PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
WBP1	1	KCNIP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERGIC3	5	STOM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RALB	0	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
SMURF1	4	ANKRD13A	1	enzymatic study	Andrews PS (2010)	1
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
ANKRD13A	1	ARHGDIA	3	affinity chromatography technology	Boldt K (2016)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
FBXO25	1	EGFR	5	enzymatic study	Teixeira FR (2013)	1
CFTR	5	XPO1	8	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
EGFR	5	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Tanno H (2012), Foerster S (2013)	2
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
FAM153B	0	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2017)	1
ANKRD13A	1	STOM	0	affinity chromatography technology	Boldt K (2016)	1
SMURF1	4	PSMD4	1	enzymatic study	Andrews PS (2010)	1
TOLLIP	3	ANKRD13A	1	affinity chromatography technology	Li S (2011)	1
ASB7	1	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	STOM	0	biochemical	Wan C (2015)	1
NTRK1	1	ANKRD13A	1	affinity chromatography technology	Emdal KB (2015)	1
WBP2	0	ANKRD13A	1	two hybrid	Lim SK (2016)	1
EGFR	5	STOM	0	affinity chromatography technology	Tong J (2014)	1
CTDSP2	1	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Arrojo E Drigo R (2013), McNeill H (2004)	2
TOLLIP	3	CAV1	0	affinity chromatography technology	Ohnuma K (2005)	1
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
FBXO25	1	ANKRD13A	1	enzymatic study	Teixeira FR (2013)	1
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
SMAD5	2	ANKRD13A	1	two hybrid	Colland F (2004)	1
ELAVL1	0	ANKRD13A	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	ANKRD13A	1	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Tanno H (2012), Zhang X (2017)	3
ZDHHC11	2	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
WBP2	0	EGFR	5	affinity chromatography technology	Lim SK (2016)	1
EGFR	5	PSMD4	1	protein complementation assay	Deribe YL (2009)	1
FAM189A2	2	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	CSNK1G3	5	affinity chromatography technology	Abdelmohsen K (2009)	1
QDPR	0	ANKRD13A	1	two hybrid	Rolland T (2014)	1
CAV1	0	VCP	6	affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Kirchner P (2013), Kirchner P (2013), Chen SF (2013), Chen SF (2013)	4
ELAVL1	0	SMAD5	2	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF11	0	SMURF1	4	two hybrid	Colland F (2004)	1
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
ARHGDIA	3	STOM	0	affinity chromatography technology	Boldt K (2016)	1
RNF11	0	ANKRD13A	1	two hybrid	Colland F (2004)	1
UBC	7	STOM	0	affinity chromatography technology	Matsumoto M (2005)	1
CFTR	5	ANKRD13A	1	affinity chromatography technology	Pankow S (2015)	1
CSNK1G3	5	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
FAM189A2	2	FAM189B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	TOLLIP	3	affinity chromatography technology	Kirli K (2015)	1
SMAD5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, two hybrid, two hybrid, enzymatic study	Lu K (2008), Komuro A (2004), Ebisawa T (2001), Nie J (2010), Alarcon C (2009), Murakami G (2003), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Haag J (2006), Colland F (2004), Lu K (2008)	12
WBP2	0	UBC	7	two hybrid	Lim SK (2016)	1
SMURF1	4	VCP	6	affinity chromatography technology	Xie Y (2013)	1
ELAVL1	0	TOLLIP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	SMAD5	2	affinity chromatography technology	Kirli K (2015)	1
FAM189B	2	VCP	6	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
ARRDC1	4	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANKRD13A	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Burana D (2016), Burana D (2016), Burana D (2016), Burana D (2016)	4
TMEM51	2	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2015)	1
PSMD4	1	ANKRD13A	1	biochemical	Wan C (2015)	1
IZUMO1	1	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXO25	1	PSMD4	1	affinity chromatography technology, enzymatic study	Teixeira FR (2010), Teixeira FR (2013)	2
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
CAV1	0	NTRK1	1	affinity chromatography technology	Bilderback TR (1999)	1
FBXO25	1	XPO1	8	affinity chromatography technology	Teixeira FR (2010)	1
KCNIP2	0	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	CAV1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, pull down, biochemical	Couet J (1997), Couet J (1997), Khan EM (2006), Feldman R (2009), Hua H (2003), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Park WY (2000), Abulrob A (2004), Abulrob A (2004)	12
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
SLAMF1	2	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2015)	1
LDLRAD4	1	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
WBP1	1	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2015)	1
CFTR	5	CAV1	0	affinity chromatography technology	Pankow S (2015)	1
ERGIC3	5	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	ARRDC1	4	affinity chromatography technology	Kirli K (2015)	1
LAPTM5	3	ANKRD13A	1	two hybrid	Colland F (2004)	1
FAM189B	2	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	ANKRD13A	1	affinity chromatography technology	Kirli K (2015)	1
RNF11	0	CSNK1G3	5	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	ARHGDIA	3	affinity chromatography technology	Emdal KB (2015)	1
LDLRAD4	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
NTRK1	1	PSMD4	1	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	LAPTM5	3	pull down	Pak Y (2006)	1
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
RNF11	0	PSMD4	1	affinity chromatography technology	Poulsen SL (2013)	1
ANKRD13A	1	CAV1	0	affinity chromatography technology, affinity chromatography technology	Burana D (2016), Burana D (2016)	2
CFTR	5	PSMD4	1	affinity chromatography technology	Pankow S (2015)	1
WBP2	0	TOLLIP	3	two hybrid	Lim SK (2016)	1