PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	RASA1	3	pull down, unspecified method, pull down	Daly RJ (1996), Jones RB (2006), Marengere LE (1992)	3
EGFR	5	CAV2	0	affinity chromatography technology, two hybrid, protein complementation assay, pull down	Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Abulrob A (2004)	4
CAV2	0	NCK1	0	pull down	Lee H (2002)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
RASA1	3	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, pull down, affinity chromatography technology	Holland SJ (1997), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011)	7
KCNMA1	10	CAV1	0	affinity chromatography technology, affinity chromatography technology	Brainard AM (2005), Brainard AM (2005)	2
MALL	0	CAV1	0	affinity chromatography technology, affinity chromatography technology	de Marco MC (2001), de Marco MC (2001)	2
CAV2	0	RASA1	3	pull down, affinity chromatography technology, affinity chromatography technology	Lee H (2002), Lee H (2002), Lee H (2002)	3
EGFR	5	PLD2	1	affinity chromatography technology	Slaaby R (1998)	1
DNAJA1	2	PLD2	1	affinity chromatography technology	Huttlin EL (2015)	1
CAV1	0	SRC	2	pull down	Li S (1996)	1
PLD2	1	CAV2	0	biochemical	Czarny M (2000)	1
CAV1	0	PLD2	1	affinity chromatography technology, affinity chromatography technology, biochemical	Zheng X (2003), Zheng X (2003), Czarny M (2000)	3
EGFR	5	DNAJA1	2	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
RASA1	3	SRC	2	affinity chromatography technology, enzymatic study	Brott BK (1991), Giglione C (2001)	2
SRC	2	PLD2	1	enzymatic study, affinity chromatography technology, pull down	Ahn BH (2003), Ahn BH (2003), Ahn BH (2003)	3
MALL	0	CAV2	0	affinity chromatography technology	de Marco MC (2001)	1
PTGS1	4	CAV2	0	affinity chromatography technology, affinity chromatography technology	Cha SH (2004), Cha SH (2004)	2
NCK1	0	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Tang J (1997), Li W (1992), Braverman LE (1999), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	6
EGFR	5	CAV1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, pull down, biochemical	Couet J (1997), Couet J (1997), Khan EM (2006), Feldman R (2009), Hua H (2003), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Park WY (2000), Abulrob A (2004), Abulrob A (2004)	12
PTGS1	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Cha SH (2004), Cha SH (2004)	2
KCNMA1	10	CAV2	0	affinity chromatography technology, affinity chromatography technology	Brainard AM (2005), Brainard AM (2005)	2
CAV2	0	CAV1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Breuza L (2002), Scherer PE (1997), Scherer PE (1997), Sowa G (2008)	4
SRC	2	CSNK2A1	15	affinity chromatography technology	Liang K (2010)	1
CAV2	0	DNAJA1	2	two hybrid	Vinayagam A (2011)	1
CSNK2A1	15	CAV2	0	enzymatic study	Sowa G (2003)	1
CAV2	0	SRC	2	pull down	Lee H (2002)	1
EGFR	5	CSNK2A1	15	affinity chromatography technology	Tong J (2014)	1