PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FOXA1	2	ESR1	0	affinity chromatography technology, imaging technique	Jozwik KM (2016), Toska E (2017)	2
LHX9	2	LDB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSBP4	0	LHX4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LMX1B	1	SSBP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SP1	0	TAL1	0	pull down, two hybrid, affinity chromatography technology	Lecuyer E (2002), Lecuyer E (2002), Lecuyer E (2002)	3
SP1	0	LMO2	2	pull down	Lecuyer E (2002)	1
SSBP2	2	SSBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IRAK3	0	LDB1	2	two hybrid	Wang J (2011)	1
LDB1	2	POLR1B	2	two hybrid	Wang J (2011)	1
TRIM33	4	TAL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bai X (2010), Bai X (2010), Bai X (2010)	3
TRIM33	4	LDB1	2	affinity chromatography technology, affinity chromatography technology	Bai X (2010), Howard PW (2010)	2
LDB1	2	SSBP3	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
HNRNPL	3	SSBP3	7	affinity chromatography technology	Fei T (2017)	1
SP1	0	ESR1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Koslowski M (2009), Jin W (2008), Dong J (2006), Dong J (2006), Castet A (2006), He S (2005), He S (2005), Varshochi R (2005), Varshochi R (2005), Petz LN (2004), Li D (2007), Itoh Y (2007), Saville B (2000), Gibson LL (2005)	14
TAL1	0	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Hu X (2009)	2
HNRNPL	3	TCF3	7	affinity chromatography technology	Fei T (2017)	1
IDI2	0	SSBP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN1	2	TOLLIP	3	two hybrid	Lim J (2006)	1
TOLLIP	3	RLIM	1	affinity chromatography technology	Li S (2011)	1
SSBP4	0	LMO4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IDI2	0	SSBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM33	4	SSBP3	7	affinity chromatography technology	Bai X (2010)	1
LMO2	2	SSBP4	0	affinity chromatography technology	Huttlin EL (2017)	1
TAL1	0	LDB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Hu X (2009)	4
PSMD10	1	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Higashitsuji H (2000), Higashitsuji H (2000), Li J (2002), Li J (2002), Nagao T (2003)	5
DNMT3L	2	ESR1	0	pull down	Pacaud R (2014)	1
TCF3	7	RB1	2	affinity chromatography technology, affinity chromatography technology	Vitelli L (2000), Vitelli L (2000)	2
FOXC1	0	LDB1	2	affinity chromatography technology	Li X (2015)	1
TCF3	7	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology, pull down	Goardon N (2006), Goardon N (2006), Goardon N (2006)	3
LDB1	2	LMO2	2	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Deane JE (2003), Xu Z (2007), Wang J (2011), Rolland T (2014), Huttlin EL (2017)	5
CETN1	0	LHX4	1	affinity chromatography technology	Huttlin EL (2017)	1
SSBP3	7	LMO4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSBP2	2	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSBP2	2	LHX4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LMO2	2	TRIM33	4	affinity chromatography technology	Huttlin EL (2017)	1
SSBP2	2	LMO2	2	affinity chromatography technology, affinity chromatography technology	Xu Z (2007), Huttlin EL (2017)	2
LDB1	2	PSMA1	1	two hybrid	Wang J (2011)	1
TAL1	0	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu X (2009), Vitelli L (2000), Vitelli L (2000)	3
LHX6	1	SSBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	LSM7	0	affinity chromatography technology	Fei T (2017)	1
DNMT3L	2	LDB1	2	pull down	Pacaud R (2014)	1
LMO1	0	LDB1	2	two hybrid	Rolland T (2014)	1
LDB1	2	LHX2	0	two hybrid	Ravasi T (2010)	1
TAL1	0	TCF3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Goardon N (2006), Hsu HL (1994), Hsu HL (1994), Hu X (2009)	7
SP1	0	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singh J (2002), Chang YC (2001), Opitz OG (2000)	3
IDI2	0	LDB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDB1	2	PSMD10	1	two hybrid	Wang J (2011)	1
LMO1	0	TAL1	0	pull down, affinity chromatography technology, two hybrid	Valge-Archer VE (1994), Valge-Archer VE (1994), Wadman I (1994)	3
ATXN1	2	LDB1	2	two hybrid	Lim J (2006)	1
LHX4	1	LDB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	LDB1	2	affinity chromatography technology	Huttlin EL (2017)	1
LDB1	2	ESR1	0	pull down	Johnsen SA (2009)	1
LMX1B	1	SSBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LMO2	2	RB1	2	affinity chromatography technology	Vitelli L (2000)	1
LDB1	2	SSBP2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
TAL1	0	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Goardon N (2006), Hu X (2009)	5
LDB1	2	RNF38	4	affinity chromatography technology	Hiratani I (2003)	1
TCF3	7	LDB1	2	affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Goardon N (2006)	2
TAL1	0	LMO2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid	Wadman I (1994), Valge-Archer VE (1994), Goardon N (2006), Osada H (1995), Osada H (1995), Osada H (1995), Osada H (1995), Wadman I (1994), Wadman I (1994), Wadman I (1994)	10
FOXA1	2	LDB1	2	affinity chromatography technology	Li X (2015)	1
LMX1B	1	LDB1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
FOXE1	2	LDB1	2	affinity chromatography technology	Li X (2015)	1
RLIM	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Johnsen SA (2009), Johnsen SA (2009), Johnsen SA (2009)	3
HNRNPL	3	LDB1	2	affinity chromatography technology	Fei T (2017)	1
LMO4	1	ESR1	0	pull down, pull down, affinity chromatography technology	Singh RR (2005), Singh RR (2005), Singh RR (2005)	3
SSBP2	2	LMO4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDB1	2	RNF6	4	affinity chromatography technology	Hiratani I (2003)	1
LDB1	2	RB1	2	affinity chromatography technology	Vitelli L (2000)	1
LHX6	1	SSBP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDB1	2	SSBP4	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
HNRNPL	3	ATXN1	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	PSMA1	1	affinity chromatography technology	Fei T (2017)	1
LMO4	1	LDB1	2	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid	Sutherland KD (2003), Deane JE (2003), Deane JE (2003), Colland F (2004), Rolland T (2014)	5
IDI2	0	LMO4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXE1	2	HNRNPL	3	affinity chromatography technology	Li X (2015)	1
SP1	0	LDB1	2	pull down	Lecuyer E (2002)	1
LDB1	2	TOLLIP	3	two hybrid	Rual JF (2005)	1
DNMT3L	2	LHX2	0	pull down	Pacaud R (2014)	1
LHX6	1	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSBP4	0	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAL1	0	SSBP2	2	affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Hu X (2009)	2
LDB1	2	RLIM	1	affinity chromatography technology, affinity chromatography technology	Xu Z (2007), Howard PW (2010)	2
LDB1	2	LHX6	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
LMX1B	1	SSBP3	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2015), Huttlin EL (2017)	3
TRIM33	4	SSBP4	0	affinity chromatography technology	Bai X (2010)	1
LMO2	2	SSBP3	7	affinity chromatography technology	Huttlin EL (2017)	1
TRIM33	4	SSBP2	2	affinity chromatography technology	Bai X (2010)	1
IDI2	0	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LHX9	2	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXA1	2	TRIM33	4	affinity chromatography technology	Jozwik KM (2016)	1
TRIM33	4	CBFA2T3	3	affinity chromatography technology	Bai X (2010)	1
TRIM33	4	TCF3	7	affinity chromatography technology	Bai X (2010)	1
IDI2	0	LMX1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSBP4	0	LHX8	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CETN1	0	LDB1	2	affinity chromatography technology	Huttlin EL (2017)	1
LDB1	2	LHX8	1	two hybrid	Rolland T (2014)	1
LDB1	2	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Goardon N (2006)	2
LHX9	2	SSBP4	0	affinity chromatography technology	Huttlin EL (2015)	1
LDB1	2	LMO3	0	two hybrid	Rual JF (2005)	1
LDB1	2	LSM7	0	two hybrid	Wang J (2011)	1
LHX6	1	TRIM33	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2