Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ALDH1A2 8854 TRETINOIN CHEMBL38 NCI, DrugBank 15366004, 15950488, 15069081, 15299009, 15950969, 11306068, 14623241, 15652703
ALDH1A2 8854 MEDRONIC ACID CHEMBL180570 PharmGKB
ALDH1A2 8854 CHEMBL1161866 CHEMBL1161866 DrugBank 17139284, 17016423, 11872149, 10320326
ALDH1A2 8854 RETINOL CHEMBL986 NCI, DrugBank 16982809, 17270546, 17098734, 17184764, 16538685, 9666306, 11133156
ALDH1A2 8854 ETRETINATE CHEMBL464 NCI 11751205

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ALDH1A2 rs261316 T atenolol efficacy yes T allele associated with increased odds of uncontrolled blood pressure following thiazide diuretic/beta-blocker combination therapy. Variant only reached suggestive significance in discovery GWAS. Consistent direction of association found across discovery and replication cohorts and approached genome-wide significance in meta-analysis of all cohorts. Allele T is associated with decreased response to atenolol and hydrochlorothiazide in people with Hypertension as compared to allele C. 29097388 1449576280