PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	TSC22D4	1	affinity chromatography technology	Fei T (2017)	1
TP53	0	GNB2	3	affinity chromatography technology	Horikawa I (2014)	1
GSTK1	1	EPPK1	24	affinity chromatography technology	Ewing RM (2007)	1
TGFBR2	0	ACVR1	4	two hybrid	Kawabata M (1995)	1
NUP50	0	TSC22D1	1	biochemical	Kristensen AR (2012)	1
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
TSC22D1	1	ZC3HC1	1	two hybrid	Vinayagam A (2011)	1
OTUB1	0	ELP1	5	affinity chromatography technology	Scholz CC (2016)	1
ACVR1B	1	ACVR1	4	affinity chromatography technology, affinity chromatography technology	De Winter JP (1996), Huttlin EL (2015)	2
TSC22D1	1	UNC119	4	two hybrid	Vinayagam A (2011)	1
SMAD7	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Asano Y (2004), Koinuma D (2003), Kavsak P (2000), Hayashi H (1997), Hayashi H (1997), Datta PK (2000), Wicks SJ (2005), Lallemand F (2005), Seong HA (2007), Yan X (2011), Cai Y (2012), Cai Y (2012), Seo SR (2004), Zhu L (2012), Zhu L (2012), Nakao A (1997), Yan X (2009), Kamiya Y (2010), Suzuki C (2002), Hsu HY (2014)	21
RPL5	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai MS (2004), Dai MS (2004), Bursac S (2012), Fogeron ML (2013)	4
PTN	0	TSC22D1	1	two hybrid	Wang J (2011)	1
HNRNPL	3	CHD3	19	affinity chromatography technology	Fei T (2017)	1
ALB	1	TSC22D1	1	affinity chromatography technology	Zhou M (2004)	1
TSC22D1	1	SETDB1	3	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
TSC22D1	1	CRMP1	0	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	LARP7	3	biochemical	Kristensen AR (2012)	1
BMPR1B	3	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
TSC22D1	1	SPRED1	3	two hybrid	Vinayagam A (2011)	1
CACNA1A	21	GNB2	3	affinity chromatography technology	Qin N (1997)	1
TGFBR1	2	OTUB1	0	enzymatic study, affinity chromatography technology	Herhaus L (2015), Herhaus L (2015)	2
HNRNPM	1	RPL5	3	biochemical	Havugimana PC (2012)	1
VIM	0	SETDB1	3	two hybrid	Goehler H (2004)	1
TSC22D1	1	IARS	5	affinity chromatography technology	Ewing RM (2007)	1
TSC22D1	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
IARS	5	QARS	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TSC22D1	1	DNMT3B	3	two hybrid	Vinayagam A (2011)	1
BMPR1B	3	OTUB1	0	enzymatic study	Herhaus L (2015)	1
HNRNPL	3	PRKCI	1	affinity chromatography technology	Fei T (2017)	1
SMAD6	9	ACVR1B	1	affinity chromatography technology	Kamiya Y (2010)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
NRBP1	3	LRIF1	3	two hybrid	Stelzl U (2005)	1
NUP50	0	TTI1	3	biochemical	Kristensen AR (2012)	1
TSC22D1	1	DDAH2	1	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	TLE1	6	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	SFXN1	0	affinity chromatography technology	Ewing RM (2007)	1
TSC22D1	1	CDK2	0	affinity chromatography technology	Ewing RM (2007)	1
ALB	1	GCN1	6	affinity chromatography technology	Zhou M (2004)	1
TSC22D1	1	GCN1	6	affinity chromatography technology	Ewing RM (2007)	1
ASAH1	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
CDK2	0	GCN1	6	affinity chromatography technology	Neganova I (2011)	1
BMPR1B	3	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Itoh F (2001), Hata A (1998)	2
CD2AP	0	TSC22D1	1	biochemical	Kristensen AR (2012)	1
TSC22D1	1	HMGXB4	0	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	RPL5	3	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	FAF1	1	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	KMT2C	28	two hybrid	Vinayagam A (2011)	1
TSC22D3	1	TSC22D1	1	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1A	5	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
CDK2	0	HNRNPM	1	affinity chromatography technology	Neganova I (2011)	1
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
UNK	3	COPB2	3	affinity chromatography technology	Murn J (2015)	1
ELP1	5	DYNC1H1	41	affinity chromatography technology	Johansen LD (2008)	1
TSC22D4	1	WNK1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DHDH	2	TSC22D1	1	affinity chromatography technology	Huttlin EL (2015)	1
TSC22D1	1	PRKCI	1	two hybrid	Vinayagam A (2011)	1
ACVR1B	1	BAG6	2	two hybrid	Wang J (2011)	1
TSC22D1	1	CORO2B	2	two hybrid	Stelzl U (2005)	1
CDK2	0	QARS	1	affinity chromatography technology	Neganova I (2011)	1
TSC22D1	1	EMC1	5	affinity chromatography technology	Ewing RM (2007)	1
TSC22D3	1	NRBP1	3	affinity chromatography technology	Huttlin EL (2017)	1
SMAD7	1	TGFBR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Nakao A (1997), Hsu HY (2014)	3
TSC22D4	1	TSC22D3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSC22D1	1	NRBP1	3	affinity chromatography technology	Ewing RM (2007)	1
GCN1	6	HNRNPL	3	biochemical	Havugimana PC (2012)	1
TSC22D1	1	OTUB1	0	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	NCOA5	1	two hybrid	Vinayagam A (2011)	1
TP53	0	TAF5L	1	affinity chromatography technology	Gamper AM (2008)	1
ACVR1B	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
TSC22D1	1	HNRNPM	1	affinity chromatography technology	Ewing RM (2007)	1
SNRNP200	15	TSC22D1	1	biochemical	Kristensen AR (2012)	1
UNK	3	HNRNPL	3	affinity chromatography technology	Murn J (2015)	1
RGS1	1	MAP3K12	2	two hybrid	Stelzl U (2005)	1
TSC22D1	1	SRPRB	0	affinity chromatography technology	Ewing RM (2007)	1
TSC22D1	1	MTR	4	affinity chromatography technology	Ewing RM (2007)	1
UBE2D1	0	UNK	3	biochemical	Havugimana PC (2012)	1
TGFBR1	2	TSC22D1	1	two hybrid, affinity chromatography technology, pull down	Yan X (2011), Yan X (2011), Yan X (2011)	3
TSC22D4	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
TSC22D1	1	SPACA9	0	two hybrid	Vinayagam A (2011)	1
HNRNPL	3	KMT2C	28	affinity chromatography technology	Fei T (2017)	1
VIM	0	EPPK1	24	affinity chromatography technology	Huttlin EL (2017)	1
GSTK1	1	DNAAF5	4	affinity chromatography technology	Ewing RM (2007)	1
BMPR1A	5	BMPR1B	3	affinity chromatography technology, imaging technique	Gilboa L (2000), Gilboa L (2000)	2
TSC22D1	1	LRIF1	3	two hybrid	Vinayagam A (2011)	1
TGFBR2	0	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RGS1	1	TSC22D1	1	two hybrid	Stelzl U (2005)	1
TSC22D1	1	GNB5	2	two hybrid	Vinayagam A (2011)	1
CDK2	0	IARS	5	affinity chromatography technology	Neganova I (2011)	1
GNB2	3	PDHB	1	two hybrid	Wang J (2011)	1
CA10	5	NRBP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GSTK1	1	IARS	5	affinity chromatography technology	Ewing RM (2007)	1
TSC22D1	1	WDR73	2	two hybrid	Vinayagam A (2011)	1
TP53	0	HNRNPM	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
CACNA1A	21	TSC22D1	1	two hybrid	Kahle JJ (2011)	1
TSC22D1	1	ERG28	0	two hybrid	Vinayagam A (2011)	1
SMAD7	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Yan X (2011), Yan X (2011)	2
BAG6	2	SETDB1	3	two hybrid	Stelzl U (2005)	1
DYNC1H1	41	HNRNPL	3	biochemical	Havugimana PC (2012)	1
TSC22D1	1	DYNC1H1	41	affinity chromatography technology	Ewing RM (2007)	1
TSC22D1	1	KMT2B	22	two hybrid	Vinayagam A (2011)	1
RPA3	2	HNRNPM	1	affinity chromatography technology	Marechal A (2014)	1
CD2AP	0	ELP1	5	biochemical	Kristensen AR (2012)	1
CD2AP	0	NRBP1	3	biochemical	Kristensen AR (2012)	1
DYNC1H1	41	EPPK1	24	biochemical	Havugimana PC (2012)	1
TSC22D1	1	QARS	1	two hybrid	Vinayagam A (2011)	1
DYNC1H1	41	NCOA5	1	biochemical	Havugimana PC (2012)	1
TSC22D1	1	RPA3	2	affinity chromatography technology	Ewing RM (2007)	1
WNK1	7	TSC22D1	1	two hybrid	Bandyopadhyay S (2010)	1
TSC22D1	1	CARHSP1	1	two hybrid	Vinayagam A (2011)	1
CA10	5	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA3	2	SNRNP200	15	affinity chromatography technology	Marechal A (2014)	1
WDYHV1	0	NCOA5	1	two hybrid	Rolland T (2014)	1
EED	1	WIZ	2	affinity chromatography technology	Cao Q (2014)	1
TSC22D1	1	WDYHV1	0	two hybrid	Rolland T (2014)	1
SMAD6	9	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Hata A (1998), Kamiya Y (2010)	2
TSC22D1	1	TAF5L	1	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	TSC22D1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
ACVR1	4	BMPR1A	5	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Lavery K (2008), Lavery K (2008), Huttlin EL (2015), Huttlin EL (2017)	4
SMAD6	9	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
OTUB1	0	NUP93	5	affinity chromatography technology	Scholz CC (2016)	1
TSC22D1	1	FAM20C	2	two hybrid	Vinayagam A (2011)	1
ACVR1B	1	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu X (2002), Yamaguchi T (2006), Yamaguchi T (2006), Kamiya Y (2010)	4
TSC22D3	1	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Ayroldi E (2014), Ayroldi E (2014), Ayroldi E (2014), Ayroldi E (2014), Ayroldi E (2014)	5
RPA3	2	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
TSC22D1	1	TP53	0	two hybrid, affinity chromatography technology	Yoon CH (2012), Yoon CH (2012)	2
SMAD6	9	BMPR1A	5	affinity chromatography technology	Kamiya Y (2010)	1
HNRNPL	3	FAF1	1	affinity chromatography technology	Fei T (2017)	1
TGFBR2	0	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
VIM	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
TGFBR2	0	ACVR1B	1	affinity chromatography technology	Huttlin EL (2015)	1
VIM	0	CRMP1	0	two hybrid, pull down, two hybrid	Vinayagam A (2011), Goehler H (2004), Goehler H (2004)	3
BAG6	2	ELP1	5	two hybrid	Stelzl U (2005)	1
ASAH1	0	TSC22D1	1	two hybrid	Stelzl U (2005)	1
TSC22D1	1	SP110	3	two hybrid	Vinayagam A (2011)	1
UNK	3	DYNC1H1	41	affinity chromatography technology	Murn J (2015)	1
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
TSC22D1	1	GSTK1	1	affinity chromatography technology	Ewing RM (2007)	1
TSC22D1	1	FBN3	13	two hybrid	Vinayagam A (2011)	1
CDK2	0	VIM	0	affinity chromatography technology	Neganova I (2011)	1
TSC22D1	1	EED	1	two hybrid	Vinayagam A (2011)	1
UNK	3	TSC22D1	1	affinity chromatography technology	Murn J (2015)	1
TSC22D1	1	NUP93	5	affinity chromatography technology	Ewing RM (2007)	1
ACVR1	4	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
UNK	3	RPA3	2	affinity chromatography technology	Murn J (2015)	1
HNRNPL	3	MAP3K12	2	affinity chromatography technology	Fei T (2017)	1
OTUB1	0	UBE2D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sun XX (2011), Herhaus L (2013), Li Y (2014), Scholz CC (2016)	4
HNRNPL	3	CD2AP	0	affinity chromatography technology	Fei T (2017)	1
TSC22D1	1	MCM3AP	6	two hybrid	Vinayagam A (2011)	1
HNRNPL	3	HNRNPM	1	biochemical	Havugimana PC (2012)	1
SMAD7	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Kamiya Y (2010)	2
TSC22D1	1	VIM	0	two hybrid	Vinayagam A (2011)	1
CHD3	19	TP53	0	two hybrid, two hybrid	Minty A (2000), Goehler H (2004)	2
HNRNPL	3	SFXN1	0	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	DNAAF5	4	affinity chromatography technology	Fei T (2017)	1
FAF1	1	BAG6	2	affinity chromatography technology	Baron Y (2014)	1
HNRNPL	3	TSC22D1	1	affinity chromatography technology	Fei T (2017)	1
TSC22D1	1	MAP3K12	2	two hybrid	Stelzl U (2005)	1
BMPR1A	5	OTUB1	0	enzymatic study	Herhaus L (2015)	1
TSC22D1	1	WIZ	2	two hybrid	Vinayagam A (2011)	1
NRBP1	3	TSC22D4	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
TSC22D1	1	A2M	8	two hybrid	Vinayagam A (2011)	1
CHD3	19	LRIF1	3	two hybrid	Goehler H (2004)	1
TSC22D1	1	DNAAF5	4	affinity chromatography technology	Ewing RM (2007)	1
ELP1	5	NUP50	0	biochemical	Kristensen AR (2012)	1
APLP1	1	SETDB1	3	two hybrid	Goehler H (2004)	1
APLP1	1	LRIF1	3	two hybrid	Goehler H (2004)	1
BAG6	2	PTN	0	two hybrid	Wang J (2011)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
TSC22D1	1	NDUFA9	1	affinity chromatography technology	Ewing RM (2007)	1
TSC22D1	1	APLP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
TSC22D1	1	BAG6	2	affinity chromatography technology	Ewing RM (2007)	1
TSC22D1	1	COPB2	3	affinity chromatography technology	Ewing RM (2007)	1
TP53	0	VIM	0	affinity chromatography technology	Horikawa I (2014)	1
PTN	0	CHD3	19	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
TSC22D1	1	GNB2	3	two hybrid	Vinayagam A (2011)	1
ACVR1	4	OTUB1	0	enzymatic study	Herhaus L (2015)	1
SMAD6	9	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Kamiya Y (2010), Zhang X (2013)	2
TSC22D1	1	EPPK1	24	affinity chromatography technology	Ewing RM (2007)	1
COPB2	3	TTI1	3	biochemical	Kristensen AR (2012)	1
EED	1	NUP93	5	affinity chromatography technology	Cao Q (2014)	1
EED	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
EED	1	HNRNPM	1	affinity chromatography technology	Cao Q (2014)	1
EED	1	DNMT3B	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Vire E (2006), Vire E (2006), OHagan HM (2011)	3
TP53	0	OTUB1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Sun XX (2011), Sun XX (2011), Sun XX (2011), Li Y (2014), Fernandez-Majada V (2016)	5
TSC22D1	1	SLC25A22	1	affinity chromatography technology	Ewing RM (2007)	1
ELP1	5	TSC22D1	1	biochemical	Kristensen AR (2012)	1
CDK2	0	DYNC1H1	41	affinity chromatography technology	Neganova I (2011)	1
CD2AP	0	LARP7	3	biochemical	Kristensen AR (2012)	1
ACVR1B	1	OTUB1	0	enzymatic study	Herhaus L (2015)	1
HNRNPL	3	BMPR1B	3	affinity chromatography technology	Fei T (2017)	1
TSC22D1	1	CHD3	19	two hybrid	Vinayagam A (2011)	1
CACNA1A	21	CRMP1	0	two hybrid	Kahle JJ (2011)	1
ACVRL1	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
SMAD7	1	ACVR1	4	affinity chromatography technology	Kamiya Y (2010)	1
ACVR1	4	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSC22D1	1	CCDC90B	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
ACVRL1	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
EED	1	SNRNP200	15	affinity chromatography technology	Cao Q (2014)	1
TSC22D1	1	TTI1	3	biochemical	Kristensen AR (2012)	1
TSC22D1	1	PDHB	1	two hybrid	Vinayagam A (2011)	1
SETDB1	3	DNMT3B	3	affinity chromatography technology	Li H (2006)	1
VIM	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
GSTK1	1	HNRNPM	1	affinity chromatography technology	Ewing RM (2007)	1
OTUB1	0	BAG6	2	affinity chromatography technology	Scholz CC (2016)	1
OTUB1	0	SRPRB	0	affinity chromatography technology	Scholz CC (2016)	1
CDK2	0	GNB2	3	affinity chromatography technology	Neganova I (2011)	1