PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	RASA1	3	pull down, unspecified method, pull down	Daly RJ (1996), Jones RB (2006), Marengere LE (1992)	3
PTPN11	20	JAK1	6	pull down, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Lehmann U (2003)	3
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
INSR	9	JAK1	6	affinity chromatography technology	Le MN (2002)	1
JAK2	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Olayioye MA (1999), Olayioye MA (1999), Jones RB (2006), He K (2013)	4
PTK2	2	JAK2	1	affinity chromatography technology, affinity chromatography technology	Zhu T (1998), Ryu H (2000)	2
ELAVL1	0	MAPK6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PIN1	0	RELA	1	affinity chromatography technology	Ryo A (2003)	1
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
VHL	0	PIN1	0	affinity chromatography technology	Ewing RM (2007)	1
SOCS3	0	PRLR	0	affinity chromatography technology	Dif F (2001)	1
IRS1	7	APP	1	pull down	Olah J (2011)	1
NFKB1	2	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	4
SOCS3	0	REL	5	affinity chromatography technology, affinity chromatography technology	Nair S (2011), Nair S (2011)	2
BIK	0	APP	1	pull down	Olah J (2011)	1
SOCS3	0	TRDN	0	two hybrid	Grossmann A (2015)	1
ELOC	0	GHR	1	unspecified method	Bulatov E (2015)	1
MAP3K7	2	NFKBIA	0	enzymatic study	Kanayama A (2004)	1
RPL7A	1	SOCS3	0	two hybrid	Wang J (2011)	1
LEPR	3	PIN1	0	two hybrid	Stelzl U (2005)	1
CXCR4	0	JAK3	3	affinity chromatography technology	Vila-Coro AJ (1999)	1
IRS2	6	JAK1	6	affinity chromatography technology	Johnston JA (1995)	1
IRS1	7	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
SOCS3	0	LEPR	3	pull down, affinity chromatography technology	Bjorbak C (2000), Palianopoulou M (2011)	2
ELAVL1	0	PTK2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TBK1	1	APP	1	pull down	Olah J (2011)	1
SOCS2	1	PTK2B	6	two hybrid, affinity chromatography technology, affinity chromatography technology	Lee SH (2010), Lee SH (2010), Lee SH (2010)	3
NFKBIA	0	NFKB1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hay DC (2001), Malek S (1998), Fagan-Garcia K (2011), Jeon YJ (2010), Roff M (1996), Keutgens A (2010), Inan MS (2000), Wang J (2011), Arenzana-Seisdedos F (1995), Jaffray E (1995), Wood KM (1998), Bell S (1996), Cockman ME (2006), Cockman ME (2006), Lu Y (2005), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	19
EGFR	5	YES1	1	affinity chromatography technology	Tong J (2014)	1
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
TES	1	APP	1	affinity chromatography technology	Sala S (2017)	1
INSR	9	PTPN11	20	pull down, affinity chromatography technology, pull down	Maegawa H (1994), Kharitonenkov A (1995), Kharitonenkov A (1995)	3
JAK2	1	MAP3K5	1	affinity chromatography technology, enzymatic study	Yu L (2009), Yu L (2009)	2
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
SOCS3	0	TFR2	3	two hybrid	Wang J (2011)	1
ELAVL1	0	ETV6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Abdelmohsen K (2009), Datta K (2005), Datta K (2005), Yuen JS (2007)	4
TBK1	1	NFKBIA	0	enzymatic study	Zhang W (2010)	1
SOCS3	0	TXNDC11	1	two hybrid	Wang J (2011)	1
PTK6	1	REL	5	two hybrid	Rolland T (2014)	1
NFKBIA	0	PIN1	0	affinity chromatography technology	Ryo A (2003)	1
HIVEP1	13	SOCS3	0	two hybrid	Wang J (2011)	1
EPOR	3	ELOC	0	pull down	Heir P (2016)	1
REL	5	NFKBIA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Spiecker M (2000), Chu ZL (1996), Chu ZL (1996), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
VHL	0	APP	1	pull down	Olah J (2011)	1
JAK2	1	EPOR	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Huang LJ (2001), Huang LJ (2001), Witthuhn BA (1993), van den Akker E (2004)	4
SOCS3	0	RNF7	0	affinity chromatography technology, pull down	Kamura T (2004), Kershaw NJ (2014)	2
TRAF6	0	YES1	1	two hybrid	Rolland T (2014)	1
FGFR3	7	VHL	0	genetic interference	Shen JP (2017)	1
SOCS3	0	CSF1R	0	affinity chromatography technology	Hoertner M (2002)	1
SOCS3	0	RELA	1	affinity chromatography technology, affinity chromatography technology	Nair S (2011), Nair S (2011)	2
DAB1	1	APP	1	pull down, pull down	Homayouni R (1999), Olah J (2011)	2
TRAF6	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999), Mochida Y (2000), Fujino G (2007), Fujino G (2007)	5
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
PDPK1	0	SOCS3	0	two hybrid	Vinayagam A (2011)	1
EGFR	5	IRS1	7	unspecified method	Jones RB (2006)	1
IRS2	6	EPOR	3	affinity chromatography technology	Verdier F (1997)	1
EGFR	5	MAPK8IP1	7	unspecified method	Jones RB (2006)	1
MAP3K5	1	PTPN11	20	affinity chromatography technology, enzymatic study	Yu L (2009), Yu L (2009)	2
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
VHL	0	EPOR	3	affinity chromatography technology, affinity chromatography technology, pull down	Heir P (2016), Heir P (2016), Heir P (2016)	3
GFRA1	0	SOCS3	0	two hybrid	Wang J (2011)	1
YWHAQ	0	IRS2	6	affinity chromatography technology, pull down	Ewing RM (2007), Meek SE (2004)	2
SOCS3	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, pull down	Xiao Z (2007), Kamura T (2004), Kershaw NJ (2014)	3
PTK2	2	IRS1	7	two hybrid, affinity chromatography technology	Lebrun P (1998), Lebrun P (1998)	2
PTK2B	6	RASA1	3	affinity chromatography technology, pull down, affinity chromatography technology	Chow A (2000), Chow A (2000), Zrihan-Licht S (2000)	3
JAK1	6	IL6ST	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Haan C (2001), Haan C (2001), Kim H (1997), Haan C (2002)	4
PIN1	0	ETV6	1	pull down	Ingham RJ (2005)	1
RASA1	3	ABL1	9	affinity chromatography technology	Druker B (1992)	1
VHL	0	ELOB	1	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Ohh M (1999), Min JH (2002), Hacker KE (2008), Menon S (2008), Kamura T (2002), Kamura T (2002), Kuznetsova AV (2003), Cockman ME (2000), Sufan RI (2009), Stickle NH (2004), Lai Y (2011), Norman JA (2006), Kinoshita K (2007), Lai Y (2012), Mahrour N (2008), Mahrour N (2008), Grosfeld A (2007), Foxler DE (2012), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017)	43
RNF7	0	GHR	1	unspecified method	Bulatov E (2015)	1
SOCS3	0	ELOC	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Xiao Z (2007), Zhang WN (2012), Haan S (2003), Haan S (2003), Kamura T (2004)	5
JAK3	3	SOCS3	0	affinity chromatography technology	Cho-Vega JH (2004)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
LCK	0	SOCS2	1	affinity chromatography technology	Venkitachalam S (2011)	1
INSR	9	JAK2	1	affinity chromatography technology, affinity chromatography technology	Maegawa H (1996), Le MN (2002)	2
IL6ST	0	JAK2	1	affinity chromatography technology	Kim H (1997)	1
TBK1	1	REL	5	affinity chromatography technology	Bouwmeester T (2004)	1
IL12RB2	3	JAK2	1	pull down, affinity chromatography technology	Yamamoto K (1999), Yamamoto K (1999)	2
IL6ST	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lehmann U (2003), Anhuf D (2000), Kim H (1997), Schmitz J (2000)	4
ELOB	1	GHR	1	unspecified method	Bulatov E (2015)	1
PTK2	2	CXCR4	0	affinity chromatography technology	Wang J (2001)	1
MAP3K7	2	RELA	1	imaging technique	Chen TC (2014)	1
PIN1	0	MAP1S	3	pull down	Ingham RJ (2005)	1
PTPN11	20	IRS1	7	pull down, affinity chromatography technology, unspecified method, pull down, enzymatic study	Kuhne MR (1993), Myers MG (1998), Liu BA (2012), Strack V (2002), Strack V (2002)	5
ELAVL1	0	TFDP1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SOCS3	0	ELOB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao Z (2007), Niwa Y (2005), Kamura T (2004)	3
ELAVL1	0	YES1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SOCS2	1	ELOC	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical	Vesterlund M (2011), Lievens S (2009), Lievens S (2009), Kim DY (2013)	4
VHL	0	RPL7A	1	affinity chromatography technology	Lai Y (2011)	1
VHL	0	ELOC	0	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Tsuchiya H (1996), Min JH (2002), Li Z (2002), Hacker KE (2008), Kim BY (2008), Baek JH (2007), Baek JH (2007), Kuznetsova AV (2003), Cockman ME (2000), Lisztwan J (1999), Stickle NH (2004), Lai Y (2011), Liu YV (2007), Norman JA (2006), Kinoshita K (2007), Cai Q (2010), Lai Y (2012), Miller F (2005), Mahrour N (2008), Mahrour N (2008), Russell RC (2011), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Stebbins CE (1999), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	48
MAP3K5	1	MAP3K7	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochida Y (2000), Mochida Y (2000), Mochida Y (2000), Kim SY (2012), Kim SY (2012)	5
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
EGFR	5	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Keely SJ (2000), Ivankovic-Dikic I (2000)	2
NME4	0	SOCS3	0	two hybrid	Wang J (2011)	1
NFKB1	2	YWHAQ	0	two hybrid	Wang J (2011)	1
BIK	0	SOCS3	0	two hybrid	Wang J (2011)	1
SOCS3	0	ETV6	1	affinity chromatography technology	Monni R (2001)	1
ABL1	9	JAK1	6	pull down	Danial NN (1998)	1
PTK2B	6	JAK3	3	affinity chromatography technology	Miyazaki T (1998)	1
SOCS3	0	TFDP1	3	affinity chromatography technology, two hybrid	Masuhiro Y (2008), Masuhiro Y (2008)	2
JAK2	1	PTK2B	6	affinity chromatography technology	Frank GD (2002)	1
PDPK1	0	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Sato S (2002), Heo SR (2009)	2
EPOR	3	SOCS2	1	two hybrid, affinity chromatography technology, protein complementation assay, pull down, protein complementation assay, unspecified method	Eyckerman S (2001), Eyckerman S (2001), Lavens D (2007), Lavens D (2007), Montoye T (2005), Bullock AN (2006)	6
SOCS3	0	TNFSF10	2	affinity chromatography technology	Horndasch M (2011)	1
TRAF6	0	CUL5	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhu Z (2016), Zhu Z (2016), Zhu Z (2017)	3
MAPK8IP1	7	MAP3K7	2	affinity chromatography technology, biochemical	Blanco S (2008), Blanco S (2008)	2
CUL5	1	GHR	1	unspecified method	Bulatov E (2015)	1
LCK	0	PTK2B	6	affinity chromatography technology	Ganju RK (1997)	1
APP	1	MAPK8IP1	7	two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kajiwara Y (2010), Scheinfeld MH (2003), Scheinfeld MH (2003), Muresan Z (2005), Muresan Z (2005)	5
IRS2	6	PTPN11	20	affinity chromatography technology	Argetsinger LS (1996)	1
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
IGF1R	5	APP	1	pull down	Olah J (2011)	1
SOCS3	0	PIN1	0	two hybrid	Stelzl U (2005)	1
PTK2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Manes S (1999), Takahashi A (2011)	2
NFKBIA	0	YES1	1	affinity chromatography technology	Huttlin EL (2015)	1
IGF1R	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Manes S (1999), Seely BL (1995), Seely BL (1995), Yao Z (2017)	4
SOCS3	0	SOCS2	1	affinity chromatography technology	Tannahill GM (2005)	1
EGFR	5	YWHAQ	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
SOCS3	0	SIGLEC7	0	affinity chromatography technology	Orr SJ (2007)	1
ABL1	9	EGFR	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
GHR	1	JAK2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Frank SJ (1995), VanderKuur JA (1994), Hellgren G (1999), Putters J (2011), Sedek M (2014)	5
SOCS2	1	RNF7	0	affinity chromatography technology	Vesterlund M (2011)	1
JAK2	1	RBMX	2	two hybrid	Wang J (2011)	1
YES1	1	SOCS3	0	two hybrid	Rolland T (2014)	1
EGFR	5	SOCS3	0	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Xia L (2002), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
PTK6	1	APP	1	pull down	Olah J (2011)	1
IRS2	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
EGFR	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology, enzymatic study	Schulze WX (2006), Tomic S (1995), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Kapoor GS (2010), Vogel W (1996)	7
YWHAQ	0	ABL1	9	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu C (2012), Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	5
EGFR	5	PTK6	1	affinity chromatography technology, unspecified method	Kamalati T (1996), Jones RB (2006)	2
DAB1	1	PIN1	0	two hybrid	Rolland T (2014)	1
SOCS3	0	ACADVL	1	two hybrid, pull down	Luo B (2011), Luo B (2011)	2
SOCS3	0	TES	1	two hybrid	Wang J (2011)	1
PTK2	2	SOCS3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Le Y (2007), Le Y (2007), Niwa Y (2005), Rolland T (2014)	4
RNF7	0	VHL	0	affinity chromatography technology	Tan M (2008)	1
SOCS2	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Vesterlund M (2011), Bennett EJ (2010), Salter JD (2012), Kim YK (2013), Huttlin EL (2017)	5
TRAF6	0	APP	1	pull down	Olah J (2011)	1
GHR	1	SOCS2	1	pull down, enzymatic study, pull down, unspecified method, unspecified method	Ram PA (1999), Vesterlund M (2011), Biener E (2002), Bulatov E (2015), Bullock AN (2006)	5
RNF31	3	SOCS3	0	two hybrid	Wang J (2011)	1
PTPN11	20	PTK2B	6	affinity chromatography technology, affinity chromatography technology, far western blotting, enzymatic study	Chauhan D (2000), Chauhan D (2000), Chauhan D (2000), Chauhan D (2000)	4
INSR	9	IRS1	7	two hybrid, two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Aguirre V (2002), Sawka-Verhelle D (1996), Strack V (2002), Wolf G (1995), Kwon H (2015), Kwon H (2015)	6
PDPK1	0	APP	1	pull down	Olah J (2011)	1
NFKB1	2	TBK1	1	affinity chromatography technology	Bouwmeester T (2004)	1
MAPK6	1	MAP3K7	2	two hybrid	Vinayagam A (2011)	1
TBK1	1	RELA	1	affinity chromatography technology, enzymatic study, enzymatic study	Bouwmeester T (2004), Buss H (2004), Fujita F (2003)	3
NONO	3	PIN1	0	two hybrid, pull down, two hybrid	Rual JF (2005), Ingham RJ (2005), Rolland T (2014)	3
JAK1	6	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Johnston JA (1995)	2
MAP3K5	1	SOCS3	0	affinity chromatography technology	He Y (2006)	1
REL	5	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Hansen SK (1994), Hansen SK (1994), Liss AS (2002), Liss AS (2002), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	8
EGFR	5	SH2D2A	2	unspecified method	Jones RB (2006)	1
IGF1R	5	PTK2	2	affinity chromatography technology	Manes S (1999)	1
CUL5	1	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
MAPK11	1	APP	1	pull down	Olah J (2011)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
SOCS3	0	MAP3K7	2	affinity chromatography technology	Frobose H (2006)	1
PTK2	2	EGFR	5	affinity chromatography technology, two hybrid, protein complementation assay	Sieg DJ (2000), Kotlyar M (2015), Petschnigg J (2014)	3
SOCS3	0	SH2D2A	2	two hybrid	Grossmann A (2015)	1
SOCS3	0	MAP1S	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Zou T (2008), Zou T (2008), Zou T (2008)	3
IRS1	7	IRS2	6	biochemical	Sun H (2003)	1
SOCS3	0	KIAA1958	5	two hybrid	Rolland T (2014)	1
PTPN11	20	GHR	1	pull down, pull down	Stofega MR (2000), Moutoussamy S (1998)	2
INSR	9	IRS2	6	two hybrid	Sawka-Verhelle D (1996)	1
YWHAQ	0	MAP3K5	1	pull down	Zhang H (2007)	1
CUL5	1	NFKB1	2	affinity chromatography technology	Bennett EJ (2010)	1
SOCS2	1	PRLR	0	affinity chromatography technology	Pezet A (1999)	1
MAP3K5	1	APP	1	imaging technique	Chen TC (2014)	1
SOCS3	0	YWHAQ	0	two hybrid	Grossmann A (2015)	1
MAPK11	1	SOCS3	0	two hybrid	Vinayagam A (2011)	1
ELAVL1	0	TES	1	affinity chromatography technology	Abdelmohsen K (2009)	1
JAK1	6	IL2RB	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miyazaki T (1994), Russell SM (1994), Usacheva A (2002), Zhu MH (1998), Migone TS (1998), Tanaka N (1994)	6
SH2D2A	2	PTK2	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
PTK2	2	APP	1	pull down	Olah J (2011)	1
JAK3	3	JAK1	6	affinity chromatography technology	Doucet C (2002)	1
SOCS3	0	TBK1	1	pull down, pull down, affinity chromatography technology	Liu D (2015), Liu D (2015), Liu D (2015)	3
SOCS3	0	CXCR4	0	affinity chromatography technology	Soriano SF (2002)	1
RBMX	2	SOCS3	0	two hybrid	Wang J (2011)	1
PRLR	0	PTPN11	20	affinity chromatography technology	Ali S (2000)	1
SOCS3	0	FGFR3	7	affinity chromatography technology	Ben-Zvi T (2006)	1
NFKBIA	0	RELA	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Lf (2001), Kiernan R (2003), Kiernan R (2003), Spencer E (1999), Spencer E (1999), Hay DC (2001), Hansen SK (1994), Malek S (1998), Cohen L (1998), Robert I (2009), Sasaki CY (2005), Wu BY (1995), Fagan-Garcia K (2011), Livolsi A (2001), Van Antwerp DJ (1996), Van Antwerp DJ (1996), Krappmann D (1996), Chen Z (1995), Bottero V (2001), Wang H (2010), DiDonato J (1996), Carvalho G (2010), Carvalho G (2010), Suzuki H (1999), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Pringle LM (2011), Pringle LM (2011), Pringle LM (2011), DiDonato J (1996), Ryo A (2003), Ryo A (2003), Inan MS (2000), Burstein E (2005), Chu ZL (1996), Chu ZL (1996), Starokadomskyy P (2013), Wang J (2011), Arenzana-Seisdedos F (1995), Arenzana-Seisdedos F (1997), Wood KM (1998), Cockman ME (2006), Cockman ME (2006), Li JM (2013), Rodriguez MS (1999), Huttlin EL (2015), Hein MY (2015), Taura M (2015), Kim MY (2015), Schweitzer K (2016), Schweitzer K (2016), Hochrainer K (2015), Jiang GM (2017), Huttlin EL (2017), Kumar S (2012), Kumar S (2012)	56
ELAVL1	0	IRS2	6	affinity chromatography technology	Abdelmohsen K (2009)	1
RASA1	3	APP	1	pull down	Olah J (2011)	1
GHR	1	JAK1	6	affinity chromatography technology	Hellgren G (1999)	1
MAPK6	1	AMBRA1	7	affinity chromatography technology	Rodriguez J (2016)	1
RNF7	0	ELOC	0	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
SOCS3	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Frobose H (2006), Zhou X (2015)	2
JAK3	3	JAK2	1	affinity chromatography technology	Doucet C (2002)	1
SOCS3	0	RASA1	3	pull down, affinity chromatography technology	Cacalano NA (2001), Cacalano NA (2001)	2
CUEDC2	0	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Zhang WN (2012), Zhang WN (2012), Zhang WN (2012), Zhang WN (2012)	4
SOCS3	0	NFKBIA	0	affinity chromatography technology, affinity chromatography technology	Nair S (2011), Nair S (2011)	2
ABL1	9	NFKBIA	0	affinity chromatography technology, pull down	Kawai H (2002), Kawai H (2002)	2
SOCS3	0	MAPK8IP1	7	affinity chromatography technology	Miao T (2008)	1
IRS1	7	JAK3	3	affinity chromatography technology	Johnston JA (1995)	1
SOCS3	0	IGF1R	5	pull down, two hybrid, affinity chromatography technology	Dey BR (2000), Dey BR (2000), Dey BR (2000)	3
SIGLEC7	0	PTPN11	20	affinity chromatography technology	Yamaji T (2005)	1
AMBRA1	7	ELOB	1	affinity chromatography technology, affinity chromatography technology	Antonioli M (2014), Antonioli M (2014)	2
IL12RB2	3	SOCS3	0	pull down, affinity chromatography technology	Yamamoto K (2003), Yamamoto K (2003)	2
CUL5	1	VHL	0	pull down	Kamura T (2001)	1
LCK	0	SOCS3	0	affinity chromatography technology	Venkitachalam S (2011)	1
SOCS3	0	NFKB1	2	affinity chromatography technology, affinity chromatography technology	Nair S (2011), Nair S (2011)	2
SOCS3	0	AMBRA1	7	affinity chromatography technology	Huttlin EL (2017)	1
SOCS2	1	ELOB	1	affinity chromatography technology, biochemical	Vesterlund M (2011), Kim DY (2013)	2
RASA1	3	NFKBIA	0	genetic interference	Spiegelman VS (2002)	1
ELAVL1	0	NONO	3	affinity chromatography technology	Abdelmohsen K (2009)	1
IL2RB	1	JAK2	1	affinity chromatography technology	Zhu MH (1998)	1
JAK2	1	TRAF6	0	two hybrid	Wang J (2011)	1
INSR	9	SOCS3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Senn JJ (2003), Calegari VC (2005), Calegari VC (2005)	3
PTK2B	6	JAK1	6	affinity chromatography technology	Benbernou N (2000)	1
RNF7	0	ELOB	1	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
SOCS3	0	VHL	0	affinity chromatography technology	Russell RC (2011)	1
CXCR4	0	PTPN11	20	affinity chromatography technology	Chernock RD (2001)	1
MAP3K7	2	PDPK1	0	affinity chromatography technology, affinity chromatography technology	Moon G (2015), Moon G (2015)	2
SOCS3	0	PTK2B	6	two hybrid, affinity chromatography technology	Masuhara M (1997), Zhang S (2008)	2
IGF1R	5	RASA1	3	affinity chromatography technology, pull down	Seely BL (1995), Seely BL (1995)	2
SOCS3	0	APP	1	pull down	Olah J (2011)	1
PTK2	2	YES1	1	affinity chromatography technology, two hybrid	Messina S (2003), Rolland T (2014)	2
EPOR	3	PTPN11	20	affinity chromatography technology, pull down	Tauchi T (1996), Tauchi T (1995)	2
ELAVL1	0	PTPN11	20	affinity chromatography technology	Abdelmohsen K (2009)	1
EPOR	3	ELOB	1	pull down	Heir P (2016)	1
SOCS3	0	EPOR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Sasaki A (2000), Sasaki A (2000), Sasaki A (2000), Hoertner M (2002)	4
PTK6	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Gao Y (2012), Gao Y (2012)	2
CXCR4	0	JAK2	1	affinity chromatography technology	Vila-Coro AJ (1999)	1
SOCS3	0	RGP1	1	affinity chromatography technology	Huttlin EL (2017)	1
JAK2	1	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Kawazoe Y (2001)	2
INSR	9	RASA1	3	affinity chromatography technology	Pronk GJ (1992)	1
JAK1	6	IGF1R	5	pull down	Gual P (1998)	1
EGFR	5	IRS2	6	affinity chromatography technology	Tong J (2008)	1
VHL	0	JAK2	1	affinity chromatography technology, affinity chromatography technology	Russell RC (2011), Russell RC (2011)	2
PTK2	2	SOCS2	1	two hybrid	Rual JF (2005)	1
PRLR	0	JAK2	1	affinity chromatography technology, affinity chromatography technology	Pezet A (1997), Ma L (2010)	2
SOCS3	0	NONO	3	affinity chromatography technology	Song KS (2008)	1
CSF1R	0	YES1	1	affinity chromatography technology	Courtneidge SA (1993)	1
YWHAQ	0	LCK	0	affinity chromatography technology	Heo SR (2009)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
EGFR	5	TBK1	1	affinity chromatography technology	Tong J (2014)	1
LEPR	3	JAK3	3	affinity chromatography technology	Sanchez-Margalet V (2001)	1
GHR	1	SOCS3	0	pull down	Ram PA (1999)	1
RNF7	0	CUL5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, enzymatic study, pull down, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ohta T (1999), Bennett EJ (2010), Tan M (2008), Kelsall IR (2013), Kelsall IR (2013), Zhou W (2014), Rolland T (2014), Huang DT (2009), Kim DY (2013), Kim DY (2013), Yu H (2011), Bulatov E (2015), Wang X (2015), Wang X (2015), Wang X (2015), Kershaw NJ (2014), Huttlin EL (2017), Kuang P (2016), Kuang P (2016), Zhou W (2017), Zhou W (2017)	21
IL6ST	0	SOCS3	0	affinity chromatography technology, pull down, pull down, enzymatic study	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Kershaw NJ (2014)	4
RELA	1	IGF1R	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RASA1	3	YES1	1	affinity chromatography technology	Cichowski K (1992)	1
SOCS3	0	ABL1	9	affinity chromatography technology	Qiu X (2012)	1
SOCS3	0	DAB1	1	affinity chromatography technology	Feng L (2007)	1
LCK	0	IL2RB	1	affinity chromatography technology	Reneer MC (2011)	1
EGFR	5	JAK1	6	affinity chromatography technology	Tong J (2008)	1
IGF1R	5	IRS1	7	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Tartare-Deckert S (1995), Dey BR (1996), Dey BR (1996), Manes S (1999)	4
ELAVL1	0	SOCS3	0	affinity chromatography technology	Do KH (2013)	1
MAPK6	1	SOCS3	0	two hybrid	Vinayagam A (2011)	1
TRAF6	0	AMBRA1	7	affinity chromatography technology, affinity chromatography technology	Nazio F (2013), Antonioli M (2014)	2
LCK	0	RASA1	3	enzymatic study	Giglione C (2001)	1
SOCS2	1	IGF1R	5	two hybrid, pull down, affinity chromatography technology	Dey BR (1998), Dey BR (1998), Dey BR (1998)	3
SOCS3	0	IL2RB	1	pull down	Cohney SJ (1999)	1