PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSPB3	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
HSPB3	1	MED8	0	two hybrid	Stelzl U (2005)	1
HSPB3	1	RBM48	1	two hybrid	Stelzl U (2005)	1
HSPB3	1	MED31	0	two hybrid	Stelzl U (2005)	1
HSPB3	1	OLFML3	0	two hybrid	Stelzl U (2005)	1
HSPB3	1	BBOX1	0	two hybrid	Stelzl U (2005)	1
OLFML3	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
HSPB2	1	HSPB3	1	affinity chromatography technology	Sugiyama Y (2000)	1
HSPB3	1	SETDB1	3	two hybrid	Stelzl U (2005)	1
HSPB3	1	ZZEF1	5	two hybrid	Stelzl U (2005)	1
HSPB3	1	RAMP3	1	two hybrid	Stelzl U (2005)	1
HSPB3	1	ANP32A	3	two hybrid	Stelzl U (2005)	1
HSPB8	0	HSPB2	1	two hybrid, affinity chromatography technology, two hybrid	Sun X (2004), Sun X (2004), Benndorf R (2001)	3
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
HSPB8	0	HSPB3	1	two hybrid	Fontaine JM (2005)	1
HSPB3	1	MRPL38	2	two hybrid	Stelzl U (2005)	1
HSPB3	1	RTL8A	0	two hybrid	Stelzl U (2005)	1
HSPB3	1	NSMF	1	two hybrid	Stelzl U (2005)	1
HSPB3	1	UNC119	4	two hybrid	Stelzl U (2005)	1
HSPB3	1	PRPF4B	3	two hybrid	Stelzl U (2005)	1