PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TGFBR2	0	ACVR1	4	two hybrid	Kawabata M (1995)	1
PEG10	2	ACVR2A	0	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
BMPR1A	5	FKBP1A	0	two hybrid	Kurozumi K (1998)	1
ACVR1B	1	ACVR1	4	affinity chromatography technology, affinity chromatography technology	De Winter JP (1996), Huttlin EL (2015)	2
ACVRL1	1	PEG10	2	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, imaging technique	Lux A (2005), Lux A (2005), Lux A (2005), Lux A (2005), Lux A (2005)	5
USP15	4	BMPR1A	5	affinity chromatography technology, imaging technique, enzymatic study	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
ACVR1	4	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
BMPR1A	5	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
GDF5	0	BMPR2	1	pull down	Erlacher L (1998)	1
SMAD5	2	SMAD6	9	affinity chromatography technology	Murakami G (2003)	1
TGFBR2	0	CD320	1	affinity chromatography technology	Huttlin EL (2015)	1
SMAD6	9	ACVR1B	1	affinity chromatography technology	Kamiya Y (2010)	1
MRAP2	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
FKBP1A	0	ACVR1	4	affinity chromatography technology	Chaikuad A (2012)	1
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
BMPR1A	5	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
LRRIQ1	5	ACVR2A	0	affinity chromatography technology	Huttlin EL (2017)	1
MRAP2	0	ACVR2A	0	affinity chromatography technology	Huttlin EL (2017)	1
MRAP2	0	BMPR2	1	affinity chromatography technology	Huttlin EL (2017)	1
ACVR1	4	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
TNFRSF10A	0	RNF149	0	affinity chromatography technology	Huttlin EL (2017)	1
SMAD7	1	TGFBR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Nakao A (1997), Hsu HY (2014)	3
TSC22D1	1	OTUB1	0	two hybrid	Vinayagam A (2011)	1
ACVR1	4	MED16	5	affinity chromatography technology	Huttlin EL (2015)	1
ACVRL1	1	SMAD1	0	enzymatic study	Lee NY (2009)	1
ACVR1B	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
MRAP2	0	CD320	1	affinity chromatography technology	Huttlin EL (2017)	1
RGMB	1	ACVR2A	0	affinity chromatography technology	Samad TA (2005)	1
TGFBR2	0	ACVR2A	0	affinity chromatography technology	Huttlin EL (2015)	1
SMAD6	9	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
TGFBR2	0	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP15	4	ACVR1	4	affinity chromatography technology	Herhaus L (2014)	1
ACVR1	4	ARV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACVR1B	1	FKBP1A	0	affinity chromatography technology, protein complementation assay	Yamaguchi T (2006), Eyckerman S (2005)	2
ACVR1	4	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
SMAD7	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Yan X (2011), Yan X (2011)	2
PEG10	2	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
ACVR1	4	CD320	1	affinity chromatography technology	Huttlin EL (2017)	1
MRAP2	0	ACVR1B	1	affinity chromatography technology	Huttlin EL (2017)	1
INHBA	1	ACVR1B	1	affinity chromatography technology	Martens JW (1997)	1
BMP7	3	SMAD1	0	genetic interference	Guo X (2001)	1
ACVR1	4	GRAMD1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACVR1B	1	IGSF1	3	affinity chromatography technology, affinity chromatography technology	Chapman SC (2001), Chapman SC (2001)	2
ACVR1B	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Yamaguchi T (2006), Murakami G (2003)	2
BMP7	3	BMPR2	1	affinity chromatography technology, affinity chromatography technology	Liu F (1995), Rosenzweig BL (1995)	2
BMP7	3	BMPR1A	5	pull down	ten Dijke P (1994)	1
ACVR1	4	RNF149	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACVR1	4	BMPR1A	5	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Lavery K (2008), Lavery K (2008), Huttlin EL (2015), Huttlin EL (2017)	4
SMAD6	9	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
PEG10	2	ACVR1B	1	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
ACVR1B	1	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu X (2002), Yamaguchi T (2006), Yamaguchi T (2006), Kamiya Y (2010)	4
LRRIQ1	5	CD320	1	affinity chromatography technology	Huttlin EL (2017)	1
IGSF1	3	INHBA	1	imaging technique	Chapman SC (2001)	1
SMAD6	9	BMPR1A	5	affinity chromatography technology	Kamiya Y (2010)	1
TNFRSF10A	0	ACVR2A	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO7	1	ACVR1	4	enzymatic study	Teixeira FR (2016)	1
TNFRSF10A	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
TGFBR2	0	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMAD5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, two hybrid, two hybrid, enzymatic study	Lu K (2008), Komuro A (2004), Ebisawa T (2001), Nie J (2010), Alarcon C (2009), Murakami G (2003), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Haag J (2006), Colland F (2004), Lu K (2008)	12
TGFBR2	0	ACVR1B	1	affinity chromatography technology	Huttlin EL (2015)	1
LRRIQ1	5	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1A	5	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
ACVR1	4	SMAD5	2	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
SMAD7	1	USP15	4	affinity chromatography technology	Eichhorn PJ (2012)	1
ACVR1	4	ACVR2A	0	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
ENG	5	BMP7	3	affinity chromatography technology	Barbara NP (1999)	1
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
ACVR1	4	FNTA	0	two hybrid	Wang T (1996)	1
SMAD1	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
ACVR1	4	INHBA	1	affinity chromatography technology	Attisano L (1993)	1
ACVR1	4	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
ACVRL1	1	BAMBI	3	pull down	Yan X (2009)	1
ACVR2A	0	INHBA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lewis KA (2000), Martens JW (1997), Attisano L (1993)	3
BMP7	3	ACVR2A	0	affinity chromatography technology	Macias-Silva M (1998)	1
SMAD6	9	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
BMPR2	1	ACVR1	4	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Liu F (1995), Liu F (1995), Liu F (1995), Liu F (1995), Kawabata M (1995), Huttlin EL (2017)	6
SMAD7	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Kamiya Y (2010)	2
ENG	5	ACVR1	4	affinity chromatography technology	Barbara NP (1999)	1
ENG	5	ACVR2A	0	affinity chromatography technology	Barbara NP (1999)	1
SMURF1	4	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Ebisawa T (2001), Johansson E (2016)	2
BMPR1A	5	OTUB1	0	enzymatic study	Herhaus L (2015)	1
RGMB	1	ACVR1	4	affinity chromatography technology	Samad TA (2005)	1
ACVR1	4	GDF5	0	affinity chromatography technology	Nishitoh H (1996)	1
ACVRL1	1	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
ACVR1B	1	ACVR2A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lebrun JJ (1999), De Winter JP (1996), Yamakawa N (2002)	3
TGFBR2	0	TGFBRAP1	2	affinity chromatography technology	Wurthner JU (2001)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
MRAP2	0	ACVR1	4	affinity chromatography technology	Huttlin EL (2017)	1
BMPR2	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
LRRIQ1	5	ACVR1	4	affinity chromatography technology	Huttlin EL (2017)	1
GDF5	0	BMPR1A	5	pull down	Erlacher L (1998)	1
ACVRL1	1	FKBP1A	0	two hybrid	Lee NY (2009)	1
SMAD7	1	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
FKBP1A	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Yamaguchi T (2006), Yamaguchi T (2006)	2
ACVR1	4	OTUB1	0	enzymatic study	Herhaus L (2015)	1
SMAD6	9	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Kamiya Y (2010), Zhang X (2013)	2
MRAP2	0	RNF149	0	affinity chromatography technology	Huttlin EL (2017)	1
RGMB	1	BMPR1A	5	affinity chromatography technology	Samad TA (2005)	1
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
BMP7	3	ACVR1	4	pull down	ten Dijke P (1994)	1
ACVR2A	0	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
ACVR1	4	TGFBRAP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BMPR1A	5	SMAD1	0	enzymatic study	Kretzschmar M (1997)	1
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
ACVR1	4	BAMBI	3	pull down	Yan X (2009)	1
ACVR1B	1	BAMBI	3	pull down	Yan X (2009)	1
BMPR2	1	ACVR1B	1	two hybrid	Liu F (1995)	1
SMAD7	1	BAMBI	3	affinity chromatography technology, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
TGFBR2	0	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Barbara NP (1999), Blanco FJ (2005)	6
ACVR1B	1	OTUB1	0	enzymatic study	Herhaus L (2015)	1
TNFRSF10A	0	CD320	1	affinity chromatography technology	Huttlin EL (2017)	1
SMAD6	9	BAMBI	3	affinity chromatography technology	Yan X (2009)	1
SMAD7	1	ACVR1	4	affinity chromatography technology	Kamiya Y (2010)	1
BMPR1A	5	BAMBI	3	pull down	Yan X (2009)	1
ACVR1	4	ACVR1	4	fluorescent resonance energy transfe	Lavery K (2008)	1
ACVR1	4	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACVRL1	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
ENG	5	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Blanco FJ (2005), Blanco FJ (2005)	2
ACVR2A	0	GDF5	0	affinity chromatography technology	Nishitoh H (1996)	1
TNFRSF10A	0	ACVR1	4	affinity chromatography technology	Huttlin EL (2017)	1
ACVRL1	1	INHBA	1	affinity chromatography technology	Attisano L (1993)	1
PEG10	2	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1
PEG10	2	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
LRRIQ1	5	BMPR2	1	affinity chromatography technology	Huttlin EL (2017)	1