PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MYH3	5	TPM2	2	biochemical	Wan C (2015)	1
CFTR	5	ACTN2	2	affinity chromatography technology	Pankow S (2015)	1
PSMA3	1	CFTR	5	biochemical, affinity chromatography technology	Oberdorf J (2006), Pankow S (2015)	2
ACTN1	5	ACTN3	2	two hybrid	Rolland T (2014)	1
HSPB1	2	ACTN4	4	two hybrid	Katsogiannou M (2014)	1
ACTN2	2	ACTN4	4	biochemical	Havugimana PC (2012)	1
ACTN2	2	TNN	5	pull down	Gregorio CC (1998)	1
MYH7	3	ACTN3	2	biochemical	Wan C (2015)	1
PSMA3	1	YWHAQ	0	pull down, affinity chromatography technology	Wang B (2010), Wang B (2010)	2
SNW1	0	ACTN2	2	two hybrid	Albers M (2005)	1
HSPB1	2	PDLIM1	1	biochemical	Wan C (2015)	1
YWHAQ	0	CAPN1	3	biochemical	Kristensen AR (2012)	1
ACTN1	5	ACTN4	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
CFTR	5	MYH1	2	affinity chromatography technology	Pankow S (2015)	1
ACTN2	2	BRMS1L	1	two hybrid	Rolland T (2014)	1
KAT2B	2	ACTN2	2	two hybrid	Albers M (2005)	1
MYPN	7	ACTN3	2	two hybrid	Bang ML (2001)	1
ACTN2	2	TPM1	0	biochemical	Wan C (2015)	1
ACTN4	4	PDLIM1	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Vallenius T (2000), Huttlin EL (2015), Huttlin EL (2017)	4
IGSF8	1	RPL35	1	affinity chromatography technology	Perez-Hernandez D (2013)	1
ACTN4	4	TPM1	0	biochemical	Wan C (2015)	1
MYH2	2	ACTN4	4	biochemical	Wan C (2015)	1
TNNI1	0	TPM2	2	biochemical	Wan C (2015)	1
ACTN2	2	SAXO1	1	two hybrid	Rolland T (2014)	1
TPM3	0	TPM4	0	biochemical	Havugimana PC (2012)	1
ACTN4	4	TPM3	0	biochemical	Wan C (2015)	1
CFTR	5	ACTN4	4	affinity chromatography technology	Pankow S (2015)	1
CAPN1	3	GRIN2B	30	imaging technique	Chen TC (2014)	1
DLG4	11	ACTN2	2	pull down	Eldstrom J (2002)	1
CFTR	5	MYH6	12	affinity chromatography technology	Pankow S (2015)	1
DISC1	6	ACTN2	2	affinity chromatography technology, two hybrid	Morris JA (2003), Morris JA (2003)	2
NOS3	7	ACTN2	2	two hybrid	Soler-Lopez M (2011)	1
MYH6	12	TPM2	2	biochemical	Wan C (2015)	1
ACTN2	2	MYOZ2	2	two hybrid	Rolland T (2014)	1
ACTN2	2	MYOZ1	1	two hybrid, pull down	Faulkner G (2000), Faulkner G (2000)	2
ACTN2	2	PDLIM3	2	two hybrid	Rolland T (2014)	1
DISC1	6	YWHAQ	0	two hybrid	Camargo LM (2007)	1
TPM2	2	TPM3	0	biochemical	Havugimana PC (2012)	1
YWHAQ	0	ACTN2	2	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
KCNN2	3	ACTN2	2	pull down	Lu L (2009)	1
ACTN2	2	MOS	1	two hybrid	Rolland T (2014)	1
CFTR	5	MYH3	5	affinity chromatography technology	Pankow S (2015)	1
YWHAQ	0	HSPB1	2	affinity chromatography technology, two hybrid	Pozuelo-Rubio M (2010), Katsogiannou M (2014)	2
ACTN2	2	DLG1	2	affinity chromatography technology, affinity chromatography technology	Eldstrom J (2003), Eldstrom J (2003)	2
COIL	1	ACTN4	4	two hybrid	Lim J (2006)	1
PSMA3	1	RTP5	4	two hybrid	Rolland T (2014)	1
KAT2B	2	ACTN1	5	two hybrid	Albers M (2005)	1
HSPB1	2	ACTN2	2	two hybrid	Katsogiannou M (2014)	1
ACTN4	4	MYOZ2	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014)	3
ERBIN	5	GRIN2B	30	pull down	Jaulin-Bastard F (2001)	1
ATXN7	0	ACTN2	2	two hybrid	Kahle JJ (2011)	1
ERBIN	5	ACTN2	2	unspecified method	Boisguerin P (2004)	1
ITGB3BP	0	ACTN2	2	two hybrid	Albers M (2005)	1
ACTN2	2	ACTN2	2	two hybrid	Rolland T (2014)	1
TNNI1	0	MYH7	3	biochemical	Wan C (2015)	1
MYH2	2	TPM1	0	biochemical	Wan C (2015)	1
COIL	1	ACTN2	2	two hybrid	Lim J (2006)	1
TNNI1	0	MYH3	5	biochemical	Wan C (2015)	1
ERBIN	5	KCNA5	2	unspecified method	Boisguerin P (2004)	1
PDLIM1	1	ACTN3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED14	0	ACTN1	5	two hybrid	Albers M (2005)	1
NR1I2	5	ACTN2	2	two hybrid	Albers M (2005)	1
ACTN4	4	ACTN3	2	two hybrid	Rolland T (2014)	1
YWHAQ	0	TPM1	0	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
ACTN4	4	TPM4	0	biochemical	Wan C (2015)	1
TPM2	2	ACTN1	5	biochemical	Wan C (2015)	1
CFTR	5	TPM4	0	affinity chromatography technology	Pankow S (2015)	1
SYNPO2	1	ACTN2	2	pull down	Linnemann A (2010)	1
KCNA5	2	DLG1	2	affinity chromatography technology, affinity chromatography technology	Godreau D (2003), Mathur R (2006)	2
HSPB1	2	TPM3	0	biochemical	Havugimana PC (2012)	1
ACTN2	2	GRIN2B	30	two hybrid, biochemical	Wyszynski M (1997), Wyszynski M (1997)	2
TPM1	0	MYH6	12	biochemical	Wan C (2015)	1
KCNA5	2	DLG4	11	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Eldstrom J (2003), Eldstrom J (2002), Eldstrom J (2002), Eldstrom J (2002), Mathur R (2006)	5
IGSF8	1	ACTN4	4	affinity chromatography technology	Perez-Hernandez D (2013)	1
HSPB1	2	ACTN1	5	two hybrid	Katsogiannou M (2014)	1
MYH8	2	TPM1	0	biochemical	Wan C (2015)	1
ERBIN	5	ACTN1	5	unspecified method	Boisguerin P (2004)	1
MYH3	5	ACTN2	2	biochemical	Wan C (2015)	1
TPM3	0	ACTN2	2	biochemical	Wan C (2015)	1
TPM1	0	TPM2	2	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Brown HR (1985), Brown HR (1985), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	5
TNNI1	0	MYH6	12	biochemical	Wan C (2015)	1
CFTR	5	MYH8	2	affinity chromatography technology	Pankow S (2015)	1
ATXN2	3	ACTN1	5	two hybrid	Lim J (2006)	1
TPM1	0	ACTN1	5	biochemical	Wan C (2015)	1
KCNA5	2	ACTN2	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Eldstrom J (2003), Maruoka ND (2000), Maruoka ND (2000), Maruoka ND (2000), Maruoka ND (2000), Cukovic D (2001), Cukovic D (2001)	7
TPM1	0	TPM4	0	biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
GRIN2B	30	DLG1	2	affinity chromatography technology, two hybrid	Inanobe A (2002), Niethammer M (1996)	2
CFTR	5	MYH2	2	affinity chromatography technology	Pankow S (2015)	1
TPM4	0	ACTN1	5	biochemical	Wan C (2015)	1
CFTR	5	TPM2	2	affinity chromatography technology	Pankow S (2015)	1
IGSF8	1	ACTN2	2	affinity chromatography technology	Perez-Hernandez D (2013)	1
MED14	0	ACTN2	2	two hybrid	Albers M (2005)	1
PSMA3	1	ACTN2	2	affinity chromatography technology	Fedorova OA (2011)	1
ST7	2	ACTN2	2	two hybrid	Battle MA (2003)	1
ATXN2	3	ACTN2	2	two hybrid	Lim J (2006)	1
ACTN2	2	ZNF446	1	two hybrid	Wang J (2011)	1
ACTN2	2	PDLIM1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Kotaka M (2000), Huttlin EL (2015), Huttlin EL (2017)	3
PSMA3	1	ACTN4	4	affinity chromatography technology	Fedorova OA (2011)	1
CFTR	5	PSMB5	3	affinity chromatography technology	Pankow S (2015)	1
MYH7	3	ACTN2	2	biochemical	Wan C (2015)	1
IGSF8	1	MYH3	5	affinity chromatography technology	Perez-Hernandez D (2013)	1
YWHAQ	0	MYH2	2	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
CFTR	5	ERBIN	5	affinity chromatography technology	Wang X (2006)	1
TPM1	0	TPM3	0	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015)	3
CFTR	5	TPM1	0	affinity chromatography technology	Pankow S (2015)	1
ACTN2	2	ADAM12	1	affinity chromatography technology, pull down	Galliano MF (2000), Galliano MF (2000)	2
MYH4	6	ACTN2	2	biochemical	Wan C (2015)	1
ACTN2	2	RTP5	4	two hybrid	Rolland T (2014)	1
CAPN1	3	ACTN2	2	two hybrid	Jiang LQ (2002)	1
ATXN7	0	ACTN1	5	two hybrid	Kahle JJ (2011)	1
ACTN2	2	TNNI1	0	biochemical	Wan C (2015)	1
DISC1	6	MYH7	3	two hybrid	Morris JA (2003)	1
FBXL22	2	ACTN2	2	two hybrid, affinity chromatography technology, enzymatic study	Spaich S (2012), Spaich S (2012), Spaich S (2012)	3
TPM1	0	MYH4	6	biochemical	Wan C (2015)	1
TNNI1	0	TPM1	0	biochemical	Wan C (2015)	1
MYPN	7	ACTN2	2	two hybrid, two hybrid	Bang ML (2001), Bang ML (2001)	2
MYH2	2	ACTN1	5	biochemical	Wan C (2015)	1
PSMB5	3	ACTN4	4	biochemical	Wan C (2015)	1
ACTN1	5	TPM3	0	biochemical	Wan C (2015)	1
TPM2	2	TPM4	0	biochemical	Havugimana PC (2012)	1
MYH1	2	TPM1	0	biochemical	Wan C (2015)	1
MYH2	2	ACTN2	2	biochemical	Wan C (2015)	1
ACTN1	5	IGSF8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Perez-Hernandez D (2013), Perez-Hernandez D (2013), Perez-Hernandez D (2013)	3
CFTR	5	MYH7	3	affinity chromatography technology	Pankow S (2015)	1
ACTN3	2	ACTN2	2	far western blotting, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Chan Y (1998), Chan Y (1998), Chan Y (1998), Chan Y (1998), Chan Y (1998), Chan Y (1998)	6
HSPB1	2	PSMA3	1	two hybrid	Katsogiannou M (2014)	1
CFTR	5	HSPB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahner A (2013), Wang X (2006), Gong X (2016), Pankow S (2015)	4
ATXN7	0	ACTN4	4	two hybrid	Kahle JJ (2011)	1
TPM2	2	ACTN4	4	biochemical	Wan C (2015)	1
PSMB5	3	PSMA3	1	two hybrid, two hybrid, biochemical, biochemical, biochemical	Jayarapu K (2004), Fricke B (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
PSMB5	3	ACTN2	2	biochemical	Wan C (2015)	1
ACTN2	2	MICALL2	5	two hybrid	Rolland T (2014)	1
ACTN2	2	TPM2	2	biochemical	Wan C (2015)	1
NRIP1	4	ACTN2	2	two hybrid	Albers M (2005)	1
TPM4	0	ACTN2	2	biochemical	Wan C (2015)	1
ACTN1	5	MYOZ2	2	two hybrid	Rolland T (2014)	1
NOS3	7	ACTN4	4	two hybrid	Soler-Lopez M (2011)	1
YWHAQ	0	NRIP1	4	pull down, genetic interference, imaging technique	Zilliacus J (2001), Zilliacus J (2001), Zilliacus J (2001)	3
ACTN1	5	MICALL2	5	two hybrid	Rolland T (2014)	1
MYH8	2	ACTN2	2	biochemical	Wan C (2015)	1
PDLIM1	1	ACTN1	5	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vallenius T (2000), Vallenius T (2000), Bauer K (2000), Bauer K (2000), Huttlin EL (2015), Huttlin EL (2017)	6
ACTN2	2	RPL35	1	two hybrid	Wang J (2011)	1
ACTN2	2	SNAI1	1	two hybrid	Rolland T (2014)	1
ACTN2	2	SP100	4	two hybrid	Rolland T (2014)	1
ACTN1	5	MYOZ1	1	two hybrid	Rual JF (2005)	1
CFTR	5	MYH4	6	affinity chromatography technology	Pankow S (2015)	1
ACTN4	4	MYOZ1	1	two hybrid	Rual JF (2005)	1
ACTN1	5	ACTN2	2	biochemical	Havugimana PC (2012)	1
HSPB1	2	SNW1	0	two hybrid, affinity chromatography technology	Katsogiannou M (2014), Lleres D (2010)	2
SP100	4	RTP5	4	two hybrid	Rolland T (2014)	1
CFTR	5	ACTN1	5	affinity chromatography technology	Pankow S (2015)	1
MYH7	3	TPM2	2	biochemical	Wan C (2015)	1
COIL	1	ACTN1	5	two hybrid	Lim J (2006)	1
GRIN2B	30	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down	Sans N (2003), Inanobe A (2002), Irie M (1997), Niethammer M (1998), Lim IA (2002), Kornau HC (1995), Kornau HC (1995), Niethammer M (1996), Niethammer M (1996), Imamura F (2002)	10
YWHAQ	0	MYH7	3	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
MYH1	2	ACTN2	2	biochemical	Wan C (2015)	1
LDB3	2	ACTN2	2	two hybrid	Faulkner G (1999)	1
CFTR	5	ACTN3	2	affinity chromatography technology	Pankow S (2015)	1
MYH6	12	ACTN2	2	biochemical	Wan C (2015)	1