PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
UNC119	4	LIMK2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CD4	1	UNC119	4	affinity chromatography technology, pull down	Gorska MM (2004), Gorska MM (2004)	2
RAP1B	0	UNC119	4	two hybrid	Vinayagam A (2011)	1
ARL15	0	UNC119	4	two hybrid	Stelzl U (2005)	1
PIN1	0	UNC119	4	two hybrid	Vinayagam A (2011)	1
ARL3	1	UNC119B	1	affinity chromatography technology	Boldt K (2016)	1
RSPRY1	0	PDE9A	4	affinity chromatography technology	Boldt K (2016)	1
TSC22D1	1	UNC119	4	two hybrid	Vinayagam A (2011)	1
PCDHA4	1	UNC119	4	two hybrid	Stelzl U (2005)	1
QTRT1	4	UNC119	4	two hybrid	Stelzl U (2005)	1
PSMD2	2	UNC119	4	two hybrid	Stelzl U (2005)	1
LIG4	0	UNC119	4	two hybrid	Woods NT (2012)	1
UNC119	4	NISCH	11	affinity chromatography technology	Huttlin EL (2017)	1
CCL18	0	UNC119	4	two hybrid	Stelzl U (2005)	1
CDKN1A	1	CKS2	0	affinity chromatography technology	Fogeron ML (2013)	1
UBQLN4	2	PIN1	0	two hybrid	Lim J (2006)	1
UNC119	4	UNC119B	1	affinity chromatography technology	Huttlin EL (2017)	1
UNC119	4	283458	0	affinity chromatography technology	Huttlin EL (2015)	1
IL5RA	0	UNC119	4	affinity chromatography technology, two hybrid	Cen O (2003), Cen O (2003)	2
MPHOSPH6	1	UNC119	4	two hybrid	Stelzl U (2005)	1
PSKH2	0	UNC119B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NPHP3	2	FMNL2	4	affinity chromatography technology	Boldt K (2016)	1
ARL2	0	KDM1A	2	genetic interference	Horlbeck MA (2018)	1
UNC119	4	NOCT	1	affinity chromatography technology	Huttlin EL (2017)	1
AMOT	6	TP53BP2	5	bioid	Couzens AL (2013)	1
BRIX1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
SMN1	0	UNC119	4	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
MAPK8IP2	5	TP53BP2	5	two hybrid	Vinayagam A (2011)	1
CKMT2	2	UNC119	4	two hybrid	Stelzl U (2005)	1
FYN	1	UNC119	4	affinity chromatography technology, pull down	Gorska MM (2004), Gorska MM (2004)	2
NPHP3	2	PDE9A	4	affinity chromatography technology	Boldt K (2016)	1
UNC119	4	CAPN15	7	affinity chromatography technology	Huttlin EL (2017)	1
ALDH2	2	HSPE1	0	two hybrid	Lee KH (2002)	1
MAPK10	0	UNC119	4	two hybrid	Stelzl U (2005)	1
NPHP3	2	OGT	4	affinity chromatography technology	Boldt K (2016)	1
ORAI2	0	UNC119	4	two hybrid	Stelzl U (2005)	1
ZNF24	1	UNC119	4	two hybrid	Stelzl U (2005)	1
COX17	0	UNC119	4	two hybrid	Stelzl U (2005)	1
PSMD11	0	PSMD2	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ARL3	1	UNC119	4	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Van Valkenburgh H (2001), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	5
RGL2	2	RAP1B	0	two hybrid, pull down, two hybrid	Peterson SN (1996), Peterson SN (1996), Wang J (2011)	3
PRKG2	2	PDE9A	4	affinity chromatography technology	Boldt K (2016)	1
RPS6KA5	2	MAP3K20	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TP53I3	1	UNC119	4	two hybrid	Stelzl U (2005)	1
LAMA4	8	UNC119	4	two hybrid	Stelzl U (2005)	1
GNAT2	0	UNC119B	1	affinity chromatography technology	Huttlin EL (2015)	1
UBE2I	0	UNC119	4	two hybrid	Stelzl U (2005)	1
CKMT2	2	HSPE1	0	biochemical	Wan C (2015)	1
ZNF24	1	HMGB1	0	pull down	Miyamoto-Sato E (2010)	1
CDKN1A	1	AMOT	6	affinity chromatography technology	Fogeron ML (2013)	1
UNC119	4	PDE8A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2B	3	UNC119	4	two hybrid	Stelzl U (2005)	1
CYB561D2	1	UNC119	4	two hybrid	Stelzl U (2005)	1
MAPK8IP2	5	MAPK10	0	pull down	Negri S (2000)	1
FKBPL	1	UNC119	4	two hybrid	Stelzl U (2005)	1
RPA2	0	RFC5	2	affinity chromatography technology	Marechal A (2014)	1
ANXA1	1	UNC119	4	two hybrid	Vinayagam A (2011)	1
TRDMT1	1	UNC119	4	two hybrid	Stelzl U (2005)	1
CDKN1A	1	FKBPL	1	pull down, affinity chromatography technology, affinity chromatography technology	Jascur T (2005), Jascur T (2005), Jascur T (2005)	3
S100A4	0	UNC119	4	two hybrid	Stelzl U (2005)	1
UNC119	4	ARL2	0	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Kobayashi A (2003), Kobayashi A (2003), Kobayashi A (2003), Rolland T (2014), Boldt K (2016)	5
SAT1	0	LUC7L2	0	two hybrid	Stelzl U (2005)	1
UNC119	4	PRKG2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K20	1	UNC119	4	two hybrid	Vinayagam A (2011)	1
SERPINB9	0	UNC119	4	two hybrid	Stelzl U (2005)	1
NPHP3	2	C12orf75	0	affinity chromatography technology	Boldt K (2016)	1
ITSN1	5	UNC119	4	two hybrid	Stelzl U (2005)	1
ALDH2	2	UNC119	4	two hybrid	Stelzl U (2005)	1
OGT	4	UNC119	4	affinity chromatography technology	Boldt K (2016)	1
UBE2I	0	ZNF24	1	enzymatic study	Gocke CB (2005)	1
TP53BP2	5	UNC119	4	two hybrid	Stelzl U (2005)	1
CDKN1A	1	S100A8	0	two hybrid	Vinayagam A (2011)	1
ITSN1	5	CDC42	3	affinity chromatography technology, pull down, x-ray crystallography	Hussain NK (2001), Hussain NK (2001), Snyder JT (2002)	3
ID2	0	UNC119	4	two hybrid	Stelzl U (2005)	1
UBQLN4	2	UNC119	4	two hybrid	Stelzl U (2005)	1
ARL2	0	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
LCK	0	LZTS2	4	two hybrid	Rolland T (2014)	1
GIPC2	2	UNC119	4	two hybrid	Stelzl U (2005)	1
CD4	1	LCK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Hawash IY (2002), Foti M (2002), Bernhard OK (2004), Loewenberg M (2006), Py B (2007)	5
CDC42	3	MAP3K20	1	affinity chromatography technology	Hein MY (2015)	1
UNC119	4	PDE9A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NPHP3	2	RSPRY1	0	affinity chromatography technology	Boldt K (2016)	1
PTPRS	15	UNC119	4	two hybrid	Stelzl U (2005)	1
ID2	0	KDM1A	2	two hybrid	Weimann M (2013)	1
CDC42	3	FMNL2	4	two hybrid	Bandyopadhyay S (2010)	1
ANXA3	0	UNC119	4	two hybrid	Stelzl U (2005)	1
RGL2	2	UNC119	4	two hybrid	Stelzl U (2005)	1
BCR	3	UNC119	4	two hybrid	Stelzl U (2005)	1
PSMD2	2	CDKN1A	1	biochemical, affinity chromatography technology	Jin Y (2008), Jin Y (2008)	2
BTBD2	4	UNC119	4	two hybrid	Stelzl U (2005)	1
UBE2B	3	UBQLN4	2	biochemical	Havugimana PC (2012)	1
LCK	0	UNC119	4	affinity chromatography technology, pull down	Gorska MM (2004), Gorska MM (2004)	2
CDC42	3	UNC119	4	two hybrid	Stelzl U (2005)	1
UNC119	4	FMNL2	4	affinity chromatography technology	Huttlin EL (2017)	1
OGT	4	ASH2L	2	affinity chromatography technology	Hauri S (2016)	1
UNC119	4	LYN	2	pull down, affinity chromatography technology	Cen O (2003), Cen O (2003)	2
SMN1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
SAT1	0	HSPE1	0	two hybrid	Stelzl U (2005)	1
SMN1	0	ERH	0	affinity chromatography technology	Fuller HR (2010)	1
TK1	0	ITSN1	5	two hybrid	Vinayagam A (2011)	1
LIG4	0	PHF10	3	two hybrid	Wang J (2011)	1
NPHP3	2	PALD1	2	affinity chromatography technology	Boldt K (2016)	1
RPA2	0	UNC119	4	two hybrid	Stelzl U (2005)	1
UNC119	4	LZTS2	4	affinity chromatography technology	Huttlin EL (2017)	1
UNC119	4	RFTN1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK8IP2	5	ITSN1	5	two hybrid	Vinayagam A (2011)	1
CD247	1	LCK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Yang M (2015)	3
KDM1A	2	UNC119	4	two hybrid	Stelzl U (2005)	1
MAP3K20	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
CKS2	0	UNC119	4	two hybrid	Stelzl U (2005)	1
ASH2L	2	UNC119	4	two hybrid	Stelzl U (2005)	1
NPHP3	2	PDE8A	4	affinity chromatography technology	Boldt K (2016)	1
MRPS12	0	UNC119	4	two hybrid	Stelzl U (2005)	1
UNC119	4	HECTD4	13	affinity chromatography technology	Huttlin EL (2017)	1
RUFY3	3	UNC119	4	two hybrid	Stelzl U (2005)	1
GSTM4	0	UNC119	4	two hybrid	Stelzl U (2005)	1
RFC5	2	UNC119	4	two hybrid	Stelzl U (2005)	1
EIF2S2	0	UNC119	4	two hybrid	Stelzl U (2005)	1
PHF10	3	UNC119	4	two hybrid	Stelzl U (2005)	1
UBE2I	0	ANXA1	1	enzymatic study	Hirata F (2010)	1
S100A8	0	UNC119	4	two hybrid	Stelzl U (2005)	1
C12orf75	0	PDE9A	4	affinity chromatography technology	Boldt K (2016)	1
PAFAH1B3	1	UNC119	4	two hybrid	Stelzl U (2005)	1
CD4	1	ANXA1	1	affinity chromatography technology	Bernhard OK (2004)	1
UNC119	4	AMOT	6	two hybrid	Rolland T (2014)	1
RNF34	1	UNC119B	1	affinity chromatography technology	Huttlin EL (2017)	1
CDKN2C	0	UNC119	4	two hybrid	Stelzl U (2005)	1
UNC119	4	CD247	1	affinity chromatography technology, pull down	Gorska MM (2004), Gorska MM (2004)	2
PFN1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
BCR	3	HCK	5	affinity chromatography technology, affinity chromatography technology	Stanglmaier M (2003), Lionberger JM (2000)	2
SAT1	0	SEPHS1	0	two hybrid	Stelzl U (2005)	1
CDKN1A	1	UNC119	4	two hybrid	Vinayagam A (2011)	1
UNC119	4	HCK	5	pull down	Cen O (2003)	1
BCR	3	CDC42	3	pull down	Zhang B (1998)	1
CKMT2	2	283458	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPE1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
ARL4D	0	UNC119	4	two hybrid	Stelzl U (2005)	1
RPS6KA5	2	ITSN1	5	two hybrid	Vinayagam A (2011)	1
UNC119	4	C16orf74	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TK1	0	UNC119	4	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
UNC119	4	C5orf30	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SEPHS1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
SAT1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
LIG4	0	PFN1	0	affinity chromatography technology	Woods NT (2012)	1
SULT1E1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
UNC119	4	RNF34	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPDEF	2	UNC119	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPA1	1	UNC119	4	two hybrid	Stelzl U (2005)	1
ANKRD24	5	UNC119	4	two hybrid	Stelzl U (2005)	1
ANXA7	0	UNC119	4	two hybrid	Vinayagam A (2011)	1
UBE2I	0	RCC1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
HMGB1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
SPDEF	2	C5orf30	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA2	0	EIF2S2	0	affinity chromatography technology	Marechal A (2014)	1
CEP97	0	LYN	2	affinity chromatography technology	Al-Hakim AK (2012)	1
PSMD2	2	UBQLN4	2	affinity chromatography technology, affinity chromatography technology	Li X (2008), Su V (2013)	2
HLA-DQA1	1	UNC119	4	two hybrid	Stelzl U (2005)	1
PLPP2	4	UNC119	4	two hybrid	Stelzl U (2005)	1
GNAT2	0	UNC119	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAP1B	0	CDC42	3	biochemical	Wan C (2015)	1
CBX8	3	UNC119	4	two hybrid	Stelzl U (2005)	1
RPA2	0	KDM1A	2	affinity chromatography technology	Marechal A (2014)	1
CEP97	0	UNC119	4	affinity chromatography technology	Boldt K (2016)	1
ERH	0	UNC119	4	two hybrid	Stelzl U (2005)	1
MAPK8IP2	5	UNC119	4	two hybrid	Vinayagam A (2011)	1
PAPSS1	1	UNC119	4	two hybrid	Stelzl U (2005)	1
RCC1	2	UNC119	4	two hybrid	Vinayagam A (2011)	1
UNC119	4	C12orf75	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSKH2	0	UNC119	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LUC7L2	0	UNC119	4	two hybrid	Stelzl U (2005)	1
RPS6KA5	2	UNC119	4	two hybrid	Vinayagam A (2011)	1
ZFP64	4	UNC119	4	two hybrid	Stelzl U (2005)	1
PDE9A	4	SULT1E1	0	two hybrid	Rolland T (2014)	1
FAM13A	2	UNC119	4	affinity chromatography technology	Huttlin EL (2017)	1
UNC119	4	PSKH1	0	affinity chromatography technology	Huttlin EL (2017)	1
PIN1	0	AMOT	6	two hybrid	Rolland T (2014)	1
UNC119	4	NPHP3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
UNC119	4	PALD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPS6KA5	2	ERH	0	two hybrid	Vinayagam A (2011)	1
FYN	1	KDM1A	2	two hybrid	Weimann M (2013)	1
TP53BP2	5	ANXA1	1	affinity chromatography technology	Hauri S (2013)	1
LZTS2	4	LZTS1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSPE1	0	PIN1	0	biochemical	Wan C (2015)	1
MAPK10	0	CDKN2C	0	pull down	Choi BY (2005)	1
NPHP3	2	PRKG2	2	affinity chromatography technology	Boldt K (2016)	1
CBX8	3	LZTS2	4	two hybrid	Rolland T (2014)	1
NPHP3	2	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
UNC119	4	LZTS1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	KDM1A	2	enzymatic study	Gocke CB (2005)	1
NPHP3	2	UNC119B	1	affinity chromatography technology	Huttlin EL (2017)	1
FXYD6	0	UNC119	4	two hybrid	Stelzl U (2005)	1
RSPRY1	0	C5orf30	1	affinity chromatography technology	Huttlin EL (2017)	1
HSPB3	1	UNC119	4	two hybrid	Stelzl U (2005)	1
UNC119	4	RSPRY1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMD11	0	UNC119	4	two hybrid	Stelzl U (2005)	1
CEP97	0	TP53BP2	5	bioid	Gupta GD (2015)	1
CETN3	0	UNC119	4	two hybrid	Stelzl U (2005)	1