PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NUMB	1	DPYSL2	3	affinity chromatography technology, pull down, pull down	Nishimura T (2003), Nishimura T (2003), Nishimura T (2003)	3
DBN1	1	CLTB	0	affinity chromatography technology	Hein MY (2015)	1
NUMB	1	OLIG1	0	two hybrid	Grossmann A (2015)	1
NUMB	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Colaluca IN (2008), Colaluca IN (2008), Amson R (2011), Sheng W (2013), Liu D (2016), Liu D (2016), Sheng W (2017)	7
FRS3	0	NUMB	1	two hybrid	Grossmann A (2015)	1
NUMB	1	LNX2	2	two hybrid, enzymatic study	Grossmann A (2015), Nayak D (2015)	2
IRS1	7	APP	1	pull down	Olah J (2011)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
L1CAM	3	NUMB	1	affinity chromatography technology, affinity chromatography technology	Nishimura T (2003), Nishimura T (2003)	2
DBN1	1	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
GTSE1	3	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
CTDSPL	1	TULP3	0	bioid	St-Denis N (2016)	1
EGFR	5	AP2M1	5	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	5
CLTB	0	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
GAK	5	CLTB	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
IGBP1	1	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	PRKCZ	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HNRNPL	3	CTDSPL	1	affinity chromatography technology	Fei T (2017)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
XPO1	8	FBXO7	1	pull down	Nelson DE (2011)	1
PRKCB	4	EGFR	5	enzymatic study	Khaled Z (1995)	1
STAMBPL1	2	EPS15	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Foerster S (2013), Tong J (2014), Li J (2013)	4
DBN1	1	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
TP53	0	CLTC	12	affinity chromatography technology	Horikawa I (2014)	1
GAK	5	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
GAK	5	EPS15	1	affinity chromatography technology	Hein MY (2015)	1
ITCH	1	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
CAPZA2	1	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
LNX1	7	AP2M1	5	affinity chromatography technology	Lenihan JA (2017)	1
CLTB	0	EPS15	1	affinity chromatography technology	Hein MY (2015)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
NUMB	1	APP	1	pull down, imaging technique	Olah J (2011), Chen TC (2014)	2
EGLN3	0	GTSE1	3	affinity chromatography technology	Rodriguez J (2016)	1
TMEM17	0	NUMB	1	bioid	Gupta GD (2015)	1
AP2M1	5	KBTBD7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	IRS1	7	unspecified method	Jones RB (2006)	1
AP2M1	5	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
DCAF7	4	NUMB	1	affinity chromatography technology	Boldt K (2016)	1
CTDSPL	1	NOTCH1	25	bioid	St-Denis N (2016)	1
LNX2	2	PRKCA	7	affinity chromatography technology	Wolting CD (2011)	1
HNRNPL	3	DPYSL2	3	affinity chromatography technology	Fei T (2017)	1
GTSE1	3	CLTB	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
FBXO7	1	PRKCB	4	enzymatic study	Teixeira FR (2016)	1
ITCH	1	NUMB	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	McGill MA (2003), McGill MA (2003), McGill MA (2003), Chastagner P (2008), Di Marcotullio L (2011), Di Marcotullio L (2011)	6
HNRNPL	3	NUMB	1	affinity chromatography technology	Fei T (2017)	1
KBTBD7	3	GTSE1	3	affinity chromatography technology	Huttlin EL (2017)	1
GTSE1	3	RALBP1	2	affinity chromatography technology	Hein MY (2015)	1
NOTCH1	25	LNX2	2	two hybrid	Daakour S (2016)	1
GTSE1	3	DCAF7	4	affinity chromatography technology	Hein MY (2015)	1
LNX1	7	AP2A1	1	affinity chromatography technology	Lenihan JA (2017)	1
GTSE1	3	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
XPO1	8	AP2A1	1	affinity chromatography technology	Kirli K (2015)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
LNX1	7	LNX2	2	two hybrid	Guo Z (2012)	1
NUMB	1	TERF2	2	two hybrid	Grossmann A (2015)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
CAPZA2	1	GTSE1	3	affinity chromatography technology	Hein MY (2015)	1
TULP3	0	NUMB	1	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
CDH1	4	EPS15	1	bioid	Guo Z (2014)	1
GAK	5	STAMBPL1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CLTC	12	CLTB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015), Zlatic SA (2011)	3
STAMBPL1	2	CLTC	12	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura M (2006), Nakamura M (2006), Hein MY (2015), Huttlin EL (2017)	4
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
FBXO7	1	PRKCA	7	enzymatic study	Teixeira FR (2016)	1
GTSE1	3	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
GAK	5	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
GLI1	3	TP53	0	affinity chromatography technology	Li X (2015)	1
NUMB	1	RPL3	0	two hybrid	Wang J (2011)	1
DBN1	1	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	PRKCE	6	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	EPS15	1	affinity chromatography technology	Fei T (2017)	1
ANLN	2	CLTC	12	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	NOTCH1	25	bioid	Guo Z (2014)	1
TULP3	0	KBTBD7	3	affinity chromatography technology	Huttlin EL (2017)	1
L1CAM	3	AP2A1	1	affinity chromatography technology	Nishimura T (2003)	1
RALBP1	2	NUMB	1	affinity chromatography technology	Rosse C (2003)	1
EGLN3	0	CAPZA2	1	affinity chromatography technology	Rodriguez J (2016)	1
MDM2	2	CDH1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang JY (2006), Yang JY (2006), Yang JY (2006), Adhikary A (2014)	4
LNX1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	NUMB	1	affinity chromatography technology	Kirli K (2015)	1
GTSE1	3	GAK	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
FBXO7	1	CLTC	12	affinity chromatography technology	Teixeira FR (2016)	1
CAPZA2	1	EPS15	1	affinity chromatography technology	Hein MY (2015)	1
CLTB	0	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
PRKCA	7	NUMB	1	enzymatic study	Smith CA (2007)	1
ATP6AP2	2	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
GAK	5	APP	1	pull down	Olah J (2011)	1
EGFR	5	PRKCE	6	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ANLN	2	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
AP2M1	5	CDH1	4	affinity chromatography technology	Li J (2013)	1
XPO1	8	GTSE1	3	affinity chromatography technology	Kirli K (2015)	1
CDH1	4	DBN1	1	bioid	Guo Z (2014)	1
UNC5CL	5	NUMB	1	affinity chromatography technology	Huttlin EL (2017)	1
ANLN	2	EPS15	1	affinity chromatography technology	Hein MY (2015)	1
KBTBD7	3	NUMB	1	affinity chromatography technology	Huttlin EL (2017)	1
STAMBPL1	2	NUMB	1	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
PRKCE	6	NUMB	1	enzymatic study	Smith CA (2007)	1
CLTC	12	EPS15	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Chi S (2008)	2
DBN1	1	CLTC	12	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	NUMB	1	bioid	Guo Z (2014)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGFR	5	RPL3	0	affinity chromatography technology	Yao Z (2017)	1
GAK	5	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
L1CAM	3	EGFR	5	affinity chromatography technology	Donier E (2012)	1
GAK	5	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
KIAA1107	3	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	IGBP1	1	bioid	Guo Z (2014)	1
ANLN	2	CAPZA2	1	affinity chromatography technology	Hein MY (2015)	1
NUMB	1	GLI1	3	pull down, affinity chromatography technology	Di Marcotullio L (2011), Di Marcotullio L (2011)	2
TERF2	2	SIAH1	2	pull down, enzymatic study	Fujita K (2010), Fujita K (2010)	2
CAPZA2	1	CLTC	12	affinity chromatography technology	Hein MY (2015)	1
PRKCA	7	RALBP1	2	enzymatic study	Singhal SS (2005)	1
CTDSPL	1	EGFR	5	bioid	St-Denis N (2016)	1
DBN1	1	GTSE1	3	affinity chromatography technology	Hein MY (2015)	1
MAPK8IP2	5	NUMB	1	two hybrid	Grossmann A (2015)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
DPYSL2	3	AP2A1	1	affinity chromatography technology, pull down	Nishimura T (2003), Nishimura T (2003)	2
NUMB	1	EPS15	1	affinity chromatography technology	Confalonieri S (2000)	1
EGLN3	0	DBN1	1	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	DCAF7	4	affinity chromatography technology	Kirli K (2015)	1
GTSE1	3	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
CTDSPL	1	NUMB	1	bioid	St-Denis N (2016)	1
ANLN	2	CLTB	0	affinity chromatography technology	Hein MY (2015)	1
GTSE1	3	STAMBPL1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
EGFR	5	KBTBD7	3	affinity chromatography technology	Yao Z (2017)	1
LNX1	7	PRKCA	7	affinity chromatography technology	Wolting CD (2011)	1
HNRNPL	3	PRKCZ	5	affinity chromatography technology	Fei T (2017)	1
ANLN	2	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
MDM2	2	XPO1	8	affinity chromatography technology	Jacob AG (2014)	1
AP2M1	5	CLTC	12	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Hein MY (2015)	2
GAK	5	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
PRKCB	4	NUMB	1	enzymatic study	Smith CA (2007)	1
MDM2	2	NUMB	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yogosawa S (2003), Yogosawa S (2003), Yogosawa S (2003), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Sczaniecka M (2012), Tian LF (2006), Pettersson S (2012), Liu D (2016), Liu D (2016), Sheng W (2017)	12
AP2M1	5	NUMB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	3
TMEM17	0	NOTCH1	25	bioid	Gupta GD (2015)	1
AP2A1	1	RALBP1	2	affinity chromatography technology, affinity chromatography technology	Kariya K (2000), Huttlin EL (2017)	2
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
EGLN3	0	IRS1	7	affinity chromatography technology	Rodriguez J (2016)	1
PRKCA	7	EGFR	5	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gauthier ML (2003), Gauthier ML (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
GLI1	3	CAPZA2	1	affinity chromatography technology	Agarwal NK (2016)	1
LNX1	7	NUMB	1	enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2002), Nie J (2002), Nie J (2004), Nie J (2004), Chen J (2005), Lenihan JA (2017)	6
EGLN3	0	NUMB	1	affinity chromatography technology	Rodriguez J (2016)	1
GLI1	3	ITCH	1	affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology	Di Marcotullio L (2011), Di Marcotullio L (2011), Di Marcotullio L (2011), Di Marcotullio L (2011), Di Marcotullio L (2011)	5
HNRNPL	3	TULP3	0	affinity chromatography technology	Fei T (2017)	1
COL10A1	1	NUMB	1	affinity chromatography technology	Huttlin EL (2017)	1
IGBP1	1	APP	1	pull down	Olah J (2011)	1
ANLN	2	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
CAPZA2	1	CLTB	0	affinity chromatography technology	Hein MY (2015)	1
SIAH1	2	NUMB	1	two hybrid, pull down, pull down, affinity chromatography technology, two hybrid	Susini L (2001), Susini L (2001), Susini L (2001), Susini L (2001), Wang J (2011)	5
TP53	0	DBN1	1	affinity chromatography technology	Horikawa I (2014)	1
CLTC	12	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
ANLN	2	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
IRS1	7	NUMB	1	two hybrid	Grossmann A (2015)	1
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
DCAF7	4	APP	1	pull down	Olah J (2011)	1
CAPZA2	1	NUMB	1	affinity chromatography technology	Hein MY (2015)	1
TMEM17	0	EPS15	1	bioid	Gupta GD (2015)	1
EPS15	1	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Delft S (1997), Kariya K (2000), Confalonieri S (2000), Brehme M (2009)	4
TMEM17	0	ATP6AP2	2	bioid	Gupta GD (2015)	1
GTSE1	3	EPS15	1	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	AP2M1	5	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	MAPK8IP2	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
CAPZA2	1	STAMBPL1	2	affinity chromatography technology	Hein MY (2015)	1
AP2M1	5	RALBP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOTCH1	25	APP	1	genetic interference, affinity chromatography technology	Kim SY (2007), Kim SY (2007)	2
EGLN3	0	IGBP1	1	affinity chromatography technology	Rodriguez J (2016)	1
CLTB	0	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
ANLN	2	GTSE1	3	affinity chromatography technology	Hein MY (2015)	1
ITCH	1	HNRNPL	3	pull down, affinity chromatography technology	Ingham RJ (2005), Fei T (2017)	2
TP53	0	CLTB	0	affinity chromatography technology	Horikawa I (2014)	1
CDH1	4	ANLN	2	bioid	Guo Z (2014)	1
FBXO7	1	NUMB	1	enzymatic study	Teixeira FR (2016)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
PRKCZ	5	NUMB	1	enzymatic study, pull down	Smith CA (2007), Smith CA (2007)	2
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
TP53	0	DCAF7	4	affinity chromatography technology	Fogeron ML (2013)	1
MDM2	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lim SO (2011), Lim SO (2011), Pettersson S (2012), Pettersson S (2012), Pettersson S (2012)	5
APP	1	MAPK8IP2	5	affinity chromatography technology	Muresan Z (2005)	1
NUMB	1	AP2A1	1	affinity chromatography technology, pull down	Nishimura T (2003), Nishimura T (2003)	2
CAPZA2	1	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
NOTCH1	25	NUMB	1	pull down, pull down	Zhong W (1996), Pettersson S (2012)	2
DBN1	1	EPS15	1	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	NUMB	1	unspecified method	Jones RB (2006)	1
XPO1	8	EPS15	1	affinity chromatography technology	Kirli K (2015)	1
TP53	0	RPL3	0	affinity chromatography technology	Fogeron ML (2013)	1
CLTC	12	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
DBN1	1	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2