PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRPK1	2	TNFRSF10C	0	enzymatic study	Varjosalo M (2013)	1
RAP1A	1	TNFRSF10C	0	pull down	Stoletov KV (2004)	1
LMNA	2	TNFRSF10C	0	two hybrid	Dittmer TA (2014)	1
SLC27A6	2	TNFRSF10C	0	two hybrid	Stelzl U (2005)	1
TNFRSF10C	0	APOA1	0	two hybrid	Stelzl U (2005)	1
SRPK2	1	LMNA	2	enzymatic study	Lipp JJ (2015)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
TNFRSF10C	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
SRPK2	1	TNFRSF10C	0	enzymatic study	Varjosalo M (2013)	1
TNFRSF10C	0	RFLNB	2	two hybrid	Stelzl U (2005)	1