PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
CFLAR	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
YOD1	0	RIPK1	2	enzymatic study	Mevissen TE (2013)	1
TNFRSF1B	4	CHUK	5	affinity chromatography technology	Wicovsky A (2009)	1
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
CFLAR	1	TNFRSF1A	3	genetic interference	Ma Y (2017)	1
TRAF5	1	NUMBL	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Tao T (2012), Tao T (2012), Wang J (2011)	3
TLR3	2	TAB2	5	affinity chromatography technology	Jiang Z (2003)	1
PELI1	1	UBC	7	enzymatic study, enzymatic study	Smith H (2009), Smith H (2011)	2
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
MAP3K14	1	IKBKB	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Luftig MA (2001), Woronicz JD (1997), Li Q (2006), Huttlin EL (2017)	4
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
THSD4	1	RIPK1	2	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	TRAF3	1	pull down	Mosialos G (1995)	1
RIPK2	0	CFLAR	1	affinity chromatography technology	Inohara N (1998)	1
PELI1	1	BIRC3	1	affinity chromatography technology, pull down, pull down	Jeon YK (2016), Jeon YK (2016), Jeon YK (2016)	3
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
LRRK2	5	TRADD	0	affinity chromatography technology	Ho CC (2009)	1
ITCH	1	RIPK1	2	affinity chromatography technology	Shembade N (2009)	1
RNF216	2	TLR3	2	two hybrid	Chuang TH (2004)	1
MAP3K7	2	ITCH	1	affinity chromatography technology	Kathania M (2015)	1
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
TLR3	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Cusson-Hermance N (2005), Zinngrebe J (2016)	2
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
HSP90AA1	7	UBE2N	1	pull down	Zhang M (2005)	1
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
TICAM1	3	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Nguyen VP (2014)	2
TNF	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	4
RIPK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fearns C (2006), Taipale M (2012)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
UBE2N	1	TRIM27	2	two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011)	2
TRAF1	0	SQSTM1	0	affinity chromatography technology	Greenfeld H (2015)	1
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
IKBKB	1	ITCH	1	affinity chromatography technology	Agarwal NK (2016)	1
TRAF5	1	MAP3K14	1	affinity chromatography technology	Song HY (1997)	1
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
XIAP	0	TAB2	5	affinity chromatography technology	Sanna MG (2002)	1
TNFRSF1A	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moquin DM (2013), Nakazawa S (2016), Elliott PR (2016)	3
RIPK1	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wright A (2007), Nagabhushana A (2011), ODonnell MA (2012), Wu GR (2017)	4
TNFRSF1B	4	TRAF3	1	pull down, affinity chromatography technology	Mosialos G (1995), Mosialos G (1995)	2
RNF11	0	IKBKG	0	two hybrid	Colland F (2004)	1
LRRK2	5	RIPK2	0	enzymatic study, enzymatic study	Zach S (2010), Zach S (2010)	2
HSP90AA1	7	TAB2	5	affinity chromatography technology	Gano JJ (2010)	1
LRRK2	5	HERC2	9	affinity chromatography technology, affinity chromatography technology	Imai Y (2015), Imai Y (2015)	2
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
CASP10	1	TNFRSF10B	1	biochemical, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997)	2
XPO1	8	NUMBL	1	affinity chromatography technology	Kirli K (2015)	1
TRPC4AP	4	IKBKB	1	affinity chromatography technology	Soond SM (2003)	1
XIAP	0	RIPK2	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Bertrand MJ (2011), Damgaard RB (2012), Krieg A (2009), Krieg A (2009), Krieg A (2009), Conde C (2012), Damgaard RB (2013), Damgaard RB (2013), Rolland T (2014)	9
TICAM1	3	TRAF5	1	affinity chromatography technology	Jiang Z (2004)	1
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
CHUK	5	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
TRAF2	1	RIPK3	2	affinity chromatography technology	Yu PW (1999)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
RIPK2	0	TRAF5	1	affinity chromatography technology	McCarthy JV (1998)	1
TRIM27	2	RIPK1	2	affinity chromatography technology	Zaman MM (2013)	1
TLR3	2	FADD	1	affinity chromatography technology	Zinngrebe J (2016)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
CYLD	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
SQSTM1	0	FAS	2	affinity chromatography technology, affinity chromatography technology	Liang X (2013), Liang X (2013)	2
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
RIPK1	2	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
FAS	2	TRAF3	1	pull down	Mosialos G (1995)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
TRAF2	1	USP4	3	affinity chromatography technology, enzymatic study	Xiao N (2011), Xiao N (2011)	2
OTUD1	3	RIPK1	2	enzymatic study	Mevissen TE (2013)	1
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
IKBKB	1	PELI1	1	enzymatic study	Smith H (2011)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TNFRSF25	1	TRADD	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Kitson J (1996), Kitson J (1996), Pobezinskaya YL (2011)	3
RIPK2	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Hasegawa M (2008)	2
NOD2	1	TNFAIP3	3	affinity chromatography technology	Draber P (2015)	1
RNF11	0	USP2	0	affinity chromatography technology	Poulsen SL (2013)	1
EGFR	5	XIAP	0	affinity chromatography technology	Yao Z (2017)	1
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
MLF1	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	TICAM1	3	affinity chromatography technology	Kirli K (2015)	1
USP2	0	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011)	2
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
RIPK1	2	MAP3K8	2	affinity chromatography technology	Eliopoulos AG (2006)	1
CLIP3	4	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fujikura D (2012), Ding Z (2015), Ding Z (2015)	3
THSD4	1	MLF1	2	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
CASP8	1	USP2	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
RIPK2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hasegawa M (2008), Kim JY (2008), Yang Y (2007), Yang Y (2007), Windheim M (2007)	5
SQSTM1	0	RIPK1	2	pull down, affinity chromatography technology, affinity chromatography technology	Sanz L (1999), Sanz L (1999), Sanz L (1999)	3
USP2	0	TRIM27	2	two hybrid, two hybrid	Hayes SD (2012), Rolland T (2014)	2
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
MAP3K14	1	MAP3K8	2	affinity chromatography technology	Lin X (1999)	1
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
TNF	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Draber P (2015), Schlicher L (2016)	2
TLR3	2	TRAF3	1	affinity chromatography technology	Li S (2011)	1
EGFR	5	ANXA1	1	affinity chromatography technology	Li J (2013)	1
IKBKG	0	TRAF3	1	affinity chromatography technology	Belgnaoui SM (2012)	1
EGFR	5	MAP3K14	1	affinity chromatography technology	Habib AA (2001)	1
MLKL	1	RIPK3	2	affinity chromatography technology	Pescatore A (2016)	1
SQSTM1	0	TAX1BP1	3	affinity chromatography technology	Mildenberger J (2017)	1
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
NOD2	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
TNFAIP3	3	CCDC50	0	two hybrid, affinity chromatography technology	Bohgaki M (2008), Bohgaki M (2008)	2
OPTN	1	IKBKG	0	affinity chromatography technology	Nakazawa S (2016)	1
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
EGLN3	0	BIRC3	1	affinity chromatography technology	Fu J (2016)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
CLIP3	4	TNFRSF1A	3	two hybrid, affinity chromatography technology	Fujikura D (2012), Fujikura D (2012)	2
RNF11	0	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
TRPC4AP	4	CHUK	5	affinity chromatography technology	Soond SM (2003)	1
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
EGFR	5	MAP3K3	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
XPO1	8	MAP3K8	2	affinity chromatography technology	Kirli K (2015)	1
TRAF2	1	ERN1	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kaneko M (2003), Zhu X (2014), Chen TC (2014), Zeng T (2015)	4
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
CASP8	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pan JA (2011), Huang S (2013), Huang S (2013)	3
TICAM1	3	RNF216	2	affinity chromatography technology	Fearns C (2006)	1
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
IKBKG	0	ANXA1	1	affinity chromatography technology, biochemical, affinity chromatography technology	Bist P (2011), Bist P (2011), Bist P (2011)	3
MAP3K14	1	CHUK	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Regnier CH (1997), Regnier CH (1997), Xiao G (2000), Luftig MA (2001), Ninomiya-Tsuji J (1999), Ninomiya-Tsuji J (1999), Qing G (2007), Sanjo H (2010), Hu WH (2004), Liao G (2004), Li Q (2006), Chen TC (2014), Huttlin EL (2017)	13
ITCH	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2008), Shembade N (2008)	2
MAP3K7	2	TRAF5	1	affinity chromatography technology	Hong S (2007)	1
CASP10	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
EGFR	5	AP1M2	2	affinity chromatography technology	Foerster S (2013)	1
UBC	7	HERC2	9	affinity chromatography technology, pull down	Rendtlew Danielsen J (2012), Zhang X (2017)	2
CFLAR	1	HSP90AA1	7	affinity chromatography technology	Wang Q (2012)	1
EGLN3	0	CHUK	5	affinity chromatography technology	Fu J (2013)	1
USP21	2	RBCK1	0	two hybrid	Hayes SD (2012)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
TRAF3	1	CFLAR	1	affinity chromatography technology	Kataoka T (2000)	1
TNF	0	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Legler DF (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Skaug B (2011), Fu J (2013), Fritsch J (2014), Schlicher L (2016)	10
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
TNFSF10	2	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
TNFRSF1A	3	USP4	3	affinity chromatography technology	Fan YH (2011)	1
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
TRAF2	1	DAB2IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004), Dai X (2014)	3
SQSTM1	0	MAP3K3	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Yamazaki K (2009)	6
AP1M2	2	RIPK1	2	affinity chromatography technology	Huttlin EL (2015)	1
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
TRAF3	1	RNF216	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Nakhaei P (2009), Nakhaei P (2009), Zhao K (2016), Zhao K (2016)	4
XPO1	8	CYLD	2	affinity chromatography technology	Kirli K (2015)	1
CFLAR	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011), Panner A (2009), Panner A (2009), Murata E (2008)	6
TNF	0	CASP8	1	affinity chromatography technology	Fritsch J (2014)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
USP2	0	TRADD	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
CHUK	5	TAB2	5	affinity chromatography technology	Kishida S (2005)	1
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
CHUK	5	TRADD	0	biochemical	Poyet JL (2000)	1
FADD	1	RIPK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vanlangenakker N (2011), Lee EW (2012), Lee EW (2012), Moriwaki K (2016), Pescatore A (2016)	5
EGFR	5	NUMBL	1	unspecified method	Jones RB (2006)	1
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
OTUD1	3	UBC	7	enzymatic study, pull down	Mevissen TE (2013), Kwasna D (2018)	2
LRRK2	5	RIPK1	2	affinity chromatography technology	Ho CC (2009)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
CFLAR	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
TNF	0	FAS	2	affinity chromatography technology	Legler DF (2003)	1
TNF	0	UBE2N	1	genetic interference, affinity chromatography technology	Deng L (2000), Fritsch J (2014)	2
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
TRAF3	1	RIPK2	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Cai X (2013), Cai X (2013), Cai X (2013), Cai X (2013)	4
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
RIPK1	2	TRAF5	1	affinity chromatography technology	Tada K (2001)	1
XPO1	8	CHUK	5	affinity chromatography technology	Kirli K (2015)	1
MAP3K14	1	UBC	7	affinity chromatography technology	Sanjo H (2010)	1
TRADD	0	DAB2IP	3	affinity chromatography technology	Zhang H (2004)	1
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
EGFR	5	HERC2	9	affinity chromatography technology	Yao Z (2017)	1
ITCH	1	LRRK2	5	affinity chromatography technology	OConnor HF (2015)	1
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
FAS	2	CASP10	1	biochemical, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Vincenz C (1997), MacFarlane M (1997)	3
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	TRADD	0	affinity chromatography technology	Kirli K (2015)	1
TICAM1	3	TRAF1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Jiang Z (2004), Su X (2006), Su X (2006), Su X (2006), Takaki H (2009)	5
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
TLR3	2	CASP8	1	affinity chromatography technology	Zinngrebe J (2016)	1
EGLN3	0	BIRC2	1	affinity chromatography technology	Fu J (2016)	1
TNF	0	FADD	1	affinity chromatography technology	Fritsch J (2014)	1
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
TNFRSF1A	3	CRADD	0	affinity chromatography technology	Duan H (1997)	1
USP2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
NOD2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
XIAP	0	XAF1	1	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Liston P (2001), Liston P (2001), Liston P (2001), Arora V (2007), Tse MK (2012), Ju JH (2013), Ju JH (2013)	7
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
IKBKG	0	TAX1BP1	3	two hybrid	Wang J (2011)	1
TNFRSF10B	1	ITCH	1	affinity chromatography technology	Panner A (2009)	1
USP4	3	MAP3K7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Fan YH (2011), Fan YH (2011), Fan YH (2011)	3
ITCH	1	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down	Ahmed N (2011), Ahmed N (2011), Ahmed N (2011)	3
FADD	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Saitoh Y (2016)	2
TAB2	5	UBC	7	pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Kulathu Y (2009), Kulathu Y (2009), Sato Y (2009), van Wijk SJ (2012), Kanayama A (2004), Niu J (2011), van Wijk SJ (2013), Hooper C (2014), Komander D (2009), Emmerich CH (2013), Wauer T (2015), Kristariyanto YA (2015), Zhang X (2017)	13
MAP3K3	3	RIPK1	2	affinity chromatography technology	Yang J (2001)	1
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
TICAM1	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meylan E (2004), Meylan E (2004), Chang M (2009), Hu YH (2015)	4
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TNFSF10	2	RIPK1	2	affinity chromatography technology	Bellail AC (2012)	1
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
TRPC4AP	4	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Soond SM (2003), Soond SM (2006)	2
CASP8	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
NOD2	1	UBC	7	x-ray crystallography	Ver Heul AM (2013)	1
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
UBE2N	1	HERC2	9	affinity chromatography technology, pull down	Bekker-Jensen S (2010), Bai B (2016)	2
MAP3K3	3	CHUK	5	imaging technique	Chen TC (2014)	1
TRAF1	0	TRADD	0	affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Wicovsky A (2009)	2
TNFRSF25	1	RIPK1	2	affinity chromatography technology	Pobezinskaya YL (2011)	1
MAP3K14	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Ninomiya-Tsuji J (1999), Hofer-Warbinek R (2000)	2
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
NOD2	1	BIRC3	1	affinity chromatography technology	Damgaard RB (2012)	1
IKBKG	0	NUMBL	1	affinity chromatography technology	Swarnkar G (2017)	1
TNFRSF1B	4	TRAF2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Song HY (1995), Song HY (1995), Takeuchi M (1996), Hostager BS (2002), Rothe M (1996), Marsters SA (1997), Carpentier I (2008), Rothe M (1995), Park YC (1999), Boucher LM (1997), Rothe M (1994), Rothe M (1994)	13
BIRC3	1	XAF1	1	affinity chromatography technology	Arora V (2007)	1
TNF	0	MAP3K7	2	affinity chromatography technology	Ea CK (2006)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
FAS	2	TRADD	0	affinity chromatography technology	Kumar A (2001)	1
XIAP	0	RIPK3	2	pull down	Bertrand MJ (2011)	1
CASP8	1	TRADD	0	affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kolliputi N (2009)	2
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
TRAF5	1	UBC	7	enzymatic study	Middleton AJ (2017)	1
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
PYCARD	1	RIPK1	2	affinity chromatography technology	Kotlyar M (2015)	1
TLR3	2	BIRC2	1	affinity chromatography technology	Zinngrebe J (2016)	1
BIRC3	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
TNFRSF25	1	TRAF2	1	affinity chromatography technology	Pobezinskaya YL (2011)	1
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
USP21	2	XPO1	8	imaging technique	Garcia-Santisteban I (2012)	1
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
PELI1	1	UBE2N	1	pull down	Smith H (2011)	1
RFFL	0	RIPK1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Liao W (2008), Liao W (2008), Liao W (2008)	3
XPO1	8	RIPK1	2	affinity chromatography technology	Kirli K (2015)	1
NTAN1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
OPTN	1	CYLD	2	two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Nagabhushana A (2011), Nagabhushana A (2011), Nagabhushana A (2011), Genin P (2015), Genin P (2015)	5
BIRC2	1	XAF1	1	affinity chromatography technology	Arora V (2007)	1
TLR3	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Cusson-Hermance N (2005)	2
TNF	0	OPTN	1	affinity chromatography technology	Klingseisen L (2012)	1
PIDD1	5	CRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tinel A (2004), Janssens S (2005), Logette E (2011), Jeong WJ (2012)	4
XPO1	8	MAP3K3	3	affinity chromatography technology	Kirli K (2015)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
USP4	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan YH (2011), Hou X (2013), Hou X (2013)	3
TLR3	2	BIRC3	1	affinity chromatography technology	Zinngrebe J (2016)	1
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
TRAF2	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Kataoka T (2000), Kataoka T (2000)	3
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
RBCK1	0	MAP3K7	2	affinity chromatography technology	Tian Y (2007)	1
PYCARD	1	IKBKB	1	affinity chromatography technology	Stehlik C (2002)	1
RIPK1	2	DAB2IP	3	affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004)	2
USP21	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Xu G (2010), Xu G (2010)	2
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
EGLN3	0	CYLD	2	affinity chromatography technology	Rodriguez J (2016)	1
LRRK2	5	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Park S (2016), Park S (2016)	2
NOD2	1	BIRC2	1	affinity chromatography technology	Damgaard RB (2012)	1
MLKL	1	RIPK1	2	affinity chromatography technology	Pescatore A (2016)	1
HSP90AA1	7	CHUK	5	affinity chromatography technology, affinity chromatography technology	Qu X (2012), Gano JJ (2010)	2
MAP3K3	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fang S (2009), Fang S (2009)	2
TNFRSF1B	4	TRADD	0	affinity chromatography technology	Wicovsky A (2009)	1
RIPK1	2	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2008)	2
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFSF10	2	CASP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Gonzalvez F (2012), Jennewein C (2012), Li Y (2013), Xu J (2015)	6
XPO1	8	OTUD1	3	affinity chromatography technology	Kirli K (2015)	1
CASP8	1	OPTN	1	affinity chromatography technology, affinity chromatography technology	Nakazawa S (2016), Nakazawa S (2016)	2
YOD1	0	BIRC3	1	two hybrid	Schimmack G (2017)	1
RNF31	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
HSP90AA1	7	LRRK2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ding X (2009), Ding X (2009), Nichols RJ (2010), Zach S (2010), Daechsel JC (2007), Wang L (2008), Sen S (2009), Rudenko IN (2012), Gloeckner CJ (2006), Imai Y (2015)	10
UBE2N	1	RNF11	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Scheper J (2009), Colland F (2004), Poulsen SL (2013)	5
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
RIPK1	2	EGLN3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fu J (2016), Fu J (2016), Rodriguez J (2016)	3
CYLD	2	TAB2	5	affinity chromatography technology	Elliott PR (2016)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
NOD2	1	RIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogura Y (2001), Tao M (2009), Abbott DW (2004), Abbott DW (2004), Tigno-Aranjuez JT (2010), Tigno-Aranjuez JT (2010), Damgaard RB (2012), Marinis JM (2011), Draber P (2015)	9
FAS	2	RIPK1	2	two hybrid	Stanger BZ (1995)	1
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
RIPK2	0	RNF31	3	affinity chromatography technology	Damgaard RB (2012)	1
IKBKB	1	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
CASP8	1	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
MAP3K8	2	CHUK	5	enzymatic study, affinity chromatography technology	Lin X (1999), Lin X (1999)	2
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
HSP90AA1	7	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Qing G (2007), Taipale M (2012)	2
TNFAIP3	3	CHUK	5	affinity chromatography technology	Zetoune FS (2001)	1
CASP8	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
MAP3K3	3	XIAP	0	pull down, enzymatic study	Takeda AN (2014), Takeda AN (2014)	2
PIDD1	5	RIPK1	2	affinity chromatography technology	Janssens S (2005)	1
NOD2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Kim JY (2008), Chen CM (2004), Chen CM (2004), Chen CM (2004), Chen CM (2004), Windheim M (2007)	6
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
TNFRSF10B	1	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
TNFRSF1A	3	KHDRBS1	1	affinity chromatography technology	Pincheira R (2008)	1
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
TNF	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
RNF11	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shembade N (2009), Pranski EL (2012), Kelly C (2012), Colland F (2004)	4
RIPK1	2	CRADD	0	pull down, pull down	Ahmad M (1997), Duan H (1997)	2
MAP3K3	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Yamazaki K (2009), Yamazaki K (2009), Blonska M (2005), Blonska M (2005), Blonska M (2005)	5
RNF11	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2009)	2
TNF	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
LRRK2	5	FADD	1	affinity chromatography technology	Ho CC (2009)	1
RIPK2	0	TAB2	5	affinity chromatography technology	Hasegawa M (2008)	1
TNFRSF10B	1	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
PIDD1	5	FADD	1	affinity chromatography technology, affinity chromatography technology	Telliez JB (2000), Janssens S (2005)	2
LRRK2	5	TRAF2	1	enzymatic study	Zach S (2010)	1
MAP3K8	2	TAB2	5	affinity chromatography technology	Chan H (2005)	1
XPO1	8	DAB2IP	3	affinity chromatography technology	Kirli K (2015)	1
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
YOD1	0	UBC	7	pull down, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study	Ernst R (2009), Mevissen TE (2013), Mevissen TE (2013), Ernst R (2009), Flierman D (2016)	5
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
MLKL	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Petersen SL (2015), Petersen SL (2015)	2
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
EGLN3	0	MAP3K7	2	affinity chromatography technology	Rodriguez J (2016)	1
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
XAF1	1	TRAF2	1	affinity chromatography technology	Lin B (2016)	1
MAP3K8	2	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Eliopoulos AG (2002), Chan H (2005)	2
UBC	7	CCDC50	0	pull down, two hybrid, pull down, pull down	Fenner BJ (2009), Bohgaki M (2008), Bohgaki M (2008), Zhang X (2017)	4
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
TRIM27	2	IKBKB	1	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
TNFRSF1B	4	TNF	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Bouwmeester T (2004), Kuai J (2004), Montaldo PG (1994), Liu LS (1998), Zhang L (1994), Higuchi M (1992), Chaturvedi MM (1994), Chainy GB (1996), Nielsen FS (2004), Ameloot P (2001)	10
TNFSF10	2	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	4
TNF	0	CHUK	5	affinity chromatography technology, genetic interference	Haas TL (2009), Sahu I (2014)	2
TNFRSF1A	3	TRPC4AP	4	affinity chromatography technology, pull down, affinity chromatography technology	Soond SM (2003), Soond SM (2003), Mace KE (2010)	3
CFLAR	1	FADD	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Han DK (1997), Kerr E (2012), Rebe C (2007), Choi H (2011), Feoktistova M (2011), Ranjan K (2016), Jeong M (2017)	13
FADD	1	TRADD	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henshall DC (2003), Hsu H (1996), Hsu H (1996), Thomas LR (2002), Guan YJ (2011), Park KJ (2003), Qi Z (2014)	7
NOD2	1	IKBKG	0	affinity chromatography technology	Damgaard RB (2012)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
IKBKG	0	FADD	1	affinity chromatography technology	Biton S (2011)	1
SQSTM1	0	NOD2	1	affinity chromatography technology	Park S (2013)	1
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
CYLD	2	HSP90AA1	7	affinity chromatography technology	Elliott PR (2016)	1
TAX1BP1	3	OPTN	1	affinity chromatography technology, affinity chromatography technology	Journo C (2009), Journo C (2009)	2
NOD2	1	XIAP	0	affinity chromatography technology, pull down	Damgaard RB (2012), Krieg A (2009)	2
TNFRSF1A	3	DAB2IP	3	affinity chromatography technology	Zhang H (2004)	1
RIPK1	2	PELI1	1	affinity chromatography technology, enzymatic study	Chang M (2009), Chang M (2009)	2
RIPK3	2	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu PW (1999), Yu PW (1999), Li S (2011), Lee EW (2012), Petersen SL (2015), Moquin DM (2013), Moriwaki K (2016)	7
XPO1	8	RNF216	2	affinity chromatography technology	Kirli K (2015)	1
CHUK	5	RIPK2	0	enzymatic study	Marinis JM (2012)	1
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
RNF11	0	RNF216	2	two hybrid	Colland F (2004)	1
UBC	7	KHDRBS1	1	pull down	Zhang X (2017)	1
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
GPX7	0	RIPK1	2	affinity chromatography technology	Huttlin EL (2017)	1
RIPK3	2	TNFRSF1A	3	affinity chromatography technology	Yu PW (1999)	1
NOD2	1	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
TRPC4AP	4	TRADD	0	affinity chromatography technology	Soond SM (2003)	1
FAS	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), MacFarlane M (1997), Jeong M (2017)	3
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
EGLN3	0	SQSTM1	0	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology	Rantanen K (2013), Rantanen K (2013), Rantanen K (2013), Rodriguez J (2016)	4
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
RIPK1	2	RNF216	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Chen D (2002), Fearns C (2006), Fearns C (2006), Husain N (2017)	5
FADD	1	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Ramakrishnan P (2011), Ramakrishnan P (2011)	2
TRPC4AP	4	IKBKG	0	affinity chromatography technology	Soond SM (2003)	1
CHUK	5	PYCARD	1	affinity chromatography technology, affinity chromatography technology	Stehlik C (2002), Stehlik C (2002)	2
NUMBL	1	RIPK1	2	two hybrid	Wang J (2011)	1
IKBKB	1	HSP90AA1	7	affinity chromatography technology	Xue J (2010)	1
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
TRAF5	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TLR3	2	IKBKG	0	affinity chromatography technology	Zinngrebe J (2016)	1
USP21	2	USP4	3	enzymatic study	Loch CM (2012)	1
OPTN	1	UBC	7	affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down	Wild P (2011), Fenner BJ (2009), Zhu G (2007), Zhu G (2007), Wagner S (2008), Gleason CE (2011), Nagabhushana A (2011), Korac J (2012), Wild P (2011), Tumbarello DA (2015), Heo JM (2015), Ordureau A (2015), Richter B (2016), Richter B (2016), Nakazawa S (2016), Zhang X (2017), Kliza K (2017), Bansal M (2018)	18
FADD	1	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
CASP8	1	RIPK3	2	affinity chromatography technology	Lee EW (2012)	1
FGL1	3	RIPK1	2	affinity chromatography technology	Huttlin EL (2015)	1
OPTN	1	SQSTM1	0	affinity chromatography technology, pull down	Liu Z (2014), Liu Z (2014)	2
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
EGFR	5	TNFRSF10B	1	affinity chromatography technology	Tong J (2014)	1
TNFRSF1B	4	RIPK1	2	affinity chromatography technology	Wicovsky A (2009)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
TNFSF10	2	TRAF2	1	affinity chromatography technology	Bellail AC (2012)	1
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
MAP3K7	2	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sanna MG (2002), Resch U (2009), Sanna MG (2002), Sanna MG (2002)	4
RNF11	0	OPTN	1	two hybrid	Colland F (2004)	1
MAP3K7	2	USP2	0	affinity chromatography technology	Li Y (2013)	1
FAS	2	TNFRSF10B	1	biochemical	Gajate C (2005)	1
TLR3	2	RNF31	3	affinity chromatography technology	Zinngrebe J (2016)	1
HSP90AA1	7	MAP3K8	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
TNFSF10	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Jennewein C (2012)	2
XPO1	8	TAB2	5	affinity chromatography technology	Kirli K (2015)	1
RIPK1	2	ANXA1	1	affinity chromatography technology, biochemical, affinity chromatography technology	Bist P (2011), Bist P (2011), Bist P (2011)	3
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
XIAP	0	RIPK1	2	pull down	Bertrand MJ (2011)	1
ERN1	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Estornes Y (2014), Estornes Y (2014)	2
IKBKB	1	EGLN3	0	affinity chromatography technology, pull down, affinity chromatography technology	Xue J (2010), Xue J (2010), Fu J (2013)	3
RIPK1	2	XAF1	1	affinity chromatography technology	Lin B (2016)	1
USP21	2	YOD1	0	enzymatic study	Loch CM (2012)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
BIRC2	1	MAP3K3	3	enzymatic study	Takeda AN (2014)	1
TRAF3	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang PX (2016), Wang PX (2016), Wang PX (2016)	3
UBE2N	1	CHUK	5	enzymatic study	Deng L (2000)	1
TRAF1	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shu HB (1997), Kataoka T (2000), Kataoka T (2000), Rolland T (2014)	4
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
RBCK1	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Tian Y (2007), Tian Y (2007)	2
RIPK2	0	TNFRSF1A	3	affinity chromatography technology	McCarthy JV (1998)	1
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
MLKL	1	CASP8	1	affinity chromatography technology	Hein MY (2015)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
TRAF3	1	TAX1BP1	3	affinity chromatography technology	Gao L (2011)	1
MAP3K14	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varfolomeev E (2007), Kanno Y (2010), Lee S (2014), Lee S (2014)	4
NOD2	1	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Zurek B (2012), Zurek B (2012)	2
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
KHDRBS1	1	RIPK1	2	pull down, affinity chromatography technology	Ramakrishnan P (2011), Ramakrishnan P (2011)	2
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
TRIM27	2	CHUK	5	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
TNFRSF1B	4	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Marsters SA (1997), Mosialos G (1995), Mosialos G (1995), Boucher LM (1997), Rothe M (1994), Kato T (2008)	6
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
RIPK1	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma Q (2008), Ea CK (2006), Kanayama A (2004), Kanayama A (2004)	4
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
KHDRBS1	1	CASP8	1	affinity chromatography technology	Ramakrishnan P (2011)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
OPTN	1	TRADD	0	affinity chromatography technology	Zhu G (2007)	1
LRRK2	5	CASP8	1	affinity chromatography technology	Ho CC (2009)	1
NUMBL	1	TAB2	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Ma Q (2008), Ma Q (2008), Ma Q (2008), Ma Q (2008), Wang J (2011)	5
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
NOD2	1	CYLD	2	affinity chromatography technology	Draber P (2015)	1
RNF11	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Shembade N (2009), Colland F (2004)	2
TNFRSF1A	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahmad R (2007), Fan YH (2011), Cusson-Hermance N (2005), Blonska M (2005), Mitsuhashi S (2008)	5
IKBKG	0	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Li Y (1999), Huttlin EL (2017)	2
OPTN	1	TNFRSF1A	3	affinity chromatography technology	Klingseisen L (2012)	1
TAB2	5	IKBKB	1	enzymatic study	Niu J (2011)	1
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
OPTN	1	RIPK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nagabhushana A (2011), Zhu G (2007), Zhu G (2007), Klingseisen L (2012), Nakazawa S (2016)	5
TNFSF10	2	TNFRSF10B	1	pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaptein A (2000), Walczak H (1997), Hymowitz SG (1999), Hymowitz SG (1999), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	7
TNFRSF1B	4	TNFRSF1A	3	affinity chromatography technology	Wicovsky A (2009)	1
OPTN	1	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Mankouri J (2010), Mankouri J (2010)	2
RIPK1	2	CDC42BPB	16	two hybrid	Bandyopadhyay S (2010)	1
IKBKG	0	EGLN3	0	affinity chromatography technology, affinity chromatography technology, pull down	Fu J (2013), Fu J (2013), Fu J (2013)	3
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
PYCARD	1	SQSTM1	0	affinity chromatography technology	Shi CS (2012)	1
MAP3K14	1	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Sanjo H (2010), Sanjo H (2010), Song HY (1997), Hu WH (2004), Liao G (2004), Liao G (2004), Choudhary S (2013), Lee S (2014), Huttlin EL (2017)	10
CCDC50	0	RIPK1	2	affinity chromatography technology	Bohgaki M (2008)	1
TRPC4AP	4	RIPK1	2	affinity chromatography technology	Soond SM (2003)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
EGLN3	0	TAB2	5	affinity chromatography technology	Rodriguez J (2016)	1
RIPK1	2	RIPK1	2	enzymatic study, two hybrid, enzymatic study	Xu LG (2004), Rolland T (2014), Chirieleison SM (2016)	3
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
ATG7	2	RIPK1	2	affinity chromatography technology	Huttlin EL (2017)	1
TRADD	0	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Hsu H (1996), Ea CK (2006), Guan YJ (2011), Jeon J (2014), Lin B (2016)	7
ERN1	1	HSP90AA1	7	affinity chromatography technology, pull down	Marcu MG (2002), Marcu MG (2002)	2
TRAF3	1	RIPK1	2	affinity chromatography technology	Hsu H (1996)	1
HERC2	9	RIPK1	2	affinity chromatography technology	Huttlin EL (2015)	1
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
SQSTM1	0	ATG7	2	affinity chromatography technology	Tanji K (2012)	1
USP4	3	IKBKB	1	affinity chromatography technology	Fan YH (2011)	1
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
RIPK3	2	TICAM1	3	affinity chromatography technology	Meylan E (2004)	1
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
TICAM1	3	TNFAIP3	3	affinity chromatography technology	Wang YY (2004)	1
TICAM1	3	TLR3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Hu YH (2015), Zinngrebe J (2016)	3
MAP3K7	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Koga T (2008), Elliott PR (2016)	2
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
CASP10	1	CFLAR	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Micheau O (2003), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Feoktistova M (2011), Chen TC (2014)	7
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
PIDD1	5	IKBKG	0	affinity chromatography technology	Janssens S (2005)	1
TLR3	2	RBCK1	0	affinity chromatography technology	Zinngrebe J (2016)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
RBCK1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
TNFAIP3	3	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Valck D (1999), De Valck D (1999), Klinkenberg M (2001), Kelly C (2012), Huttlin EL (2017)	5
EGFR	5	CCDC50	0	affinity chromatography technology, affinity chromatography technology	Tashiro K (2006), Tashiro K (2006)	2