PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SPEN	22	RUNX1	0	unspecified method	Salat D (2008)	1
UBE2L6	0	LONRF1	4	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBA1	1	UBE2L6	0	enzymatic study	Kumar S (1997)	1
TYK2	1	SIAH2	0	affinity chromatography technology	Mueller S (2014)	1
NEDD4L	3	UBE2L6	0	pull down	Todaro DR (2017)	1
MCM2	3	MAP3K1	4	affinity chromatography technology	Drissi R (2015)	1
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
XIAP	0	ARHGDIA	3	affinity chromatography technology, affinity chromatography technology	Liu J (2011), Liu J (2012)	2
UBE2L6	0	FLT3	5	affinity chromatography technology, pull down	Buchwald M (2010), Buchwald M (2010)	2
UBA7	2	ISG15	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Takeuchi T (2006), Zhao C (2005), Bade VN (2012), Pitha-Rowe I (2004), Aichem A (2010), Rolland T (2014)	7
TRIM25	5	RNF216	2	affinity chromatography technology	Choudhury NR (2017)	1
UBE2L6	0	DTX3	4	two hybrid	Markson G (2009)	1
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
SIAH2	0	UBE2L6	0	affinity chromatography technology	Wheeler TC (2002)	1
ISG15	0	UBE2L6	0	affinity chromatography technology	Zhao C (2005)	1
RNF19A	3	UBE2L6	0	affinity chromatography technology	Niwa J (2001)	1
UBE2L6	0	ARIH2	4	two hybrid, affinity chromatography technology, two hybrid	Markson G (2009), Pietschmann K (2012), Rolland T (2014)	3
RBX1	2	UBE2L6	0	pull down	Johansson P (2014)	1
ARIH2	4	TRIM27	2	two hybrid	Woodsmith J (2012)	1
UBE2L6	0	RNF122	0	two hybrid	van Wijk SJ (2009)	1
TYK2	1	UBE2L6	0	affinity chromatography technology	Mueller S (2014)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
UBE2L6	0	CBLC	1	two hybrid	Markson G (2009)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
HERC5	2	UBE2L6	0	pull down	Shi HX (2010)	1
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
RAD21	3	UBA1	1	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
UBE2L6	0	TRAF7	11	two hybrid	Markson G (2009)	1
UBA6	4	UBE2L6	0	enzymatic study	Huang DT (2009)	1
UBE3A	4	UBE2L6	0	fluorescent resonance energy transfe, enzymatic study	Eletr ZM (2007), Kumar S (1997)	2
PRKN	1	HERC5	2	affinity chromatography technology, affinity chromatography technology	Im E (2016), Im E (2016)	2
TRIM25	5	TRAF7	11	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K1	4	RBCK1	0	enzymatic study	Charlaftis N (2014)	1
RAD21	3	MCM2	3	affinity chromatography technology	Panigrahi AK (2011)	1
UBE2L6	0	ARIH1	3	affinity chromatography technology	Pietschmann K (2012)	1
UBE2L6	0	RNF150	2	two hybrid	van Wijk SJ (2009)	1
BIRC2	1	UBE2L6	0	affinity chromatography technology	Hu S (2003)	1
RNF216	2	UBE2L6	0	affinity chromatography technology	Chuang TH (2004)	1
HERC6	0	UBE2L6	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2L6	0	RBCK1	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
RNF40	11	UBE2L6	0	affinity chromatography technology	Chin LS (2002)	1
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
UBE2L6	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
UBE2L6	0	RNF144B	0	two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Huang J (2006)	3
UBE2L6	0	ARHGDIA	3	two hybrid	Vinayagam A (2011)	1
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
ISG15	0	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Zou W (2007), Zou W (2007)	2
SIAH1	2	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008)	2
PRKN	1	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
RNF19B	0	UBE2L6	0	affinity chromatography technology	Fortier JM (2006)	1
UBE2L6	0	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2L6	0	RUNX1	0	pull down	Kraemer OH (2008)	1
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
MCM2	3	SIAH2	0	affinity chromatography technology	Drissi R (2015)	1
UBE2L6	0	UBE2L6	0	enzymatic study, pull down	David Y (2010), David Y (2010)	2
TRIM27	2	RBX1	2	two hybrid	Woodsmith J (2012)	1
XIAP	0	UBE2L6	0	affinity chromatography technology	Hu S (2003)	1
ARHGDIA	3	NEDD4L	3	two hybrid	Stelzl U (2005)	1
UBE2L6	0	TRIM25	5	affinity chromatography technology	Urano T (2002)	1
BIRC2	1	CBLC	1	two hybrid	Woodsmith J (2012)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
TRIM25	5	RNF4	1	affinity chromatography technology	Choudhury NR (2017)	1
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TRIM25	5	ARIH1	3	affinity chromatography technology	Choudhury NR (2017)	1
RAD21	3	UBE2L6	0	affinity chromatography technology	Panigrahi AK (2011)	1
UBE2L6	0	RNF4	1	two hybrid	van Wijk SJ (2009)	1
XIAP	0	LONRF1	4	two hybrid	Rolland T (2014)	1
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
XIAP	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
TRIM25	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2L6	0	RNF125	0	two hybrid	Markson G (2009)	1
MCM2	3	UBE2L6	0	affinity chromatography technology	Drissi R (2015)	1
UBE2L6	0	TRIM27	2	two hybrid	Markson G (2009)	1
SIAH1	2	XIAP	0	affinity chromatography technology, affinity chromatography technology	Garrison JB (2011), Garrison JB (2011)	2
UBE2L6	0	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
UBE2L6	0	TIMM8A	0	affinity chromatography technology	Pietschmann K (2012)	1
UBE2L6	0	SIAH1	2	pull down	Kraemer OH (2008)	1
SIAH1	2	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBA7	2	UBE2L6	0	enzymatic study	Huang DT (2009)	1
MCM2	3	SIAH1	2	affinity chromatography technology	Drissi R (2015)	1
SPEN	22	UBE2L6	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Li J (2006), Li J (2006), Li J (2006), Li J (2006)	4
SIAH1	2	FLT3	5	pull down, affinity chromatography technology	Buchwald M (2010), Buchwald M (2010)	2
UBE2L6	0	PJA2	4	two hybrid	van Wijk SJ (2009)	1
PRKN	1	UBE2L6	0	affinity chromatography technology, affinity chromatography technology, pull down	Zhang Y (2000), Um JW (2012), Chaugule VK (2011)	3
UBE2L6	0	RNF144A	1	two hybrid, two hybrid	Markson G (2009), Martinez-Noel G (2001)	2
ISG15	0	HERC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Wong JJ (2006), Woods MW (2014)	3
UBE2L6	0	RNF25	1	two hybrid	van Wijk SJ (2009)	1
UBE2L6	0	MUL1	1	two hybrid	van Wijk SJ (2009)	1