PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GABARAP	0	WDFY3	17	affinity chromatography technology, pull down, pull down, x-ray crystallography, imaging technique	Lystad AH (2014), Lystad AH (2014), Lystad AH (2014), Lystad AH (2014), Lystad AH (2014)	5
WDFY3	17	ATG16L1	1	affinity chromatography technology	Filimonenko M (2010)	1
PLSCR1	0	APP	1	pull down	Olah J (2011)	1
ATG12	1	AUP1	0	affinity chromatography technology	Ewing RM (2007)	1
WDFY3	17	MDFI	1	two hybrid	Yu H (2011)	1
XPO1	8	ATG12	1	affinity chromatography technology	Kirli K (2015)	1
EXOC4	2	ATG5	0	affinity chromatography technology	Bodemann BO (2011)	1
ATG12	1	ATG16L1	1	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Behrends C (2010)	2
ATG5	0	WDFY3	17	affinity chromatography technology, pull down	Filimonenko M (2010), Filimonenko M (2010)	2
ATG3	4	ATG5	0	affinity chromatography technology, pull down, affinity chromatography technology	Behrends C (2010), Qiu Y (2013), Huttlin EL (2017)	3
XPO1	8	ATG5	0	affinity chromatography technology	Kirli K (2015)	1
ATG3	4	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
CAV1	0	ATG12	1	affinity chromatography technology, affinity chromatography technology	Chen ZH (2014), Chen ZH (2014)	2
ATG3	4	ATG16L1	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
ATG12	1	TECPR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Chen D (2012)	3
CRX	0	ATG12	1	two hybrid	Rolland T (2014)	1
ATG12	1	DHX36	3	affinity chromatography technology	Ewing RM (2007)	1
PLSCR1	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
WIPI2	5	ATG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dooley HC (2014), Huttlin EL (2015), Huttlin EL (2017)	3
EXOC4	2	ATG12	1	affinity chromatography technology	Bodemann BO (2011)	1
ATG16L1	1	ATG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, x-ray crystallography, two hybrid, pull down, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Chen D (2012), Chen D (2012), Ravikumar B (2010), Itoh T (2008), Kristensen AR (2012), Gammoh N (2013), Otomo C (2013), Wan C (2015), Kim JH (2014), Kim JH (2014), Kim JH (2014), Zheng Y (2017)	14
CAV1	0	MCL1	1	affinity chromatography technology, affinity chromatography technology	Chunhacha P (2012), Chunhacha P (2012)	2
ATG7	2	GABARAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Tanida I (2001), Sou YS (2006), Sou YS (2006), Dunlop EA (2014)	6
ATG10	0	ATG3	4	affinity chromatography technology	Behrends C (2010)	1
WIPI2	5	ATG12	1	affinity chromatography technology	Dooley HC (2014)	1
PLSCR1	0	ATG12	1	two hybrid	Rual JF (2005)	1
ATG3	4	ATG7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanida I (2002), Tanida I (2002), Behrends C (2010), Behrends C (2010), Qiu Y (2013), Huttlin EL (2017)	6
XPO1	8	ATG16L1	1	affinity chromatography technology	Kirli K (2015)	1
ATG10	0	MAP1B	5	affinity chromatography technology	Behrends C (2010)	1
ATG12	1	SF3A1	1	affinity chromatography technology	Ewing RM (2007)	1
ATG3	4	MAP1B	5	affinity chromatography technology	Behrends C (2010)	1
ATG12	1	OTUD4	2	affinity chromatography technology	Ewing RM (2007)	1
ATG12	1	BCL2	0	affinity chromatography technology	Rubinstein AD (2011)	1
ATG12	1	ATG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Behrends C (2010), Behrends C (2010), Chen D (2012), Zheng Y (2017)	5
ATG12	1	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
ATG5	0	TECPR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, biochemical, x-ray crystallography, two hybrid, pull down	Behrends C (2010), Behrends C (2010), Chen D (2012), Chen D (2012), Chen D (2012), Chen D (2012), Chen D (2012), Chen D (2012), Kim JH (2014), Kim JH (2014), Kim JH (2014)	11
XPO1	8	OTUD4	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	ATG3	4	affinity chromatography technology	Kirli K (2015)	1
PTK2	2	ATG12	1	two hybrid	Rual JF (2005)	1
ATG12	1	APP	1	pull down	Olah J (2011)	1
SF3A1	1	SF3B1	12	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ATG3	4	TECPR1	0	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010)	2
FADD	1	ATG12	1	affinity chromatography technology	Pyo JO (2005)	1
CRX	0	MDFI	1	two hybrid	Rual JF (2005)	1
PTK2	2	APP	1	pull down	Olah J (2011)	1
CAV1	0	ATG5	0	affinity chromatography technology, affinity chromatography technology	Chen ZH (2014), Chen ZH (2014)	2
ATG3	4	GABARAP	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Sou YS (2006), Sou YS (2006), Huttlin EL (2017)	5
ATG7	2	APP	1	pull down	Olah J (2011)	1
ATG12	1	MCL1	1	affinity chromatography technology	Rubinstein AD (2011)	1
ATG10	0	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
ATG10	0	ATG7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2015), Huttlin EL (2017)	3
ATG3	4	ATG12	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanida I (2002), Behrends C (2010), Behrends C (2010), Radoshevich L (2010), Qiu Y (2013), Huttlin EL (2017)	6
ATG12	1	ATG7	2	affinity chromatography technology, two hybrid	Behrends C (2010), Tanida I (2001)	2
MDFI	1	ATG12	1	two hybrid	Rual JF (2005)	1
ATG12	1	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
APP	1	CAV1	0	biochemical, unspecified method	Ikezu T (1998), Ikezu T (1998)	2
GABARAP	0	ATG4B	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Behrends C (2010), Dunlop EA (2014)	4
WDFY3	17	ATG12	1	affinity chromatography technology	Filimonenko M (2010)	1
ATG12	1	ATG10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017)	3
ATG12	1	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
ATG12	1	SF3B1	12	affinity chromatography technology	Ewing RM (2007)	1
WIPI2	5	ATG16L1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dooley HC (2014), Huttlin EL (2015), Huttlin EL (2017)	3
ATG16L1	1	APP	1	pull down	Olah J (2011)	1
ATG5	0	FADD	1	pull down, affinity chromatography technology, imaging technique	Pyo JO (2005), Pyo JO (2005), Pyo JO (2005)	3
ATG12	1	MAP1B	5	affinity chromatography technology	Behrends C (2010)	1