupta M (2011), Zhi Y (2012), Zhi Y (2012)	5
AAMP	3	BHLHE40	5	two hybrid	Rolland T (2014)	1
BHLHE40	5	ZHX1	1	two hybrid	Stelzl U (2005)	1
RBPMS	0	KRTAP23-1	0	two hybrid	Rolland T (2014)	1
UBE2I	0	RXRA	1	enzymatic study	Ogawa H (2009)	1