PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IL33	2	USP21	2	affinity chromatography technology, affinity chromatography technology	Tao L (2014), Tao L (2014)	2
USP21	2	HIST2H2AA3	0	enzymatic study	Richly H (2010)	1
USP21	2	XPO1	8	imaging technique	Garcia-Santisteban I (2012)	1
IL33	2	IL1RL1	1	pull down, pull down	Luethi AU (2009), Luethi AU (2009)	2
IL33	2	HIST2H2BE	1	pull down	Roussel L (2008)	1
IL33	2	HIST2H2AA3	0	pull down	Roussel L (2008)	1
IL33	2	USP17L2	0	affinity chromatography technology, affinity chromatography technology	Ni Y (2015), Ni Y (2015)	2
XPO1	8	IL33	2	affinity chromatography technology	Kirli K (2015)	1
CASP1	1	IL33	2	enzymatic study	Schmitz J (2005)	1