PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPN11	20	JAK1	6	pull down, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Lehmann U (2003)	3
NTRK1	1	RPTOR	4	affinity chromatography technology	Emdal KB (2015)	1
IRS2	6	DVL2	5	affinity chromatography technology, affinity chromatography technology	Geng Y (2014), Geng Y (2014)	2
INSR	9	JAK1	6	affinity chromatography technology	Le MN (2002)	1
XPO1	8	RPTOR	4	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	EPN1	4	affinity chromatography technology	Emdal KB (2015)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
XPO1	8	YWHAG	5	affinity chromatography technology	Kirli K (2015)	1
MYC	2	XPO1	8	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Kirli K (2015)	2
PIK3R1	6	IRS1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology	Hadari YR (1992), Morrison KB (2002), Gual P (2003), Hamer I (2002), Bazuine M (2003), Tzatsos A (2006), Calegari VC (2005), Tzatsos A (2009), Liu BA (2012), Sung CK (1994), Ren W (2013), Sung CK (1998), Grossmann A (2015), Grossmann A (2015), Antonetti DA (1996), Luo M (2007), Luo M (2007)	17
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
IRS1	7	UBTF	8	affinity chromatography technology, affinity chromatography technology	Sun H (2003), Dalmizrak O (2007)	2
PIK3R1	6	PIK3CA	8	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017)	9
IRS1	7	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Zhang J (2007), Froejdoe S (2011)	2
NTRK1	1	USP7	14	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	IRS2	6	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	YWHAH	0	biochemical	Kristensen AR (2012)	1
TYK2	1	JAK1	6	affinity chromatography technology	Domanski P (1995)	1
IRS2	6	JAK1	6	affinity chromatography technology	Johnston JA (1995)	1
IRS1	7	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
ESR1	0	SFN	1	affinity chromatography technology	Tarallo R (2011)	1
RPTOR	4	IRS1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tzatsos A (2006), Tzatsos A (2009), Tzatsos A (2009), Tzatsos A (2009)	4
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
YWHAG	5	PIK3R1	6	affinity chromatography technology	Jin J (2004)	1
IRS2	6	USP7	14	affinity chromatography technology	Fukushima T (2017)	1
BCL2	0	MYC	2	affinity chromatography technology, imaging technique	Jin Z (2004), Jin Z (2004)	2
INSR	9	PTPN11	20	pull down, affinity chromatography technology, pull down	Maegawa H (1994), Kharitonenkov A (1995), Kharitonenkov A (1995)	3
EGFR	5	YWHAB	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
XPO1	8	GRB10	4	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	YWHAE	0	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
ESR1	0	SRPK2	1	affinity chromatography technology	Tarallo R (2011)	1
FBXW11	2	IRS2	6	affinity chromatography technology	Coyaud E (2015)	1
YWHAZ	1	IRS2	6	affinity chromatography technology	Hein MY (2015)	1
GRB10	4	YWHAE	0	pull down, affinity chromatography technology, affinity chromatography technology	Urschel S (2005), Urschel S (2005), Urschel S (2005)	3
EGLN3	0	RPTOR	4	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	SRPK2	1	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	NISCH	11	affinity chromatography technology	Rodriguez J (2016)	1
IRS2	6	GRB2	2	unspecified method, affinity chromatography technology	Liu BA (2012), Bisson N (2011)	2
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
RPTOR	4	RPS6KB1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Ali SM (2005), Ha SH (2006), Hara K (2002), Nojima H (2003), Kwak D (2012), Carriere A (2011), Ha SH (2006), Li L (2013), Garcia-Martinez JM (2009)	9
ELAVL1	0	YWHAG	5	affinity chromatography technology	Abdelmohsen K (2009)	1
IRS2	6	UBTF	8	affinity chromatography technology	Sun H (2003)	1
EPOR	3	GRB2	2	pull down, pull down, affinity chromatography technology	Tauchi T (1995), Feng GS (1996), Barber DL (1997)	3
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
EGFR	5	EPN1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sigismund S (2005), Bertelsen V (2011), Kazazic M (2009)	3
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
EGFR	5	IRS1	7	unspecified method	Jones RB (2006)	1
IRS2	6	EPOR	3	affinity chromatography technology	Verdier F (1997)	1
XPO1	8	EPN1	4	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
ELAVL1	0	DVL2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
SIRT1	3	MTOR	14	affinity chromatography technology, affinity chromatography technology	Back JH (2011), Singh BK (2016)	2
NTRK1	1	PLCG1	6	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Ohmichi M (1991), Qian X (1998), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	6
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
YWHAQ	0	IRS2	6	affinity chromatography technology, pull down	Ewing RM (2007), Meek SE (2004)	2
GRB10	4	EGFR	5	pull down, two hybrid, protein complementation assay	He W (1998), Kotlyar M (2015), Petschnigg J (2014)	3
YWHAH	0	IRS2	6	affinity chromatography technology	Hein MY (2015)	1
IRS1	7	PIK3R3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Xia X (1999), Mothe I (1997), Grossmann A (2015), Grossmann A (2015)	4
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
SIRT1	3	JAK1	6	affinity chromatography technology	Lin Z (2012)	1
EGLN3	0	YWHAE	0	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	JAK1	6	affinity chromatography technology	Emdal KB (2015)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
NISCH	11	IRS2	6	affinity chromatography technology	Sano H (2002)	1
PIK3R1	6	GRB10	4	affinity chromatography technology	Deng Y (2003)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
YWHAZ	1	SFN	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
YWHAE	0	IRS2	6	affinity chromatography technology	Gloeckner CJ (2007)	1
SIRT1	3	MYC	2	pull down, affinity chromatography technology	Menssen A (2012), Menssen A (2012)	2
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
GRB2	2	YWHAZ	1	affinity chromatography technology	Bisson N (2011)	1
EGLN3	0	YWHAZ	1	affinity chromatography technology	Rodriguez J (2016)	1
FBXW11	2	YWHAE	0	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
PTPN11	20	IRS1	7	pull down, affinity chromatography technology, unspecified method, pull down, enzymatic study	Kuhne MR (1993), Myers MG (1998), Liu BA (2012), Strack V (2002), Strack V (2002)	5
MTOR	14	YWHAZ	1	affinity chromatography technology, genetic interference	Vander Haar E (2007), Srivas R (2016)	2
NTRK1	1	YWHAB	1	affinity chromatography technology	Emdal KB (2015)	1
NISCH	11	PIK3R1	6	affinity chromatography technology	Boldt K (2016)	1
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
IRS2	6	SIRT1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang J (2007), Zhang J (2007), Froejdoe S (2011)	3
SIRT1	3	DVL2	5	affinity chromatography technology, affinity chromatography technology	Holloway KR (2010), Holloway KR (2010)	2
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
YWHAQ	0	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
NISCH	11	IRS1	7	affinity chromatography technology	Sano H (2002)	1
NETO2	1	IRS2	6	affinity chromatography technology	Hein MY (2015)	1
ESR1	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Castoria G (2001), Simoncini T (2000), Simoncini T (2000)	3
PIK3R3	0	NISCH	11	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	NISCH	11	affinity chromatography technology	Bisson N (2011)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
SOCS1	1	IRS2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rui L (2002), Rui L (2002), McCormick SM (2016), McCormick SM (2016)	4
IRS2	6	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Argetsinger LS (1996), Verdier F (1997), Kim B (1998), Hamer I (2002), Calegari VC (2005), Tzatsos A (2009), Ren W (2013), Hein MY (2015)	8
GRB2	2	YWHAG	5	affinity chromatography technology	Bisson N (2011)	1
ELAVL1	0	RPS6KB1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
GRB2	2	YWHAB	1	affinity chromatography technology	Bisson N (2011)	1
ESR1	0	IRS1	7	affinity chromatography technology, affinity chromatography technology	Morelli C (2003), Morelli C (2003)	2
GRB10	4	NEDD4	2	affinity chromatography technology	Murdaca J (2004)	1
IRS2	6	PTPN11	20	affinity chromatography technology	Argetsinger LS (1996)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
NEDD4	2	IRS2	6	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down	Fukushima T (2015), Fukushima T (2015), Fukushima T (2015), Fukushima T (2015), Fukushima T (2015)	5
RPTOR	4	ESR1	0	affinity chromatography technology, affinity chromatography technology	Alayev A (2016), Alayev A (2016)	2
SOCS1	1	PIK3R1	6	two hybrid	Grossmann A (2015)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
IRS2	6	EPN1	4	affinity chromatography technology, affinity chromatography technology	Fukushima T (2015), Fukushima T (2015)	2
SIRT1	3	RPTOR	4	affinity chromatography technology, affinity chromatography technology	Back JH (2011), Back JH (2011)	2
INSR	9	GRB2	2	affinity chromatography technology	Ishihara H (1997)	1
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
MYC	2	IRS2	6	genetic interference	Toyoshima M (2012)	1
BCL2	0	IRS2	6	affinity chromatography technology	Ueno H (2000)	1
ELAVL1	0	GRB10	4	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	YWHAZ	1	affinity chromatography technology	Emdal KB (2015)	1
IRS1	7	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Skolnik EY (1993), Skolnik EY (1993), Skolnik EY (1993), Morrison KB (2002), Giorgetti-Peraldi S (1995), Liu BA (2012), Bisson N (2011)	7
NTRK1	1	USP15	4	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	IRS2	6	affinity chromatography technology	Rodriguez J (2016)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
MYC	2	NTRK1	1	genetic interference	Toyoshima M (2012)	1
FBXW11	2	ELAVL1	0	affinity chromatography technology	Low TY (2014)	1
FBXW11	2	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
YWHAH	0	IRS1	7	affinity chromatography technology	Ichimura T (2002)	1
EGFR	5	YWHAQ	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
YWHAQ	0	ESR1	0	pull down	Zilliacus J (2001)	1
SRPK2	1	IRS2	6	enzymatic study	Lipp JJ (2015)	1
EGFR	5	SOCS3	0	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Xia L (2002), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
YWHAB	1	IRS2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004), Couzens AL (2013)	3
IRS2	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
ELAVL1	0	YWHAB	1	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology, enzymatic study	Schulze WX (2006), Tomic S (1995), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Kapoor GS (2010), Vogel W (1996)	7
PIK3R3	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
IRS2	6	TYK2	1	pull down	Platanias LC (1996)	1
NTRK1	1	PIK3R1	6	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
JAK1	6	SOCS1	1	affinity chromatography technology	Park ES (2000)	1
TYK2	1	SOCS1	1	affinity chromatography technology	Piganis RA (2011)	1
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
YWHAE	0	IRS1	7	pull down, two hybrid	Craparo A (1997), Craparo A (1997)	2
USP7	14	MYC	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Tavana O (2016), Tavana O (2016), Tavana O (2016), Tavana O (2016)	4
INSR	9	IRS1	7	two hybrid, two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Aguirre V (2002), Sawka-Verhelle D (1996), Strack V (2002), Wolf G (1995), Kwon H (2015), Kwon H (2015)	6
NTRK1	1	DVL2	5	affinity chromatography technology	Emdal KB (2015)	1
ELAVL1	0	NETO2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MYC	2	YWHAQ	0	affinity chromatography technology	Koch HB (2007)	1
MRPL1	0	IRS2	6	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
JAK1	6	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Johnston JA (1995)	2
NTRK1	1	INSR	9	affinity chromatography technology	Emdal KB (2015)	1
PIK3R1	6	EPOR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology	Shigematsu H (1997), Shigematsu H (1997), Damen JE (1995), Damen JE (1995), Montoye T (2005), Bulut GB (2013)	6
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
MYC	2	YWHAB	1	affinity chromatography technology	Koch HB (2007)	1
RPS6KB1	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chiang GG (2005), Holz MK (2005), Holz MK (2005), Hara K (2002), Isotani S (1999), Long X (2005), Toral-Barza L (2005), Ali SM (2005), Saitoh M (2002), Kim DH (2002), Edinger AL (2003), Leone M (2006), Takahashi T (2000), Burnett PE (1998), Sarbassov DD (2005), Agrawal P (2012), Sancak Y (2007), Oshiro N (2004), Sarbassov DD (2005), Kim DH (2003), Kim DH (2003), Nojima H (2003), Martin J (2008), Wing LY (2005), Ren HY (2015)	25
SFN	1	IRS1	7	affinity chromatography technology	Benzinger A (2005)	1
IRS1	7	IRS2	6	biochemical	Sun H (2003)	1
GRB2	2	YWHAE	0	affinity chromatography technology	Bisson N (2011)	1
INSR	9	IRS2	6	two hybrid	Sawka-Verhelle D (1996)	1
YWHAQ	0	MTOR	14	pull down	Meek SE (2004)	1
RPS6KB1	1	IRS1	7	enzymatic study, pull down, enzymatic study	Xu X (2012), Xu X (2012), Xu X (2008)	3
NTRK1	1	PTPN11	20	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	USP15	4	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	YWHAH	0	affinity chromatography technology	Emdal KB (2015)	1
SOCS3	0	YWHAQ	0	two hybrid	Grossmann A (2015)	1
PIK3R3	0	PIK3CA	8	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Mothe I (1997), Grossmann A (2015), Hein MY (2015), Huttlin EL (2017)	4
IRS2	6	USP15	4	affinity chromatography technology, affinity chromatography technology	Fukushima T (2017), Fukushima T (2017)	2
IRS1	7	DVL2	5	affinity chromatography technology, affinity chromatography technology	Geng Y (2014), Geng Y (2014)	2
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
IRS2	6	RPTOR	4	pull down	Tzatsos A (2009)	1
JAK1	6	PLCG1	6	affinity chromatography technology	Chang YJ (2004)	1
ELAVL1	0	IRS2	6	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	YWHAG	5	affinity chromatography technology	Emdal KB (2015)	1
INSR	9	SOCS1	1	affinity chromatography technology	Mooney RA (2001)	1
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
EGLN3	0	YWHAQ	0	affinity chromatography technology	Rodriguez J (2016)	1
MTOR	14	ESR1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Alayev A (2016), Alayev A (2016), Alayev A (2016)	3
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
ESR1	0	UBTF	8	affinity chromatography technology	Tarallo R (2011)	1
IRS1	7	MTOR	14	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ozes ON (2001), Tzatsos A (2006), Tzatsos A (2006)	3
YWHAQ	0	RPTOR	4	affinity chromatography technology	Gwinn DM (2008)	1
FBXW11	2	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
IRS1	7	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tzatsos A (2006), Bazuine M (2003), Whiteman EL (2003), Kuchay S (2013)	4
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PLCG1	6	IRS2	6	affinity chromatography technology, affinity chromatography technology, unspecified method	Sozzani P (1998), Sozzani P (1998), Liu BA (2012)	3
NEDD4	2	NTRK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Arevalo JC (2006), Arevalo JC (2006), Arevalo JC (2006), Georgieva MV (2011), Georgieva MV (2011), Persaud A (2009), Persaud A (2009), Emdal KB (2015)	8
IRS2	6	RPS6KB1	1	affinity chromatography technology	Warren KJ (2016)	1
BCL2	0	IRS1	7	affinity chromatography technology, affinity chromatography technology	Ueno H (2000), Ueno H (2000)	2
NEDD4	2	RPS6KB1	1	enzymatic study	Persaud A (2009)	1
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
GRB10	4	INSR	9	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Langlais P (2000), Hansen H (1996), Hansen H (1996), Hansen H (1996), Liu F (1995), Liu F (1995), Liu F (1995), He W (1998), He W (1998), Frantz JD (1997), Mori K (2005)	11
YWHAZ	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	DVL2	5	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	SIRT1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
IRS1	7	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Rui L (2002), Li JY (2007)	2
IRS2	6	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Whiteman EL (2003), Fukushima T (2015)	2
INSR	9	SOCS3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Senn JJ (2003), Calegari VC (2005), Calegari VC (2005)	3
EGFR	5	SFN	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Li J (2013)	5
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
SFN	1	IRS2	6	affinity chromatography technology	Benzinger A (2005)	1
EGLN3	0	SIRT1	3	affinity chromatography technology	Rodriguez J (2016)	1
SIRT1	3	ESR1	0	affinity chromatography technology	Elangovan S (2011)	1
INSR	9	PLCG1	6	unspecified method	Liu BA (2012)	1
NTRK1	1	PIK3CA	8	affinity chromatography technology	Emdal KB (2015)	1
YWHAG	5	IRS2	6	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
IRS2	6	MTOR	14	affinity chromatography technology	Warren KJ (2016)	1
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
EGLN3	0	IRS1	7	affinity chromatography technology	Rodriguez J (2016)	1
ESR1	0	IRS2	6	affinity chromatography technology, affinity chromatography technology	Morelli C (2003), Morelli C (2003)	2
NTRK1	1	YWHAQ	0	affinity chromatography technology	Emdal KB (2015)	1
MYC	2	YWHAE	0	affinity chromatography technology	Koch HB (2007)	1
NTRK1	1	SFN	1	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
IRS2	6	PIK3R3	0	affinity chromatography technology, affinity chromatography technology	Xia X (1999), Huttlin EL (2017)	2
EGLN3	0	DVL2	5	affinity chromatography technology	Rodriguez J (2016)	1
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
EPOR	3	PTPN11	20	affinity chromatography technology, pull down	Tauchi T (1996), Tauchi T (1995)	2
ELAVL1	0	PTPN11	20	affinity chromatography technology	Abdelmohsen K (2009)	1
SOCS3	0	EPOR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Sasaki A (2000), Sasaki A (2000), Sasaki A (2000), Hoertner M (2002)	4
GRB10	4	IRS1	7	pull down, affinity chromatography technology	Hansen H (1996), Deng Y (2003)	2
SIRT1	3	PIK3R1	6	affinity chromatography technology	Froejdoe S (2011)	1
XPO1	8	IRS2	6	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	YWHAH	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ESR1	0	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Simoncini T (2000), Yoshimaru T (2013)	2
SRPK2	1	YWHAB	1	enzymatic study, affinity chromatography technology	Varjosalo M (2013), Jang SW (2009)	2
XPO1	8	MTOR	14	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	UBTF	8	affinity chromatography technology	Emdal KB (2015)	1
PIK3CA	8	EGFR	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAB	1	IRS1	7	pull down	Kosaki A (1998)	1
COPS2	5	IRS2	6	biochemical	Havugimana PC (2012)	1
GRB2	2	YWHAQ	0	affinity chromatography technology	Bisson N (2011)	1
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
EGFR	5	IRS2	6	affinity chromatography technology	Tong J (2008)	1
GRB10	4	IRS2	6	affinity chromatography technology, affinity chromatography technology	Deng Y (2003), Warren KJ (2016)	2
EPN1	4	DVL2	5	affinity chromatography technology, affinity chromatography technology	Chang B (2015), Chang B (2015)	2
UBTF	8	PIK3CA	8	affinity chromatography technology	Dalmizrak O (2007)	1
PIK3R1	6	EPN1	4	affinity chromatography technology	Bulut GB (2013)	1
NEDD4	2	IRS1	7	pull down	Persaud A (2009)	1
YWHAH	0	PIK3CA	8	affinity chromatography technology	Ichimura T (2002)	1
EGLN3	0	PIK3R3	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	COPS2	5	affinity chromatography technology	Rodriguez J (2016)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
SFN	1	YWHAB	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
PIK3CA	8	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GRB2	2	PIK3R3	0	affinity chromatography technology	Bisson N (2011)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
EGFR	5	SOCS1	1	affinity chromatography technology	Xia L (2002)	1
RPS6KB1	1	XPO1	8	affinity chromatography technology	Panasyuk G (2006)	1
GRB2	2	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	3
EGFR	5	MTOR	14	affinity chromatography technology	Foerster S (2013)	1
EPOR	3	EGLN3	0	affinity chromatography technology, pull down	Heir P (2016), Heir P (2016)	2
EPOR	3	PLCG1	6	protein complementation assay	Montoye T (2005)	1
SOCS1	1	PTPN11	20	affinity chromatography technology	Ali S (2003)	1
FBXW11	2	YWHAZ	1	affinity chromatography technology	Coyaud E (2015)	1
EGFR	5	JAK1	6	affinity chromatography technology	Tong J (2008)	1
GRB2	2	YWHAH	0	affinity chromatography technology	Bisson N (2011)	1
ELAVL1	0	SOCS3	0	affinity chromatography technology	Do KH (2013)	1
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3