PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
RB1	2	KAT2B	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nguyen DX (2004), Nguyen DX (2004), Nguyen DX (2004), Ianari A (2009)	4
HIF1A	1	RUNX2	2	affinity chromatography technology, affinity chromatography technology, pull down	Lee SH (2012), Lee SH (2012), Lee SH (2012)	3
SMAD5	2	YAP1	0	affinity chromatography technology, affinity chromatography technology	Alarcon C (2009), Alarcon C (2009)	2
CREBBP	29	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chuang HC (2006), Chuang HC (2006), Chuang HC (2006), Chuang HC (2006)	4
STUB1	4	RUNX2	2	affinity chromatography technology, two hybrid	Li X (2008), Li X (2008)	2
HDAC4	10	SUV39H1	0	affinity chromatography technology	Zhang CL (2002)	1
SMAD5	2	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
EP300	36	SOX9	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furumatsu T (2010), Furumatsu T (2010), Tsuda M (2003), Furumatsu T (2005)	4
FHL2	0	SMAD3	1	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
ETS1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee S (2008), Lee S (2008), Kim E (2003), Zhu M (2014)	4
STAT3	0	RB1	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Barre B (2005), Barre B (2005), Barre B (2005), Barre B (2005)	4
HIF1A	1	FBXW7	2	affinity chromatography technology	Cassavaugh JM (2011)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
PML	7	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Alcalay M (1998), Alcalay M (1998), Alcalay M (1998)	3
SMAD3	1	SUV39H1	0	affinity chromatography technology	Wakabayashi Y (2011)	1
FBXW7	2	STAT3	0	affinity chromatography technology, affinity chromatography technology	Yao S (2017), Yao S (2017)	2
BMPR1A	5	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
CREBBP	29	FOS	0	pull down, affinity chromatography technology, two hybrid	Fan S (2002), Bossis G (2005), Patel D (1999)	3
RUNX2	2	SOX9	2	fluorescent resonance energy transfe	Cheng A (2010)	1
TLE1	6	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn JW (2009), Ahn JW (2009), Su L (2012), Su L (2012)	4
XRCC5	5	RUNX2	2	affinity chromatography technology	Willis DM (2002)	1
PML	7	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015)	7
RUNX2	2	HIVEP3	12	affinity chromatography technology, pull down	Jones DC (2006), Jones DC (2006)	2
YAP1	0	RUNX2	2	pull down	Yagi R (1999)	1
YAP1	0	SMAD2	5	affinity chromatography technology	Pefani DE (2016)	1
NR0B2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yang Z (2012), Yang Z (2012), Yang Z (2012), Yang Z (2012), Yang Z (2012)	5
PML	7	FOS	0	pull down	Vallian S (1998)	1
XRCC6	3	MSX2	1	affinity chromatography technology	Willis DM (2002)	1
ALYREF	0	RUNX2	2	pull down	Bruhn L (1997)	1
RUNX2	2	JUN	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Hess J (2001), Hess J (2001), DAlonzo RC (2002), DAlonzo RC (2002), DAlonzo RC (2002)	5
HDAC1	4	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahon PC (2001), Yoo YG (2006), Kim SH (2007), Kim SH (2007), Bodily JM (2011), Yeh IJ (2013), Yeh IJ (2013)	7
KAT2B	2	ETS1	4	affinity chromatography technology	Tsai LN (2008)	1
FHL2	0	EP300	36	pull down, affinity chromatography technology	Labalette C (2004), Labalette C (2004)	2
STAT3	0	SMAD1	0	affinity chromatography technology	Nakashima K (1999)	1
HIF1A	1	CREBBP	29	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Ema M (1999), Ema M (1999), Bhattacharya S (1999), Park YK (2008), Choi SM (2006), Matt T (2004), Hubbi ME (2012), Ruas JL (2010), Ruas JL (2010), Ruas JL (2010), Ruas JL (2010), Ruas JL (2005), Arany Z (1996), Ruas JL (2005), Gradin K (2002)	15
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
YAP1	0	XRCC5	5	affinity chromatography technology	Enzo E (2015)	1
SMAD3	1	HDAC4	10	affinity chromatography technology, pull down	Kang JS (2005), Kang JS (2005)	2
SMAD3	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Seo SR (2004), Rolland T (2014)	3
SMAD1	0	STUB1	4	affinity chromatography technology, x-ray crystallography, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang L (2011), Wang L (2011), Wang L (2011), Li L (2004), Li L (2004), Li L (2004), Li L (2004), Shimamoto S (2013), Shimamoto S (2013)	9
SMAD5	2	WWP1	3	affinity chromatography technology, two hybrid	Komuro A (2004), Colland F (2004)	2
HDAC1	4	HES1	0	affinity chromatography technology	Shen Q (2005)	1
SMURF1	4	XRCC6	3	affinity chromatography technology	Xie Y (2013)	1
HIF1A	1	FHL2	0	affinity chromatography technology, affinity chromatography technology, pull down	Hubbi ME (2012), Hubbi ME (2012), Hubbi ME (2012)	3
HDAC6	0	STUB1	4	affinity chromatography technology	Cook C (2012)	1
SMAD3	1	SOX9	2	affinity chromatography technology	Furumatsu T (2005)	1
STAT3	0	PML	7	affinity chromatography technology, pull down	Kawasaki A (2003), Kawasaki A (2003)	2
YAP1	0	JUN	0	affinity chromatography technology	Enzo E (2015)	1
HIF1A	1	HDAC5	4	affinity chromatography technology, pull down	Seo HW (2009), Seo HW (2009)	2
SOX9	2	FBXW7	2	affinity chromatography technology, pull down	Hong X (2016), Hong X (2016)	2
EP300	36	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kitagawa M (2008), Inuzuka H (2012), Inuzuka H (2012), Oh M (2016)	4
HDAC3	5	HIF1A	1	pull down, affinity chromatography technology, pull down	Mahon PC (2001), Kim SH (2007), Kim SH (2007)	3
XRCC6	3	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian C (2011), Chaudhary N (2014), Chaudhary N (2014)	3
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
HDAC4	10	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Fischle W (2002), Fischle W (2002), Fischle W (2001), Grozinger CM (2000), Wang X (2008)	7
HIF1A	1	RB1	2	unspecified method, pull down, affinity chromatography technology	Budde A (2005), Budde A (2005), Budde A (2005)	3
HDAC1	4	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015)	10
HDAC1	4	UBTF	8	imaging technique, affinity chromatography technology, biochemical	Ali SA (2012), Ali SA (2012), Ali SA (2012)	3
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
SMAD2	5	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
HDAC7	4	HDAC5	4	pull down	Dressel U (2001)	1
SMAD3	1	JUN	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Verrecchia F (2000), Liberati NT (1999), Liberati NT (2001), Lee SY (2011)	7
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
HDAC5	4	XRCC6	3	affinity chromatography technology	Greco TM (2011)	1
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
EP300	36	HDAC6	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Han Y (2009), Han Y (2009), Liu Y (2012), Kirilyuk A (2012), Girdwood D (2003)	5
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
JUN	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alfranca A (2002), Yu B (2009), Yu B (2009)	3
PML	7	HDAC3	5	affinity chromatography technology, pull down	Wu WS (2001), Wu WS (2001)	2
RUNX2	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Jones DC (2006), Jones DC (2006)	2
CREBBP	29	XRCC6	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Barlev NA (1998), Barlev NA (1998), Cohen HY (2004), Cohen HY (2004), Cohen HY (2004)	5
YAP1	0	PML	7	affinity chromatography technology, affinity chromatography technology	Lapi E (2008), Lapi E (2008)	2
SMAD3	1	FOS	0	two hybrid, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Lee SY (2011)	3
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
XRCC6	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Feki A (2005), Feki A (2005)	2
ETS1	4	SMAD3	1	imaging technique	Chen TC (2014)	1
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
RBM14	5	EP300	36	pull down	Iwasaki T (2001)	1
EP300	36	FOS	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang WM (2011), Pekarsky Y (2008), Wang C (2001)	3
RB1	2	SUV39H1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Nielsen SJ (2001), Nielsen SJ (2001), Vandel L (2001), Vandel L (2001), Vandel L (2001)	5
XRCC5	5	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Um JH (2004), Um JH (2004)	2
HDAC5	4	SUV39H1	0	affinity chromatography technology	Zhang CL (2002)	1
STAT5A	4	HDAC1	4	affinity chromatography technology	Xu M (2003)	1
HES1	0	STAT3	0	affinity chromatography technology, pull down, enzymatic study	Kamakura S (2004), Kamakura S (2004), Kamakura S (2004)	3
JUN	0	FBXW7	2	two hybrid, pull down, enzymatic study, unspecified method, affinity chromatography technology	Nateri AS (2004), Nateri AS (2004), Nateri AS (2004), Nateri AS (2004), Takada M (2017)	5
JUN	0	ETS1	4	pull down, pull down	Logan SK (1996), Miyamoto-Sato E (2010)	2
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
YAP1	0	XRCC6	3	affinity chromatography technology	Enzo E (2015)	1
CBFB	1	RUNX2	2	affinity chromatography technology	Kim DY (2013)	1
RUNX2	2	HDAC5	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeon EJ (2006), Kang JS (2005), Kang JS (2005)	3
TP53	0	RUNX2	2	affinity chromatography technology, affinity chromatography technology	Ozaki T (2013), Ozaki T (2013)	2
HIF1A	1	STAT3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jung JE (2008), Jung JE (2008), Gray MJ (2005), Gray MJ (2005), Pawlus MR (2013), Pawlus MR (2013)	6
EP300	36	RUNX2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee HW (2006), Jeon EJ (2006), Jeon EJ (2006), Jun JH (2010)	4
RUNX2	2	STAT5A	4	affinity chromatography technology	Dieudonne FX (2013)	1
HDAC6	0	PML	7	affinity chromatography technology	Joshi P (2013)	1
SMAD1	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
RB1	2	HDAC1	4	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Dick FA (2000), Fuks F (2000), Puri PL (2001), Puri PL (2001), Wang S (2002), Luo RX (1998), Luo RX (1998), Lai A (1999), Lai A (1999), Ferreira R (1998), Kimura H (2003), Qiu Z (2008), Fedele M (2006), Brown VD (2002), Khan MM (2001), Dasgupta P (2004), Chang YC (2001), Dahiya A (2000), Zhang HS (2000), Tokitou F (1999), Nguyen DX (2004), Takaki T (2004), Magnaghi-Jaulin L (1998), Magnaghi-Jaulin L (1998), Brehm A (1998), Brehm A (1998), Brehm A (1998), Sun JM (2007), Fan LX (2012), Harbour JW (1999), Brehm A (1999), Joshi P (2013), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	36
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
JUN	0	STAT3	0	affinity chromatography technology, affinity chromatography technology, pull down	Zhang X (1999), Zhang X (1999), Zhang X (1999)	3
SMAD3	1	KAT2B	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Prokova V (2005), Itoh S (2000), Itoh S (2000), Kahata K (2004), Dai M (2012)	5
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
RUNX2	2	SKP2	2	affinity chromatography technology	Thacker G (2016)	1
KAT2B	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Jin Y (2002), Wang H (2008), Zhao Y (2006), Roe JS (2006), Perez RE (2010), Tang Y (2006), Zhao LY (2003), Liu L (1999), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Harrod R (2003), MacPartlin M (2005), Chen H (1999), Kang H (2009)	15
SMAD2	5	STUB1	4	pull down	Li L (2004)	1
YAP1	0	EP300	36	imaging technique	Strano S (2005)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
HDAC6	0	HIF1A	1	affinity chromatography technology	Qian DZ (2006)	1
YAP1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology, genetic interference	Tu K (2014), Tu K (2014), Tu K (2014)	3
HDAC5	4	TP53	0	affinity chromatography technology	Greco TM (2011)	1
SKP2	2	RB1	2	affinity chromatography technology, affinity chromatography technology	Ji P (2004), Ji P (2004)	2
KAT2B	2	RUNX2	2	affinity chromatography technology	Jeon EJ (2006)	1
PML	7	RUNX2	2	affinity chromatography technology	Nguyen LA (2005)	1
STAT3	0	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yuan ZL (2005), Yuan ZL (2005), Gupta M (2011), Tsuruma R (2008), Kato M (2015)	5
KAT2B	2	JUN	0	affinity chromatography technology	Tsai LN (2008)	1
RB1	2	UBTF	8	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Hannan KM (2000), Hannan KM (2000), Hannan KM (2000), Hannan KM (2000), Cavanaugh AH (1995), Cavanaugh AH (1995)	6
UBTF	8	KAT2B	2	imaging technique	Shen M (2013)	1
SMAD3	1	STUB1	4	pull down	Li L (2004)	1
YAP1	0	STUB1	4	affinity chromatography technology	Hauri S (2013)	1
SMAD3	1	HDAC5	4	affinity chromatography technology, pull down	Kang JS (2005), Kang JS (2005)	2
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
SMAD2	5	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
HDAC6	0	XRCC5	5	affinity chromatography technology	New M (2013)	1
RB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Iyer NG (2007), Iyer NG (2007), Chan HM (2001)	3
SMAD5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, two hybrid, two hybrid, enzymatic study	Lu K (2008), Komuro A (2004), Ebisawa T (2001), Nie J (2010), Alarcon C (2009), Murakami G (2003), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Haag J (2006), Colland F (2004), Lu K (2008)	12
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
HIF1A	1	SMAD3	1	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2002)	5
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
RUNX2	2	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Jun JH (2010), Wang Q (2007)	5
RUNX2	2	HES1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Shen Q (2005), Shen Q (2005), Shen Q (2005)	3
NR0B2	1	HDAC3	5	pull down, pull down, affinity chromatography technology	Gobinet J (2005), Sanyal S (2007), Sanyal S (2007)	3
EP300	36	ETS1	4	genetic interference, unspecified method, pull down, pull down	Pastorcic M (2000), Foulds CE (2004), Jayaraman G (1999), Jayaraman G (1999)	4
SMURF2	3	RBM14	5	affinity chromatography technology	Zhang L (2013)	1
KAT6B	27	RUNX2	2	pull down, affinity chromatography technology, enzymatic study	Pelletier N (2002), Pelletier N (2002), Pelletier N (2002)	3
RUNX2	2	UBTF	8	affinity chromatography technology, affinity chromatography technology, biochemical	Ali SA (2012), Ali SA (2012), Ali SA (2012)	3
RUNX2	2	RBM14	5	imaging technique, affinity chromatography technology, pull down	Li X (2009), Li X (2009), Li X (2009)	3
XRCC5	5	WWP1	3	affinity chromatography technology	Hein MY (2015)	1
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
SMAD5	2	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
PML	7	HDAC7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao C (2008), Gao C (2008), Satow R (2012)	3
EP300	36	SMAD5	2	affinity chromatography technology, two hybrid	Jeon EJ (2006), Haag J (2006)	2
RUNX2	2	RB1	2	affinity chromatography technology	Thomas DM (2004)	1
TP53	0	ALYREF	0	affinity chromatography technology	Horikawa I (2014)	1
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
NR0B2	1	RUNX2	2	affinity chromatography technology	Jeong BC (2010)	1
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
HES1	0	TLE1	6	pull down, affinity chromatography technology, affinity chromatography technology	Buscarlet M (2008), Tremblay CS (2009), Tremblay CS (2009)	3
SMURF2	3	RUNX2	2	enzymatic study	Lu K (2011)	1
RUNX2	2	HDAC7	4	imaging technique, affinity chromatography technology, pull down	Jensen ED (2008), Jensen ED (2008), Jensen ED (2008)	3
SMAD5	2	STUB1	4	affinity chromatography technology	Wang L (2011)	1
HDAC3	5	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fajas L (2002), Lai A (1999), Lai A (1999), Dahiya A (2000)	4
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SMAD3	1	YAP1	0	affinity chromatography technology	Alarcon C (2009)	1
ETS1	4	RUNX2	2	pull down	Sato M (1998)	1
XRCC6	3	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Um JH (2004), Um JH (2004)	2
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
YAP1	0	HDAC1	4	affinity chromatography technology	Enzo E (2015)	1
RUNX2	2	BMPR1A	5	affinity chromatography technology	Jeon EJ (2006)	1
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
SMAD2	5	SOX9	2	affinity chromatography technology	Furumatsu T (2005)	1
EP300	36	XRCC6	3	enzymatic study	Cohen HY (2004)	1
FBXW7	2	RUNX2	2	affinity chromatography technology	Kumar Y (2015)	1
HIVEP3	12	WWP1	3	affinity chromatography technology	Jones DC (2006)	1
SUV39H1	0	SMAD5	2	affinity chromatography technology	Frontelo P (2004)	1
RUNX2	2	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shimizu E (2010), Shimizu E (2010), Jeon EJ (2006), Vega RB (2004)	4
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
RUNX2	2	SMURF1	4	imaging technique	Wang Q (2007)	1
SMAD3	1	XRCC6	3	two hybrid	Colland F (2004)	1
HDAC5	4	XRCC5	5	affinity chromatography technology	Greco TM (2011)	1
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
XRCC5	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Zhang Z (2017), Zhang Z (2017)	2
EP300	36	STAT5A	4	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Pfitzner E (1998), Pfitzner E (1998), Pfitzner E (1998), Kotla S (2015)	4
HDAC7	4	EP300	36	affinity chromatography technology	Kato H (2004)	1
JUN	0	RB1	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down	Nishitani J (1999), Nishitani J (1999), Nishitani J (1999), Nead MA (1998), Nead MA (1998)	5
NR0B2	1	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Gobinet J (2005), Gobinet J (2005), Kanamaluru D (2011), Miao J (2011), Sanyal S (2007), Sanyal S (2007)	6
CREBBP	29	FHL2	0	affinity chromatography technology	Labalette C (2004)	1
FHL2	0	SMAD2	5	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
HDAC7	4	HDAC1	4	pull down	Dressel U (2001)	1
PML	7	SMAD2	5	affinity chromatography technology	Lin HK (2004)	1
FHL2	0	RUNX2	2	affinity chromatography technology, pull down	Guenther T (2005), Guenther T (2005)	2
CREBBP	29	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Sun Y (2001)	2
KAT2B	2	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Itoh S (2000), Kahata K (2004), Dai M (2012)	3
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
SMURF1	4	XRCC5	5	affinity chromatography technology	Xie Y (2013)	1
HDAC5	4	RBM14	5	affinity chromatography technology	Greco TM (2011)	1
SUV39H1	0	HDAC1	4	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
XRCC5	5	MSX2	1	affinity chromatography technology	Willis DM (2002)	1
SMAD1	0	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Alarcon C (2009), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011)	5
KAT2B	2	HDAC3	5	pull down, affinity chromatography technology	Gregoire S (2007), Gregoire S (2007)	2
MSX2	1	TLE1	6	two hybrid	Ravasi T (2010)	1
NR0B2	1	HDAC6	0	pull down	Gobinet J (2005)	1
FHL2	0	STAT3	0	two hybrid	Gao J (2008)	1
HDAC6	0	HES1	0	two hybrid	Vinayagam A (2011)	1
SKP2	2	STUB1	4	affinity chromatography technology	Huang Z (2004)	1
EP300	36	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Nakashima K (1999), Nakashima K (1999), Jeon EJ (2006), Jun JH (2010), Weng Q (2012)	6
PML	7	JUN	0	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vallian S (1998), Yasuda S (1999), Salomoni P (2005), Salomoni P (2005), Seo SR (2006), Seo SR (2006), Seo SR (2006)	7
HDAC3	5	RUNX2	2	affinity chromatography technology, pull down, affinity chromatography technology	Schroeder TM (2004), Schroeder TM (2004), Makita N (2008)	3
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
HIF1A	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Luo W (2010), Luo W (2010), Luo W (2010), Luo W (2010)	4
HDAC3	5	JUN	0	affinity chromatography technology	Weiss C (2003)	1
RUNX2	2	CREBBP	29	affinity chromatography technology	Makita N (2008)	1
BMPR1A	5	SMAD1	0	enzymatic study	Kretzschmar M (1997)	1
SMAD3	1	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
HDAC7	4	HDAC3	5	pull down, affinity chromatography technology, affinity chromatography technology	Fischle W (2001), Fischle W (2001), Joshi P (2013)	3
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
CREBBP	29	STAT3	0	affinity chromatography technology, enzymatic study	Sun Y (2001), Yuan ZL (2005)	2
RUNX2	2	TLE1	6	affinity chromatography technology, imaging technique	Ali SA (2010), Ali SA (2010)	2
HIF1A	1	HDAC4	10	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Seo HW (2009), Seo HW (2009), Qian DZ (2006), Bodily JM (2011), Kato H (2004)	5
RBM14	5	XRCC5	5	affinity chromatography technology	Iwasaki T (2001)	1
RUNX2	2	MSX2	1	affinity chromatography technology	Shirakabe K (2001)	1
SMAD1	0	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Li L (2004), Chong PA (2010), Colland F (2004), Huttlin EL (2017), Zhou F (2017)	10
EP300	36	HIF1A	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Lando D (2002), Freedman SJ (2002), Lewis MD (2004), Matt T (2004), Sang N (2002), Luo W (2010), Freedman SJ (2003), Bodily JM (2011), Lee YM (2009), Lee YM (2009), Lee YM (2009), Kung AL (2004), Kung AL (2004), Kung AL (2004), Land SC (2007), Zhang Y (2010), Zhang Y (2010), Fath DM (2006), Fath DM (2006), Lee SJ (2013), Wang D (2014), Kaluz S (2006), Kaluz S (2006), Kaluz S (2006), Shin DH (2008), Shin DH (2008), Wang Y (2012), Huang C (2009), Hewitson KS (2002), Cook KM (2009), Cook KM (2009), Hubbi ME (2012), Kim SY (2014), Sang N (2003), Sang N (2003), Sang N (2003), Yasinska IM (2003), Na YR (2013), Na YR (2013), Mendonca DB (2011), Arany Z (1996), Arany Z (1996), Chen R (2012), Li SH (2008), Galbraith MD (2013), Chen Z (2014), Li Q (2012), Geng H (2012), Geng H (2012), Kato H (2004), Lim JH (2010), Kyle HF (2015), Kyle HF (2015), Rath S (2016), Kimura M (2008), Dubey R (2013)	56
STAT3	0	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima K (1999), Nakashima K (1999), Ray S (2002), Ray S (2002), Yuan ZL (2005), Yuan ZL (2005), Gupta M (2011), Wang R (2005), Gray MJ (2005), Hou T (2008), Kotla S (2015)	11
RUNX2	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, genetic interference	Lee HW (2006), Zhang Z (2012), Ali SA (2012), Ali SA (2012), Ali SA (2012)	5
RUNX2	2	SUV39H1	0	affinity chromatography technology, affinity chromatography technology	Tandon M (2012), Tandon M (2012)	2
SMAD3	1	RUNX2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Ohyama Y (2011)	4
RUNX2	2	FOS	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Hess J (2001), Hess J (2001), DAlonzo RC (2002), DAlonzo RC (2002), DAlonzo RC (2002)	5
XRCC6	3	RUNX2	2	affinity chromatography technology	Willis DM (2002)	1
SMAD2	5	JUN	0	affinity chromatography technology, pull down	Pessah M (2001), Miyamoto-Sato E (2010)	2
UBTF	8	TLE1	6	affinity chromatography technology	Ali SA (2010)	1
FBXW7	2	TP53	0	affinity chromatography technology	Huttlin EL (2017)	1
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
HDAC7	4	HIF1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Bodily JM (2011), Kato H (2004), Kato H (2004), Kato H (2004)	4
ETS1	4	CREBBP	29	unspecified method, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Foulds CE (2004), Foulds CE (2004), Yang C (1998), Yang C (1998), Giese K (1995), Tsai LN (2008)	6
HDAC7	4	HDAC4	10	pull down	Dressel U (2001)	1
HDAC6	0	STAT3	0	affinity chromatography technology, affinity chromatography technology, imaging technique	M L (2016), M L (2016), M L (2016)	3
SMAD5	2	SMURF2	3	affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology	Komuro A (2004), Nie J (2010), Colland F (2004), Huttlin EL (2017)	4
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
KAT2B	2	XRCC6	3	enzymatic study	Cohen HY (2004)	1
KAT2B	2	HIF1A	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Bodily JM (2011), Geng H (2012), Geng H (2012), Lim JH (2010)	4
HDAC6	0	RUNX2	2	affinity chromatography technology, affinity chromatography technology	Westendorf JJ (2002), Ozaki T (2013)	2
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
SUV39H1	0	HDAC3	5	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
STAT3	0	RUNX2	2	affinity chromatography technology	Fan D (2007)	1
STAT3	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang Q (2005), Yuan ZL (2005), Gupta M (2011), Zhi Y (2012), Zhi Y (2012)	5
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1
FOS	0	RB1	2	pull down	Nead MA (1998)	1