PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
VCP	6	DUSP9	0	affinity chromatography technology	Yu CC (2013)	1
TNF	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	4
DSTN	0	OTULIN	0	biochemical	Havugimana PC (2012)	1
DVL2	5	OTULIN	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rivkin E (2013), Rivkin E (2013)	3
SHARPIN	1	OTULIN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Elliott PR (2014), Draber P (2015), Elliott PR (2016)	4
VIPR2	1	OTULIN	0	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	OTULIN	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
DSTN	0	VCP	6	biochemical	Havugimana PC (2012)	1
CFTR	5	ICAM1	6	affinity chromatography technology	Pankow S (2015)	1
OTULIN	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rivkin E (2013), Schaeffer V (2014), Elliott PR (2014), Draber P (2015)	4
CFTR	5	TES	1	affinity chromatography technology	Pankow S (2015)	1
OTULIN	0	LAMP2	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF31	3	VCP	6	affinity chromatography technology, pull down, x-ray crystallography, unspecified method	Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014)	4
SHARPIN	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical	Verhelst K (2012), Keusekotten K (2013), Schaeffer V (2014), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), Draber P (2015), Draber P (2015), Draber P (2015), Stieglitz B (2012), Huttlin EL (2017), Elliott PR (2016), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017)	21
SNW1	0	OTULIN	0	affinity chromatography technology	Lleres D (2010)	1
ELAVL1	0	DVL2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
CFTR	5	DSTN	0	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	OTULIN	0	affinity chromatography technology	Pankow S (2015)	1
EGLN3	0	OTULIN	0	affinity chromatography technology	Rodriguez J (2016)	1
OTULIN	0	BCL10	0	enzymatic study	Yang YK (2016)	1
TNF	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	5
OTULIN	0	DUSP14	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TES	1	OTULIN	0	affinity chromatography technology	Sala S (2017)	1
ELAVL1	0	LAMP2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	FAM168A	0	affinity chromatography technology	Rodriguez J (2016)	1
TNF	0	OTULIN	0	affinity chromatography technology	Schaeffer V (2014)	1
OTULIN	0	VCP	6	unspecified method, biochemical	Elliott PR (2014), Elliott PR (2014)	2
ELAVL1	0	DAZAP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
DUSP9	0	OTULIN	0	affinity chromatography technology	Li X (2016)	1
SHARPIN	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Verhelst K (2012), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Draber P (2015), Liu J (2017)	6
OTULIN	0	SELENBP1	2	affinity chromatography technology	Huttlin EL (2015)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
DAZAP2	1	FAM168A	0	two hybrid	Rolland T (2014)	1
OTULIN	0	LRRC15	2	affinity chromatography technology	Huttlin EL (2015)	1
FAM168A	0	OTULIN	0	two hybrid	Rolland T (2014)	1
ICAM1	6	OTULIN	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF31	3	OTULIN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, unspecified method, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Rivkin E (2013), Rivkin E (2013), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Schimmack G (2017)	20
EGLN3	0	DUSP9	0	affinity chromatography technology	Rodriguez J (2016)	1
DUSP23	1	OTULIN	0	affinity chromatography technology	Li X (2016)	1
SNW1	0	ELAVL1	0	affinity chromatography technology	Lleres D (2010)	1
CUL4A	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Wu K (2016)	4
TES	1	ICAM1	6	affinity chromatography technology	Sala S (2017)	1
ELAVL1	0	TES	1	affinity chromatography technology	Abdelmohsen K (2009)	1
23246	0	OTULIN	0	affinity chromatography technology	Kellner M (2015)	1
UBC	7	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ELAVL1	0	BCL10	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BCL10	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
EGLN3	0	VCP	6	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	DVL2	5	affinity chromatography technology	Rodriguez J (2016)	1
SLC18A1	2	OTULIN	0	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	CFTR	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gentzsch M (2003), Gentzsch M (2003), Wang S (2000), Li C (2007)	4
CUL4A	2	OTULIN	0	affinity chromatography technology	Bennett EJ (2010)	1
ELAVL1	0	TNF	0	affinity chromatography technology	Xin H (2011)	1
PDZK1	0	OTULIN	0	affinity chromatography technology	Huttlin EL (2017)	1
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
DAZAP2	1	OTULIN	0	two hybrid	Rolland T (2014)	1
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
EGLN3	0	DSTN	0	affinity chromatography technology	Rodriguez J (2016)	1
OTULIN	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Keusekotten K (2013), Keusekotten K (2013), Rivkin E (2013), Schaeffer V (2014), Mevissen TE (2013), Wauer T (2015), Kliza K (2017), Kwasna D (2018)	8
TES	1	CUL4A	2	affinity chromatography technology	Sala S (2017)	1
EGLN3	0	SNW1	0	affinity chromatography technology	Rodriguez J (2016)	1
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
TNF	0	LAMP2	0	affinity chromatography technology	Fritsch J (2014)	1