PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FYN	1	SKAP2	1	affinity chromatography technology, enzymatic study	Kouroku Y (1998), Takahashi T (2003)	2
PRAM1	4	SKAP2	1	affinity chromatography technology	Moog-Lutz C (2001)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
GRB2	2	KHDRBS1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, two hybrid	Liu SK (1998), Oneyama C (2002), Shen Z (1999), Shen Z (1999), Bandyopadhyay S (2010), Asbach B (2012), Bisson N (2011), Wang J (2011)	8
KHDRBS1	1	HCK	5	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Asbach B (2012), Asbach B (2012), Asbach B (2012)	3
PTK2B	6	FYN	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ganju RK (1997), Katagiri T (2000), Qian D (1997), Qian D (1997), Marie-Cardine A (1999)	5
SKAP1	0	GRB2	2	affinity chromatography technology	Wu L (2002)	1
FYN	1	KHDRBS1	1	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study	Oneyama C (2002), Fusaki N (1997), Loewenberg M (2006), Asbach B (2012), Asbach B (2012), Kaabeche K (2004)	6
RGS3	0	APP	1	pull down	Olah J (2011)	1
FASLG	0	FYN	1	pull down, pull down, pull down, unspecified method, imaging technique	Wenzel J (2001), Hane M (1995), Zuccato E (2007), Voss M (2009), Chen TC (2014)	5
LYN	2	SKAP1	0	pull down	Marie-Cardine A (1997)	1
SRC	2	KHDRBS1	1	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Stelzl U (2005), Oneyama C (2002), Koch CA (1992), Shen Z (1999), Shen Z (1999), Finan PM (1996), Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004), Pincheira R (2008), Wong G (1992), Williger BT (1997), Wong BR (1999)	14
PTK2B	6	GRB2	2	affinity chromatography technology, affinity chromatography technology	Blaukat A (1999), Bruzzaniti A (2009)	2
FASLG	0	GRB2	2	affinity chromatography technology, pull down, pull down	Ghadimi MP (2002), Ghadimi MP (2002), Wenzel J (2001)	3
KHDRBS1	1	LYN	2	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004)	4
FASLG	0	SRC	2	unspecified method	Voss M (2009)	1
SRC	2	PTK2B	6	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Keely SJ (2000), Kumar S (1999), Dikic I (1996), Dikic I (1996), Bruzzaniti A (2009)	5
FYN	1	SKAP1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marie-Cardine A (1997), Wu L (2002), Marie-Cardine A (1998), Marie-Cardine A (1999)	4
ABHD5	2	SKAP2	1	affinity chromatography technology	Huttlin EL (2017)	1
APP	1	SRC	2	affinity chromatography technology	Austin SA (2009)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
SNRPN	0	SKAP2	1	affinity chromatography technology	Huttlin EL (2017)	1
HCK	5	SKAP2	1	affinity chromatography technology	Kouroku Y (1998)	1
FRMD1	1	SKAP2	1	affinity chromatography technology	Huttlin EL (2017)	1
HCK	5	SRC	2	affinity chromatography technology	Howlett CJ (2002)	1
LYN	2	SKAP2	1	affinity chromatography technology	Kouroku Y (1998)	1
PTK2B	6	LYN	2	affinity chromatography technology	Yamasaki M (2001)	1
SKAP1	0	APP	1	pull down	Olah J (2011)	1
SKAP2	1	APP	1	pull down	Olah J (2011)	1
APP	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
FASLG	0	SKAP2	1	unspecified method	Voss M (2009)	1
SKAP2	1	PTK2B	6	affinity chromatography technology, two hybrid, affinity chromatography technology	Takahashi T (2003), Takahashi T (2003), Takahashi T (2003)	3
HCK	5	APP	1	pull down	Olah J (2011)	1
KHDRBS1	1	SKAP2	1	unspecified method	Asbach B (2012)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
LYN	2	FASLG	0	pull down, unspecified method	Zuccato E (2007), Voss M (2009)	2
SRC	2	SKAP1	0	pull down	Marie-Cardine A (1997)	1
SKAP1	0	PRAM1	4	two hybrid	Rolland T (2014)	1
PRAM1	4	LYN	2	affinity chromatography technology	Moog-Lutz C (2001)	1
SKAP1	0	SKAP2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FASLG	0	HCK	5	unspecified method	Voss M (2009)	1
SRC	2	SKAP2	1	enzymatic study	Takahashi T (2003)	1
RGS3	0	SKAP2	1	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	SKAP2	1	affinity chromatography technology	Brehme M (2009)	1