PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
SOCS3	0	PRLR	0	affinity chromatography technology	Dif F (2001)	1
ELOC	0	GHR	1	unspecified method	Bulatov E (2015)	1
SOCS2	1	PTK2B	6	two hybrid, affinity chromatography technology, affinity chromatography technology	Lee SH (2010), Lee SH (2010), Lee SH (2010)	3
IL7R	2	SOCS1	1	affinity chromatography technology	Ghazawi FM (2016)	1
SOCS1	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang JG (1999), Nie L (2011), Qiu X (2012)	3
EPOR	3	ELOC	0	pull down	Heir P (2016)	1
SOCS3	0	RNF7	0	affinity chromatography technology, pull down	Kamura T (2004), Kershaw NJ (2014)	2
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
STK38	0	SOCS2	1	affinity chromatography technology, affinity chromatography technology	Paul I (2017), Paul I (2017)	2
SOCS3	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, pull down	Xiao Z (2007), Kamura T (2004), Kershaw NJ (2014)	3
RNF7	0	GHR	1	unspecified method	Bulatov E (2015)	1
BMI1	0	23429	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
SOCS3	0	ELOC	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Xiao Z (2007), Zhang WN (2012), Haan S (2003), Haan S (2003), Kamura T (2004)	5
LCK	0	SOCS2	1	affinity chromatography technology	Venkitachalam S (2011)	1
ELOB	1	GHR	1	unspecified method	Bulatov E (2015)	1
SOCS3	0	ELOB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao Z (2007), Niwa Y (2005), Kamura T (2004)	3
SOCS2	1	ELOC	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical	Vesterlund M (2011), Lievens S (2009), Lievens S (2009), Kim DY (2013)	4
BMI1	0	SOCS2	1	two hybrid	Wang J (2011)	1
SOCS2	1	SOCS1	1	affinity chromatography technology	Wu KL (2007)	1
LCK	0	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Venkitachalam S (2011), Venkitachalam S (2011)	2
EPOR	3	SOCS2	1	two hybrid, affinity chromatography technology, protein complementation assay, pull down, protein complementation assay, unspecified method	Eyckerman S (2001), Eyckerman S (2001), Lavens D (2007), Lavens D (2007), Montoye T (2005), Bullock AN (2006)	6
CUL5	1	GHR	1	unspecified method	Bulatov E (2015)	1
LCK	0	PTK2B	6	affinity chromatography technology	Ganju RK (1997)	1
SOCS2	1	23429	0	two hybrid	Lee SH (2010)	1
PLA2G1B	0	SOCS2	1	two hybrid	Wang J (2011)	1
SOCS3	0	SOCS2	1	affinity chromatography technology	Tannahill GM (2005)	1
SOCS2	1	RNF7	0	affinity chromatography technology	Vesterlund M (2011)	1
PTK2	2	SOCS3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Le Y (2007), Le Y (2007), Niwa Y (2005), Rolland T (2014)	4
SOCS2	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Vesterlund M (2011), Bennett EJ (2010), Salter JD (2012), Kim YK (2013), Huttlin EL (2017)	5
GHR	1	SOCS2	1	pull down, enzymatic study, pull down, unspecified method, unspecified method	Ram PA (1999), Vesterlund M (2011), Biener E (2002), Bulatov E (2015), Bullock AN (2006)	5
IGF1R	5	PTK2	2	affinity chromatography technology	Manes S (1999)	1
SOCS2	1	PRLR	0	affinity chromatography technology	Pezet A (1999)	1
RNF7	0	ELOC	0	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
IL7R	2	SOCS2	1	affinity chromatography technology	Ghazawi FM (2016)	1
ELOB	1	SOCS1	1	affinity chromatography technology	Nie L (2011)	1
SOCS3	0	IGF1R	5	pull down, two hybrid, affinity chromatography technology	Dey BR (2000), Dey BR (2000), Dey BR (2000)	3
LCK	0	SOCS3	0	affinity chromatography technology	Venkitachalam S (2011)	1
SOCS2	1	TPD52	0	two hybrid	Wang J (2011)	1
FLT3	5	SOCS2	1	affinity chromatography technology, affinity chromatography technology	Kazi JU (2013), Kazi JU (2013)	2
SOCS2	1	ELOB	1	affinity chromatography technology, biochemical	Vesterlund M (2011), Kim DY (2013)	2
GHR	1	SOCS1	1	affinity chromatography technology, pull down	Ram PA (1999), Ram PA (1999)	2
RNF7	0	ELOB	1	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
SOCS3	0	PTK2B	6	two hybrid, affinity chromatography technology	Masuhara M (1997), Zhang S (2008)	2
SOCS1	1	FLT3	5	affinity chromatography technology	De Sepulveda P (1999)	1
SOCS2	1	CCNC	0	affinity chromatography technology	Piessevaux J (2008)	1
PTK2B	6	IL7R	2	affinity chromatography technology	Benbernou N (2000)	1
EPOR	3	ELOB	1	pull down	Heir P (2016)	1
SOCS3	0	EPOR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Sasaki A (2000), Sasaki A (2000), Sasaki A (2000), Hoertner M (2002)	4
PTK2	2	SOCS2	1	two hybrid	Rual JF (2005)	1
GHR	1	SOCS3	0	pull down	Ram PA (1999)	1
RNF7	0	CUL5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, enzymatic study, pull down, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ohta T (1999), Bennett EJ (2010), Tan M (2008), Kelsall IR (2013), Kelsall IR (2013), Zhou W (2014), Rolland T (2014), Huang DT (2009), Kim DY (2013), Kim DY (2013), Yu H (2011), Bulatov E (2015), Wang X (2015), Wang X (2015), Wang X (2015), Kershaw NJ (2014), Huttlin EL (2017), Kuang P (2016), Kuang P (2016), Zhou W (2017), Zhou W (2017)	21
SOCS1	1	IGF1R	5	two hybrid	Dey BR (1998)	1
SOCS2	1	IGF1R	5	two hybrid, pull down, affinity chromatography technology	Dey BR (1998), Dey BR (1998), Dey BR (1998)	3
ARFIP2	0	SOCS2	1	two hybrid	Wang J (2011)	1