PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LCK	0	TRAT1	0	pull down	Brdicka T (2000)	1
SLA	2	ZAP70	5	affinity chromatography technology	Tang J (1999)	1
CD3E	0	LCK	0	affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003)	2
PTPN22	3	CD247	1	affinity chromatography technology	Wu J (2006)	1
JAK3	3	STAT5A	4	two hybrid, affinity chromatography technology	Fujitani Y (1997), Cheng H (2008)	2
PTPRC	1	LCK	0	affinity chromatography technology, pull down, affinity chromatography technology	Koretzky GA (1993), Ng DH (1996), Jury EC (2004)	3
LCK	0	PIK3R1	6	pull down	Kapeller R (1994)	1
CSK	3	CD3E	0	pull down	Catipovic B (1996)	1
CD3E	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	de Aos I (1997), Alcazar I (2009)	2
NCR1	1	CD247	1	affinity chromatography technology	Vitale M (1998)	1
TUBA1B	0	CD247	1	affinity chromatography technology	Serrador JM (2004)	1
LAT	0	PIK3R1	6	affinity chromatography technology, pull down	Paz PE (2001), Paz PE (2001)	2
PTPN22	3	LCK	0	affinity chromatography technology, affinity chromatography technology	Wu J (2006), Wu J (2006)	2
LCK	0	LAT	0	biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Jiang Y (2007), Jiang Y (2007)	4
CD247	1	DOCK2	3	affinity chromatography technology, imaging technique	Nishihara H (2002), Chen TC (2014)	2
CD38	0	CD247	1	affinity chromatography technology, biochemical	Munoz P (2003), Munoz P (2003)	2
LY6E	1	CD247	1	affinity chromatography technology	Kosugi A (1998)	1
STAT5A	4	CBL	7	affinity chromatography technology, two hybrid	Dieudonne FX (2013), Grossmann A (2015)	2
PTPN22	3	CSK	3	bioid, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
CD247	1	RNF41	2	affinity chromatography technology, affinity chromatography technology	Yang M (2015), Yang M (2015)	2
CBL	7	ZAP70	5	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, x-ray crystallography	Lupher ML (1996), Meng W (1999), Wang HY (2001), Rao N (2000), Lupher ML (1997), Okabe S (2006), Zhang Z (1999), Lupher ML (1996), Dou H (2012), Dou H (2012), Gabrielsen M (2017)	11
GAB2	3	CD247	1	affinity chromatography technology	Yamasaki S (2001)	1
PTPN22	3	CBL	7	affinity chromatography technology	Cohen S (1999)	1
CD3E	0	JAK3	3	affinity chromatography technology	Tomita K (2001)	1
TUBA1B	0	ZAP70	5	affinity chromatography technology	Serrador JM (2004)	1
CD247	1	PCGF2	3	two hybrid	Wang J (2011)	1
LAT	0	CBL	7	affinity chromatography technology	Jiang Y (2007)	1
STAT5B	3	CD247	1	affinity chromatography technology	Welte T (1999)	1
SLA	2	LAT	0	affinity chromatography technology	Tang J (1999)	1
STAT5A	4	STAT5B	3	affinity chromatography technology	Huttlin EL (2017)	1
LCK	0	UNC119	4	affinity chromatography technology, pull down	Gorska MM (2004), Gorska MM (2004)	2
CD247	1	VTN	1	two hybrid	Wang J (2011)	1
LCK	0	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pelosi M (1999), Thome M (1995), Lupher ML (1996)	3
JAK3	3	STAT5B	3	two hybrid	Fujitani Y (1997)	1
CD247	1	JAK3	3	affinity chromatography technology, pull down	Tomita K (2001), Tomita K (2001)	2
CD247	1	LCK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Yang M (2015)	3
CD247	1	ZNF281	1	two hybrid	Wang J (2011)	1
LCK	0	CBL	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005)	4
GAB2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down	Lynch DK (2002), Crouin C (2001), Crouin C (2001), Schaeper U (2000), Ren SY (2005), Momose H (2003)	6
STAT5A	4	CD247	1	affinity chromatography technology	Welte T (1999)	1
ZAP70	5	LAT	0	enzymatic study, enzymatic study, imaging technique, affinity chromatography technology	Paz PE (2001), Perez-Villar JJ (2002), Houtman JC (2006), Xie JJ (2013)	4
RNF41	2	ZAP70	5	affinity chromatography technology, pull down	Yang M (2015), Yang M (2015)	2
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
CSK	3	ZAP70	5	pull down	Catipovic B (1996)	1
CD38	0	ZAP70	5	biochemical	Munoz P (2003)	1
PTPN22	3	ZAP70	5	affinity chromatography technology, affinity chromatography technology	Wu J (2006), Wu J (2006)	2
UNC119	4	CD247	1	affinity chromatography technology, pull down	Gorska MM (2004), Gorska MM (2004)	2
CD247	1	TRAT1	0	affinity chromatography technology	Kirchgessner H (2001)	1
CD247	1	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mustelin T (1995), Wang HY (2001), La Face DM (1997), Huang H (2010), Huang H (2010), Hubert P (1996), Yang M (2015)	7
PIK3R1	6	TUBA1B	0	affinity chromatography technology, pull down	Kapeller R (1995), Kapeller R (1995)	2
ZAP70	5	CD3E	0	pull down, affinity chromatography technology	Bu JY (1995), Hubert P (1996)	2
PIK3R1	6	CD247	1	affinity chromatography technology	Fang D (2001)	1
SLA2	1	ZAP70	5	affinity chromatography technology	Pandey A (2002)	1
CBL	7	SLA	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang J (1999), Myers MD (2006), Sirvent A (2008), Swaminathan G (2007)	4
PTPN22	3	CD3E	0	affinity chromatography technology, affinity chromatography technology	Wu J (2006), Wu J (2006)	2
SLA	2	CD247	1	affinity chromatography technology	Tang J (1999)	1
PTPRC	1	CD247	1	pull down	Furukawa T (1994)	1
CD3E	0	CD247	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Munoz P (2003), Munoz P (2003), Chen TC (2014)	3
CD38	0	LCK	0	affinity chromatography technology	Munoz P (2003)	1
CD38	0	CD3E	0	affinity chromatography technology, biochemical	Munoz P (2003), Munoz P (2003)	2
CBL	7	CD247	1	affinity chromatography technology, affinity chromatography technology	Wang HY (2001), Wang HY (2001)	2
SLA2	1	CD247	1	affinity chromatography technology	Pandey A (2002)	1
GAB2	3	LAT	0	affinity chromatography technology	Yamasaki S (2001)	1
LAT	0	CD247	1	affinity chromatography technology	Munoz P (2003)	1
CBL	7	CD38	0	fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Shen M (2009), Shen M (2008), Shen M (2008)	3
SLA2	1	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pandey A (2002), Pandey A (2002), Pakuts B (2007), Pakuts B (2007), Holland SJ (2001), Manes GA (2006), Loreto MP (2003), Loreto MP (2003)	8
GAB2	3	ZAP70	5	affinity chromatography technology	Yamasaki S (2001)	1
ICK	1	CD247	1	affinity chromatography technology	August A (1996)	1
CBL	7	CSK	3	affinity chromatography technology, affinity chromatography technology	Sanjay A (2001), Brehme M (2009)	2
CSK	3	CD247	1	pull down, affinity chromatography technology	Catipovic B (1996), Catipovic B (1996)	2
LAT	0	CD3E	0	affinity chromatography technology	Munoz P (2003)	1
PIK3R1	6	ZAP70	5	affinity chromatography technology	Moon KD (2005)	1