PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
ATXN1L	0	CBFA2T2	3	two hybrid	Lim J (2006)	1
CBFA2T2	3	PRDM6	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCOR1	9	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Farhana L (2007)	2
PRDM14	1	CBFA2T3	3	affinity chromatography technology	Huttlin EL (2017)	1
CBFA2T2	3	WDYHV1	0	two hybrid	Rual JF (2005)	1
CBFA2T2	3	CBFA2T2	3	two hybrid	Rolland T (2014)	1
NCOR1	9	RUNX1T1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid	Amann JM (2001), Zhang J (2001), Amann JM (2005), Zhang J (2004), Minucci S (2000), Gelmetti V (1998), Gelmetti V (1998), Wei Y (2007)	8
TCF4	26	PRDM6	5	affinity chromatography technology	Li X (2015)	1
CBFA2T3	3	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Lindberg SR (2003), Hoogeveen AT (2002)	2
GTF2E1	1	CBFA2T2	3	two hybrid	Ravasi T (2010)	1
SIN3A	13	CBFA2T2	3	affinity chromatography technology	Amann JM (2005)	1
ID3	0	TCF4	26	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Chen B (1997), Chen B (1997), Langlands K (1997), Rolland T (2014), Li X (2015), Huttlin EL (2017)	6
TCF4	26	CBFA2T2	3	affinity chromatography technology	Li X (2015)	1
RERE	9	ATN1	2	pull down, pull down, two hybrid, two hybrid	Yanagisawa H (2000), Yanagisawa H (2000), Lim J (2006), Lim J (2006)	4
HDAC3	5	TCP1	0	affinity chromatography technology, pull down, affinity chromatography technology	Guenther MG (2002), Guenther MG (2002), Joshi P (2013)	3
NCOR1	9	CBFA2T2	3	affinity chromatography technology	Amann JM (2005)	1
RUNX1T1	1	SIN3A	13	pull down, affinity chromatography technology, affinity chromatography technology	Hildebrand D (2001), Amann JM (2005), Zhang J (2004)	3
CBFA2T2	3	LBP	2	two hybrid	Wang J (2011)	1
HNRNPL	3	RERE	9	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	CBFA2T2	3	affinity chromatography technology	Fei T (2017)	1
CBFA2T3	3	CBFA2T2	3	affinity chromatography technology	Hoogeveen AT (2002)	1
TAL2	1	CBFA2T2	3	two hybrid	Ravasi T (2010)	1
HNRNPL	3	NOTCH3	9	affinity chromatography technology	Fei T (2017)	1
CBFA2T2	3	FBXL19	5	two hybrid	Ravasi T (2010)	1
PRDM14	1	PRDM6	5	affinity chromatography technology	Huttlin EL (2017)	1
RUNX1	0	CBFA2T2	3	affinity chromatography technology, affinity chromatography technology	Kitabayashi I (1998), Shia WJ (2012)	2
CBFA2T3	3	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Hoogeveen AT (2002), Amann JM (2001)	2
TAL1	0	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Goardon N (2006), Hu X (2009)	5
SIN3A	13	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Imai Y (2004), Imai Y (2004)	2
TCF4	26	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TAL1	0	TCF4	26	pull down, affinity chromatography technology, two hybrid	Goldfarb AN (1996), Goardon N (2006), Langlands K (1997)	3
RUNX1	0	CBFA2T3	3	affinity chromatography technology	Shia WJ (2012)	1
NEUROG1	0	TCF4	26	two hybrid	Rolland T (2014)	1
TAL1	0	SIN3A	13	affinity chromatography technology, pull down, pull down	Huang S (2000), Huang S (2000), Huang S (2000)	3
GTF2E1	1	APP	1	pull down	Olah J (2011)	1
RERE	9	CBFA2T2	3	two hybrid	Lim J (2006)	1
NEUROG1	0	CBFA2T2	3	two hybrid	Ravasi T (2010)	1
RUNX1	0	RUNX1T1	1	biochemical, affinity chromatography technology	Minucci S (2000), Shia WJ (2012)	2
TCF4	26	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
HDAC3	5	RUNX1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Reed-Inderbitzin E (2006), Guo H (2011), Guo H (2011), Guo H (2011), Leong WY (2016)	5
MDFI	1	WDYHV1	0	two hybrid	Rual JF (2005)	1
ATN1	2	RUNX1T1	1	two hybrid, affinity chromatography technology, two hybrid	Wood JD (2000), Wood JD (2000), Lim J (2006)	3
NCOR1	9	RUNX1	0	pull down	Minucci S (2000)	1
RUNX1T1	1	CBFA2T2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Lindberg SR (2003), Hoogeveen AT (2002), Zhang J (2004)	4
NCOR1	9	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology	Amann JM (2001), Olsson A (2008)	2
TAL1	0	CBFA2T2	3	affinity chromatography technology	Goardon N (2006)	1
CBFA2T2	3	PRDM14	1	two hybrid, two hybrid, affinity chromatography technology	Ravasi T (2010), Rolland T (2014), Huttlin EL (2017)	3
TAL1	0	RUNX1	0	affinity chromatography technology	Hu X (2009)	1
ID3	0	CBFA2T2	3	two hybrid	Ravasi T (2010)	1
NOTCH3	9	CBFA2T2	3	pull down	Jung JG (2014)	1
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
ATN1	2	MDFI	1	two hybrid	Lim J (2006)	1
ID3	0	PRDM14	1	two hybrid	Ravasi T (2010)	1
CBFA2T2	3	PDP1	1	two hybrid	Rolland T (2014)	1
PRDM6	5	HDAC3	5	affinity chromatography technology	Davis CA (2006)	1
RUNX1T1	1	NEUROG1	0	two hybrid	Ravasi T (2010)	1
RUNX1T1	1	TAL2	1	two hybrid	Ravasi T (2010)	1
RUNX1T1	1	PRDM14	1	two hybrid, two hybrid, affinity chromatography technology	Ravasi T (2010), Rolland T (2014), Huttlin EL (2017)	3
MDFI	1	CBFA2T2	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Yu H (2011)	3
HDAC3	5	CBFA2T2	3	affinity chromatography technology	Amann JM (2005)	1
TCP1	0	CBFA2T2	3	two hybrid	Rolland T (2014)	1
ATN1	2	CBFA2T2	3	two hybrid	Lim J (2006)	1
CBFA2T2	3	APP	1	pull down	Olah J (2011)	1
HDAC3	5	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Amann JM (2001), Zhang J (2004)	2
TCF4	26	TAL2	1	two hybrid, two hybrid	Langlands K (1997), Rolland T (2014)	2
NCOR1	9	ATXN1L	0	two hybrid	Mizutani A (2005)	1