PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PEA15	0	SON	20	two hybrid	Nagarajan A (2014)	1
COPS5	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei T (2017)	2
LGR4	3	PEA15	0	affinity chromatography technology	Carmon KS (2014)	1
STIL	3	PEA15	0	bioid	Gupta GD (2015)	1
PEA15	0	FAM103A1	0	two hybrid	Nagarajan A (2014)	1
PEA15	0	SNRPG	0	two hybrid	Nagarajan A (2014)	1
PDPK1	0	LUC7L2	0	two hybrid	Vinayagam A (2011)	1
HNRNPL	3	TJP1	2	affinity chromatography technology	Fei T (2017)	1
PEA15	0	DNAJB1	1	two hybrid	Nagarajan A (2014)	1
HNRNPL	3	CEP170	4	affinity chromatography technology	Fei T (2017)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
PEA15	0	TRAPPC13	0	two hybrid	Nagarajan A (2014)	1
TERF2IP	1	TALDO1	2	two hybrid	Lee OH (2011)	1
PDPK1	0	PEA15	0	two hybrid	Vinayagam A (2011)	1
CACYBP	0	MAPK1	1	enzymatic study	Kilanczyk E (2011)	1
PLD2	1	PEA15	0	affinity chromatography technology	Zhang Y (2000)	1
RPS6KA3	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Zhao Y (1996), Smith JA (1999), Wang J (2011), Varjosalo M (2013), Chrestensen CA (2002), Chen TC (2014), Kang S (2008)	7
CEP120	5	CEP170	4	bioid	Gupta GD (2015)	1
PEA15	0	FADD	1	pull down, affinity chromatography technology	Kitsberg D (1999), Condorelli G (1999)	2
PEA15	0	OSBPL1A	1	two hybrid	Nagarajan A (2014)	1
ABCD4	2	PEA15	0	two hybrid	Stelzl U (2005)	1
IQCB1	3	PEA15	0	affinity chromatography technology	Sang L (2011)	1
PEA15	0	CEP120	5	two hybrid	Nagarajan A (2014)	1
CEP170	4	PEA15	0	bioid	Gupta GD (2015)	1
HNRNPL	3	TERF2IP	1	affinity chromatography technology	Fei T (2017)	1
PEA15	0	DYRK1A	36	two hybrid	Nagarajan A (2014)	1
RPS6KA3	2	PDPK1	0	affinity chromatography technology, imaging technique	Froedin M (2000), Chen TC (2014)	2
PEA15	0	KLHL12	4	two hybrid	Nagarajan A (2014)	1
PLD1	5	PEA15	0	two hybrid, pull down, affinity chromatography technology, two hybrid	Zhang Y (2000), Zhang Y (2000), Zhang Y (2000), Nagarajan A (2014)	4
PEA15	0	PDE4DIP	10	two hybrid	Nagarajan A (2014)	1
CASP8	1	MAPK1	1	affinity chromatography technology	Yao Z (2007)	1
FBF1	2	PEA15	0	bioid	Gupta GD (2015)	1
COPS5	0	LUC7L2	0	affinity chromatography technology	Bennett EJ (2010)	1
PEA15	0	PGM1	2	two hybrid	Nagarajan A (2014)	1
COPS5	0	SNRPG	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	FAM103A1	0	affinity chromatography technology	Bennett EJ (2010)	1
PEA15	0	COPS5	0	two hybrid, affinity chromatography technology, enzymatic study	Nagarajan A (2014), Nagarajan A (2014), Nagarajan A (2014)	3
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
PEA15	0	TALDO1	2	two hybrid	Nagarajan A (2014)	1
PEA15	0	PAPD5	3	two hybrid	Nagarajan A (2014)	1
CEP170	4	PDE4DIP	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PGM1	2	TALDO1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PEA15	0	ATP1B3	0	two hybrid	Nagarajan A (2014)	1
MAPK1	1	MTIF3	1	two hybrid	Wang J (2011)	1
TERF2IP	1	PGM1	2	two hybrid	Lee OH (2011)	1
LUC7L2	0	PEA15	0	two hybrid	Stelzl U (2005)	1
PEA15	0	TJP1	2	two hybrid	Nagarajan A (2014)	1
PEA15	0	MAPK1	1	two hybrid, pull down, affinity chromatography technology	Formstecher E (2001), Formstecher E (2001), Casar B (2007)	3
PEA15	0	PPP4R3A	3	two hybrid	Nagarajan A (2014)	1
FBF1	2	CEP170	4	bioid	Gupta GD (2015)	1
PEA15	0	RSL24D1	0	two hybrid	Nagarajan A (2014)	1
PEA15	0	MAPK3	4	two hybrid, two hybrid	Formstecher E (2001), Vinayagam A (2011)	2
HNRNPL	3	PEA15	0	affinity chromatography technology	Fei T (2017)	1
L1CAM	3	PEA15	0	two hybrid	Stelzl U (2005)	1
COPS5	0	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
PEA15	0	CACYBP	0	two hybrid	Nagarajan A (2014)	1
PEA15	0	PUS3	1	two hybrid	Nagarajan A (2014)	1
PEA15	0	RPS6KA3	2	affinity chromatography technology, pull down, affinity chromatography technology	Vaidyanathan H (2003), Vaidyanathan H (2003), Vaidyanathan H (2003)	3
RPS6KA3	2	MAPK3	4	affinity chromatography technology, imaging technique	Zhao Y (1996), Chen TC (2014)	2
FBF1	2	TJP1	2	bioid	Gupta GD (2015)	1
PEA15	0	CASP8	1	pull down, affinity chromatography technology	Kitsberg D (1999), Condorelli G (1999)	2
TERF2IP	1	PEA15	0	two hybrid	Lee OH (2011)	1
PEA15	0	MTIF3	1	two hybrid	Nagarajan A (2014)	1