PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUMO2	0	KDM1A	2	pull down	Ouyang J (2009)	1
NXF1	0	CCT2	1	affinity chromatography technology	Castello A (2012)	1
ZSCAN5A	1	RCOR1	0	affinity chromatography technology	Huttlin EL (2017)	1
ZMYM2	5	RCOR1	0	affinity chromatography technology, pull down	Gocke CB (2008), Gocke CB (2008)	2
CBX3	1	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
ZSCAN5A	1	ZMYM4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	3
ZMYM4	4	UBQLN4	2	affinity chromatography technology	Hauri S (2016)	1
NXF1	0	ZMYM3	0	affinity chromatography technology	Castello A (2012)	1
UBQLN1	1	ZRANB2	0	biochemical	Havugimana PC (2012)	1
CBX1	0	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	3
HNRNPL	3	ROR2	0	affinity chromatography technology	Fei T (2017)	1
CBX1	0	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	3
CBX6	1	ZMYM4	4	affinity chromatography technology	Vandamme J (2011)	1
KDM1A	2	ZMYM3	0	affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Lee MG (2005)	2
CBX1	0	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Chang CW (2008), Chang CW (2008), Ryan RF (1999), Rosnoblet C (2011), Moriyama T (2015), Huttlin EL (2017), Hauri S (2016)	8
CBX1	0	E2F6	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
ZMYM4	4	CTCF	15	two hybrid	Rolland T (2014)	1
FOXJ2	3	ZMYM4	4	affinity chromatography technology	Li X (2015)	1
DYNLL1	0	ZMYM2	5	affinity chromatography technology	Hein MY (2015)	1
FOXJ2	3	ADNP	37	affinity chromatography technology	Li X (2015)	1
CUL3	17	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
MOV10	6	FBL	1	affinity chromatography technology	Castello A (2012)	1
SUMO2	0	ZMYM3	0	pull down	Guzzo CM (2014)	1
HIST3H3	0	ADNP	37	unspecified method	Vermeulen M (2010)	1
CBX1	0	ZSWIM9	0	affinity chromatography technology	Hauri S (2016)	1
CLEC3A	2	YY1AP1	0	affinity chromatography technology	Huttlin EL (2017)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
NXF1	0	CIPC	2	affinity chromatography technology	Castello A (2012)	1
CUL3	17	MOV10	6	affinity chromatography technology	Bennett EJ (2010)	1
ZMYM4	4	DYNLL2	0	affinity chromatography technology	Hauri S (2016)	1
ZMYM4	4	ILVBL	4	affinity chromatography technology	Hauri S (2016)	1
MOV10	6	ZMYM3	0	affinity chromatography technology	Castello A (2012)	1
HIST3H3	0	CBX6	1	unspecified method, x-ray crystallography, affinity chromatography technology	Kaustov L (2011), Kaustov L (2011), Vandamme J (2011)	3
YY1AP1	0	ZMYM4	4	affinity chromatography technology	Huttlin EL (2017)	1
MOV10	6	ROR2	0	affinity chromatography technology	Castello A (2012)	1
HIST3H3	0	ZMYM4	4	unspecified method	Vermeulen M (2010)	1
CTCF	15	ZMYM2	5	biochemical	Havugimana PC (2012)	1
POGZ	49	ZMYM4	4	affinity chromatography technology	Vermeulen M (2010)	1
FOXJ2	3	POGZ	49	affinity chromatography technology	Li X (2015)	1
SUMO2	0	RCOR1	0	pull down	Ouyang J (2009)	1
ZMYM4	4	ZRANB2	0	affinity chromatography technology	Hauri S (2016)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
DYNLL1	0	ZMYM3	0	affinity chromatography technology	Hein MY (2015)	1
SUMO2	0	TRIM28	1	pull down	Ouyang J (2009)	1
EGFR	5	TRIM28	1	affinity chromatography technology	Liccardi G (2014)	1
CUL3	17	CCT2	1	affinity chromatography technology	Bennett EJ (2010)	1
CBX3	1	CHD4	22	affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Hauri S (2016)	2
CUL3	17	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	ZRANB2	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SRPK2	1	affinity chromatography technology	Bennett EJ (2010)	1
CBX3	1	TRIM28	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Bandyopadhyay S (2010), Ryan RF (1999), Higo S (2010), Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	7
ZMYM4	4	ACTC1	5	affinity chromatography technology	Hauri S (2016)	1
PCK2	3	ZMYM3	0	affinity chromatography technology	Huttlin EL (2017)	1
CHAMP1	8	ZMYM4	4	affinity chromatography technology	Hein MY (2015)	1
ZMYM4	4	TRIM28	1	affinity chromatography technology	Hauri S (2016)	1
SUMO2	0	POGZ	49	pull down	Ouyang J (2009)	1
FBL	1	RNF19B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST3H3	0	CBX1	0	unspecified method, unspecified method, affinity chromatography technology, unspecified method	Kaustov L (2011), Pichler G (2012), Pichler G (2012), Vermeulen M (2010)	4
CBX1	0	POGZ	49	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016)	4
CBX3	1	ZSWIM9	0	affinity chromatography technology	Hauri S (2016)	1
ZMYM4	4	KDM1A	2	affinity chromatography technology	Hauri S (2016)	1
DYNLL1	0	ADNP	37	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	ZMYM4	4	affinity chromatography technology	Castello A (2012)	1
SRPK2	1	ZRANB2	0	enzymatic study	Varjosalo M (2013)	1
CUL3	17	FBL	1	affinity chromatography technology	Bennett EJ (2010)	1
DYNLL1	0	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hauri S (2016)	2
TRIM28	1	HIST3H3	0	affinity chromatography technology	Kubota S (2013)	1
UBQLN4	2	NXF1	0	two hybrid	Lim J (2006)	1
FOXJ2	3	ZMYM3	0	affinity chromatography technology	Li X (2015)	1
NXF1	0	ROR2	0	affinity chromatography technology	Castello A (2012)	1
GMNN	0	ZMYM4	4	biochemical	Wan C (2015)	1
CBX3	1	POGZ	49	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016)	4
ZMYM4	4	ZMYM3	0	affinity chromatography technology	Hauri S (2016)	1
FOXE1	2	ADNP	37	affinity chromatography technology	Li X (2015)	1
ROR2	0	ZMYM4	4	two hybrid	Rolland T (2014)	1
CUL3	17	ILVBL	4	affinity chromatography technology	Bennett EJ (2010)	1
FHL2	0	ZMYM4	4	two hybrid	Rolland T (2014)	1
SUMO2	0	CHAMP1	8	pull down	Ouyang J (2009)	1
HIST3H3	0	CHAMP1	8	unspecified method	Vermeulen M (2010)	1
CBX1	0	ZMYM4	4	affinity chromatography technology	Hauri S (2016)	1
SCGN	1	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBL	1	CTCF	15	affinity chromatography technology	Huttlin EL (2015)	1
CUL3	17	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
NXF1	0	POGZ	49	affinity chromatography technology	Castello A (2012)	1
RCOR1	0	HIST3H3	0	enzymatic study	Shi Y (2003)	1
POGZ	49	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Vermeulen M (2010), Hein MY (2015)	3
EGFR	5	ILVBL	4	affinity chromatography technology	Tong J (2014)	1
CLEC3A	2	ZMYM4	4	affinity chromatography technology	Huttlin EL (2017)	1
PCK2	3	ZMYM2	5	affinity chromatography technology	Huttlin EL (2017)	1
HIST3H3	0	CBX3	1	unspecified method, x-ray crystallography, unspecified method	Kaustov L (2011), Kaustov L (2011), Vermeulen M (2010)	3
CUL3	17	SNRPE	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL13	0	ZMYM4	4	affinity chromatography technology	Sowa ME (2009)	1
HNRNPL	3	ZMYM4	4	affinity chromatography technology	Fei T (2017)	1
CBX3	1	E2F6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogawa H (2002), Hauri S (2016), Hauri S (2016)	3
KDM1A	2	TRIM28	1	affinity chromatography technology	Cui S (2011)	1
RHOC	0	ZMYM4	4	affinity chromatography technology	Huttlin EL (2017)	1
HIST3H3	0	POGZ	49	affinity chromatography technology, unspecified method	Vermeulen M (2010), Vermeulen M (2010)	2
ZMYM4	4	RCOR1	0	affinity chromatography technology	Hauri S (2016)	1
FOXE1	2	ZMYM4	4	affinity chromatography technology	Li X (2015)	1
CHD4	22	HIST3H3	0	unspecified method, unspecified method, affinity chromatography technology	Morra R (2012), Vermeulen M (2010), Quan J (2014)	3
FOXE1	2	HNRNPL	3	affinity chromatography technology	Li X (2015)	1
MOV10	6	POGZ	49	affinity chromatography technology	Castello A (2012)	1
ZMYM4	4	SNRPE	0	affinity chromatography technology	Hauri S (2016)	1
CBX6	1	MOV10	6	affinity chromatography technology	Vandamme J (2011)	1
PCK2	3	ZMYM4	4	affinity chromatography technology	Huttlin EL (2017)	1
CBX3	1	ADNP	37	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	4
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
ZMYM4	4	ZSWIM9	0	affinity chromatography technology	Hauri S (2016)	1
UBQLN1	1	ZMYM3	0	biochemical	Wan C (2015)	1
FOXE1	2	CHD4	22	affinity chromatography technology	Li X (2015)	1
E2F6	2	ZMYM4	4	affinity chromatography technology	Hauri S (2016)	1
CUL3	17	ZMYM4	4	affinity chromatography technology	Bennett EJ (2010)	1
CIPC	2	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SUMO2	0	ZMYM4	4	pull down	Ouyang J (2009)	1
NXF1	0	FBL	1	affinity chromatography technology	Castello A (2012)	1
FOXJ2	3	ZMYM2	5	affinity chromatography technology	Li X (2015)	1
ZMYM4	4	UBQLN1	1	two hybrid, biochemical	Rolland T (2014), Wan C (2015)	2
UBQLN4	2	RUNX1T1	1	two hybrid	Lim J (2006)	1
CHD4	22	KDM1A	2	affinity chromatography technology, affinity chromatography technology	Cui S (2011), Cui S (2011)	2
ZSCAN5A	1	KDM1A	2	affinity chromatography technology	Huttlin EL (2017)	1
FBL	1	YY1AP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZMYM4	4	CHD4	22	affinity chromatography technology	Hauri S (2016)	1
EGFR	5	FBL	1	affinity chromatography technology	Tong J (2014)	1
HIST3H3	0	HNRNPL	3	unspecified method	Vermeulen M (2010)	1
ZMYM4	4	ADNP	37	affinity chromatography technology	Hauri S (2016)	1
CBX3	1	DYNLL1	0	affinity chromatography technology	Hauri S (2016)	1
ZMYM2	5	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Gocke CB (2008), Hauri S (2016)	2
DYNLL1	0	DYNLL2	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
CBX1	0	ADNP	37	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	4
SUMO2	0	ZMYM2	5	pull down, two hybrid, pull down, pull down, affinity chromatography technology	Gocke CB (2008), Hecker CM (2006), Ouyang J (2009), Guzzo CM (2014), Guzzo CM (2014)	5
CBX3	1	ZMYM3	0	affinity chromatography technology	Hauri S (2016)	1
HNRNPL	3	SRPK2	1	affinity chromatography technology	Fei T (2017)	1
MOV10	6	CIPC	2	affinity chromatography technology	Castello A (2012)	1
CUL3	17	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
SRPK2	1	NXF1	0	enzymatic study	Lipp JJ (2015)	1
CCT2	1	TRIM28	1	biochemical	Havugimana PC (2012)	1
ZSCAN5A	1	ZMYM2	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
RNF19B	0	ZMYM4	4	affinity chromatography technology	Huttlin EL (2017)	1
KDM1A	2	ZMYM2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Gocke CB (2008), Shi YJ (2005), Lee MG (2005)	4
CBX1	0	DYNLL1	0	affinity chromatography technology	Hauri S (2016)	1
FBL	1	ZMYM4	4	affinity chromatography technology	Huttlin EL (2015)	1
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
MOV10	6	ZMYM4	4	affinity chromatography technology	Castello A (2012)	1
CHAMP1	8	CBX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	3
FOXJ2	3	CHD4	22	affinity chromatography technology	Li X (2015)	1
EGFR	5	ZMYM4	4	affinity chromatography technology	Yao Z (2017)	1
ZMYM4	4	CCT2	1	affinity chromatography technology	Hauri S (2016)	1
SRPK2	1	ZMYM4	4	enzymatic study	Lipp JJ (2015)	1
RUNX1T1	1	ZMYM4	4	two hybrid	Rolland T (2014)	1
SUMO2	0	CHD4	22	pull down	Ouyang J (2009)	1