PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
H1FX	0	NMI	3	biochemical	Kristensen AR (2012)	1
LSM4	1	NMI	3	two hybrid	Lehner B (2004)	1
CDKN2A	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique	He L (2008), He L (2008), He L (2008)	3
HDDC3	1	390535	0	two hybrid	Rolland T (2014)	1
APEH	2	NMI	3	biochemical	Kristensen AR (2012)	1
CDKN2A	1	HSPA8	4	pull down	Souza-Rodrigues E (2007)	1
STAT1	1	APEH	2	biochemical	Kristensen AR (2012)	1
TBCD	4	APEH	2	biochemical	Kristensen AR (2012)	1
JAK3	3	STAT5A	4	two hybrid, affinity chromatography technology	Fujitani Y (1997), Cheng H (2008)	2
NMI	3	DCTN3	2	affinity chromatography technology	Huttlin EL (2015)	1
EXOSC4	1	NMI	3	biochemical	Kristensen AR (2012)	1
BRCA1	7	HSPA8	4	two hybrid, affinity chromatography technology	Yu X (1998), Ertych N (2016)	2
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
TRIP12	20	MYC	2	pull down, affinity chromatography technology	Chen D (2010), Chen D (2010)	2
STAT3	0	KDM1A	2	affinity chromatography technology, enzymatic study	Yang J (2010), Yang J (2010)	2
HOXC9	0	NMI	3	two hybrid	Ravasi T (2010)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
NAA10	9	VPS26A	0	biochemical	Kristensen AR (2012)	1
NMI	3	TXLNA	3	two hybrid	Rolland T (2014)	1
H1FX	0	HIST1H1B	4	biochemical	Kristensen AR (2012)	1
BRCA1	7	KDM1A	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Woods NT (2012), Ertych N (2016)	3
MYC	2	HSPH1	0	affinity chromatography technology	Koch HB (2007)	1
MYC	2	MYCN	2	affinity chromatography technology	Li X (2015)	1
TBCD	4	STAT3	0	biochemical	Kristensen AR (2012)	1
HSPA8	4	HSPH1	0	affinity chromatography technology, affinity chromatography technology, biochemical	Taipale M (2014), Taipale M (2014), Wan C (2015)	3
HSPH1	0	NMI	3	affinity chromatography technology, pull down	Saito Y (2014), Saito Y (2014)	2
MYC	2	TRIM21	0	affinity chromatography technology	Agrawal P (2010)	1
BRCA1	7	APEH	2	affinity chromatography technology	Ertych N (2016)	1
NMI	3	LCA5L	1	two hybrid	Rolland T (2014)	1
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
HSPA8	4	NECAP2	0	biochemical	Havugimana PC (2012)	1
MTMR9	1	KDM1A	2	two hybrid	Weimann M (2013)	1
CDKN2A	1	NMI	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Li Z (2012), Li Z (2012), Li Z (2012), Li Z (2012)	4
CYHR1	0	TOLLIP	3	biochemical	Kristensen AR (2012)	1
HGS	5	HSPA8	4	pull down	Pridgeon JW (2009)	1
JAK3	3	STAT3	0	affinity chromatography technology	Doucet C (2002)	1
TRIP12	20	NMI	3	affinity chromatography technology, affinity chromatography technology, pull down	Li Z (2012), Li Z (2012), Li Z (2012)	3
UBE2I	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rizos H (2005), Wang S (2015), Ivanschitz L (2015), Ivanschitz L (2015), Ivanschitz L (2015)	5
TXLNA	3	TXLNB	0	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Li S (2011), Li S (2011), Rolland T (2014), Huttlin EL (2017)	4
NMI	3	C9orf72	0	two hybrid	Rolland T (2014)	1
MTMR9	1	MTMR6	2	pull down, affinity chromatography technology, two hybrid, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Mochizuki Y (2003), Mochizuki Y (2003), Rolland T (2014), Wan C (2015), Yu H (2011), St-Denis N (2016), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017)	9
BRCA1	7	HSPH1	0	affinity chromatography technology	Ertych N (2016)	1
UBE2I	0	NMI	3	two hybrid	Yu H (2011)	1
MYC	2	PSMA1	1	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Hein MY (2015)	2
TOLLIP	3	NMI	3	biochemical	Kristensen AR (2012)	1
VPS26A	0	APEH	2	biochemical	Kristensen AR (2012)	1
IFI35	1	NMI	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen J (2000), Chen J (2000), Huttlin EL (2015), Das A (2015), Das A (2015), Huttlin EL (2017)	6
STAT1	1	TBCD	4	biochemical	Kristensen AR (2012)	1
MYC	2	NMI	3	affinity chromatography technology, pull down, two hybrid	Li H (2002), Li H (2002), Bannasch D (1999)	3
VPS26A	0	PSMG3	0	biochemical	Kristensen AR (2012)	1
IRF7	2	TRIM21	0	affinity chromatography technology	Higgs R (2010)	1
MYC	2	UBE2I	0	genetic interference	Toyoshima M (2012)	1
HSPA8	4	NMI	3	two hybrid	Rolland T (2014)	1
TRIP12	20	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Chen D (2010), Chen D (2010), Chen D (2010), Chio II (2012), Li Z (2012), Li Z (2012), Lo D (2014), Lee S (2016)	8
TRIM21	0	UBE2I	0	two hybrid	Rolland T (2014)	1
H1FX	0	CYHR1	0	biochemical	Kristensen AR (2012)	1
STAT3	0	KAT5	1	affinity chromatography technology	Xiao H (2003)	1
STAT5B	3	STAT3	0	imaging technique	Chen TC (2014)	1
TBCD	4	NMI	3	biochemical	Kristensen AR (2012)	1
NMI	3	CNP	2	affinity chromatography technology	Huttlin EL (2015)	1
TUBA3C	1	NMI	3	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
NMI	3	HDDC3	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NMI	3	STAT1	1	pull down	Zhu M (1999)	1
STAT1	1	VPS26A	0	biochemical	Kristensen AR (2012)	1
CYHR1	0	VPS26A	0	biochemical	Kristensen AR (2012)	1
H1FX	0	APEH	2	biochemical	Kristensen AR (2012)	1
NMI	3	SFR1	0	two hybrid	Rolland T (2014)	1
NMI	3	STAT3	0	pull down	Zhu M (1999)	1
ME1	1	NMI	3	biochemical	Kristensen AR (2012)	1
NMI	3	KDM1A	2	two hybrid, two hybrid, two hybrid	Weimann M (2013), Rolland T (2014), Yu H (2011)	3
MCPH1	4	KDM1A	2	two hybrid	Weimann M (2013)	1
DSTN	0	NMI	3	biochemical	Havugimana PC (2012)	1
STAT1	1	NAA10	9	biochemical	Kristensen AR (2012)	1
HIST1H1B	4	NMI	3	biochemical	Kristensen AR (2012)	1
KAT5	1	NMI	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhang K (2007), Zhang K (2007), Zhang K (2007)	3
STAT5A	4	STAT5B	3	affinity chromatography technology	Huttlin EL (2017)	1
STAT1	1	STAT5A	4	imaging technique	Chen TC (2014)	1
NMI	3	COPS7B	0	two hybrid	Rolland T (2014)	1
CDKN2A	1	KAT5	1	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
IFI35	1	TRIM21	0	affinity chromatography technology, affinity chromatography technology	Das A (2015), Das A (2015)	2
PSMA1	1	EXOSC4	1	biochemical	Wan C (2015)	1
GCSH	0	NMI	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
EMILIN1	1	MTMR9	1	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014), Yu H (2011)	4
SINHCAF	0	BRMS1	1	affinity chromatography technology	Huttlin EL (2017)	1
NMI	3	TRIM21	0	affinity chromatography technology, affinity chromatography technology	Das A (2015), Das A (2015)	2
JAK3	3	STAT5B	3	two hybrid	Fujitani Y (1997)	1
UBE2I	0	HGS	5	two hybrid	Rual JF (2005)	1
SINHCAF	0	NMI	3	two hybrid	Yu H (2011)	1
UBE2I	0	STAT1	1	enzymatic study	Wu PY (2003)	1
SCEL	0	NMI	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PSMG3	0	NMI	3	biochemical	Kristensen AR (2012)	1
NMI	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Li H (2002), Li H (2002), Li H (2002), Li H (2002)	4
BRCA1	7	STAT5A	4	affinity chromatography technology	Vidarsson H (2002)	1
NMI	3	MAD2L1BP	0	two hybrid	Rolland T (2014)	1
STAT3	0	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology	Gunaje JJ (2001), Spiekermann K (2001), Xia L (2002), Chen TC (2014), Li X (2015), Ghosh MK (2005), Huttlin EL (2017)	7
NMI	3	CNKSR3	3	two hybrid	Rolland T (2014)	1
NMI	3	TUBA3E	0	two hybrid	Rolland T (2014)	1
NMI	3	STAT5B	3	two hybrid	Zhu M (1999)	1
TRAF5	1	NMI	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
NAA10	9	NMI	3	biochemical	Kristensen AR (2012)	1
BRMS1	1	NMI	3	two hybrid, affinity chromatography technology, two hybrid	Hurst DR (2006), Hurst DR (2006), Rolland T (2014)	3
TXLNA	3	BRCA1	7	two hybrid	Hill SJ (2014)	1
KAT5	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Frank SR (2003), Frank SR (2003), Liu T (2007), Liu T (2007), Kim J (2010), Kim J (2010)	6
JAK3	3	NMI	3	affinity chromatography technology	Hein MY (2015)	1
MYCN	2	NMI	3	two hybrid	Bannasch D (1999)	1
NMI	3	TXLNB	0	two hybrid	Rolland T (2014)	1
PSMA1	1	GCSH	0	biochemical	Wan C (2015)	1
NMI	3	MOCS3	0	affinity chromatography technology	Huttlin EL (2015)	1
NMI	3	SNAPC5	4	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
ME1	1	TBCD	4	biochemical	Kristensen AR (2012)	1
KAT5	1	UBE2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheng Z (2008), Cheng Z (2008), Cheng Z (2008)	3
IRF7	2	NMI	3	affinity chromatography technology, affinity chromatography technology	Wang J (2013), Wang J (2013)	2
MCPH1	4	NMI	3	two hybrid	Liu X (2017)	1
H1FX	0	EXOSC4	1	biochemical	Kristensen AR (2012)	1
SOX10	2	NMI	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Schlierf B (2005), Schlierf B (2005), Schlierf B (2005)	3
CYP2E1	0	NMI	3	two hybrid	Wang J (2011)	1
NMI	3	POMZP3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
NMI	3	NECAP2	0	two hybrid	Rual JF (2005)	1
TOLLIP	3	APEH	2	biochemical	Kristensen AR (2012)	1
TOLLIP	3	OXR1	3	biochemical	Kristensen AR (2012)	1
STAT3	0	PSMG3	0	biochemical	Kristensen AR (2012)	1
NMI	3	OXR1	3	biochemical	Kristensen AR (2012)	1
NMI	3	NMI	3	two hybrid, two hybrid, affinity chromatography technology	Rolland T (2014), Yu H (2011), Lee ND (1999)	3
NMI	3	TARSL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NMI	3	EMILIN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
BRCA1	7	PSMA1	1	affinity chromatography technology	Ertych N (2016)	1
NMI	3	ASRGL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NMI	3	390535	0	two hybrid	Rolland T (2014)	1
NMI	3	STAT5A	4	pull down, two hybrid, affinity chromatography technology	Zhu M (1999), Zhu M (1999), Zhu M (1999)	3
IFI35	1	KDM1A	2	two hybrid	Weimann M (2013)	1
CYHR1	0	NMI	3	biochemical	Kristensen AR (2012)	1
H1FX	0	VPS26A	0	biochemical	Kristensen AR (2012)	1
MTMR6	2	NMI	3	two hybrid	Rolland T (2014)	1
NMI	3	C1orf216	1	two hybrid	Rolland T (2014)	1
HIST1H1B	4	CYHR1	0	biochemical	Kristensen AR (2012)	1
MYC	2	KDM1A	2	two hybrid	Weimann M (2013)	1
MYCN	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology	Amente S (2007), Amente S (2007)	2
MYC	2	TARSL2	1	affinity chromatography technology	Hein MY (2015)	1
VPS26A	0	NMI	3	biochemical	Kristensen AR (2012)	1
NMI	3	HHLA3	0	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3
MCPH1	4	KAT5	1	two hybrid	Liu X (2017)	1
PSMA1	1	NMI	3	two hybrid	Rual JF (2005)	1
KAT5	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
HSPA8	4	HIST1H1B	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	KDM1A	2	enzymatic study	Gocke CB (2005)	1
PSMA1	1	PSMG3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAD2L1BP	0	KAT5	1	two hybrid	Stelzl U (2005)	1
NMI	3	HGS	5	two hybrid	Rual JF (2005)	1
NMI	3	MTMR9	1	two hybrid	Rolland T (2014)	1
CYHR1	0	APEH	2	biochemical	Kristensen AR (2012)	1
BRCA1	7	STAT1	1	affinity chromatography technology, pull down, two hybrid	Ouchi T (2000), Ouchi T (2000), Ouchi T (2000)	3