PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GORAB	1	APP	1	pull down	Olah J (2011)	1
FBXO7	1	GORAB	1	enzymatic study	Teixeira FR (2016)	1
RCHY1	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Corcoran CA (2009), Wang L (2011), Wang L (2011), Corcoran CA (2009)	4
TMEM216	0	GORAB	1	bioid	Gupta GD (2015)	1
FBXO7	1	FARSA	6	affinity chromatography technology	Teixeira FR (2016)	1
IL17RE	1	GORAB	1	affinity chromatography technology	Huttlin EL (2017)	1
GORAB	1	NKG7	0	two hybrid	Wang J (2011)	1
MDM2	2	GORAB	1	affinity chromatography technology, affinity chromatography technology, pull down	Yan J (2010), Yan J (2010), Yan J (2010)	3
GORAB	1	NEDD4L	3	two hybrid	Wang J (2011)	1
GORAB	1	RCHY1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Zhang L (2005), Zhang L (2005), Zhang L (2005), Zhang L (2005), Wang J (2011)	5
BET1L	0	GORAB	1	two hybrid	Wang J (2011)	1
TMEM17	0	GORAB	1	bioid	Gupta GD (2015)	1
TMEM216	0	APP	1	bioid	Gupta GD (2015)	1
FARSA	6	GORAB	1	two hybrid	Wang J (2011)	1
TMEM216	0	BET1L	0	bioid	Gupta GD (2015)	1
GORAB	1	SCYL1	5	two hybrid	Wang J (2011)	1
SCYL1	5	APP	1	pull down	Olah J (2011)	1
TMEM17	0	BET1L	0	bioid	Gupta GD (2015)	1
BET1L	0	APP	1	pull down	Olah J (2011)	1
GORAB	1	HSD17B7	1	two hybrid	Wang J (2011)	1
GORAB	1	HOXD9	1	two hybrid	Wang J (2011)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
TMEM17	0	SCYL1	5	bioid	Gupta GD (2015)	1
GORAB	1	PTAFR	1	two hybrid	Wang J (2011)	1
LMO2	2	GORAB	1	affinity chromatography technology	Huttlin EL (2017)	1
GORAB	1	ZNF16	2	two hybrid	Wang J (2011)	1
CRKL	1	GORAB	1	affinity chromatography technology	Hein MY (2015)	1