PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ITSN1	5	SYNJ1	3	affinity chromatography technology	Tsyba L (2008)	1
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
GTSE1	3	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
CLTA	1	CLTC	12	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
CDH1	4	SYNJ1	3	bioid	Guo Z (2014)	1
CDH1	4	SH3GL1	3	bioid	Guo Z (2014)	1
ITSN1	5	PACSIN3	2	two hybrid	Wong KA (2012)	1
GRB2	2	SYNJ1	3	affinity chromatography technology, affinity chromatography technology	Bisson N (2011), Huttlin EL (2017)	2
PACSIN2	0	PACSIN1	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Bandyopadhyay S (2010), Rolland T (2014), Huttlin EL (2017)	8
AP2A1	1	AMPH	4	unspecified method, affinity chromatography technology	Brett TJ (2002), Huttlin EL (2017)	2
GTSE1	3	CLTA	1	affinity chromatography technology	Hein MY (2015)	1
AP2M1	5	ITSN1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNX9	1	SYNJ1	3	affinity chromatography technology	Huttlin EL (2017)	1
AP2M1	5	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
CDH1	4	PACSIN2	0	bioid	Guo Z (2014)	1
PACSIN2	0	PACSIN3	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Huttlin EL (2015), Huttlin EL (2017)	5
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
AMPH	4	ITSN1	5	affinity chromatography technology	Dergai M (2011)	1
ITSN1	5	CLTC	12	two hybrid	Wong KA (2012)	1
SYNJ1	3	SH3GL1	3	unspecified method	Cestra G (1999)	1
GTSE1	3	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CDH1	4	SNX9	1	bioid	Guo Z (2014)	1
GTSE1	3	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	AP2A1	1	affinity chromatography technology	Blagoev B (2003)	1
SNX9	1	AP2A1	1	affinity chromatography technology	Huttlin EL (2017)	1
SYNJ1	3	CLTA	1	pull down	Brett TJ (2002)	1
ALKBH2	0	SYNJ1	3	affinity chromatography technology	Huttlin EL (2017)	1
SH3GL2	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
SH3KBP1	1	CLTC	12	affinity chromatography technology	Kowanetz K (2003)	1
AP2M1	5	CDH1	4	affinity chromatography technology	Li J (2013)	1
GTSE1	3	SNX9	1	affinity chromatography technology	Hein MY (2015)	1
PACSIN3	2	SYNJ1	3	pull down	Modregger J (2000)	1
SH3KBP1	1	SH3GL2	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Soubeyran P (2002), Soubeyran P (2002), Soubeyran P (2002), Schmidt MH (2004), Schmidt MH (2004), Vinayagam A (2011)	6
PACSIN1	0	SYNJ1	3	pull down	Modregger J (2000)	1
SH3KBP1	1	SYNJ1	3	affinity chromatography technology, far western blotting, affinity chromatography technology	Kurakin AV (2003), Kurakin AV (2003), Havrylov S (2009)	3
CDH1	4	SH3KBP1	1	bioid	Guo Z (2014)	1
SNX9	1	CLTC	12	affinity chromatography technology	Lundmark R (2003)	1
AP2A1	1	SYNJ1	3	unspecified method, pull down	Brett TJ (2002), Brett TJ (2002)	2
SH3KBP1	1	GTSE1	3	affinity chromatography technology	Havrylov S (2009)	1
ITSN1	5	SH3KBP1	1	affinity chromatography technology	Nikolaienko O (2009)	1
SYNJ1	3	AMPH	4	pull down, affinity chromatography technology, unspecified method	Micheva KD (1997), Micheva KD (1997), Cestra G (1999)	3
AMPH	4	CLTC	12	pull down, affinity chromatography technology	Ramjaun AR (1998), Slepnev VI (2000)	2
PACSIN2	0	SYNJ1	3	pull down	Modregger J (2000)	1
AP2M1	5	CLTC	12	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Hein MY (2015)	2
SYNJ1	3	CLTC	12	pull down	Brett TJ (2002)	1
SNX9	1	AP2M1	5	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	CLTC	12	affinity chromatography technology	Brehme M (2009)	1
AMPH	4	SH3GL2	1	pull down	Micheva KD (1997)	1
PACSIN1	0	PACSIN3	2	two hybrid, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Rolland T (2014), Huttlin EL (2017)	6
AMPH	4	AP2M1	5	affinity chromatography technology	Huttlin EL (2017)	1
GTSE1	3	SYNJ1	3	affinity chromatography technology	Hein MY (2015)	1
SH3GL2	1	SH3GL1	3	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
SYNJ1	3	AP2M1	5	pull down, affinity chromatography technology, affinity chromatography technology	Brett TJ (2002), Huttlin EL (2015), Huttlin EL (2017)	3
CLTC	12	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
SYNJ1	3	SH3GL2	1	pull down, pull down, affinity chromatography technology	Micheva KD (1997), Micheva KD (1997), Micheva KD (1997)	3