PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASK	18	ABLIM1	3	affinity chromatography technology	So J (2015)	1
ERBIN	5	ATP2B4	5	unspecified method	Boisguerin P (2004)	1
ERBIN	5	CASK	18	unspecified method	Boisguerin P (2004)	1
CASK	18	SDC1	0	pull down	Cohen AR (1998)	1
F11R	0	CASK	18	affinity chromatography technology, pull down	Martinez-Estrada OM (2001), Ebnet K (2000)	2
ELAVL1	0	CDK9	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CASK	18	ARHGEF26	1	affinity chromatography technology	So J (2015)	1
DLG1	2	APBA1	6	affinity chromatography technology	Leonoudakis D (2004)	1
CASK	18	ELL2	4	two hybrid	Wang J (2011)	1
DLG4	11	KCNJ4	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nehring RB (2000), Leonoudakis D (2004), Inanobe A (2002), Nehring RB (2000)	4
MYBPHL	1	CASK	18	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIN7C	0	ARHGEF26	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	MARS	1	affinity chromatography technology	Fei T (2017)	1
PTPDC1	3	CASK	18	affinity chromatography technology	Huttlin EL (2017)	1
SLC16A6	0	CASK	18	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	FCHSD2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TBR1	12	TSPYL2	4	affinity chromatography technology	Wang GS (2004)	1
ELAVL1	0	CASK	18	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	DUSP3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
KIF26B	11	CASK	18	affinity chromatography technology	Hein MY (2015)	1
KCNJ4	5	LIN7B	0	two hybrid, affinity chromatography technology	Olsen O (2002), Olsen O (2002)	2
CEP128	1	CASK	18	bioid	Gupta GD (2015)	1
HNRNPL	3	WNT7B	2	affinity chromatography technology	Fei T (2017)	1
CEP128	1	DTNB	1	bioid	Gupta GD (2015)	1
FRMD7	1	CASK	18	affinity chromatography technology	Watkins RJ (2013)	1
CDK9	3	PCBP2	3	affinity chromatography technology	Jeronimo C (2007)	1
ELAVL1	0	MLLT6	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CASK	18	RPH3A	7	pull down, affinity chromatography technology	Zhang Y (2001), Zhang Y (2001)	2
NTRK1	1	SRPK2	1	affinity chromatography technology	Emdal KB (2015)	1
LIN7B	0	CASK	18	affinity chromatography technology	Leonoudakis D (2004)	1
CASK	18	PPP4R3A	3	two hybrid	Wang J (2011)	1
KCNJ4	5	LIN7A	1	affinity chromatography technology	Leonoudakis D (2004)	1
CASK	18	PCM1	5	two hybrid	Wang J (2011)	1
HGS	5	CASK	18	pull down	Pridgeon JW (2009)	1
KCNJ12	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
HNRNPL	3	DTNB	1	affinity chromatography technology	Fei T (2017)	1
DLG1	2	EPB41	2	pull down	Lue RA (1994)	1
CASK	18	MLLT6	2	two hybrid	Wang J (2011)	1
NTRK1	1	PRKD2	3	affinity chromatography technology	Emdal KB (2015)	1
CASK	18	PLK2	0	two hybrid	Wang J (2011)	1
NTRK1	1	MARS	1	affinity chromatography technology	Emdal KB (2015)	1
CASK	18	PCBP2	3	two hybrid	Wang J (2011)	1
LIN7C	0	KIF26B	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
CEP128	1	NEDD1	1	bioid	Gupta GD (2015)	1
ELAVL1	0	SLC16A6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CASK	18	DTNB	1	affinity chromatography technology	So J (2015)	1
CASK	18	MARS	1	two hybrid	Wang J (2011)	1
NTRK1	1	HGS	5	affinity chromatography technology	Emdal KB (2015)	1
TMEM17	0	ERBIN	5	bioid	Gupta GD (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
NTRK1	1	PPP4R3A	3	affinity chromatography technology	Emdal KB (2015)	1
PRKD2	3	CASK	18	two hybrid	Colland F (2004)	1
NTRK1	1	EPB41	2	affinity chromatography technology	Emdal KB (2015)	1
DUSP10	3	CASK	18	affinity chromatography technology	St-Denis N (2016)	1
FCHSD2	3	CASK	18	pull down	Ohno H (2003)	1
CASK	18	TRIM22	2	two hybrid	Wang J (2011)	1
LIN7C	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	EPB41	2	affinity chromatography technology	Fei T (2017)	1
ATP2B4	5	DLG1	2	pull down	Schuh K (2003)	1
KCNJ12	0	ABLIM1	3	affinity chromatography technology	Leonoudakis D (2004)	1
SPATA2	2	UIMC1	4	affinity chromatography technology	Sowa ME (2009)	1
CDK9	3	ELL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu M (2012), He N (2011), Takahashi H (2011), Takahashi H (2011)	4
ELAVL1	0	LIN7C	0	affinity chromatography technology	Abdelmohsen K (2009)	1
KCNJ4	5	CASK	18	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
LIN7C	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	4
KCNJ12	0	SNTB2	4	affinity chromatography technology	Leonoudakis D (2004)	1
LIN7C	0	APBA1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	3
CASK	18	IL18	0	two hybrid	Wang J (2011)	1
ELAVL1	0	PTGS2	0	unspecified method, affinity chromatography technology, unspecified method	Kim I (2012), Kim I (2012), Sureban SM (2007)	3
CASK	18	IL15RA	2	two hybrid	Wang J (2011)	1
ZNF785	0	ERBIN	5	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	TRIM26	1	affinity chromatography technology	Fei T (2017)	1
UIMC1	4	CASK	18	affinity chromatography technology	Sowa ME (2009)	1
CNTNAP4	4	CASK	18	pull down	Spiegel I (2002)	1
KCNJ12	0	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
CASK	18	P2RX7	2	two hybrid	Wang J (2011)	1
CASK	18	SH2D4A	0	two hybrid	Rolland T (2014)	1
CNTNAP4	4	APBA1	6	pull down	Spiegel I (2002)	1
HNRNPL	3	PRKN	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	NEDD1	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	PCM1	5	affinity chromatography technology	Fei T (2017)	1
CEP128	1	TRIM26	1	bioid	Gupta GD (2015)	1
TMEM17	0	DLG1	2	bioid	Gupta GD (2015)	1
ELAVL1	0	PCBP2	3	affinity chromatography technology, biochemical	Abdelmohsen K (2009), Wan C (2015)	2
HNRNPL	3	ARHGEF26	1	affinity chromatography technology	Fei T (2017)	1
ID1	0	CASK	18	two hybrid, pull down	Qi J (2005), Qi J (2005)	2
ATP2B4	5	CASK	18	pull down, biochemical	Schuh K (2003), Schuh K (2003)	2
CASK	18	EPB41	2	pull down	Cohen AR (1998)	1
CASK	18	SNTB2	4	affinity chromatography technology	So J (2015)	1
HNRNPL	3	TSPYL2	4	affinity chromatography technology	Fei T (2017)	1
CEP128	1	SPATA2	2	bioid	Gupta GD (2015)	1
HNRNPL	3	ABLIM1	3	affinity chromatography technology	Fei T (2017)	1
KCNJ4	5	LIN7C	0	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
EEF2	11	HNRNPL	3	biochemical	Havugimana PC (2012)	1
NTRK1	1	PCM1	5	affinity chromatography technology	Emdal KB (2015)	1
CNTNAP2	5	CASK	18	pull down	Spiegel I (2002)	1
TBR1	12	CASK	18	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsueh YP (2000), Wang GS (2004), Hsueh YP (2000), Hsueh YP (2000)	4
LIN7A	1	SNTB2	4	affinity chromatography technology	Hauri S (2013)	1
KCNJ12	0	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
PTGS2	0	CASK	18	two hybrid	Corominas R (2014)	1
CASK	18	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
CASK	18	CDK9	3	two hybrid	Wang J (2011)	1
PRKN	1	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
CASK	18	WNT7B	2	two hybrid	Wang J (2011)	1
SPATA2	2	CASK	18	affinity chromatography technology	Sowa ME (2009)	1
CASK	18	DLG4	11	affinity chromatography technology, two hybrid	Chetkovich DM (2002), Chetkovich DM (2002)	2
HNRNPL	3	PTPDC1	3	affinity chromatography technology	Fei T (2017)	1
TMEM17	0	ATP2B4	5	bioid	Gupta GD (2015)	1
FOXRED2	0	LIN7C	0	affinity chromatography technology	Christianson JC (2012)	1
NTRK1	1	EEF2	11	affinity chromatography technology	Emdal KB (2015)	1
KCNJ4	5	DLG1	2	affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001)	3
NTRK1	1	DLG1	2	affinity chromatography technology	Emdal KB (2015)	1
HNRNPL	3	DLG1	2	affinity chromatography technology	Fei T (2017)	1
DLG1	2	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Hauri S (2013)	3
HNRNPL	3	ARIH1	3	affinity chromatography technology	Fei T (2017)	1
CASK	18	DUSP3	1	two hybrid	Wang J (2011)	1
ELAVL1	0	F11R	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
PRKN	1	CASK	18	pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Fallon L (2002), Fallon L (2002), Fallon L (2002), Parelkar SS (2012)	4
DLG1	2	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	4
PPM1B	2	CASK	18	biochemical	Wan C (2015)	1
CASK	18	GCNT3	1	two hybrid	Wang J (2011)	1
ELAVL1	0	SDC2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TMEM17	0	HGS	5	bioid	Gupta GD (2015)	1
NEDD1	1	CASK	18	affinity chromatography technology	Fogeron ML (2013)	1
HNRNPL	3	CASK	18	affinity chromatography technology	Fei T (2017)	1
TMEM17	0	LIN7C	0	bioid	Gupta GD (2015)	1
NTRK1	1	KIF26B	11	affinity chromatography technology	Emdal KB (2015)	1
DLG4	11	HGS	5	two hybrid, affinity chromatography technology	Chetkovich DM (2002), Chetkovich DM (2002)	2
ZNF414	1	CASK	18	affinity chromatography technology	Huttlin EL (2017)	1
CDK9	3	MARS	1	affinity chromatography technology	Mak AB (2010)	1
KCNJ12	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
DLG4	11	LIN7A	1	pull down	Jo K (1999)	1
KLHL2	0	CASK	18	affinity chromatography technology	Huttlin EL (2017)	1
LIN7B	0	DLG4	11	affinity chromatography technology	Jo K (1999)	1
TRIM26	1	CASK	18	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	ABLIM1	3	bioid	Gupta GD (2015)	1
LIN7C	0	ABLIM1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BNIP3L	1	DUSP3	1	two hybrid	Wang J (2011)	1
PRKN	1	DLG4	11	affinity chromatography technology	Fallon L (2002)	1
SPATA2	2	LIN7C	0	affinity chromatography technology	Sowa ME (2009)	1
ELAVL1	0	SPATA2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
LIN7A	1	CASK	18	affinity chromatography technology, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Rolland T (2014), Hauri S (2013)	3
PRKN	1	DLG1	2	imaging technique	Chen TC (2014)	1
ZNF785	0	PPP4R3A	3	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	SNTB2	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	DLG4	11	affinity chromatography technology	Abdelmohsen K (2009)	1
CASK	18	EEF2	11	affinity chromatography technology	So J (2015)	1
UIMC1	4	LIN7C	0	affinity chromatography technology	Sowa ME (2009)	1
PCM1	5	NEDD1	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
TMEM17	0	CASK	18	bioid	Gupta GD (2015)	1
KIF26B	11	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
KCNJ12	0	APBA1	6	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
HNRNPL	3	SRPK2	1	affinity chromatography technology	Fei T (2017)	1
FOXRED2	0	CASK	18	affinity chromatography technology	Christianson JC (2012)	1
LIN7B	0	APBA1	6	affinity chromatography technology	Leonoudakis D (2004)	1
BNIP3L	1	CASK	18	two hybrid	Wang J (2011)	1
SRPK2	1	CASK	18	enzymatic study	Varjosalo M (2013)	1
SDC2	0	CASK	18	affinity chromatography technology, pull down	Maximov A (2003), Cohen AR (1998)	2
DLG1	2	CASK	18	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Chetkovich DM (2002), Nix SL (2000), Nix SL (2000), Nix SL (2000), Nix SL (2000), So J (2015)	8
APBA1	6	CASK	18	pull down	Borg JP (1999)	1
PCBP2	3	HNRNPL	3	two hybrid, two hybrid, pull down, pull down	Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000)	4
NTRK1	1	PCBP2	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CASK	18	affinity chromatography technology	Emdal KB (2015)	1
KCNJ12	0	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
ZNF414	1	ERBIN	5	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
MYCL	0	CASK	18	affinity chromatography technology	Huttlin EL (2017)	1
KCNJ12	0	DLG1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001), Leonoudakis D (2001)	6
HNRNPL	3	ERBIN	5	affinity chromatography technology	Fei T (2017)	1
ZNF785	0	CASK	18	affinity chromatography technology	Huttlin EL (2017)	1
CASK	18	TSPYL2	4	two hybrid, affinity chromatography technology	Wang GS (2004), Wang GS (2004)	2
NTRK1	1	RPH3A	7	affinity chromatography technology	Emdal KB (2015)	1
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1