PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DEDD	0	SHMT1	1	two hybrid	Wang J (2011)	1
DEDD	0	GTF3C3	2	two hybrid, affinity chromatography technology, pull down	Zhan Y (2002), Zhan Y (2002), Zhan Y (2002)	3
DEDD	0	KHK	2	affinity chromatography technology	Ewing RM (2007)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
DEDD	0	DEDD	0	affinity chromatography technology, pull down	Alcivar A (2003), Zhan Y (2002)	2
CASP10	1	DEDD2	1	affinity chromatography technology	Alcivar A (2003)	1
TRIM25	5	USP22	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	APLP2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	DEDD	0	affinity chromatography technology	Choudhury NR (2017)	1
USP22	1	DEDD	0	affinity chromatography technology	Sowa ME (2009)	1
DEDD	0	RANBP3	0	affinity chromatography technology	Ewing RM (2007)	1
HOXD4	2	DEDD	0	two hybrid	Ravasi T (2010)	1
SMAD3	1	DEDD	0	two hybrid, affinity chromatography technology, pull down	Xue JF (2010), Xue JF (2010), Xue JF (2010)	3
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
DEDD	0	CASP8	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Alcivar A (2003), Stegh AH (1998), Stegh AH (1998)	4
DEDD	0	CCDC59	1	affinity chromatography technology	Ewing RM (2007)	1
CFLAR	1	SMAD3	1	two hybrid	Wang J (2011)	1
CASP10	1	DEDD	0	affinity chromatography technology	Alcivar A (2003)	1
NXF1	0	DEDD	0	affinity chromatography technology	Castello A (2012)	1
CFLAR	1	DEDD	0	affinity chromatography technology, pull down	Roth W (2002), Zhan Y (2002)	2
DEDD2	1	CFLAR	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Roth W (2002), Roth W (2002), Zhan Y (2002), Zhan Y (2002)	4
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
SMAD3	1	APP	1	pull down	Olah J (2011)	1
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
DEDD	0	APLP2	2	pull down	Miyamoto-Sato E (2010)	1
NXF1	0	USP22	1	affinity chromatography technology	Castello A (2012)	1
DEDD2	1	CASP8	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Zhan Y (2002), Alcivar A (2003)	3
CFLAR	1	FADD	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Han DK (1997), Kerr E (2012), Rebe C (2007), Choi H (2011), Feoktistova M (2011), Ranjan K (2016), Jeong M (2017)	13
KRT18	2	DEDD	0	affinity chromatography technology	Lee JC (2002)	1
ENO1	3	DEDD	0	affinity chromatography technology	Castello A (2012)	1
FADD	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology	Roth W (2002), Stegh AH (1998), Stegh AH (1998)	3
NXF1	0	RANBP3	0	affinity chromatography technology	Castello A (2012)	1
DEDD	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CCDC59	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
BATF2	0	DEDD	0	two hybrid	Wang J (2011)	1
DEDD2	1	GTF3C3	2	affinity chromatography technology, pull down	Zhan Y (2002), Zhan Y (2002)	2
RANBP3	0	KHK	2	affinity chromatography technology	Ewing RM (2007)	1
TRIM25	5	ENO1	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CASP10	1	CFLAR	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Micheau O (2003), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Feoktistova M (2011), Chen TC (2014)	7
DEDD2	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zhan Y (2002), Alcivar A (2003), Alcivar A (2003), Alcivar A (2003), Zhan Y (2002), Zhan Y (2002)	6