PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
CFLAR	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
CFLAR	1	TNFRSF1A	3	genetic interference	Ma Y (2017)	1
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
TNFRSF1A	3	TRAF3	1	pull down	Mosialos G (1995)	1
RIPK2	0	CFLAR	1	affinity chromatography technology	Inohara N (1998)	1
CASP8	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
USP8	7	CFLAR	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Jeong M (2017), Jeong M (2017), Jeong M (2017), Jeong M (2017)	4
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
TNFRSF10A	0	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Sinha SK (2004), Guo F (2005), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	6
ITCH	1	RIPK1	2	affinity chromatography technology	Shembade N (2009)	1
CFLAR	1	BCL2L1	0	affinity chromatography technology	Han DK (1997)	1
TICAM1	3	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Nguyen VP (2014)	2
RIPK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fearns C (2006), Taipale M (2012)	2
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
CASP10	1	TNFRSF10B	1	biochemical, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997)	2
CASP3	0	GSN	3	enzymatic study	Walsh JG (2008)	1
CASP10	1	FASLG	0	biochemical	Gajate C (2005)	1
RAF1	3	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Kataoka T (2000), Kataoka T (2000), Shimada K (2006), Wang J (2011)	4
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
FAS	2	TRAF3	1	pull down	Mosialos G (1995)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
DAXX	5	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, unspecified method	Tang J (2006), Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Wethkamp N (2011), Zhao LY (2004), Zhao LY (2004), Zhao LY (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Zhao LY (2004), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Chen TC (2014), Li Z (2017)	23
FAS	2	DAXX	5	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down	Ko YG (2001), Kim YY (2003), Cermak L (2002), Yang X (1997), Yang X (1997), Yang X (1997), Charette SJ (2000), Chen TC (2014), Chang HY (1999)	9
TNFRSF10A	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Kaunisto A (2009), Sinha SK (2004), Guo F (2005), Jin Z (2009), Gonzalvez F (2012), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	10
CASP10	1	DEDD2	1	affinity chromatography technology	Alcivar A (2003)	1
STUB1	4	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Wang Q (2012), Wang Q (2012)	2
TNFSF10	2	CASP3	0	enzymatic study	Gillissen B (2013)	1
HSP90AA1	7	SF3B3	4	affinity chromatography technology	Taipale M (2012)	1
CFLAR	1	SPATS1	2	two hybrid	Wang J (2011)	1
DAXX	5	TRAF3	1	two hybrid	Wang J (2011)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
CASP10	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
CFLAR	1	HSP90AA1	7	affinity chromatography technology	Wang Q (2012)	1
TRAF3	1	CFLAR	1	affinity chromatography technology	Kataoka T (2000)	1
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
TNFRSF10A	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Gonzalvez F (2012), Jeong M (2017)	4
CFLAR	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011), Panner A (2009), Panner A (2009), Murata E (2008)	6
SMAD3	1	DEDD	0	two hybrid, affinity chromatography technology, pull down	Xue JF (2010), Xue JF (2010), Xue JF (2010)	3
CFLAR	1	NOL3	0	genetic interference	Koseki T (1998)	1
TRAF3	1	CBLB	3	affinity chromatography technology	Qiao G (2007)	1
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
DEDD	0	CASP8	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Alcivar A (2003), Stegh AH (1998), Stegh AH (1998)	4
REV3L	8	CFLAR	1	genetic interference	Kotov IN (2014)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
CFLAR	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
FASLG	0	CFLAR	1	affinity chromatography technology	Tao RH (2011)	1
TRAF3	1	RIPK2	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Cai X (2013), Cai X (2013), Cai X (2013), Cai X (2013)	4
NOD1	3	CASP8	1	affinity chromatography technology	Inohara N (1999)	1
GSN	3	ITCH	1	affinity chromatography technology	Abedini MR (2014)	1
FAS	2	CASP10	1	biochemical, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Vincenz C (1997), MacFarlane M (1997)	3
XRCC6	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Feki A (2005), Feki A (2005)	2
CFLAR	1	SMAD3	1	two hybrid	Wang J (2011)	1
CFLAR	1	CBLB	3	affinity chromatography technology	Zhang G (2012)	1
TICAM1	3	TRAF1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Jiang Z (2004), Su X (2006), Su X (2006), Su X (2006), Takaki H (2009)	5
CASP8	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011)	4
TNFRSF10B	1	ITCH	1	affinity chromatography technology	Panner A (2009)	1
TICAM1	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meylan E (2004), Meylan E (2004), Chang M (2009), Hu YH (2015)	4
TNFSF10	2	RIPK1	2	affinity chromatography technology	Bellail AC (2012)	1
CASP8	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
CASP10	1	DEDD	0	affinity chromatography technology	Alcivar A (2003)	1
CFLAR	1	DEDD	0	affinity chromatography technology, pull down	Roth W (2002), Zhan Y (2002)	2
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
DEDD2	1	CFLAR	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Roth W (2002), Roth W (2002), Zhan Y (2002), Zhan Y (2002)	4
GSN	3	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Abedini MR (2014), Abedini MR (2014)	2
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
BCL2L1	0	TP53	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vinayagam A (2011), Tang WH (2014), Saxena R (2016), Stegh AH (2010), Kim EM (2014)	5
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
TRAF2	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Kataoka T (2000), Kataoka T (2000)	3
CFLAR	1	PLIN5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFSF10	2	CASP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Gonzalvez F (2012), Jennewein C (2012), Li Y (2013), Xu J (2015)	6
SMAD3	1	STUB1	4	pull down	Li L (2004)	1
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
NOD1	3	RIPK2	0	affinity chromatography technology, affinity chromatography technology, pull down	Inohara N (1999), Hirata Y (2006), Ver Heul AM (2013)	3
TP53	0	GSN	3	affinity chromatography technology	Horikawa I (2014)	1
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
FAS	2	RIPK1	2	two hybrid	Stanger BZ (1995)	1
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
CFLAR	1	CASP3	0	affinity chromatography technology, pull down, two hybrid	Shu HB (1997), Han DK (1997), Han DK (1997)	3
CFLAR	1	CFLAR	1	two hybrid	Srinivasula SM (1997)	1
CBLB	3	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
CBLB	3	TICAM1	3	affinity chromatography technology	Han C (2010)	1
HSP90AA1	7	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Qing G (2007), Taipale M (2012)	2
CASP8	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
CFLAR	1	DOK2	2	affinity chromatography technology	Ewing RM (2007)	1
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
XRCC6	3	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Kerr E (2012), Kerr E (2012)	2
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
FAS	2	NOL3	0	genetic interference	Koseki T (1998)	1
CBLB	3	TNFRSF10B	1	affinity chromatography technology	Xu L (2017)	1
CFLAR	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Abedini MR (2008), Saha A (2011), Saha A (2011)	4
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
TNFRSF10A	0	CASP10	1	affinity chromatography technology	MacFarlane M (1997)	1
DEDD2	1	CASP8	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Zhan Y (2002), Alcivar A (2003)	3
TNFSF10	2	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	4
CFLAR	1	FADD	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Han DK (1997), Kerr E (2012), Rebe C (2007), Choi H (2011), Feoktistova M (2011), Ranjan K (2016), Jeong M (2017)	13
MAP3K14	1	CASP3	0	imaging technique	Chen TC (2014)	1
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
TNFRSF10A	0	TNFRSF10B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guo F (2005), Jin Z (2009), Huttlin EL (2017)	3
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
FADD	1	DAXX	5	affinity chromatography technology	Meinecke I (2007)	1
FADD	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011), Chen TC (2014)	5
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
FASLG	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
FAS	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), MacFarlane M (1997), Jeong M (2017)	3
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
SMAD3	1	XRCC6	3	two hybrid	Colland F (2004)	1
TNFRSF10A	0	TRAF2	1	affinity chromatography technology	Gonzalvez F (2012)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
TNFRSF1A	3	DAXX	5	two hybrid, pull down	Yang X (1997), Yang X (1997)	2
FADD	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology	Roth W (2002), Stegh AH (1998), Stegh AH (1998)	3
TNFSF10	2	TRAF2	1	affinity chromatography technology	Bellail AC (2012)	1
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
FAS	2	TNFRSF10B	1	biochemical	Gajate C (2005)	1
RAF1	3	BCL2L1	0	pull down, imaging technique	Wang HG (1996), Chen TC (2014)	2
TNFSF10	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Jennewein C (2012)	2
DAXX	5	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Kim YY (2003), Kim YY (2003)	2
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
NOD1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Mayor A (2007), da Silva Correia J (2007)	2
NOL3	0	DAXX	5	affinity chromatography technology, affinity chromatography technology	Donath S (2016), Donath S (2016)	2
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
CASP8	1	NOL3	0	genetic interference, affinity chromatography technology	Koseki T (1998), Koseki T (1998)	2
TRAF1	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shu HB (1997), Kataoka T (2000), Kataoka T (2000), Rolland T (2014)	4
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
RIPK2	0	TNFRSF1A	3	affinity chromatography technology	McCarthy JV (1998)	1
RAF1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stancato LF (1993), Dogan T (2008), Mollapour M (2010), Du J (2006), Maloney A (2007), Fiskus W (2007), Giommarelli C (2010), Arlander SJ (2006), ONeill E (2004), Taipale M (2012), Zhu J (2005), Schneider C (1996), Mollapour M (2014), Atabakhsh E (2012), Mitra S (2016)	15
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
RAF1	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study	Dogan T (2008), Dogan T (2008), Alberti S (2004), Westhoff B (2005), Dreiseidler M (2012)	5
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
CFLAR	1	SF3B3	4	affinity chromatography technology	Ewing RM (2007)	1
TNFRSF1A	3	NOL3	0	genetic interference	Koseki T (1998)	1
ATG3	4	CFLAR	1	affinity chromatography technology	Lee JS (2009)	1
FADD	1	NOL3	0	genetic interference	Koseki T (1998)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
FASLG	0	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Legler DF (2003)	2
FAS	2	FASLG	0	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Starling GC (1997), Schneider P (1997), Legler DF (2003), Tao RH (2011), Chen TC (2014)	7
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
CASP8	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yao Z (2007), Yao Z (2007)	2
TNFSF10	2	TNFRSF10B	1	pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaptein A (2000), Walczak H (1997), Hymowitz SG (1999), Hymowitz SG (1999), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	7
MAP3K14	1	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Sanjo H (2010), Sanjo H (2010), Song HY (1997), Hu WH (2004), Liao G (2004), Liao G (2004), Choudhary S (2013), Lee S (2014), Huttlin EL (2017)	10
DAXX	5	STUB1	4	affinity chromatography technology, pull down	McDonough H (2009), McDonough H (2009)	2
ITCH	1	SMAD3	1	pull down	Feng L (2004)	1
TRAF3	1	RIPK1	2	affinity chromatography technology	Hsu H (1996)	1
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
CASP10	1	CFLAR	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Micheau O (2003), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Feoktistova M (2011), Chen TC (2014)	7
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
CASP3	0	TRAF3	1	enzymatic study, enzymatic study	Lee ZH (2001), Leo E (2001)	2
DEDD2	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zhan Y (2002), Alcivar A (2003), Alcivar A (2003), Alcivar A (2003), Zhan Y (2002), Zhan Y (2002)	6
NOD1	3	CFLAR	1	affinity chromatography technology	Inohara N (1999)	1
TNFRSF10A	0	TNFSF10	2	affinity chromatography technology	Pan G (1997)	1