PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC25B	4	TIAM1	3	affinity chromatography technology	Boldt K (2016)	1
TRIM9	3	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Shi M (2014), Shi M (2014), Shi M (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Coyaud E (2015), Huttlin EL (2017)	8
NFKB2	3	BTRC	1	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid	Fong A (2002), Vatsyayan J (2008), Liang C (2006), Liang C (2006), Xiao G (2004), Amir RE (2004), Busino L (2012), Coyaud E (2015), Coyaud E (2015)	9
BTRC	1	CDC25B	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uchida S (2011), Uchida S (2011), Kanemori Y (2005), Kim TY (2014), Coyaud E (2015), Loveless TB (2015), Coyaud E (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017)	10
CUL1	7	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
FBXW11	2	BCL2L11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dehan E (2009), Kim TY (2014), Huttlin EL (2015), Huttlin EL (2017)	4
NFKBIA	0	NFKB1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hay DC (2001), Malek S (1998), Fagan-Garcia K (2011), Jeon YJ (2010), Roff M (1996), Keutgens A (2010), Inan MS (2000), Wang J (2011), Arenzana-Seisdedos F (1995), Jaffray E (1995), Wood KM (1998), Bell S (1996), Cockman ME (2006), Cockman ME (2006), Lu Y (2005), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	19
APC	5	CTNNB1	30	affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su LK (1993), Su LK (1993), Kucerova D (2001), Tickenbrock L (2003), Davies G (2001), Ryo A (2001), Homma MK (2002), Tickenbrock L (2003), Davies G (2001), Satoh K (1997), Eklof Spink K (2001), Eklof Spink K (2001), Sierra J (2006), Choi J (2004), Huang X (2009), Brocardo MG (2011), Xing Y (2004), Xing Y (2004), Xing Y (2004), Hamada F (2004), Hamada F (2004), Schneikert J (2013), Hsi LC (1999), Hein MY (2015), Hein MY (2015), Chen TC (2014), Kuslansky Y (2016), Novellasdemunt L (2017), Novellasdemunt L (2017)	29
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
USP37	1	CUL1	7	affinity chromatography technology	Burrows AC (2012)	1
FBXW11	2	USP47	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Peschiaroli A (2010), Gao D (2011), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Coyaud E (2015), Huttlin EL (2017)	9
FBXW11	2	CDC34	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu K (2010), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014)	5
FBXW11	2	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
NFKB1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Heissmeyer V (2001), Lang V (2003), Lang V (2003), Winston JT (1999), Winston JT (1999), Busino L (2012), Amir RE (2002), Coyaud E (2015), Coyaud E (2015), Zhang Z (2015), Huttlin EL (2017)	11
FBXW11	2	TFAP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), DAnnibale S (2014), DAnnibale S (2014), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	8
CDC25B	4	SKP1	0	affinity chromatography technology	Li X (2016)	1
FBXW11	2	TIAM1	3	affinity chromatography technology	Kim TY (2014)	1
CDC34	3	BTRC	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, bioid, affinity chromatography technology	Semplici F (2002), Cenciarelli C (1999), Sowa ME (2009), Fernandez-Sanchez ME (2010), Chong RA (2014), Burrows AC (2012), Coyaud E (2015), Huttlin EL (2017)	8
NFKB1	2	NFKB2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Bouwmeester T (2004), Wang J (2011), Li X (2015)	4
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
FBXW11	2	NFKB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao D (2011), Kim TY (2014), Coyaud E (2015), Low TY (2014)	4
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
FBXW11	2	CDC25B	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Uchida S (2011), Uchida S (2011), Gao D (2011), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Liu X (2017)	12
FBXW11	2	DEPTOR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Duan S (2011), Gao D (2011), Gao D (2011), Kim TY (2014), Zhao Y (2011), Zhao Y (2011)	6
BTRC	1	TIAM1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Magliozzi R (2014), Magliozzi R (2014), Magliozzi R (2014), Magliozzi R (2014), Magliozzi R (2014), Magliozzi R (2014)	6
USP37	1	SKP1	0	affinity chromatography technology, bioid	Burrows AC (2012), Yeh C (2015)	2
CUL1	7	DEPTOR	1	affinity chromatography technology	Gao D (2011)	1
FBXW11	2	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Suzuki H (2000), Tan P (1999), Suzuki H (1999), Suzuki H (1999), Herter JR (2002), Chong RA (2014), Herter JR (2002), Huttlin EL (2015), Huttlin EL (2017), Gazdoiu S (2007)	10
BTRC	1	USP47	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Peschiaroli A (2010), Kim TY (2014), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	6
CDC34	3	NFKBIA	0	enzymatic study	Wu K (2010)	1
WWTR1	1	FBXW11	2	affinity chromatography technology	Huttlin EL (2015)	1
FBXW11	2	NFKB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao D (2011), Kim TY (2014), Low TY (2014), Huttlin EL (2017)	4
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kitagawa M (1999), Hart M (1999), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Novellasdemunt L (2017)	7
BTRC	1	DEPTOR	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, pull down	Duan S (2011), Duan S (2011), Duan S (2011), Gao D (2011), Gao D (2011), Gao D (2011), Gao D (2011), Loveless TB (2015), Yu H (2011), Zhao Y (2011), Zhao Y (2011), Zhao Y (2011)	12
PDCD4	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Schmid T (2008), Dorrello NV (2006), Kroczynska B (2012), Kruiswijk F (2012), Blees JS (2012), Dorrello NV (2006), Coyaud E (2015), Loveless TB (2015), Coyaud E (2015), Huttlin EL (2017)	10
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
NFKB1	2	CTNNB1	30	imaging technique, affinity chromatography technology, imaging technique	Kim JH (2005), Kim JH (2005), Chen TC (2014)	3
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
BTRC	1	SUN2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Coyaud E (2015), Loveless TB (2015), Loveless TB (2015), Coyaud E (2015), Huttlin EL (2017)	7
UHRF1	3	FBXW11	2	affinity chromatography technology, affinity chromatography technology	Taniue K (2016), Taniue K (2016)	2
SMAD4	9	NFKB1	2	affinity chromatography technology	Li X (2015)	1
NFKBIA	0	NFKB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
FBXW11	2	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	3
FBXW11	2	ATF4	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Frank CL (2010), Gao D (2011), Kim TY (2014), Low TY (2014)	4
SKP1	0	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down	Hattori K (1999), Tan P (1999), Suzuki H (1999), Winston JT (1999), Surjit M (2012), Chong RA (2014)	6
BTRC	1	CLSPN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peschiaroli A (2006), Mailand N (2006), Peschiaroli A (2006), Gao D (2009), Bassermann F (2008), Kee Y (2009)	6
FBXW11	2	EEF2K	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kruiswijk F (2012), Wiseman SL (2013), Varjosalo M (2013), Kim TY (2014), Low TY (2014)	5
BTRC	1	TRIM9	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Rual JF (2005), Shi M (2014), Shi M (2014), Shi M (2014), Kim TY (2014), Rolland T (2014), Coyaud E (2015), Loveless TB (2015), Loveless TB (2015), Coyaud E (2015), Huttlin EL (2017)	11
AXIN1	1	APC	5	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hino S (2005), Kitagawa M (1999), Sue Ng S (2010), Tran H (2012), Li VS (2012), Hein MY (2015), Hein MY (2015), Novellasdemunt L (2017)	12
BTRC	1	SMAD4	9	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wan M (2004), Wan M (2004), Yang L (2006), Yang L (2006), Wan M (2005), Liang M (2004), Demagny H (2014), Li D (2015)	8
FBXW11	2	HNRNPU	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	4
TFAP4	3	CUL1	7	affinity chromatography technology	DAnnibale S (2014)	1
FBXW11	2	PDCD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kruiswijk F (2012), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	7
UHRF1	3	BTRC	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen H (2013), Chen H (2013), Chen H (2013), Taniue K (2016), Taniue K (2016), Huttlin EL (2017)	6
BTRC	1	WWTR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu CY (2011), Liu CY (2011), Varelas X (2010), Huttlin EL (2015), Loveless TB (2015), Coyaud E (2015), Lv XB (2015), Gu JJ (2016), Huttlin EL (2017)	9
USP37	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology	Burrows AC (2012), Burrows AC (2012), Burrows AC (2012), Saxena N (2014), Yeh C (2015), Huttlin EL (2017)	6
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
USP37	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Kim TY (2014), Low TY (2014), Yeh C (2015), Huttlin EL (2017)	6
BTRC	1	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Kitagawa M (1999), Kitagawa M (1999), Li VS (2012), Coyaud E (2015), Coyaud E (2015), Novellasdemunt L (2017)	6
EEF2K	3	SKP1	0	affinity chromatography technology	Kruiswijk F (2012)	1
FBXW11	2	CLSPN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peschiaroli A (2006), Gao D (2011), Bassermann F (2008), Kim TY (2014), Low TY (2014), Kee Y (2009)	6
CDC25A	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2003), Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016)	6
HNRNPU	12	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Tsuchiya Y (2010), Kim TY (2014), Coyaud E (2015), Cheon Y (2016), Cheon Y (2016), Cheon Y (2016)	6
HNRNPU	12	UHRF1	3	affinity chromatography technology	Hein MY (2015)	1
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
BTRC	1	REST	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guardavaccaro D (2008), Guardavaccaro D (2008), Kaneko N (2014), Kaneko N (2014), Valiya Veettil M (2014), Karlin KL (2014), Low TY (2014), Nesti E (2014)	8
NFKBIA	0	ATF4	2	two hybrid	Gao J (2008)	1
BTRC	1	CDC25A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Ray D (2005), Jin J (2003), Jin J (2003), Honaker Y (2010), Honaker Y (2010), Gao D (2009), Donzelli M (2004), Donzelli M (2004), Jin J (2005), Busino L (2003), Busino L (2003), Busino L (2003), Busino L (2003), Kim TY (2014), Jin J (2003), Coyaud E (2015), Loveless TB (2015), Coyaud E (2015), He N (2005), He N (2005), St-Denis N (2016), Huttlin EL (2017)	23
FBXW11	2	RAPGEF2	5	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Kim TY (2014), Kim TY (2014), Kim TY (2014), Low TY (2014), Low TY (2014)	7
CTNNB1	30	CUL1	7	affinity chromatography technology	Read MA (2000)	1
FBXW11	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Watanabe N (2004), Fuchs SY (1999), Tan P (1999), Herter JR (2002), Lievens S (2009), Lievens S (2009), DAnnibale S (2014), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), Liu X (2017), Hauri S (2016)	16
FBXW11	2	CDC25A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Ray D (2005), Ray D (2005), Jin J (2003), Jin J (2005), Gao D (2011), Busino L (2003), Busino L (2003), Kim TY (2014), Jin J (2003), Coyaud E (2015), Low TY (2014), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Liu X (2017), Liu X (2017), Yadav L (2017), Yadav L (2017)	18
CTNNB1	30	AXIN1	1	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hocevar BA (2003), Hino S (2005), Stoothoff WH (2002), Kim MJ (2008), Kitagawa M (1999), Kitagawa M (1999), Arnold HK (2009), Zhang YG (2012), Godin JD (2010), Godin JD (2010), Sue Ng S (2010), Sue Ng S (2010), Tang Y (2008), Li VS (2012), Yamamoto H (2006), Fei C (2013), Hein MY (2015), Kuslansky Y (2016), Novellasdemunt L (2017)	25
FBXW11	2	SUN2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	5
NFKBIA	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawakami T (2001), Read MA (2000), Suzuki H (1999), Surjit M (2012), Furukawa M (2000), Furukawa M (2000)	6
UHRF1	3	CUL1	7	affinity chromatography technology	Chen H (2013)	1
CDC25A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016), Yadav L (2017), Yadav L (2017)	7
CDC25B	4	CUL1	7	affinity chromatography technology	Li X (2016)	1
BTRC	1	RAPGEF2	5	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Kim TY (2014), Kim TY (2014), Loveless TB (2015), Low TY (2014)	6
BTRC	1	ATF4	2	affinity chromatography technology, two hybrid, affinity chromatography technology, x-ray crystallography, unspecified method, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Lassot I (2005), Lassot I (2001), Lassot I (2001), Evrard-Todeschi N (2008), Pons J (2008), Wang J (2011), Rolland T (2014), Loveless TB (2015), Loveless TB (2015), Yu H (2011)	10
HNRNPU	12	NFKBIA	0	affinity chromatography technology	Tsuchiya Y (2010)	1
CTNNB1	30	SKP1	0	affinity chromatography technology, unspecified method, affinity chromatography technology, imaging technique	Matsuzawa SI (2001), Winston JT (1999), Wang D (2011), Chen TC (2014)	4
TFAP4	3	SKP1	0	affinity chromatography technology	DAnnibale S (2014)	1
FBXW11	2	REST	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guardavaccaro D (2008), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	7
BTRC	1	TFAP4	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology	DAnnibale S (2014), DAnnibale S (2014), DAnnibale S (2014), Loveless TB (2015), Coyaud E (2015), Huttlin EL (2017)	6
BCL2L11	4	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Dehan E (2009), Dehan E (2009), Moustafa-Kamal M (2013), Moustafa-Kamal M (2013), Huttlin EL (2015), Huttlin EL (2017)	7
BTRC	1	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, bioid, enzymatic study, protein complementation assay	Suzuki H (2000), Spencer E (1999), Spencer E (1999), Spencer E (1999), Suzuki H (1999), Suzuki H (1999), Kroll M (1999), Kroll M (1999), Yaron A (1998), Choi YS (2010), Banerjee S (2010), Banerjee S (2010), Banerjee S (2010), Da Silva-Ferrada E (2011), Tsuchiya Y (2010), Tsuchiya Y (2010), Keutgens A (2010), Winston JT (1999), Winston JT (1999), Winston JT (1999), Winston JT (1999), Surjit M (2012), Busino L (2012), Evrard-Todeschi N (2008), Furukawa M (2000), Kovacev J (2014), Chong RA (2014), Chong RA (2014), Shi M (2014), Shirane M (1999), Read MA (2000), Tan M (2010), Coyaud E (2015), Coyaud E (2015), Wu K (2016), Villalobos V (2010)	36
BTRC	1	EEF2K	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kruiswijk F (2012), Kruiswijk F (2012), Kruiswijk F (2012), Wiseman SL (2013), Varjosalo M (2013), Coyaud E (2015), Coyaud E (2015)	7