PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAG	5	CEP95	4	two hybrid	Bandyopadhyay S (2010)	1
YWHAE	0	CEP95	4	two hybrid	Bandyopadhyay S (2010)	1
LTBR	0	CEP95	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAG	5	CLK1	1	affinity chromatography technology	Jin J (2004)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
PCM1	5	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP120	5	bioid	Gupta GD (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
PCM1	5	CEP95	4	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
NINL	1	SPERT	0	two hybrid	Rual JF (2005)	1
NXF1	0	CEP95	4	affinity chromatography technology	Castello A (2012)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CLK1	1	CEP95	4	enzymatic study	Lipp JJ (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
NXF1	0	CEP128	1	affinity chromatography technology	Castello A (2012)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
LTBR	0	CEP120	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP120	5	CEP95	4	bioid	Gupta GD (2015)	1
LSM3	2	CEP95	4	two hybrid	Lehner B (2004)	1
CEP135	2	CEP95	4	bioid	Gupta GD (2015)	1
SPICE1	2	CEP95	4	bioid	Gupta GD (2015)	1
CAV3	0	CEP95	4	affinity chromatography technology	Huttlin EL (2017)	1
MOV10	6	CEP95	4	affinity chromatography technology	Castello A (2012)	1
CEP95	4	SPERT	0	two hybrid	Rolland T (2014)	1
CEP95	4	FAM9B	0	two hybrid	Rolland T (2014)	1
YWHAE	0	PCM1	5	pull down, affinity chromatography technology	Tollenaere MA (2015), Tollenaere MA (2015)	2
CEP120	5	SPICE1	2	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	3
MTUS2	4	CEP95	4	two hybrid	Rolland T (2014)	1
NINL	1	CEP95	4	bioid	Gupta GD (2015)	1
CEP128	1	CEP95	4	bioid	Gupta GD (2015)	1
SPATA46	0	CEP95	4	affinity chromatography technology	Huttlin EL (2015)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
CEP135	2	CEP120	5	bioid	Gupta GD (2015)	1