PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MVP	1	TCF4	26	two hybrid	Corominas R (2014)	1
DISC1	6	NDE1	2	two hybrid	Corominas R (2014)	1
DISC1	6	GPRASP2	0	two hybrid	Camargo LM (2007)	1
CACNA1A	21	TSPOAP1	9	two hybrid, affinity chromatography technology	Kahle JJ (2011), Kahle JJ (2011)	2
TSPOAP1	9	TSC22D4	1	two hybrid	Corominas R (2014)	1
NDE1	2	TSPOAP1	9	two hybrid	Corominas R (2014)	1
TSPOAP1	9	TSPO	1	two hybrid, pull down	Galiegue S (1999), Galiegue S (1999)	2
NDE1	2	ARNT2	5	two hybrid	Corominas R (2014)	1
TSPOAP1	9	TSPOAP1	9	two hybrid	Corominas R (2014)	1
KIF1A	19	TSPOAP1	9	two hybrid	Corominas R (2014)	1
TSPOAP1	9	BEND5	0	two hybrid	Corominas R (2014)	1
DLGAP2	4	TSPOAP1	9	two hybrid	Corominas R (2014)	1
NDE1	2	REL	5	two hybrid	Corominas R (2014)	1
TSPOAP1	9	DLX2	0	two hybrid	Corominas R (2014)	1
MVP	1	TSPOAP1	9	two hybrid	Corominas R (2014)	1
TSPOAP1	9	TCF4	26	two hybrid	Corominas R (2014)	1
ARNT2	5	REL	5	two hybrid	Corominas R (2014)	1
KHDRBS1	1	TSPOAP1	9	unspecified method	Asbach B (2012)	1
TSPOAP1	9	CEP76	1	two hybrid	Corominas R (2014)	1
RAPGEF4	8	TSPOAP1	9	two hybrid	Corominas R (2014)	1
CADPS2	0	TSPOAP1	9	two hybrid	Corominas R (2014)	1
ANKRD11	72	TSPOAP1	9	two hybrid	Corominas R (2014)	1
TSPOAP1	9	GPRASP2	0	two hybrid	Corominas R (2014)	1
TSPOAP1	9	REL	5	two hybrid	Corominas R (2014)	1
MVP	1	DLX2	0	two hybrid	Corominas R (2014)	1
MVP	1	DISC1	6	two hybrid	Corominas R (2014)	1
CD244	1	TSPOAP1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MVP	1	REL	5	two hybrid	Corominas R (2014)	1
ARNT2	5	TSPOAP1	9	two hybrid	Corominas R (2014)	1
TSPOAP1	9	DISC1	6	two hybrid	Corominas R (2014)	1