PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
OTUD4	2	KRT36	4	affinity chromatography technology	Sowa ME (2009)	1
USP8	7	GRB2	2	pull down	Kato M (2000)	1
MAP3K1	4	KRT36	4	enzymatic study	Charlaftis N (2014)	1
GRB2	2	MAP3K1	4	pull down, affinity chromatography technology, affinity chromatography technology	Pomerance M (1998), Pomerance M (1998), Saito T (2004)	3
DNPEP	2	KRT36	4	affinity chromatography technology	Ewing RM (2007)	1
CUL3	17	KRT36	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SMURF1	4	KRT36	4	enzymatic study	Andrews PS (2010)	1
EPS15	1	KRT36	4	affinity chromatography technology	Brehme M (2009)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
KRT36	4	APP	1	pull down	Olah J (2011)	1
CUL3	17	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
TWF2	2	KRT36	4	affinity chromatography technology	Ewing RM (2007)	1
USP8	7	KRT36	4	affinity chromatography technology	Sowa ME (2009)	1
GRB2	2	KRT36	4	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	USP8	7	affinity chromatography technology, enzymatic study	Mizuno E (2006), Mizuno E (2006)	2