Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ACY3	91703	ASPARTIC ACID	CHEMBL274323		DrugBank	17139284, 17016423

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ACY3	rs2514036	T	bisoprolol	efficacy	yes	Because of the GWAS design, these p-values are suggestive, not significant. Each participant received losartan 50 mg, bisoprolol 5 mg, hydrochlorothiazide 25 mg, and amlodipine 5 mg daily, each as a monotherapy in randomized order for 4 weeks. The study started with a 4-week run-in placebo period, and all 4 drug treatments were separated by 4-week placebo periods. 24-hour ABP readings were recorded at the end of each treatment period.	Allele T is associated with increased response to bisoprolol in men with Hypertension as compared to allele C.	25622599	1448099774