PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HUWE1	22	CLTC	12	affinity chromatography technology	Thompson JW (2014)	1
MDM2	2	USO1	1	affinity chromatography technology	Jacob AG (2014)	1
BRCA1	7	HSP90B1	3	affinity chromatography technology	Ertych N (2016)	1
CDH1	4	TRIP11	5	bioid	Guo Z (2014)	1
USO1	1	GOSR1	1	biochemical, pull down	Shorter J (2002), Shorter J (2002)	2
TP53	0	USO1	1	affinity chromatography technology	How PC (2011)	1
USO1	1	VCL	6	biochemical	Havugimana PC (2012)	1
STX5	0	SCFD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
GOSR1	1	YKT6	0	affinity chromatography technology	Shorter J (2002)	1
HUWE1	22	HSP90B1	3	affinity chromatography technology	Thompson JW (2014)	1
NTRK1	1	VCL	6	affinity chromatography technology	Emdal KB (2015)	1
USO1	1	GOSR2	0	biochemical, affinity chromatography technology, pull down	Shorter J (2002), Allan BB (2000), Allan BB (2000)	3
HSP90B1	3	CLTC	12	biochemical	Wan C (2015)	1
USO1	1	ZNF593	1	biochemical	Havugimana PC (2012)	1
NTRK1	1	ACTL6A	4	affinity chromatography technology	Emdal KB (2015)	1
TMEM17	0	BET1	0	bioid	Gupta GD (2015)	1
MDM2	2	HSP90B1	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Miyamoto-Sato E (2010), Wu B (2015), Wu B (2015), Wu B (2015), Wu B (2015)	5
CDH1	4	GOLGA2	2	bioid	Guo Z (2014)	1
USO1	1	DUSP12	1	two hybrid	Rolland T (2014)	1
GAK	5	USO1	1	two hybrid	Rual JF (2005)	1
GTSE1	3	RAB1A	0	affinity chromatography technology	Hein MY (2015)	1
GOSR1	1	SCFD1	1	affinity chromatography technology	Behrends C (2010)	1
NTRK1	1	CLTC	12	affinity chromatography technology	Emdal KB (2015)	1
CDC5L	2	GOLGB1	8	affinity chromatography technology	Lleres D (2010)	1
TMEM17	0	USO1	1	bioid	Gupta GD (2015)	1
CDC5L	2	KHDRBS1	1	affinity chromatography technology	Lleres D (2010)	1
GOSR1	1	BET1	0	affinity chromatography technology	Shorter J (2002)	1
USO1	1	TRIP11	5	affinity chromatography technology	van Zuylen WJ (2012)	1
SEC16A	7	VCL	6	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	HSP90B1	3	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	VCL	6	affinity chromatography technology, affinity chromatography technology, bioid	Hazan RB (1997), Hazan RB (1998), Guo Z (2014)	3
CDC5L	2	GOLGA2	2	two hybrid	Rolland T (2014)	1
USO1	1	XPO7	5	two hybrid	Rolland T (2014)	1
TP53	0	CLTC	12	affinity chromatography technology	Horikawa I (2014)	1
AKAP9	13	C1orf94	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
USO1	1	FAM184A	2	affinity chromatography technology	van Zuylen WJ (2012)	1
PTP4A3	0	HUWE1	22	affinity chromatography technology	St-Denis N (2016)	1
USO1	1	USO1	1	affinity chromatography technology, two hybrid	How PC (2011), Rolland T (2014)	2
TMEM17	0	SCFD1	1	bioid	Gupta GD (2015)	1
USO1	1	PHYKPL	0	two hybrid	Rolland T (2014)	1
USO1	1	CEP68	2	affinity chromatography technology	van Zuylen WJ (2012)	1
STX5	0	YKT6	0	affinity chromatography technology	Shorter J (2002)	1
CDC5L	2	DNAJA1	2	affinity chromatography technology	Lleres D (2010)	1
USO1	1	AKAP9	13	two hybrid	Rolland T (2014)	1
CPNE5	4	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
PRKAR2B	1	CEP68	2	affinity chromatography technology	Hein MY (2015)	1
STX5	0	SEC22A	0	affinity chromatography technology	Shorter J (2002)	1
GTSE1	3	GOLGA2	2	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	NCOA2	2	unspecified method, pull down, pull down	Rodriguez M (2003), Park JJ (2000), Nakuci E (2006)	3
PDHA1	7	TP53	0	affinity chromatography technology	Malty RH (2017)	1
NTRK1	1	KHDRBS1	1	affinity chromatography technology	Emdal KB (2015)	1
STX5	0	TP53	0	two hybrid	Stelzl U (2005)	1
BRCA1	7	SEC16A	7	affinity chromatography technology	Ertych N (2016)	1
PRKACA	2	CLTC	12	two hybrid	Bandyopadhyay S (2010)	1
STX5	0	GOSR1	1	biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hay JC (1997), Hay JC (1998), Shorter J (2002), Shorter J (2002), Shorter J (2002), Subramaniam VN (1997), Subramaniam VN (1997)	7
FOXQ1	0	TP53	0	affinity chromatography technology	Li X (2015)	1
NTRK1	1	CDC5L	2	affinity chromatography technology	Emdal KB (2015)	1
USO1	1	XIAP	0	biochemical	Havugimana PC (2012)	1
GTSE1	3	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
SCN2B	1	USO1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKAR2B	1	AKAP9	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
CASP3	0	MDM2	2	enzymatic study, enzymatic study, enzymatic study, imaging technique	Chen L (1997), Pochampally R (1998), Cheng Q (2014), Chen TC (2014)	4
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
HSP90B1	3	TXNDC11	1	two hybrid	Wang J (2011)	1
PDHA1	7	CTTN	1	affinity chromatography technology	Malty RH (2017)	1
SCN2B	1	DDX20	4	affinity chromatography technology	Huttlin EL (2015)	1
HUWE1	22	DNAJA1	2	affinity chromatography technology	Thompson JW (2014)	1
PDHA1	7	DNAJA1	2	affinity chromatography technology	Malty RH (2017)	1
CTTN	1	USO1	1	biochemical	Wan C (2015)	1
VCL	6	PDHA1	7	biochemical	Kristensen AR (2012)	1
USO1	1	PRKACA	2	affinity chromatography technology	van Zuylen WJ (2012)	1
PTP4A3	0	USO1	1	affinity chromatography technology	Ewing RM (2007)	1
TP53	0	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Rolfo A (2012), Rolfo A (2012)	6
CDC5L	2	HUWE1	22	affinity chromatography technology	Lleres D (2010)	1
NTRK1	1	XPO7	5	affinity chromatography technology	Emdal KB (2015)	1
PDHA1	7	GOLGB1	8	affinity chromatography technology	Malty RH (2017)	1
ZNF488	0	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
FOXQ1	0	USO1	1	affinity chromatography technology	Li X (2015)	1
TMEM17	0	GOSR1	1	bioid	Gupta GD (2015)	1
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
CYP1A1	1	USO1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDHA1	7	GOLGA2	2	affinity chromatography technology	Malty RH (2017)	1
CDH1	4	CTTN	1	bioid	Guo Z (2014)	1
CASP3	0	USO1	1	enzymatic study	Chiu R (2002)	1
GOLGB1	8	USO1	1	pull down	Dirac-Svejstrup AB (2000)	1
FAM184A	2	BRCA1	7	two hybrid	Hill SJ (2014)	1
RNF114	0	USO1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USO1	1	CCDC168	9	affinity chromatography technology	van Zuylen WJ (2012)	1
DNAJA1	2	USO1	1	biochemical	Wan C (2015)	1
MAPK3	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Persons DL (2000), How PC (2011), Lin C (2011), Lin C (2011)	4
CASP3	0	CDH1	4	imaging technique	Chen TC (2014)	1
TMEM17	0	TRIP11	5	bioid	Gupta GD (2015)	1
TSNAXIP1	3	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF3	1	SEC16A	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Zuylen WJ (2012), van Zuylen WJ (2012), van Zuylen WJ (2012)	3
USO1	1	POLE3	0	biochemical	Wan C (2015)	1
MDM2	2	CDH1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang JY (2006), Yang JY (2006), Yang JY (2006), Adhikary A (2014)	4
SLCO1B1	4	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
GTSE1	3	GAK	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
TP53	0	NCOA2	2	pull down	Miyamoto-Sato E (2010)	1
CDC5L	2	AKAP9	13	two hybrid	Camargo LM (2007)	1
PRKACA	2	AKAP9	13	affinity chromatography technology	Varjosalo M (2013)	1
NTRK1	1	DDX20	4	affinity chromatography technology	Emdal KB (2015)	1
ACTL6A	4	USO1	1	affinity chromatography technology	Huttlin EL (2015)	1
BRCA1	7	CDH1	4	genetic interference	Shen JP (2017)	1
MAPK3	4	RNF114	0	two hybrid	Vinayagam A (2011)	1
HSP90B1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wu B (2015), Wu B (2015), Wu B (2015), Wu B (2015)	4
HUWE1	22	PDHA1	7	affinity chromatography technology	Thompson JW (2014)	1
NTRK1	1	CTTN	1	affinity chromatography technology	Emdal KB (2015)	1
USO1	1	YKT6	0	biochemical	Shorter J (2002)	1
GOLGA2	2	FAM184A	2	two hybrid	Rolland T (2014)	1
STX5	0	BET1	0	affinity chromatography technology	Shorter J (2002)	1
NTRK1	1	SCFD1	1	affinity chromatography technology	Emdal KB (2015)	1
TRAF3	1	USO1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), van Zuylen WJ (2012), van Zuylen WJ (2012), van Zuylen WJ (2012)	4
GABPB1	0	USO1	1	two hybrid	Rual JF (2005)	1
CLTC	12	USO1	1	affinity chromatography technology	Hein MY (2015)	1
PTP4A3	0	XPO7	5	affinity chromatography technology	Ewing RM (2007)	1
TP53	0	ACTL6A	4	affinity chromatography technology, affinity chromatography technology	Wang M (2007), Wang M (2007)	2
HSP90B1	3	USO1	1	biochemical	Wan C (2015)	1
PDHA1	7	SEC16A	7	affinity chromatography technology	Malty RH (2017)	1
RAB1A	0	GOLGA2	2	two hybrid, pull down, pull down	Weide T (2003), Valsdottir R (2001), Short B (2001)	3
SNRNP27	0	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
GAK	5	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
USP28	3	USO1	1	biochemical	Havugimana PC (2012)	1
SEMA4F	1	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP290	5	USO1	1	affinity chromatography technology	Gupta GD (2015)	1
HUWE1	22	AKAP9	13	affinity chromatography technology	Hein MY (2015)	1
VCL	6	CLTC	12	pull down	Fausser JL (1993)	1
USO1	1	RAB1A	0	pull down	Allan BB (2000)	1
KHDRBS1	1	USO1	1	biochemical	Wan C (2015)	1
USO1	1	SEC22A	0	biochemical	Shorter J (2002)	1
DDX20	4	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
GTSE1	3	USO1	1	affinity chromatography technology	Hein MY (2015)	1
USO1	1	PDE4DIP	10	affinity chromatography technology	van Zuylen WJ (2012)	1
PDE4DIP	10	AKAP9	13	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
TP53	0	DNAJA1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014), Parrales A (2016), Parrales A (2016)	4
BRCA1	7	USO1	1	affinity chromatography technology	Ertych N (2016)	1
SEC16A	7	GOLGA2	2	affinity chromatography technology	Hein MY (2015)	1
CDC5L	2	HSP90B1	3	affinity chromatography technology	Lleres D (2010)	1
TMEM17	0	STX5	0	bioid	Gupta GD (2015)	1
GTSE1	3	SEC16A	7	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
MAPK3	4	USO1	1	affinity chromatography technology	How PC (2011)	1
USO1	1	SEC16A	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Zuylen WJ (2012), van Zuylen WJ (2012), Hein MY (2015)	3
BRCA1	7	MAPK3	4	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
NTRK1	1	GOLGA2	2	affinity chromatography technology	Emdal KB (2015)	1
PRKAR2B	1	PDE4DIP	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Huttlin EL (2017)	4
USO1	1	C1orf94	1	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
NTRK1	1	PDHA1	7	affinity chromatography technology	Emdal KB (2015)	1
SEC16A	7	GAK	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
PRKACA	2	PRKAR2B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Okunishi K (2011), Huttlin EL (2017)	5
TMEM17	0	YKT6	0	bioid	Gupta GD (2015)	1
CDH1	4	USO1	1	bioid	Guo Z (2014)	1
USO1	1	SCFD1	1	biochemical, affinity chromatography technology, pull down	Shorter J (2002), Allan BB (2000), Allan BB (2000)	3
SCN2B	1	XPO7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	USO1	1	affinity chromatography technology	Emdal KB (2015)	1
EFNB2	0	USO1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGB	2	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	HUWE1	22	affinity chromatography technology	Emdal KB (2015)	1
PRKAR2B	1	SEC16A	7	affinity chromatography technology	Hein MY (2015)	1
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
TMEM17	0	EFNB2	0	bioid	Gupta GD (2015)	1
HUWE1	22	USO1	1	affinity chromatography technology	Thompson JW (2014)	1
CASP3	0	CTTN	1	enzymatic study, imaging technique	Chen YR (2001), Chen TC (2014)	2
CDC5L	2	PDE4DIP	10	two hybrid	Camargo LM (2007)	1
PDHA1	7	STX5	0	affinity chromatography technology	Malty RH (2017)	1
CDH1	4	STX5	0	bioid	Guo Z (2014)	1
PRKACA	2	PDE4DIP	10	affinity chromatography technology	Varjosalo M (2013)	1
USO1	1	PRKAR2B	1	affinity chromatography technology	van Zuylen WJ (2012)	1
HUWE1	22	MDM2	2	affinity chromatography technology, enzymatic study	Kurokawa M (2013), Kurokawa M (2013)	2
SETD9	0	USO1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDH1	4	GOLGB1	8	bioid	Guo Z (2014)	1
BRCA1	7	DNAJA1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Hill SJ (2014), Ertych N (2016)	3
TMEM17	0	GOSR2	0	bioid	Gupta GD (2015)	1
USO1	1	BET1	0	biochemical	Shorter J (2002)	1
GTSE1	3	PRKACA	2	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	YKT6	0	bioid	Guo Z (2014)	1
GOLGA2	2	USO1	1	pull down, affinity chromatography technology	Dirac-Svejstrup AB (2000), van Zuylen WJ (2012)	2
GAK	5	GOLGB1	8	affinity chromatography technology	Hein MY (2015)	1
USO1	1	STX5	0	biochemical, pull down, affinity chromatography technology, pull down	Shorter J (2002), Shorter J (2002), Allan BB (2000), Allan BB (2000)	4
NTRK1	1	SEC16A	7	affinity chromatography technology	Emdal KB (2015)	1
GOLGA2	2	ZNF488	0	two hybrid	Rolland T (2014)	1
PDHA1	7	USO1	1	affinity chromatography technology	Malty RH (2017)	1
BRCA1	7	KHDRBS1	1	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	CLTC	12	affinity chromatography technology	Ertych N (2016)	1
STX5	0	GOSR2	0	biochemical, two hybrid, affinity chromatography technology	Hay JC (1997), Hay JC (1998), Shorter J (2002)	3
PDHA1	7	RAB1A	0	affinity chromatography technology	Malty RH (2017)	1
NTRK1	1	GAK	5	affinity chromatography technology	Emdal KB (2015)	1
SNRNP27	0	MAPK3	4	affinity chromatography technology	Huttlin EL (2017)	1
SEC16A	7	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
NTRK1	1	DNAJA1	2	affinity chromatography technology	Emdal KB (2015)	1
CASP3	0	TRAF3	1	enzymatic study, enzymatic study	Lee ZH (2001), Leo E (2001)	2
TXNDC11	1	USO1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	VCL	6	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	CDC5L	2	affinity chromatography technology	Ertych N (2016)	1
CDC5L	2	USO1	1	affinity chromatography technology	Lleres D (2010)	1
CDH1	4	RAB1A	0	bioid	Guo Z (2014)	1
NCOA2	2	USO1	1	affinity chromatography technology	Jung SY (2005)	1