PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM15	0	CFL1	0	protein complementation assay	Lee OH (2015)	1
TAF9B	0	TRIM15	0	two hybrid	Ravasi T (2010)	1
VCL	6	FERMT2	0	biochemical, biochemical	Kristensen AR (2012), Wan C (2015)	2
FERMT3	4	KEAP1	0	affinity chromatography technology	Hein MY (2015)	1
PTTG1	0	TRIM15	0	genetic interference	Vizeacoumar FJ (2013)	1
NCK2	2	PTK2	2	pull down, affinity chromatography technology	Goicoechea SM (2002), Goicoechea SM (2002)	2
TRIM15	0	FERMT3	4	protein complementation assay	Lee OH (2015)	1
CRK	0	GAB1	3	affinity chromatography technology	Brehme M (2009)	1
ACD	1	ACTB	8	two hybrid	Lee OH (2011)	1
TRIM15	0	TRIM15	0	two hybrid, protein complementation assay, affinity chromatography technology	Ravasi T (2010), Lee OH (2015), Lee OH (2015)	3
CTTN	1	KEAP1	0	affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2015), Ito A (2015), Ito A (2015)	3
PTK2	2	SYK	3	affinity chromatography technology, affinity chromatography technology	Chung J (1997), Sada K (1997)	2
TRIM15	0	CRK	0	protein complementation assay, affinity chromatography technology	Lee OH (2015), Lee OH (2015)	2
AKT1	1	PTK2	2	imaging technique	Moon HE (2015)	1
VASP	0	VCL	6	affinity chromatography technology	Harbeck B (2000)	1
TRIM15	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
SRC	2	SYK	3	enzymatic study, affinity chromatography technology, enzymatic study	Kurosaki T (1994), Asazuma N (1997), Hirose M (2004)	3
TRIM15	0	FBLIM1	2	affinity chromatography technology, protein complementation assay	Lee OH (2015), Lee OH (2015)	2
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
TRIM15	0	AKT1	1	protein complementation assay, affinity chromatography technology	Lee OH (2015), Lee OH (2015)	2
UBE2U	0	TRIM15	0	two hybrid	Markson G (2009)	1
SRC	2	CFL1	0	enzymatic study	Yoo Y (2010)	1
SHC1	0	ACTB	8	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
TRIM15	0	SYK	3	protein complementation assay	Lee OH (2015)	1
VCL	6	MSN	0	biochemical	Kristensen AR (2012)	1
TRIM15	0	KEAP1	0	protein complementation assay	Lee OH (2015)	1
TRIM15	0	GAB1	3	protein complementation assay	Lee OH (2015)	1
TRIM15	0	PRNP	4	protein complementation assay	Lee OH (2015)	1
TINF2	1	ACTB	8	two hybrid	Lee OH (2011)	1
FERMT3	4	FERMT2	0	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	VIM	0	affinity chromatography technology	Lleres D (2010)	1
TRIM15	0	NEXN	3	protein complementation assay	Lee OH (2015)	1
NEXN	3	ACTB	8	affinity chromatography technology	Huttlin EL (2017)	1
BLM	2	TRIM8	6	genetic interference	Vizeacoumar FJ (2013)	1
EHMT1	18	TRIM15	0	two hybrid	Ravasi T (2010)	1
GTF2E1	1	TRIM15	0	two hybrid	Ravasi T (2010)	1
TRIM15	0	FERMT2	0	protein complementation assay	Lee OH (2015)	1
TRIM15	0	FAM151B	0	two hybrid	Rolland T (2014)	1
TINF2	1	CTTN	1	two hybrid	Lee OH (2011)	1
PTK2	2	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hecker TP (2002), Angers-Loustau A (1999), Relou IA (2003), Messina S (2003), Lebrun P (1998), Ponnala S (2011), Grossmann A (2015), Chen TC (2014), Lee J (2013), Reiske HR (2000)	11
CTTN	1	PTK2	2	affinity chromatography technology	Bharti S (2007)	1
SNW1	0	TRIM15	0	two hybrid	Ravasi T (2010)	1
CRK	0	ACTB	8	affinity chromatography technology	Brehme M (2009)	1
PXN	1	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovacic-Milivojevic B (2001), Matsuya M (1998), Turner CE (1999), Liu S (2002), Liu S (2002), Mazaki Y (1997), Zheng C (1998), Brown MC (1996), Fujita H (1998), Zhang Z (1999), Wang JF (2000), Ivankovic-Dikic I (2000)	12
RABGEF1	1	TRIM15	0	two hybrid	Rolland T (2014)	1
PFN1	0	CFL1	0	biochemical	Wan C (2015)	1
SNW1	0	ACTB	8	affinity chromatography technology	Lleres D (2010)	1
TRIM15	0	ROCK1	6	protein complementation assay	Lee OH (2015)	1
FERMT2	0	FBLIM1	2	two hybrid, pull down, affinity chromatography technology	Tu Y (2003), Tu Y (2003), Tu Y (2003)	3
AKT1	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhu QS (2011), Zhu QS (2011), Zhu QS (2011), Zhu QS (2011)	4
SYK	3	PXN	1	affinity chromatography technology	Fernandez R (1998)	1
MYBL2	2	TRIM15	0	two hybrid	Ravasi T (2010)	1
TRIM15	0	SRC	2	protein complementation assay, affinity chromatography technology	Lee OH (2015), Lee OH (2015)	2
TRIM15	0	CORO1B	6	affinity chromatography technology, protein complementation assay	Lee OH (2015), Lee OH (2015)	2
CRK	0	PTTG1	0	two hybrid	Grossmann A (2015)	1
TRIM15	0	VIM	0	protein complementation assay	Lee OH (2015)	1
SNW1	0	CTTN	1	affinity chromatography technology	Lleres D (2010)	1
SHC1	0	PTK2	2	affinity chromatography technology	Hecker TP (2002)	1
SRC	2	PXN	1	pull down	Angers-Loustau A (1999)	1
AKT1	1	ACTB	8	affinity chromatography technology	Zhu QS (2011)	1
CFL1	0	ROCK1	6	affinity chromatography technology	Maekawa M (1999)	1
ACTB	8	CFL1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM15	0	MSN	0	protein complementation assay	Lee OH (2015)	1
ACD	1	CTTN	1	two hybrid	Lee OH (2011)	1
CORO1B	6	CTTN	1	biochemical	Havugimana PC (2012)	1
CTTN	1	PXN	1	affinity chromatography technology, imaging technique	Onodera Y (2005), Chen TC (2014)	2
TINF2	1	FERMT3	4	two hybrid	Lee OH (2011)	1
TRIM15	0	PFN1	0	protein complementation assay	Lee OH (2015)	1
FAM161A	2	TRIM15	0	two hybrid	Rolland T (2014)	1
GAB1	3	SHC1	0	affinity chromatography technology, far western blotting, affinity chromatography technology	Ingham RJ (1998), Ingham RJ (1998), van den Akker E (2004)	3
SNW1	0	VASP	0	affinity chromatography technology	Lleres D (2010)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
TRIM15	0	NCK2	2	protein complementation assay, affinity chromatography technology	Lee OH (2015), Lee OH (2015)	2
TRIM15	0	VASP	0	affinity chromatography technology, protein complementation assay	Lee OH (2015), Lee OH (2015)	2
TINF2	1	TRIM15	0	two hybrid	Lee OH (2011)	1
BLM	2	TRIM15	0	genetic interference	Vizeacoumar FJ (2013)	1
PFN1	0	ACTB	8	pull down, two hybrid	Nunoi H (1999), Du Y (2009)	2
ACD	1	TRIM15	0	two hybrid	Lee OH (2011)	1
PTK2	2	CRK	0	affinity chromatography technology, pull down, two hybrid	Hsia DA (2003), Angers-Loustau A (1999), Grossmann A (2015)	3
TRIM15	0	PXN	1	affinity chromatography technology, affinity chromatography technology, pull down	Uchil PD (2014), Uchil PD (2014), Uchil PD (2014)	3
SNW1	0	BLM	2	affinity chromatography technology	Lleres D (2010)	1
CRK	0	PXN	1	pull down, affinity chromatography technology	Angers-Loustau A (1999), Abassi YA (2002)	2
SHC1	0	SRC	2	pull down	Schueller AC (2008)	1
TRIM15	0	ACTB	8	protein complementation assay	Lee OH (2015)	1
CORO1B	6	ACTB	8	biochemical	Wan C (2015)	1
IRF5	0	TRIM15	0	two hybrid	Ravasi T (2010)	1
TRIM15	0	CTTN	1	affinity chromatography technology, protein complementation assay	Lee OH (2015), Lee OH (2015)	2
MED7	1	TRIM15	0	two hybrid	Ravasi T (2010)	1
TRIM15	0	VCL	6	protein complementation assay	Lee OH (2015)	1
PXN	1	VCL	6	pull down, pull down, pull down, biochemical	Turner CE (1999), Mazaki Y (1997), Brown MC (1996), Wan C (2015)	4
TRIM15	0	SHC1	0	protein complementation assay	Lee OH (2015)	1
VASP	0	PFN1	0	two hybrid, affinity chromatography technology	Harbeck B (2000), Harbeck B (2000)	2
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
TRIM15	0	PTK2	2	protein complementation assay	Lee OH (2015)	1
ROCK1	6	GAB1	3	x-ray crystallography	Bourguignon LY (2003)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2
SYK	3	CTTN	1	affinity chromatography technology, imaging technique	Maruyama S (1996), Chen TC (2014)	2