PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CEP135	2	KIAA0753	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
MAGED2	1	TPGS1	1	affinity chromatography technology	Fogeron ML (2013)	1
BTRC	1	PCM1	5	bioid	Coyaud E (2015)	1
SSX2IP	0	TPGS1	1	bioid	Gupta GD (2015)	1
CEP128	1	LRRC49	2	bioid	Gupta GD (2015)	1
CENPJ	6	SSX2IP	0	bioid	Gupta GD (2015)	1
STIL	3	SSX2IP	0	bioid	Gupta GD (2015)	1
SPICE1	2	LRRC49	2	bioid	Gupta GD (2015)	1
CENPJ	6	STIL	3	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CNTROB	6	TPGS1	1	bioid	Gupta GD (2015)	1
MKS1	3	LRRC49	2	bioid	Gupta GD (2015)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
CENPJ	6	TPGS1	1	bioid	Gupta GD (2015)	1
NICN1	0	TTLL1	4	affinity chromatography technology	Huttlin EL (2017)	1
CENPJ	6	LRRC49	2	bioid	Gupta GD (2015)	1
CEP135	2	TPGS1	1	bioid	Gupta GD (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIAA0753	1	LRRC49	2	bioid	Gupta GD (2015)	1
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
BTRC	1	LRRC49	2	bioid	Coyaud E (2015)	1
PCM1	5	KIAA0753	1	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
NICN1	0	SMG8	2	affinity chromatography technology	Huttlin EL (2017)	1
PCM1	5	LRRC49	2	bioid, affinity chromatography technology	Gupta GD (2015), Huttlin EL (2017)	2
CEP128	1	CEP290	5	bioid	Gupta GD (2015)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
STIL	3	BTRC	1	bioid	Gupta GD (2015)	1
CEP128	1	CNTROB	6	bioid	Gupta GD (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP290	5	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIAA0753	1	TPGS1	1	bioid	Gupta GD (2015)	1
HNRNPL	3	TPGS1	1	affinity chromatography technology	Fei T (2017)	1
STIL	3	LRRC49	2	bioid	Gupta GD (2015)	1
SPICE1	2	KIAA0753	1	bioid	Gupta GD (2015)	1
SSX2IP	0	KIAA0753	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MKS1	3	TPGS1	1	bioid	Gupta GD (2015)	1
SMG8	2	TPGS1	1	affinity chromatography technology	Huttlin EL (2017)	1
STIL	3	TPGS1	1	bioid	Gupta GD (2015)	1
HNRNPL	3	PCM1	5	affinity chromatography technology	Fei T (2017)	1
NICN1	0	LRRC49	2	affinity chromatography technology	Huttlin EL (2017)	1
CEP135	2	LRRC49	2	bioid	Gupta GD (2015)	1
STIL	3	PCM1	5	bioid	Gupta GD (2015)	1
SPICE1	2	SSX2IP	0	bioid	Gupta GD (2015)	1
BTRC	1	TPGS1	1	bioid	Coyaud E (2015)	1
CEP128	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CENPJ	6	KIAA0753	1	bioid	Gupta GD (2015)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	TPGS1	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP290	5	PCM1	5	bioid	Gupta GD (2015)	1
BTRC	1	SSX2IP	0	bioid	Coyaud E (2015)	1
SSX2IP	0	LRRC49	2	bioid	Gupta GD (2015)	1
PCM1	5	CENPJ	6	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CEP128	1	TPGS1	1	bioid	Gupta GD (2015)	1
CEP135	2	SSX2IP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
TTLL1	4	LRRC49	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP290	5	TPGS1	1	bioid	Gupta GD (2015)	1
CNTROB	6	LRRC49	2	bioid	Gupta GD (2015)	1
LRRC49	2	TPGS1	1	affinity chromatography technology	Huttlin EL (2017)	1
SPICE1	2	TPGS1	1	bioid	Gupta GD (2015)	1
CEP290	5	KIAA0753	1	bioid	Gupta GD (2015)	1
CEP290	5	LRRC49	2	bioid	Gupta GD (2015)	1
TTLL1	4	TPGS1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP135	2	CEP290	5	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
NICN1	0	TPGS1	1	affinity chromatography technology	Huttlin EL (2017)	1
EIF3F	1	TPGS1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMG8	2	LRRC49	2	affinity chromatography technology	Huttlin EL (2017)	1
EIF3F	1	LRRC49	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPICE1	2	CENPJ	6	bioid	Gupta GD (2015)	1
PCM1	5	SSX2IP	0	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4