PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TFAP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
MYH9	19	GNAS	9	affinity chromatography technology	Hein MY (2015)	1
RPA3	2	DNTTIP1	0	affinity chromatography technology	Marechal A (2014)	1
HDAC2	1	ESR1	0	affinity chromatography technology, affinity chromatography technology	Itoh Y (2007), Tarallo R (2011)	2
SH3KBP1	1	RPA1	0	affinity chromatography technology	Havrylov S (2009)	1
RPA3	2	RAD51	3	two hybrid	Du Y (2009)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
RPA1	0	CCNA2	1	pull down	Gibbs E (1996)	1
HDAC1	4	ESR1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Kawai H (2003), Kawai H (2003), Varshochi R (2005), Varshochi R (2005), Kurtev V (2004), Liu XF (2004), Itoh Y (2007), Tarallo R (2011), Yoshimaru T (2013)	9
PPP4R2	0	ELMSAN1	4	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	PDLIM5	0	biochemical	Havugimana PC (2012)	1
TRERF1	1	DNTTIP1	0	affinity chromatography technology	Bantscheff M (2011)	1
ELMSAN1	4	CLTB	0	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
ESR1	0	MYH9	19	affinity chromatography technology	Tarallo R (2011)	1
CCNA2	1	DNTTIP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
SH3KBP1	1	ELMSAN1	4	affinity chromatography technology	Havrylov S (2009)	1
ELAVL1	0	TRERF1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELMSAN1	4	CDK2	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
RPA2	0	ELMSAN1	4	affinity chromatography technology	Marechal A (2014)	1
ELAVL1	0	EIF2AK2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELMSAN1	4	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
ESR1	0	EPB41L5	0	affinity chromatography technology	Tarallo R (2011)	1
MAPK14	0	HDAC1	4	biochemical	Wan C (2015)	1
EIF2AK2	1	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Huttlin EL (2015)	2
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
ELMSAN1	4	DPM1	1	affinity chromatography technology	Hein MY (2015)	1
TFAP4	3	DNTTIP1	0	affinity chromatography technology	Ku WC (2009)	1
HDAC1	4	ELMSAN1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
CDK2	0	MYH9	19	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Hein MY (2015)	2
RPA1	0	DNTTIP1	0	affinity chromatography technology	Marechal A (2014)	1
ELMSAN1	4	NDUFA10	2	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	PFKM	4	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	MYH9	19	affinity chromatography technology	Marechal A (2014)	1
DNTTIP1	0	ELMSAN1	4	affinity chromatography technology, biochemical, affinity chromatography technology	Bantscheff M (2011), Wan C (2015), Hein MY (2015)	3
TFAP4	3	ELMSAN1	4	affinity chromatography technology	Ku WC (2009)	1
ELAVL1	0	SH3KBP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MYH9	19	CLTA	1	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	RAD51	3	affinity chromatography technology	Hein MY (2015)	1
MAPK14	0	ELMSAN1	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Huttlin EL (2015), Huttlin EL (2017)	3
HDAC1	4	TRIM27	2	imaging technique, affinity chromatography technology	Kato T (2009), Shimono Y (2003)	2
SEC16A	7	CLTA	1	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	ELMSAN1	4	affinity chromatography technology	Marechal A (2014)	1
ELMSAN1	4	EPB41L3	5	affinity chromatography technology	Hein MY (2015)	1
CDV3	1	ELMSAN1	4	biochemical	Havugimana PC (2012)	1
RAD51	3	ESR1	0	affinity chromatography technology, affinity chromatography technology	Jung YS (2014), Jung YS (2014)	2
CDK2	0	SEC16A	7	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	GNAS	9	affinity chromatography technology	Hein MY (2015)	1
DNTTIP1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	5
CDK2	0	ESR1	0	enzymatic study, affinity chromatography technology	Zhou W (2014), Zhou W (2014)	2
RPA2	0	MYH9	19	affinity chromatography technology	Marechal A (2014)	1
MYH9	19	SEC16A	7	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
DNTTIP1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013)	3
CLTB	0	CLTA	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
RPA2	0	DNTTIP1	0	affinity chromatography technology	Marechal A (2014)	1
RPA3	2	ELAVL1	0	affinity chromatography technology	Marechal A (2014)	1
MYH9	19	ELMSAN1	4	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	SEC16A	7	affinity chromatography technology	Hein MY (2015)	1
HDAC2	1	ZMYM3	0	affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Bantscheff M (2011)	2
ELMSAN1	4	AVL9	0	affinity chromatography technology	Hein MY (2015)	1
RPA3	2	ELMSAN1	4	affinity chromatography technology	Marechal A (2014)	1
TFAP4	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
CCNA2	1	HDAC2	1	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	CDV3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	TFAP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ELMSAN1	4	TRIP13	0	affinity chromatography technology	Hein MY (2015)	1
SEC16A	7	CLTB	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
RAD51	3	RPA1	0	pull down, two hybrid	Sugiyama T (2002), Du Y (2009)	2
MYH9	19	CLTB	0	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	RPA1	0	enzymatic study	Pan ZQ (1993)	1
HDAC1	4	ZMYM3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
ELAVL1	0	ELMSAN1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
MAPK14	0	USP11	3	affinity chromatography technology	Varjosalo M (2013)	1
ESR1	0	ELMSAN1	4	affinity chromatography technology	Tarallo R (2011)	1
TRERF1	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
ELMSAN1	4	TRERF1	1	affinity chromatography technology	Hein MY (2015)	1
USP11	3	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	ZMYM3	0	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	EPB41L5	0	affinity chromatography technology	Hein MY (2015)	1
CCNA2	1	ELMSAN1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	4
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
CDK2	0	CLTA	1	affinity chromatography technology	Hein MY (2015)	1
HDAC2	1	ELMSAN1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015)	3
USP11	3	ELMSAN1	4	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	CLTA	1	affinity chromatography technology	Hein MY (2015)	1
ELMSAN1	4	ZC3H3	4	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	ELAVL1	0	affinity chromatography technology	Marechal A (2014)	1
ELAVL1	0	EPB41L3	5	affinity chromatography technology	Abdelmohsen K (2009)	1
RPA3	2	MYH9	19	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	ELAVL1	0	affinity chromatography technology	Marechal A (2014)	1
ELMSAN1	4	EIF2AK2	1	affinity chromatography technology	Hein MY (2015)	1