PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNAPIN	1	IMMT	0	two hybrid	Stelzl U (2005)	1
TAF1D	0	FEZ1	0	two hybrid	Vinayagam A (2011)	1
CDK5RAP2	3	KAT5	1	two hybrid	Stelzl U (2005)	1
ZNF691	0	HAP1	1	two hybrid	Stelzl U (2005)	1
BARD1	4	LRIF1	3	two hybrid	Goehler H (2004)	1
CDC73	1	HAP1	1	two hybrid	Vinayagam A (2011)	1
FEZ1	0	HTT	14	pull down, two hybrid, affinity chromatography technology	Goehler H (2004), Goehler H (2004), Huttlin EL (2017)	3
TNNT1	0	IMMT	0	two hybrid	Vinayagam A (2011)	1
NDUFB9	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
STX5	0	HAP1	1	two hybrid	Stelzl U (2005)	1
PFDN1	0	HAP1	1	two hybrid	Stelzl U (2005)	1
STX5	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
LRIF1	3	HAP1	1	two hybrid, two hybrid	Goehler H (2004), Goehler H (2004)	2
TAF1D	0	TBP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gorski JJ (2007), Hein MY (2015)	3
NOP53	2	HAP1	1	two hybrid	Stelzl U (2005)	1
PFDN1	0	IMMT	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
FAM173A	0	HAP1	1	two hybrid	Stelzl U (2005)	1
TBP	0	HAP1	1	two hybrid	Lim J (2006)	1
FAM173A	0	KAT5	1	two hybrid	Stelzl U (2005)	1
ATXN3	2	HAP1	1	affinity chromatography technology	Takeshita Y (2011)	1
GPRASP2	0	EIF3E	1	affinity chromatography technology	Li S (2014)	1
HMOX2	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
CBX8	3	KAT5	1	two hybrid, affinity chromatography technology	Stelzl U (2005), Tan J (2011)	2
PCM1	5	TSPYL1	3	affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Huttlin EL (2017)	2
CBX8	3	GPRASP2	0	two hybrid	Rolland T (2014)	1
KAT5	1	APLP1	1	two hybrid	Li Q (2004)	1
RPS25	0	HAP1	1	two hybrid	Stelzl U (2005)	1
GIT1	10	LRIF1	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
HGS	5	ING5	3	two hybrid	Rolland T (2014)	1
HAP1	1	GPRASP2	0	two hybrid	Goehler H (2004)	1
CCDC113	1	IMMT	0	two hybrid	Stelzl U (2005)	1
PPID	0	HAP1	1	two hybrid	Stelzl U (2005)	1
HAP1	1	HGS	5	two hybrid, pull down, affinity chromatography technology	Li Y (2002), Li Y (2002), Li Y (2002)	3
FEZ1	0	LRIF1	3	two hybrid	Goehler H (2004)	1
KAT7	3	LRIF1	3	two hybrid	Goehler H (2004)	1
STX5	0	APLP1	1	two hybrid	Stelzl U (2005)	1
KBTBD7	3	ZNF24	1	affinity chromatography technology	Behrends C (2010)	1
NEUROD1	0	HAP1	1	two hybrid, affinity chromatography technology	Marcora E (2003), Marcora E (2003)	2
BARD1	4	HAP1	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
BRD7	2	LRIF1	3	two hybrid	Goehler H (2004)	1
ZNF20	5	HAP1	1	two hybrid	Stelzl U (2005)	1
HAP1	1	HSPA4	3	pull down	Kenny MK (2001)	1
NIPSNAP3A	1	HAP1	1	two hybrid	Stelzl U (2005)	1
HAP1	1	GIT1	10	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
SRSF4	2	HAP1	1	two hybrid	Stelzl U (2005)	1
GADD45G	0	HAP1	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
TOMM20	0	HAP1	1	two hybrid	Stelzl U (2005)	1
BARD1	4	SRSF4	2	affinity chromatography technology	Woods NT (2012)	1
HAP1	1	PCM1	5	two hybrid	Engelender S (1997)	1
FAM173A	0	IMMT	0	two hybrid	Stelzl U (2005)	1
TOMM20	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
TNNT1	0	HAP1	1	two hybrid	Vinayagam A (2011)	1
UTP3	0	HAP1	1	two hybrid	Stelzl U (2005)	1
NAP1L5	1	KAT5	1	two hybrid	Stelzl U (2005)	1
PSMD11	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
KBTBD7	3	MRPS9	1	affinity chromatography technology	Huttlin EL (2017)	1
HAP1	1	ING5	3	two hybrid	Goehler H (2004)	1
HAP1	1	HSPA1A	0	affinity chromatography technology, pull down	Mendez F (2000), Mendez F (2000)	2
HSPA4	3	CDC73	1	two hybrid	Stelzl U (2005)	1
GIT1	10	HTT	14	pull down, pull down, affinity chromatography technology, two hybrid	Goehler H (2004), Goehler H (2004), Goehler H (2004), Goehler H (2004)	4
HAP1	1	HAP1	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Li SH (1998), Li SH (1998), Engelender S (1997), Goehler H (2004)	4
SNAPIN	1	KAT5	1	two hybrid	Stelzl U (2005)	1
NDUFB9	0	HAP1	1	two hybrid	Stelzl U (2005)	1
ZNF24	1	HAP1	1	two hybrid	Stelzl U (2005)	1
PFDN1	0	DCTN1	6	two hybrid	Vinayagam A (2011)	1
TNNT1	0	VIM	0	two hybrid	Vinayagam A (2011)	1
C8orf33	3	HAP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
ZNF24	1	APLP1	1	two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005)	2
BARD1	4	BRD7	2	two hybrid	Goehler H (2004)	1
PSMD11	0	DCTN1	6	biochemical	Wan C (2015)	1
HMOX2	0	HAP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
HAP1	1	DCTN1	6	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, biochemical	Li SH (1998), Li SH (1998), Li SH (1998), Engelender S (1997), Engelender S (1997), Engelender S (1997)	6
APLP1	1	HAP1	1	two hybrid	Goehler H (2004)	1
EIF3E	1	RPS25	0	biochemical	Kristensen AR (2012)	1
HTT	14	ING5	3	two hybrid	Suter B (2013)	1
CBX8	3	KAT7	3	two hybrid	Stelzl U (2005)	1
TAF1D	0	HAP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
NDUFB9	0	IMMT	0	two hybrid	Stelzl U (2005)	1
TAF1D	0	IMMT	0	two hybrid	Vinayagam A (2011)	1
LRIF1	3	KBTBD7	3	two hybrid	Goehler H (2004)	1
BARD1	4	KAT7	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
CDC73	1	VIM	0	affinity chromatography technology	Herr P (2015)	1
HAP1	1	KBTBD7	3	two hybrid	Goehler H (2004)	1
CCDC113	1	GIT1	10	two hybrid	Stelzl U (2005)	1
PPOX	1	IMMT	0	two hybrid	Stelzl U (2005)	1
LUC7L2	0	HAP1	1	two hybrid	Goehler H (2004)	1
KPNA2	0	HAP1	1	two hybrid	Goehler H (2004)	1
DDX49	0	HAP1	1	two hybrid	Stelzl U (2005)	1
HTT	14	GPRASP2	0	two hybrid	Goehler H (2004)	1
C7orf25	0	HAP1	1	two hybrid	Vinayagam A (2011)	1
HAP1	1	FEZ1	0	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
EIF3E	1	HAP1	1	two hybrid	Stelzl U (2005)	1
KATNBL1	0	KAT7	3	two hybrid	Stelzl U (2005)	1
RPS10	0	EIF3E	1	biochemical	Kristensen AR (2012)	1
VIM	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
IMMT	0	LRIF1	3	two hybrid	Goehler H (2004)	1
GADD45G	0	KAT5	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
C8orf33	3	FEZ1	0	two hybrid	Vinayagam A (2011)	1
ATXN3	2	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Kristensen LV (2018), Kristensen LV (2018)	2
TSPYL1	3	HAP1	1	two hybrid	Stelzl U (2005)	1
CCDC113	1	HAP1	1	two hybrid	Stelzl U (2005)	1
PSMD11	0	BRD7	2	two hybrid	Stelzl U (2005)	1
ZNF24	1	KAT5	1	two hybrid	Stelzl U (2005)	1
HMOX2	0	IMMT	0	two hybrid	Vinayagam A (2011)	1
BARD1	4	LUC7L2	0	affinity chromatography technology	Woods NT (2012)	1
HAP1	1	KAT5	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
SNAPIN	1	KAT7	3	two hybrid	Stelzl U (2005)	1
TNNT1	0	KAT5	1	two hybrid	Vinayagam A (2011)	1
BRD7	2	HAP1	1	two hybrid	Goehler H (2004)	1
GPRASP2	0	CDC73	1	affinity chromatography technology	Li S (2014)	1
ATP5J2	0	HAP1	1	two hybrid	Stelzl U (2005)	1
PPID	0	KAT7	3	two hybrid	Stelzl U (2005)	1
HAP1	1	HTT	14	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, two hybrid	Li XJ (1995), Li SH (1998), Li SH (1998), Li SH (1998), Li XJ (1995), Li XJ (1995), Li SH (1998), Goehler H (2004), Goehler H (2004)	9
BARD1	4	FEZ1	0	two hybrid	Goehler H (2004)	1
NAP1L5	1	LUC7L2	0	two hybrid	Stelzl U (2005)	1
CDC73	1	RPS10	0	affinity chromatography technology	Herr P (2015)	1
NOP53	2	UTP3	0	affinity chromatography technology	Huttlin EL (2017)	1
C8orf33	3	IMMT	0	two hybrid	Vinayagam A (2011)	1
KATNBL1	0	HAP1	1	two hybrid	Stelzl U (2005)	1
C8orf33	3	GIT1	10	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
BARD1	4	HSPA4	3	affinity chromatography technology	Tembe V (2015)	1
PFDN1	0	GIT1	10	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
COL9A2	4	HAP1	1	two hybrid	Stelzl U (2005)	1
BARD1	4	GPRASP2	0	two hybrid	Goehler H (2004)	1
VIM	0	ING5	3	two hybrid	Goehler H (2004)	1
TAF1D	0	ING5	3	two hybrid	Vinayagam A (2011)	1
IMMT	0	HAP1	1	two hybrid	Goehler H (2004)	1
COL9A2	4	FEZ1	0	two hybrid	Stelzl U (2005)	1
C8orf33	3	KBTBD7	3	two hybrid	Vinayagam A (2011)	1
BARD1	4	ING5	3	two hybrid	Goehler H (2004)	1
CBX8	3	HAP1	1	two hybrid	Stelzl U (2005)	1
APLP1	1	ING5	3	two hybrid	Goehler H (2004)	1
RER1	0	IMMT	0	two hybrid	Stelzl U (2005)	1
ATP5J2	0	NDUFB9	0	biochemical	Havugimana PC (2012)	1
GADD45G	0	LRIF1	3	two hybrid	Goehler H (2004)	1
NOP53	2	MRPS9	1	affinity chromatography technology	Huttlin EL (2017)	1
PCM1	5	ING5	3	two hybrid	Rual JF (2005)	1
KAT7	3	ING5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Iizuka M (2008), Huttlin EL (2017)	6
HMOX2	0	GIT1	10	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
PFDN1	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
HAP1	1	KAT7	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
APLP1	1	LRIF1	3	two hybrid	Goehler H (2004)	1
RER1	0	HAP1	1	two hybrid	Stelzl U (2005)	1
ZNF24	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
BARD1	4	GIT1	10	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
FEZ1	0	IMMT	0	two hybrid	Goehler H (2004)	1
BARD1	4	KAT5	1	two hybrid	Goehler H (2004)	1
RPS10	0	RPS25	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
SNAPIN	1	HAP1	1	two hybrid	Stelzl U (2005)	1
NIPSNAP3A	1	IMMT	0	two hybrid	Stelzl U (2005)	1
NAP1L5	1	HAP1	1	two hybrid	Stelzl U (2005)	1
NEUROD1	0	HTT	14	affinity chromatography technology	Marcora E (2003)	1
GADD45G	0	LUC7L2	0	two hybrid, two hybrid	Vinayagam A (2011), Goehler H (2004)	2
TNNT3	1	HAP1	1	two hybrid	Stelzl U (2005)	1
GPRASP2	0	LRIF1	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
PSMD11	0	HAP1	1	two hybrid	Stelzl U (2005)	1
CRIP1	0	HAP1	1	two hybrid	Stelzl U (2005)	1
VIM	0	HAP1	1	two hybrid	Goehler H (2004)	1
IMMT	0	KPNA2	0	two hybrid	Wang J (2011)	1
CDK5RAP2	3	LUC7L2	0	two hybrid	Stelzl U (2005)	1
CDK5RAP2	3	HAP1	1	two hybrid	Stelzl U (2005)	1
RPS10	0	KAT7	3	two hybrid	Stelzl U (2005)	1
ZNF33B	1	HAP1	1	two hybrid	Goehler H (2004)	1
VIM	0	KAT7	3	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Stelzl U (2005), Vinayagam A (2011), Goehler H (2004)	4
PDCD7	0	HAP1	1	two hybrid	Stelzl U (2005)	1
PPID	0	HSPA1A	0	biochemical	Park MS (2011)	1
RPS10	0	HAP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
PDCD7	0	FEZ1	0	two hybrid, two hybrid	Stelzl U (2005), Assmann EM (2006)	2
TAF1D	0	LRIF1	3	two hybrid	Vinayagam A (2011)	1
MPP3	0	HAP1	1	two hybrid	Stelzl U (2005)	1
STX5	0	IMMT	0	two hybrid	Stelzl U (2005)	1
KAT5	1	LRIF1	3	two hybrid	Goehler H (2004)	1
VIM	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
DCTN1	6	VIM	0	affinity chromatography technology	Payne C (2003)	1
BARD1	4	KBTBD7	3	two hybrid	Goehler H (2004)	1
PPOX	1	HAP1	1	two hybrid	Stelzl U (2005)	1
FAM173A	0	LUC7L2	0	two hybrid	Stelzl U (2005)	1
MRPS9	1	HAP1	1	two hybrid	Stelzl U (2005)	1